Does personality affect risk for dementia? a systematic review and meta-analysis

American Journal of Geriatric Psychiatry

Volumn 21, Issue 8, 2013, Pages 713-728

  Low, Lee Fay ^a   Harrison, Fleur ^a,b   Lackersteen, Steven M ^a  

^a UNIVERSITY OF NEW SOUTH WALES   (Australia)

^b Faculty of Medicine Nursing and Health Sciences   (Australia)

Author keywords

Agreeableness; Alzheimer disease; Conscientiousness; Dementia; Extraversion; Five factor model; Harm avoidance; Meta analysis; Mild cognitive impairment; Neuroticism; Openness; Personality; Systematic review

Indexed keywords

ARTICLE; COGNITIVE DEFECT; CONSCIENCE; DEMENTIA; DISEASE ASSOCIATION; EXTRAVERSION; HUMAN; META ANALYSIS; NEUROSIS; PERSONALITY; RISK ASSESSMENT; RISK FACTOR; STATISTICAL ANALYSIS; SYSTEMATIC REVIEW;

AGREEABLENESS; ALZHEIMER DISEASE; CONSCIENTIOUSNESS; DEMENTIA; EXTRAVERSION; FIVE-FACTOR MODEL; HARM AVOIDANCE; META-ANALYSIS; MILD COGNITIVE IMPAIRMENT; NEUROTICISM; OPENNESS; PERSONALITY; SYSTEMATIC REVIEW;

DEMENTIA; HUMANS; MILD COGNITIVE IMPAIRMENT; PERSONALITY; RISK FACTORS;

EID: 84884641171     PISSN: 10647481     EISSN: 15457214     Source Type: Journal    
DOI: 10.1016/j.jagp.2012.08.004     Document Type: Article

References (92)

1. Whalley LJ, Dick FD, McNeill G: A life-course approach to the aetiology of late-onset dementias. Lancet Neurol 2006; 5: 87-96
2. Krueger RF, Caspi A, Moffitt TE: Epidemiological personology: the unifying role of personality in population-based research on problem behaviors. J Person 2000; 68: 967-998
3. Friedman HS: Long-term relations of personality and health: dynamisms, mechanisms, tropisms. J Person 2000; 68: 1089-1107
4. Roberts BW, Kuncel NR, Shiner R, et al: The power of personality: the comparative validity of personality traits, socioeconomic status, and cognitive ability for predicting important life outcomes. Perspect Psychol Sci 2007; 2: 313-345
5. Chapman BP, Roberts B, Duberstein P: Personality and longevity: knowns, unknowns, and implications for public health and personalized medicine. J Aging Res 2011; 759170
6. Lahey BB: Public health significance of neuroticism. Am Psychol 2009; 64: 241-256
7. Deary IJ, Weiss A, Batty GD: Intelligence and personality as predictors of illness and death: how researchers in differential psychology and chronic disease epidemiology are collaborating to understand and address health inequalities. Psychol Sci Public Int 2010; 11(Suppl): 53-79
8. Costa PTJ, McCrae RR: Revised NEO Personality Inventory (NEOPI- R) and NEO Five-Factor Inventory (NEO-FFI) Manual. Odessa, FL, Psychological Assessment Resources, 1992
9. Caspi A, Roberts BW, Shiner RL: Personality development: stability and change. Annu Rev Psychol 2005; 56: 453-484
10. Roberts BW, Walton KE, Viechtbauer W: Patterns of mean-level change in personality traits across the life course: a metaanalysis of longitudinal studies. Psychol Bull 2006; 132: 1-25
11. Löckenhoff CE, Terracciano A, Patriciu NS, et al: Self-reported extremely adverse life events and longitudinal changes in fivefactor model personality traits in an urban sample. J Trauma Stress 2009; 22: 53-59
12. Tang TZ, DeRubeis RJ, Hollon SD, et al: Personality change during depression treatment: a placebo-controlled trial. Arch Gen Psychiatry 2009; 66: 1322-1330
13. Jackson JJ, Hill PL, Payne BR, et al: Can an old dog learn (and want to experience) new tricks? Cognitive training increases openness to experience in older adults. Psychol Aging 2012; 27: 286-292
14. Friedman HS: The multiple linkages of personality and disease. Brain Behav Immun 2008; 22: 668-675
15. Smith TW, MacKenzie J: Personality and risk of physical illness. Ann Rev Clin Psychol 2006; 2: 435-467
16. Ackerman PL,Heggestad ED: Intelligence, personality, and interests: evidence for overlapping traits. Psychol Bull 1997; 121: 219-245
17. Valenzuela MJ, Sachdev P: Brain reserve and dementia: a systematic review. Psychol Med 2006; 36: 441-454
18. Kendler KS, Gardner CO, Prescott CA: Personality and the experience of environmental adversity. Psychol Med 2003; 33: 1193-1202
19. Gunthert KC, Cohen LH, Armeli S: The role of neuroticism in daily stress and coping. J Perspect Soc Psychol 1999; 77: 1087-1100
20. Johansson L, Guo X, Waern M, et al: Midlife psychological stress and risk of dementia: a 35-year longitudinal population study. Brain 2010; 133: 2217-2224
21. Crowe M, Andel R, Pedersen NL, et al: Do work-related stress and reactivity to stress predict dementia more than 30 years later? Alzheimer Dis Assoc Disord 2007; 21: 205-209
22. Fanous A, Gardner CO, Prescott CA, et al: Neuroticism, major depression and gender: a population-based twin study. Psychol Med 2002; 32: 719-728
23. Hayward RD, Taylor WD, Smoski MJ, et al: Association of fivefactor model personality domains and facets with presence, onset, and treatment outcomes of major depression in older adults. Am J Geriatr Psychiatry 2013; 21: 88-96
24. Jorm AF: Is depression a risk factor for dementia or cognitive decline? Gerontology 2000; 46: 219-227
25. Karney BR, Bradbury TN: The longitudinal course of marital quality and stability: a review of theory, method, and research. Psychol Bull 1995; 118: 3-34
26. Hakansson K, Rovio S, Helkala E-L, et al: Association between mid-life marital status and cognitive function in later life: population based cohort study. BMJ 2009; 339; b2462
27. Kendler KS, Neale MC, Sullivan P, et al: A population-based twin study in women of smoking initiation and nicotine dependence. Psychol Med 1999; 29: 299-308
28. Heath AC, Bucholz KK, Madden PAF, et al: Genetic and environmental contributions to alcohol dependence risk in a national twin sample: consistency of findings in women and men. Psychol Med 1997; 27: 1381-1396
29. Hong RY, Paunonen SV: Personality traits and health-risk behaviours in university students. Eur J Person 2009; 23: 675-696
30. Terracciano A, Sutin AR, McCrae RR, et al: Facets of personality linked to underweight and overweight. Psychosom Med 2009; 71: 682-689
31. Anstey KJ, Cherbuin N, Budge M, et al: Body mass index in midlife and late-life as a risk factor for dementia: a meta-analysis of prospective studies. Obes Rev 2011; 12:e426-e437
32. Anstey KJ, von Sanden C, Salim A, et al: Smoking as a risk factor for dementia and cognitive decline: a meta-analysis of prospective studies. Am J Epidemiol 2007; 166: 367-378
33. Letenneur L: Risk of dementia and alcohol and wine consumption: a review of recent results. Biol Res 2004; 37: 189-193
34. Jonassaint CR, Siegler IC, Barefoot JC, et al: Low life course socioeconomic status (SES) is associated with negative NEO PI-R personality patterns. Int J Behav Med 2011; 18: 13-21
35. Al Hazzouri AZ, Haan MN, Kalbfleisch JD, et al: Life-course socioeconomic position and incidence of dementia and cognitive impairment without dementia in older Mexican Americans: results from the Sacramento Area Latino Study on Aging. Am J Epidemiol 2011; 173: 1148-1158
36. Petersen RC: Mild cognitive impairment as a diagnostic entity. J Intern Med 2004; 256: 183-194
37. Balsis S, Carpenter BD, Storandt M: Personality change precedes clinical diagnosis of dementia of the Alzheimer type. J Gerontol B Psychol Sci Soc Sci 2005; 60:P98-P101
38. Wilson RS, Evans DA, Bienias JL, et al: Proneness to psychological distress is associated with risk of Alzheimer's disease. Neurology 2003; 61: 1479-1485
39. StatCorp: Statistical Software: Release 10.0. College Station, TX, Stata Corporation, 2007
40. Higgins JPT, Thompson SG: Quantifying heterogeneity in a metaanalysis. Stat Med 2002; 21: 1539-1558
41. Tang J: Weighting bias in meta-analysis of binary outcomes. J Clinical Epidemiol 2000; 53: 1130-1136
42. Duberstein PR, Chapman BP, Tindle HA, et al: Personality and risk for Alzheimer's disease in adults 72 years of age and older: a 6-year follow-up. Psychol Aging 2011; 26: 351-362
43. Glosser G, Clark C, Freundlich B, et al: A controlled investigation of current and premorbid personality: Characteristics of Parkinson's disease patients. Mov Disord 1995; 10: 201-206
44. Hagnell O, Franck A, Grasbeck A, et al: Senile dementia of the Alzheimer type in the Lundby study. II. An attempt to identify possible risk factors. Eur Arch Psychiatry Clin Neurosci 1992; 241: 231-235
45. Kuzma E, Sattler C, Toro P, et al: Premorbid personality traits and their course in mild cognitive impairment: results from a prospective population-based study in Germany. Dement Geriatr Cogn Disord 2011; 32: 171-177
46. Meins W, Dammast J: Do personality traits predict the occurrence of Alzheimer's disease? Int J Geriatr Psychiatry 2000; 15: 120-124
47. Nicholas H, Moran P, Foy C, et al: Are abnormal premorbid personality traits associated with Alzheimer's disease? A casecontrol study. Int J Geriatr Psychiatry 2010; 25: 345-351
48. Persson G, Berg S, Nilsson L, et al: Subclinical dementia. Relation to cognition, personality and psychopathology: a nine-year prospective study. Int J Geriatr Psychiatry 1991; 6: 239-247
49. Wang HXP, Karp AP, Herlitz AP, et al: Personality and lifestyle in relation to dementia incidence. Neurology 2009; 72: 253-259
50. Wilson RS, Barnes LL, Bennett DA, et al: Proneness to psychological distress and risk of Alzheimer disease in a biracial community. Neurology 2005; 64: 380-382
51. Wilson RS, Arnold SE, Schneider JA, et al: Chronic psychological distress and risk of Alzheimer's disease in old age. Neuroepidemiology 2006; 27: 143-153
52. Wilson RS, Schneider JA, Arnold SE, et al: Conscientiousness and the incidence of Alzheimer disease and mild cognitive impairment. Arch Gen Psychiatry 2007; 64: 1204-1212
53. Wilson RS, Schneider JA, Boyle PA, et al: Chronic distress and incidence of mild cognitive impairment. Neurology 2007; 68: 2085-2092
54. Wilson RS, Begeny CT, Boyle PA, et al: Vulnerability to stress, anxiety, and development of dementia in old age. Am J Geriatr Psychiatry 2011; 19: 327-334
55. Wilson RS, Boyle PA, Buchman AS, et al: Harm avoidance and risk of Alzheimer's disease. Psychosom Med 2011; 73: 690-696
56. Von Zerssen D, Pfister H, Koeller DM: The Munich Personality Test (MPT)-a short questionnaire for self-rating and relatives' rating of personality traits: formal properties and clinical potential. Eur Arch Psychiatry Neurol Sci 1988; 238: 73-93
57. Eysenck HJ, Eysenck SBG: Manual of the Eysenck Personality Questionnaire. London, Hodder & Stoughton, 1975
58. Eysenck HJ: The questionnaire measurement of neuroticism and extraversion. Riv Psychol 1956; 50: 113-140
59. Sjöbring H: Personality structure and development. A model and its application. Acta Psychiatr Scand 1973; 244(Suppl): 1-20
60. Nyman GE, Marke S: Sjöbrings Differentiella Psykologi. Analys och Skalkonstruktion. Stockholm, Gleerups, 1962
61. Cesarec Z, Marke S: Mätning av psykogena Behov Med Frågeformulärsteknik. Stockholm, Skandinaviska Testförlaget, 1968
62. Cloninger CR, Przybeck TR, Svrakic DM, et al: The Temperament and Character Inventory (TCI): A Guide to Its Development and Use. St. Louis, MO, Center for Psychobiology of Personality, 1994
63. Segraves RT: Intercorrelations between the Sjöbring and Eysenckian personality dimensions. Acta Psychiatr Scand 1971; 47: 288-294
64. Von Zerssen D: Personality traits as vulnerability markers- problems of assessment. Fortschr Neurol Psychiatr 1994; 62: 1-13
65. Wilson RS, Arnold SE, Schneider JA, et al: Chronic distress, agerelated neuropathology, and late-life dementia. Psychosom Med 2007; 69: 47-53
66. Boyle LL, Lyness JM, Duberstein PR, et al: Trait neuroticism, depression, and cognitive function in older primary care patients. Am J Geriatr Psychiatry 2010; 18: 305-312
67. Chapman B, Duberstein P, Tindle HA, et al: Personality predicts cognitive function over 7 years in older persons. Am J Geriatr Psychiatry 2012; 20: 612-621
68. Knutson B, Momenan R, Rawlings RR, et al: Negative association of neuroticism with brain volume ratio in healthy humans. Biol Psychiatry 2001; 50: 685-690
69. Jackson J, Balota DA, Head D: Exploring the relationship between personality and regional brain volume in healthy aging. Neurobiol Aging 2011; 32: 2162-2171
70. Sapolsky RM: Depression, antidepressants, and the shrinking hippocampus. Proc Natl Acad Sci USA 2001; 98: 12320-12322
71. Lee AL, Ogle WO, Sapolsky RM: Stress and depression: possible links to neuron death in the hippocampus. Bipolar Dis 2002; 4: 117-128
72. Woon FL, Sood S, Hedges DW: Hippocampal volume deficits associated with exposure to psychological trauma and posttraumatic stress disorder in adults: a meta-analysis. Progr Neuropsychopharmacol Biol Psychiatry 2010; 34: 1181-1188
73. Bogg T, Roberts BW: Conscientiousness and health-related behaviors: a meta-analysis of the leading behavioral contributors to mortality. Psychol Bull 2004; 130: 887-919
74. Järvenpää T, Rinne JO, Koskenvuo M, et al: Binge drinking in midlife and dementia risk. Epidemiology 2005; 16: 766-771
75. Scarmeas N, Luchsinger JA, Schupf N, et al: Physical activity, diet, and risk of Alzheimer disease. JAMA 2009; 302: 627-637
76. Wajman JR, Bertolucci PHFF: Intellectual demand and formal education as cognitive protection factors in Alzheimer's disease. Dement Neuropsychol 2010; 4: 320-324
77. Karp A, Paillard-Borg S, Wang HX, et al: Mental, physical and social components in leisure activities equally contribute to decrease dementia risk. Dement Geriatr Cogn Disord 2006; 21: 65-73
78. Raine A, Venables PH, Reynolds C, et al: Stimulation seeking and intelligence: a prospective longitudinal study. J Perspect Soc Psychol 2002; 82: 663-673
79. Bagby RM, Neil AR, Kirstin B, et al: Self-report ratings and informants' ratings of personalities of depressed outpatients. Am J Psychiatry 1998; 155:437
80. Archer N, Brown RG, Boothby H, et al: The NEO-FFI is a reliable measure of premorbid personality in patients with probable Alzheimer's disease. Int J Geriatr Psychiatry 2006; 21: 477-484
81. Robins Wahlin TB: Byrne GJ: Personality changes in Alzheimer's disease: a systematic review. Int J Geriatr Psychiatry 2011; 26: 1019-1029
82. Jack CR Jr, Lowe VJ, Weigand SD, et al: Serial pib and MRI in normal, mild cognitive impairment and Alzheimer's disease: Implications for sequence of pathological events in Alzheimer's disease. Brain 2009; 132: 1355-1365
83. Kern ML, Friedman HS: Do conscientious individuals live longer? A quantitative review. Health Psych 2008; 27: 505-512
84. Ploubidis GB, Grundy E: Personality and all cause mortality: evidence for indirect links. Person Individ Diff 2009; 47: 203-208
85. Shipley BA, Weiss A, Der G, et al: Neuroticism, extraversion, and mortality in the UK Health and Lifestyle Survey: a 21-year prospective cohort study. Psychosom Med 2007; 69: 923-931
86. Friedman HS, Kern ML, Reynolds CA: Personality and health, subjective well-being, and longevity. J Personality 2010; 78: 179-216
87. Taylor MD, Whiteman MC, Fowkes GR, et al: Five factor model personality traits and all-cause mortality in the Edinburgh Artery Study Cohort. Psychosom Med 2009; 71: 631-641
88. Fry PS, Debats DL: Perfectionism and the five-factor personality traits as predictors of mortality in older adults. J Health Psychol 2009; 14: 513-524
89. Nabi H, Kivimaki M, Sabia S, et al: Hostility and trajectories of body mass index over 19 years: the Whitehall II Study. Am J Epidemiol 2009; 169: 347-354
90. Jonassaint CR, Boyle SH, Kuhn CM, et al: Personality and inflammation: the protective effect of openness to experience. Ethn Dis 2010; 20: 11-14
91. Palmgreen P, Lorch EP, Donohew L, et al: Reaching at-risk populations in a mass media drug abuse prevention campaign: sensation seeking as a targeting variable. Drugs Soc 1995; 8: 29-45
92. Rosenman S, Rodgers B: Childhood adversity and adult personality. Aust N Z J Psychiatry 2006; 40: 482-490