Differential determinants of cancer cell insensitivity to antimitotic drugs discriminated by a one-step cell imaging assay

Journal of Biomolecular Screening

Volumn 18, Issue 9, 2013, Pages 1062-1071

  Tang, Yangzhong ^a,b   Xie, Tiao ^a   Florian, Stefan ^a   Moerke, Nathan ^a   Shamu, Caroline ^a   Benes, Cyril ^a   Mitchison, Timothy J ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b SANOFI   (United States)

Author keywords

antimitotic drugs; cancer cells; drug sensitivity; high content screening; image analysis; live cell imaging assay

Indexed keywords

4 (8 CYCLOPENTYL 7 ETHYL 5,6,7,8 TETRAHYDRO 5 METHYL 6 OXO 2 PTERIDINYLAMINO) 3 METHOXY N (1 METHYL 4 PIPERIDINYL)BENZAMIDE; 4 [[9 CHLORO 7 (2,6 DIFLUOROPHENYL) 5H PYRIMIDO[5,4 D][2]BENZAZEPIN 2 YL]AMINO]BENZOIC ACID; ANTIMITOTIC AGENT; BARASERTIB; GSK 1070916; PACLITAXEL; STAUROSPORINE; TOZASERTIB; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CANCER CELL; CANCER CELL CULTURE; CANCER GROWTH; CANCER RESISTANCE; CELL ASSAY; CELL COUNT; CELL CYCLE ARREST; CELL FUNCTION; CELL LOSS; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE RESPONSE; DRUG SENSITIVITY; GENETIC VARIABILITY; HUMAN; HUMAN CELL; IMAGE ANALYSIS; IMMUNOASSAY; IMMUNOFLUORESCENCE; IN VITRO STUDY; MITOSIS INDEX; MITOSIS INHIBITION; PHENOTYPE; PRIORITY JOURNAL;

ANTIMITOTIC DRUGS; CANCER CELLS; DRUG SENSITIVITY; HIGH-CONTENT SCREENING; IMAGE ANALYSIS; LIVE CELL IMAGING ASSAY;

ANTIMITOTIC AGENTS; APOPTOSIS; BENZAMIDES; CELL CYCLE PROTEINS; CELL LINE, TUMOR; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DISCOVERY; DRUG RESISTANCE, NEOPLASM; FLUORESCENT DYES; HETEROCYCLIC COMPOUNDS, 2-RING; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; MOLECULAR IMAGING; PACLITAXEL; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; SMALL MOLECULE LIBRARIES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84884611688     PISSN: 10870571     EISSN: 1552454X     Source Type: Journal    
DOI: 10.1177/1087057113493804     Document Type: Article

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