Ubiquilin 2 Is Not Associated with Tau Pathology

PLoS ONE

Volumn 8, Issue 9, 2013, Pages

  Nölle, Anna ^a   van Haastert, Elise S ^b   Zwart, Rob ^a   Hoozemans, Jeroen J M ^b   Scheper, Wiep ^a  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

^b VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

UBIQUILIN 2; UBIQUITIN; UNCLASSIFIED DRUG;

ADULT; AGED; ALZHEIMER DISEASE; ARTICLE; CELL INCLUSION; CHROMOSOME 17; CONTROLLED STUDY; DISEASE ASSOCIATION; FAMILIAL DISEASE; FRONTOTEMPORAL DEMENTIA; HUMAN; HUMAN CELL; HUMAN TISSUE; NEUROPATHOLOGY; PARKINSONISM; PICK PRESENILE DEMENTIA; PROGRESSIVE SUPRANUCLEAR PALSY; PROTEIN FUNCTION; TAUOPATHY;

AGED; AGED, 80 AND OVER; CELL CYCLE PROTEINS; CELL LINE, TUMOR; HUMANS; MIDDLE AGED; NEURODEGENERATIVE DISEASES; TAU PROTEINS; UBIQUITINS;

EID: 84884634935     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0076598     Document Type: Article

References (26)

1. Nijholt DA, De Kimpe L, Elfrink HL, Hoozemans JJ, Scheper W, (2011) Removing protein aggregates: the role of proteolysis in neurodegeneration. Curr Med Chem 18: 2459-2476. doi:10.2174/092986711795843236. PubMed: 21568912.
2. Deng HX, Chen W, Hong ST, Boycott KM, Gorrie GH, et al. (2011) Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementia. Nature 477: 211-215. doi:10.1038/nature10353. PubMed: 21857683.
3. Brettschneider J, Van Deerlin VM, Robinson JL, Kwong L, Lee EB, et al. (2012) Pattern of ubiquilin pathology in ALS and FTLD indicates presence of C9ORF72 hexanucleotide expansion. Acta Neuropathol 123: 825-839. doi:10.1007/s00401-012-0970-z. PubMed: 22426854.
4. Mori F, Tanji K, Odagiri S, Toyoshima Y, Yoshida M, et al. (2012) Ubiquilin immunoreactivity in cytoplasmic and nuclear inclusions in synucleinopathies, polyglutamine diseases and intranuclear inclusion body disease. Acta Neuropathol 124: 149-151. doi:10.1007/s00401-012-0999-z. PubMed: 22661321.
5. Ko HS, Uehara T, Tsuruma K, Nomura Y, (2004) Ubiquilin interacts with ubiquitylated proteins and proteasome through its ubiquitin-associated and ubiquitin-like domains. FEBS Lett 566: 110-114. doi:10.1016/j.febslet.2004.04.031. PubMed: 15147878.
6. Zhou X, Zhao G, Truglio JJ, Wang L, Li G, et al. (2006) Structural and biochemical studies of the C-terminal domain of mouse peptide-N-glycanase identify it as a mannose-binding module. Proc Natl Acad Sci U S A 103: 17214-17219. doi:10.1073/pnas.0602954103. PubMed: 17088551.
7. Mah AL, Perry G, Smith MA, Monteiro MJ, (2000) Identification of ubiquilin, a novel presenilin interactor that increases presenilin protein accumulation. J Cell Biol 151: 847-862. doi:10.1083/jcb.151.4.847. PubMed: 11076969.
8. Zhang C, Saunders AJ, (2009) An emerging role for Ubiquilin 1 in regulating protein quality control system and in disease pathogenesis. Discov Med 8: 18-22. PubMed: 19772837.
9. Lim PJ, Danner R, Liang J, Doong H, Harman C, et al. (2009) Ubiquilin and p97/VCP bind erasin, forming a complex involved in ERAD. J Cell Biol 187: 201-217. doi:10.1083/jcb.200903024. PubMed: 19822669.
10. N'Diaye EN, Kajihara KK, Hsieh I, Morisaki H, Debnath J, et al. (2009) PLIC proteins or ubiquilins regulate autophagy-dependent cell survival during nutrient starvation. EMBO Rep 10: 173-179. doi:10.1038/embor.2008.238. PubMed: 19148225.
11. Rothenberg C, Srinivasan D, Mah L, Kaushik S, Peterhoff CM, et al. (2010) Ubiquilin functions in autophagy and is degraded by chaperone-mediated autophagy. Hum Mol Genet 19: 3219-3232. doi:10.1093/hmg/ddq231. PubMed: 20529957.
12. Wu S, Mikhailov A, Kallo-Hosein H, Hara K, Yonezawa K, et al. (2002) Characterization of ubiquilin 1, an mTOR-interacting protein. Biochim Biophys Acta 1542: 41-56. doi:10.1016/S0167-4889(01)00164-1. PubMed: 11853878.
13. Bertram L, Hiltunen M, Parkinson M, Ingelsson M, Lange C, et al. (2005) Family-based association between Alzheimer's disease and variants in UBQLN1. N Engl J Med 352: 884-894. doi:10.1056/NEJMoa042765. PubMed: 15745979.
14. Kamboh MI, Minster RL, Feingold E, DeKosky ST, (2006) Genetic association of ubiquilin with Alzheimer's disease and related quantitative measures. Mol Psychiatry 11: 273-279. doi:10.1038/sj.mp.4001775. PubMed: 16302009.
15. Stieren ES, El AA, Xiao Y, Siller E, Landsverk ML, et al. (2011) Ubiquilin-1 is a molecular chaperone for the amyloid precursor protein. J Biol Chem 286: 35689-35698. doi:10.1074/jbc.M111.243147. PubMed: 21852239.
16. Ford DL, Monteiro MJ, (2006) Dimerization of ubiquilin is dependent upon the central region of the protein: evidence that the monomer, but not the dimer, is involved in binding presenilins. Biochem J 399: 397-404. doi:10.1042/BJ20060441. PubMed: 16813565.
17. Haapasalo A, Viswanathan J, Kurkinen KM, Bertram L, Soininen H, et al. (2011) Involvement of ubiquilin-1 transcript variants in protein degradation and accumulation. Commun Integr Biol 4: 428-432. PubMed: 21966562.
18. Goedert M, Spillantini MG, (2011) Pathogenesis of the tauopathies. J Mol Neurosci 45: 425-431. doi:10.1007/s12031-011-9593-4. PubMed: 21785996.
19. Braak H, Braak E, (1991) Neuropathological staging of Alzheimer-related changes. Acta Neuropathol 82: 239-259.
20. Nijholt DA, van Haastert ES, Rozemuller AJ, Scheper W, Hoozemans JJ, (2012) The unfolded protein response is associated with early tau pathology in the hippocampus of tauopathies. J Pathol 226: 693-702. doi:10.1002/path.3969. PubMed: 22102449.
21. Probst A, Herzig MC, Mistl C, Ipsen S, Tolnay M, (2001) Perisomatic granules (non-plaque dystrophic dendrites) of hippocampal CA1 neurons in Alzheimer's disease and Pick's disease: a lesion distinct from granulovacuolar degeneration. Acta Neuropathol 102: 636-644. PubMed: 11761725.
22. Cairns NJ, Bigio EH, Mackenzie IR, Neumann M, Lee VM, et al. (2007) Neuropathologic diagnostic and nosologic criteria for frontotemporal lobar degeneration: consensus of the Consortium for Frontotemporal Lobar Degeneration. Acta Neuropathol 114: 5-22. doi:10.1007/s00401-007-0237-2. PubMed: 17579875.
23. Hoozemans JJ, van Haastert ES, Nijholt DA, Rozemuller AJ, Eikelenboom P, et al. (2009) The unfolded protein response is activated in pretangle neurons in Alzheimer's disease hippocampus. Am J Pathol 174: 1241-1251. doi:10.2353/ajpath.2009.080814. PubMed: 19264902.
24. Satoh J, Tabunoki H, Ishida T, Saito Y, Arima K, (2013) Ubiquilin-1 immunoreactivity is concentrated on Hirano bodies and dystrophic neurites in Alzheimer's disease brains. Neuropathol Appl Neurobiol. PubMed: 23421764.
25. Viswanathan J, Haapasalo A, Böttcher C, Miettinen R, Kurkinen KM, et al. (2011) Alzheimer's disease-associated ubiquilin-1 regulates presenilin-1 accumulation and aggresome formation. Traffic 12: 330-348. doi:10.1111/j.1600-0854.2010.01149.x. PubMed: 21143716.
26. Fecto F, Siddique T, (2012) UBQLN2/P62 cellular recycling pathways in amyotrophic lateral sclerosis and frontotemporal dementia. Muscle Nerve 45: 157-162. doi:10.1002/mus.23278. PubMed: 22246868.