A novel allosteric inhibitor of the uridine diphosphate N-acetylglucosamine pyrophosphorylase from Trypanosoma brucei

ACS Chemical Biology

Volumn 8, Issue 9, 2013, Pages 1981-1987

  Urbaniak, Michael D ^a   Collie, Iain T ^a   Fang, Wenxia ^a   Aristotelous, Tonia ^a   Eskilsson, Susanne ^a   Raimi, Olawale G ^a   Harrison, Justin ^a   Navratilova, Iva Hopkins ^a   Frearson, Julie A ^a   Van Aalten, Daan M F ^a   Ferguson, Michael A J ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME INHIBITOR; PHOSPHORYLASE; RECOMBINANT ENZYME; UNCLASSIFIED DRUG; URIDINE DIPHOSPHATE N ACETYLGLUCOSAMINE PYROPHOSPHORYLASE; URIDINE DIPHOSPHATE N ACETYLGLUCOSAMINE PYROPHOSPHORYLASE INHIBITOR;

AFRICAN TRYPANOSOMIASIS; ALLOSTERISM; ARTICLE; CONFORMATIONAL TRANSITION; DRUG BINDING SITE; DRUG SELECTIVITY; ENZYME KINETICS; ENZYME MECHANISM; ENZYME SUBSTRATE COMPLEX; HIGH THROUGHPUT SCREENING; METABOLITE; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; TRYPANOSOMA BRUCEI;

ALLOSTERIC REGULATION; CATALYTIC DOMAIN; HUMANS; NUCLEOTIDYLTRANSFERASES; PROTEIN CONFORMATION; TRYPANOCIDAL AGENTS; TRYPANOSOMA BRUCEI BRUCEI; TRYPANOSOMIASIS, AFRICAN; URIDINE DIPHOSPHATE N-ACETYLGLUCOSAMINE;

EID: 84884656627     PISSN: 15548929     EISSN: 15548937     Source Type: Journal    
DOI: 10.1021/cb400411x     Document Type: Article

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