Apamin induces early afterdepolarizations and torsades de pointes ventricular arrhythmia from failing rabbit ventricles exhibiting secondary rises in intracellular calcium

Heart Rhythm

Volumn 10, Issue 10, 2013, Pages 1516-1524

  Chang, Po Cheng ^a,b   Hsieh, Yu Cheng ^a   Hsueh, Chia Hsiang ^a   Weiss, James N ^c   Lin, Shien Fong ^a,d   Chen, Peng Sheng ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b CHANG GUNG UNIVERSITY   (Taiwan)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d NATIONAL CHIAO TUNG UNIVERSITY   (Taiwan)

Author keywords

Action potentialduration; Apamin; Opticalmapping; Potassium channels; Torsadesdepointes

Indexed keywords

APAMIN; CALCIUM;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CALCIUM CELL LEVEL; CALCIUM CONDUCTANCE; CONTROLLED STUDY; HEART DEPOLARIZATION; HEART LEFT VENTRICLE EJECTION FRACTION; HEART MUSCLE POTENTIAL; HEART REPOLARIZATION; HEART VENTRICLE; HEART VENTRICLE ARRHYTHMIA; HEART VENTRICLE EXTRASYSTOLE; ISOLATED HEART; NONHUMAN; POLYMORPHIC VENTRICULAR TACHYCARDIA; PRIORITY JOURNAL; QT INTERVAL; RABBIT; TORSADE DES POINTES;

ACTION POTENTIAL DURATION; APAMIN; APAMIN-SENSITIVE K(+) CURRENT; APD; ATRIOVENTRICULAR; AV; CA(I); CORRECTED QT; EAD; EARLY AFTERDEPOLARIZATION; HEART FAILURE; HF; I(CA,L); I(KAS); INTRACELLULAR CA(2+); L-TYPE CA(2+) CURRENT; LEFT VENTRICULAR; LV; MEMBRANE POTENTIAL; OPTICAL MAPPING; PACING CYCLE LENGTH; PCL; POTASSIUM CHANNELS; PREMATURE VENTRICULAR BEAT; PVB; QTC; SK; SMALL CONDUCTANCE CA(2+) ACTIVATED K(+); TDP; TORSADES DE POINTES; V(M);

ACTION POTENTIALS; ANIMALS; APAMIN; ATRIOVENTRICULAR BLOCK; CALCIUM; CARDIAC PACING, ARTIFICIAL; DISEASE MODELS, ANIMAL; HEART FAILURE; POTASSIUM CHANNEL BLOCKERS; RABBITS; TORSADES DE POINTES; VENTRICULAR DYSFUNCTION, LEFT;

EID: 84884616627     PISSN: 15475271     EISSN: 15563871     Source Type: Journal    
DOI: 10.1016/j.hrthm.2013.07.003     Document Type: Article

References (28)

1. G.F. Tomaselli, and D.P. Zipes What causes sudden death in heart failure? Circ Res 95 2004 754 763
2. D.S. Echt, P.R. Liebson, and L.B. Mitchell Mortality and morbidity in patients receiving encainide, flecainide, or placebo: the Cardiac Arrhythmia Suppression Trial New Engl J Med 324 1991 781 788
3. A.L. Waldo, A.J. Camm, and H. deRuyter Effect of d-sotalol on mortality in patients with left ventricular dysfunction after recent and remote myocardial infarction. The SWORD Investigators. Survival With Oral d-Sotalol [see comments] [published erratum appears in Lancet 1996;348:416] Lancet 348 1996 7 12
4. C. Torp-Pedersen, M. Moller, and P.E. Bloch-Thomsen Dofetilide in patients with congestive heart failure and left ventricular dysfunction. Danish Investigations of Arrhythmia and Mortality on Dofetilide Study Group New Engl J Med 341 1999 857 865
5. J.E. Tisdale, B.R. Overholser, and H.A. Wroblewski Enhanced sensitivity to drug-induced QT interval lengthening in patients with heart failure due to left ventricular systolic dysfunction J Clin Pharmacol 52 2012 1296 1305
6. T. Aiba, and G.F. Tomaselli Electrical remodeling in the failing heart Curr Opin Cardiol 25 2010 29 36
7. S. Nattel, A. Maguy, B.S. Le, and Y.H. Yeh Arrhythmogenic ion-channel remodeling in the heart: heart failure, myocardial infarction, and atrial fibrillation Physiol Rev 87 2007 425 456
8. S.K. Chua, P.C. Chang, and M. Maruyama Small-conductance calcium-activated potassium channel and recurrent ventricular fibrillation in failing rabbit ventricles Circ Res 108 2011 971 979
9. I.M. Bonilla, V.L. Long, and P. Vargas-Pinto Calcium-activated potassium current modulates ventricular (but not atrial) repolarization in chronic heart failure [abstract] Circulation 126 2012 A16846
10. V. Piacentino III, C.R. Weber, and X. Chen Cellular basis of abnormal calcium transients of failing human ventricular myocytes Circ Res 92 2003 651 658
11. M. Ogawa, N. Morita, and L. Tang Mechanisms of recurrent ventricular fibrillation in a rabbit model of pacing-induced heart failure Heart Rhythm 6 2009 784 792
12. M. Maruyama, B. Joung, and L. Tang Diastolic intracellular calcium-membrane voltage coupling gain and postshock arrhythmias: role of Purkinje fibers and triggered activity Circ Res 106 2010 399 408
13. Y.S. Lee, M. Maruyama, and P.C. Chang Ryanodine receptor inhibition potentiates the activity of Na channel blockers against spontaneous calcium elevations and delayed afterdepolarizations in Langendorff-perfused rabbit ventricles Heart Rhythm 9 2012 1125 1132
14. M.L. Koller, M.L. Riccio, and R.F. Gilmour Jr Dynamic restitution of action potential duration during electrical alternans and ventricular fibrillation Am J Physiol 275 1998 H1635 H1642
15. G.N. Kay, V.J. Plumb, J.G. Arciniegas, R.W. Henthorn, and A.L. Waldo Torsade de pointes: the long-short initiating sequence and other clinical features: observations in 32 patients J Am Coll Cardiol 2 1983 806 817
16. N. Nagy, V. Szuts, and Z. Horvath Does small-conductance calcium-activated potassium channel contribute to cardiac repolarization? J Mol Cell Cardiol 47 2009 656 663
17. Y. Xu, D. Tuteja, and Z. Zhang Molecular identification and functional roles of a Ca(2+)-activated K+ channel in human and mouse hearts J Biol Chem 278 2003 49085 49094
18. A. Mahajan, Y. Shiferaw, and D. Sato A rabbit ventricular action potential model replicating cardiac dynamics at rapid heart rates Biophys J 94 2008 392 410
19. 2+ dynamics which enhances dispersion of repolarization and arrhythmia risk Am J Physiol Heart Circ Physiol 304 2013 848 860
20. P.-C. Chang, I. Turker, and J.C. Lopshire Heterogeneous upregulation of apamin-sensitive potassium currents in failing human ventricles J Am Heart Assoc 1 2013 e004713
21. J.C. Dreixler, A. Jenkins, Y.J. Cao, J.D. Roizen, and K.M. Houamed Patch-clamp analysis of anesthetic interactions with recombinant SK2 subtype neuronal calcium-activated potassium channels Anesth Analg 90 2000 727 732
22. T. Yamamoto, S. Kakehata, T. Yamada, T. Saito, H. Saito, and N. Akaike Effects of potassium channel blockers on the acetylcholine-induced currents in dissociated outer hair cells of guinea pig cochlea Neuroscience Lett 236 1997 79 82
23. I. Turker, C-C Yu, and P. Chang Amiodarone Inhibits Apamin-Sensitive Potassium Currents PloS one 8 2013 e70450
24. 2+ current blocker in single heart cells Am J Physiol 262 1992 H463 H471
25. N.A. Castle, D.G. Haylett, and D.H. Jenkinson Toxins in the characterization of potassium channels Trends Neurosci 12 1989 59 65
26. J.P. Adelman, J. Maylie, and P. Sah Small-conductance Ca(2+)-activated K(+) channels: form and function Annu Rev Physiol 74 2012 245 269
27. T.M. Ishii, J. Maylie, and J.P. Adelman Determinants of apamin and d-tubocurarine block in SK potassium channels J Biol Chem 272 1997 23195 23200
28. D.M. Roden Taking the idio out of idiosyncratic: predicting torsades de pointes Pacing Clin Electrophysiol 21 1998 1029 1034