Depletion of Retinoic Acid Receptors Initiates a Novel Positive Feedback Mechanism that Promotes Teratogenic Increases in Retinoic Acid

PLoS Genetics

Volumn 9, Issue 8, 2013, Pages

  D'Aniello, Enrico ^a   Rydeen, Ariel B ^a   Anderson, Jane L ^a   Mandal, Amrita ^a   Waxman, Joshua S ^a  

^a CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450 26A1; MESSENGER RNA; RETINOIC ACID; RETINOIC ACID RECEPTOR ALPHA; RETINOIC ACID RECEPTOR ALPHAB1; RETINOIC ACID RECEPTOR ALPHAB2; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL SPECIFICITY; CONTROLLED STUDY; CYP26A1 GENE; EMBRYO; GENE EXPRESSION; HEART MUSCLE CELL; HEART SIZE; MOLECULAR DYNAMICS; NONHUMAN; NUCLEOTIDE SEQUENCE; POSITIVE FEEDBACK; PROTEIN DEGRADATION; PROTEIN DEPLETION; PROTEIN DOMAIN; PROTEIN EXPRESSION; RETINOIC ACID RECEPTOR ALPHAB1 GENE; RETINOIC ACID RECEPTOR ALPHAB2 GENE; SEQUENCE ALIGNMENT; SIGNAL TRANSDUCTION; TERATOGENESIS; ZEBRA FISH;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; CYTOCHROME P-450 ENZYME SYSTEM; EMBRYO, NONMAMMALIAN; EMBRYONIC DEVELOPMENT; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; RECEPTORS, RETINOIC ACID; SIGNAL TRANSDUCTION; TERATOGENESIS; TRETINOIN; ZEBRAFISH;

EID: 84884634939     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1003689     Document Type: Article

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