Effects of potassium channel blockers on the acetylcholine-induced currents in dissociated outer hair cells of guinea pig cochlea

Neuroscience Letters

Volumn 236, Issue 2, 1997, Pages 79-82

  Yamamoto, Takehito ^a,b   Kakehata, Seiji ^c   Yamada, Takechiyo ^a   Saito, Takehisa ^a   Saito, Hitoshi ^a   Akaike, Norio ^b  

^a University of Fukui   (Japan)

^b KYUSHU UNIVERSITY   (Japan)

^c TOHOKU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Acetylcholine; Apamin; Ca2+ activated K+ currents; Guinea pig; Outer hair cell; Patch clamp; Small conductance Ca2+ activated K+ channel

Indexed keywords

4 AMINOPYRIDINE; ACETYLCHOLINE; APAMIN; BARIUM ION; CESIUM ION; CHARYBDOTOXIN; IBERIOTOXIN; NYSTATIN; POTASSIUM CHANNEL; POTASSIUM CHANNEL BLOCKING AGENT; QUINIDINE; QUININE; TETRYLAMMONIUM CHLORIDE; TUBOCURARINE CHLORIDE;

ANIMAL CELL; COCHLEA; CONCENTRATION RESPONSE; CONTROLLED STUDY; GUINEA PIG; HAIR CELL; MICHAELIS MENTEN KINETICS; NONHUMAN; PATCH CLAMP; POTASSIUM CURRENT; PRIORITY JOURNAL; REVIEW;

EID: 0030696001     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(97)00749-0     Document Type: Article

References (20)

1. Alexander, S.P.H. and Peters, J.A., TiPS receptor and ion channel nomenclature supplement, Trends Pharmacol. Sci. (Suppl.), (1997) 79-83.
2. Art J.J., Wu Y.-C., Fettiplace R. The calcium-activated potassium channels of turtle hair cells. J. Gen. Physiol. 105:1995;49-72.
3. + channels of small conductance in cultured rat skeletal muscle. Nature. 322:1986;718-720.
4. Dallos P., He D.D.Z., Lin X., Sziklai I., Mehta S., Evans B.N. Acetylcholine, outer hair cell electromotility, and the cochlear amplifier. J. Neurosci. 17:1997;2212-2226.
5. 2+ concentration and hyperpolarizes the guinea-pig outer hair cell. Hear. Res. 67:1993;179-188.
6. Elgoyhen A.B., Johnson D.S., Boulter J., Vetter D.E., Heinemann S. α9: An acetylcholine receptor with novel pharmacological properties expressed in rat cochlear hair cells. Cell. 79:1994;705-715.
7. + in guinea pig outer hair cells. Hear. Res. 81:1994;119-129.
8. Fuchs P.A., Murrow B.W. Cholinergic inhibition of short (outer) hair cells of the chick's cochlea. J. Neurosci. 12:1992;800-809.
9. Fuchs P.A. Synaptic transmission at vertebrate hair cells. Curr. Opin. Neurobiol. 6:1996;514-519.
10. Galvez A., Gimenez-Gallego G., Reuben J.P., Roy-Contancin L., Feigenbaum P., Kaczorowski G.J., Garcia M.L. Purification and characterization of a unique, potent, peptidyl probe for the high conductance calcium-activated potassium channel from venom of the scorpion Buthus tamulus. J. Biol. Chem. 265:1990;11083-11090.
11. Hamill O.P., Marty A., Neher E., Sakmann B., Sigworth F.J. Improved patch-clamp technique for high resolution current recording from cells and cell-free membrane patch. Pflüger's Arch. 391:1981;85-100.
12. Hille, B., Ionic Channels of Excitable Membranes, 2nd edn., Sinauer, Sunderland, MA, 1992, pp. 115-139.
13. Horn R., Marty A. Muscarinic activation of ionic currents measured by a new whole-cell recording method. J. Gen. Physiol. 92:1988;145-159.
14. Housley G.D., Ashmore J.F. Direct measurement of the action of acetylcholine on isolated outer hair cells of the guinea pig cochlea. Proc. R. Soc. Lond. B. 244:1991;161-167.
15. Kakehata S., Nakagawa T., Takasaka T., Akaike N. Cellular mechanism of acetylcholine-induced response in dissociated outer hair cells of guinea-pig cochlea. J. Physiol. 463:1993;227-244.
16. Murase K., Ryu P.D., Randic M. Excitatory and inhibitory amino acids- and peptide-induced responses in acutely isolated rat spinal dorsal horn neurons. Neurosci. Lett. 103:1989;56-63.
17. + channel. Hear. Res. 101:1996;149-172.
18. Nenov A.P., Norris C., Bobbin R.P. Outwardly rectifying currents in guinea pig outer hair cells. Hear. Res. 105:1997;146-158.
19. + channel. J. Biol. Chem. 265:1990;18745-18748.
20. Yamamoto T., Kakehata S., Yamada T., Saito T., Saito H., Akaike N. Caffeine rapidly decreases potassium conductance of dissociated outer hair cells of guinea-pig cochlea. Brain Res. 677:1995;89-96.