-
1
-
-
78751644099
-
Genetic variegation of clonal architecture and propagating cells in leukaemia
-
Anderson K, Lutz C, van Delft FW, Bateman CM, Guo Y, Colman SM, Kempski H, Moorman AV, Titley I, Swansbury J, Kearney L, Enver T, Greaves M (2011) Genetic variegation of clonal architecture and propagating cells in leukaemia. Nature 469: 356-361.
-
(2011)
Nature
, vol.469
, pp. 356-361
-
-
Anderson, K.1
Lutz, C.2
Van Delft, F.W.3
Bateman, C.M.4
Guo, Y.5
Colman, S.M.6
Kempski, H.7
Moorman, A.V.8
Titley, I.9
Swansbury, J.10
Kearney, L.11
Enver, T.12
Greaves, M.13
-
2
-
-
0036566540
-
High frequency of point mutations clustered within the adenosine triphosphate-binding region of BCR/ABL in patients with chronic myeloid leukemia or Ph-positive acute lymphoblastic leukemia who develop imatinib (STI571) resistance
-
Branford S, Rudzki Z, Walsh S, Grigg A, Arthur C, Taylor K, Herrmann R, Lynch KP, Hughes TP (2002) High frequency of point mutations clustered within the adenosine triphosphate-binding region of BCR/ABL in patients with chronic myeloid leukemia or Ph-positive acute lymphoblastic leukemia who develop imatinib (STI571) resistance. Blood 99: 3472-3475.
-
(2002)
Blood
, vol.99
, pp. 3472-3475
-
-
Branford, S.1
Rudzki, Z.2
Walsh, S.3
Grigg, A.4
Arthur, C.5
Taylor, K.6
Herrmann, R.7
Lynch, K.P.8
Hughes, T.P.9
-
3
-
-
84863000299
-
The molecular evolution of acquired resistance to targeted EGFR blockade in colorectal cancers
-
Diaz Jr LA, Williams RT, Wu J, Kinde I, Hecht JR, Berlin J, Allen B, Bozic I, Reiter JG, Nowak MA, Kinzler KW, Oliner KS, Vogelstein B (2012) The molecular evolution of acquired resistance to targeted EGFR blockade in colorectal cancers. Nature 486: 537-540.
-
(2012)
Nature
, vol.486
, pp. 537-540
-
-
Diaz Jr., L.A.1
Williams, R.T.2
Wu, J.3
Kinde, I.4
Hecht, J.R.5
Berlin, J.6
Allen, B.7
Bozic, I.8
Reiter, J.G.9
Nowak, M.A.10
Kinzler, K.W.11
Oliner, K.S.12
Vogelstein, B.13
-
4
-
-
34249075147
-
MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling
-
Engelman JA, Zejnullahu K, Mitsudomi T, Song Y, Hyland C, Oh Park J, Lindeman N, Gale C-M, Zhao X, Christensen J, Kosaka T, Holmes AJ, Rogers AM, Cappuzzo F, Mok T, Lee C, Johnson BE, Cantley LC, Jänne PA (2007) MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling. Science 316: 1039-1043.
-
(2007)
Science
, vol.316
, pp. 1039-1043
-
-
Engelman, J.A.1
Zejnullahu, K.2
Mitsudomi, T.3
Song, Y.4
Hyland, C.5
Oh Park, J.6
Lindeman, N.7
Gale, C.-M.8
Zhao, X.9
Christensen, J.10
Kosaka, T.11
Holmes, A.J.12
Rogers, A.M.13
Cappuzzo, F.14
Mok, T.15
Lee, C.16
Johnson, B.E.17
Cantley, L.C.18
Jänne, P.A.19
-
5
-
-
84863393080
-
Intratumor heterogeneity and branched evolution revealed by multiregion sequencing
-
Gerlinger M, Rowan AJ, Horswell S, Larkin J, Endesfelder D, Gronroos E, Martinez P, Matthews N, Stewart A, Tarpet P, Varela I, Phillimore B, Begum S, McDonald NQ, Butler A, Jones D, Raine K, Latimer C, Santos CR, Nohadani M, Eklund AC, Spencer-Dene B, Clark G, Pickering L, Stamp G, Gore M, Szallasi Z, Downward J, Futreal PA, Swanton C (2012) Intratumor heterogeneity and branched evolution revealed by multiregion sequencing. N Engl J Med 366: 883-392.
-
(2012)
N Engl J Med
, vol.366
, pp. 883-392
-
-
Gerlinger, M.1
Rowan, A.J.2
Horswell, S.3
Larkin, J.4
Endesfelder, D.5
Gronroos, E.6
Martinez, P.7
Matthews, N.8
Stewart, A.9
Tarpet, P.10
Varela, I.11
Phillimore, B.12
Begum, S.13
McDonald, N.Q.14
Butler, A.15
Jones, D.16
Raine, K.17
Latimer, C.18
Santos, C.R.19
Nohadani, M.20
Eklund, A.C.21
Spencer-Dene, B.22
Clark, G.23
Pickering, L.24
Stamp, G.25
Gore, M.26
Szallasi, Z.27
Downward, J.28
Futreal, P.A.29
Swanton, C.30
more..
-
6
-
-
0035800507
-
Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification
-
Gorre ME, Mohammed M, Ellwood K, Hsu N, Paquette R, Rao PN, Sawyers CL (2001) Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification. Science 293: 876-880.
-
(2001)
Science
, vol.293
, pp. 876-880
-
-
Gorre, M.E.1
Mohammed, M.2
Ellwood, K.3
Hsu, N.4
Paquette, R.5
Rao, P.N.6
Sawyers, C.L.7
-
7
-
-
84872825418
-
Cancer stem cells as 'units of selection'
-
Greaves M (2013) Cancer stem cells as 'units of selection'. Evol Appl 6: 102-108.
-
(2013)
Evol Appl
, vol.6
, pp. 102-108
-
-
Greaves, M.1
-
8
-
-
84856013431
-
Clonal evolution in cancer
-
Greaves M, Maley CC (2012) Clonal evolution in cancer. Nature 481: 306-313.
-
(2012)
Nature
, vol.481
, pp. 306-313
-
-
Greaves, M.1
Maley, C.C.2
-
9
-
-
79952327332
-
Dynamics of mutant BCR-ABL-positive clones after cessation of tyrosine kinase inhibitor therapy
-
Hanfstein B, Müller MC, Kreil S, Ernst T, Schenk T, Lorentz C, Schwindel U, Leitner A, Hehlmann R, Hochhaus A (2011) Dynamics of mutant BCR-ABL-positive clones after cessation of tyrosine kinase inhibitor therapy. Haematologica 96: 360-366.
-
(2011)
Haematologica
, vol.96
, pp. 360-366
-
-
Hanfstein, B.1
Müller, M.C.2
Kreil, S.3
Ernst, T.4
Schenk, T.5
Lorentz, C.6
Schwindel, U.7
Leitner, A.8
Hehlmann, R.9
Hochhaus, A.10
-
10
-
-
34247555482
-
Chronic myeloid leukemia stem cells possess multiple unique features of resistance to BCR-ABL targeted therapies
-
Jiang X, Zhao Y, Smith C, Gasparetto M, Turhan A, Eaves A, Eaves C (2007) Chronic myeloid leukemia stem cells possess multiple unique features of resistance to BCR-ABL targeted therapies. Leukemia 21: 926-935.
-
(2007)
Leukemia
, vol.21
, pp. 926-935
-
-
Jiang, X.1
Zhao, Y.2
Smith, C.3
Gasparetto, M.4
Turhan, A.5
Eaves, A.6
Eaves, C.7
-
11
-
-
33750302365
-
Analysis of epidermal growth factor receptor gene mutation in patients with non-small cell lung cancer and acquired resistance to gefitinib
-
Kosaka T, Yatabe Y, Endoh H, Yoshida K, Hida T, Tsuboi M, Tada H, Kuwano H, Mitsudomi T (2006) Analysis of epidermal growth factor receptor gene mutation in patients with non-small cell lung cancer and acquired resistance to gefitinib. Clin Cancer Res 12: 5764-5769.
-
(2006)
Clin Cancer Res
, vol.12
, pp. 5764-5769
-
-
Kosaka, T.1
Yatabe, Y.2
Endoh, H.3
Yoshida, K.4
Hida, T.5
Tsuboi, M.6
Tada, H.7
Kuwano, H.8
Mitsudomi, T.9
-
12
-
-
79955448477
-
An analogy between the evolution of drug resistance in bacterial communities and malignant tissues
-
Lambert G, Estévez-Salmeron L, Oh S, Liao D, Emerson BM, Tlsty TD, Austin RH (2011) An analogy between the evolution of drug resistance in bacterial communities and malignant tissues. Nat Rev Cancer 11: 375-382.
-
(2011)
Nat Rev Cancer
, vol.11
, pp. 375-382
-
-
Lambert, G.1
Estévez-Salmeron, L.2
Oh, S.3
Liao, D.4
Emerson, B.M.5
Tlsty, T.D.6
Austin, R.H.7
-
13
-
-
84874663688
-
Relapse-specific mutations in NT5C2 in childhood acute lymphoblastic leukemia
-
Meyer JA, Wang J, Hogan LE, Yang JJ, Dandekar S, Patel JP, Tang Z, Zumbo P, Li S, Zavadil J, Levine RL, Cardozo T, Hunger SP, Raetz EA, Evans WE, Morrison DJ, Mason CE, Carroll WL (2013) Relapse-specific mutations in NT5C2 in childhood acute lymphoblastic leukemia. Nat Genet 45: 290-294.
-
(2013)
Nat Genet
, vol.45
, pp. 290-294
-
-
Meyer, J.A.1
Wang, J.2
Hogan, L.E.3
Yang, J.J.4
Dandekar, S.5
Patel, J.P.6
Tang, Z.7
Zumbo, P.8
Li, S.9
Zavadil, J.10
Levine, R.L.11
Cardozo, T.12
Hunger, S.P.13
Raetz, E.A.14
Evans, W.E.15
Morrison, D.J.16
Mason, C.E.17
Carroll, W.L.18
-
14
-
-
21744462100
-
Dynamics of chronic myeloid leukaemia
-
Michor F, Hughes TP, Iwasa Y, Branford S, Shah NP, Sawyers CL, Nowak MA (2005) Dynamics of chronic myeloid leukaemia. Nature 435: 1267-1270.
-
(2005)
Nature
, vol.435
, pp. 1267-1270
-
-
Michor, F.1
Hughes, T.P.2
Iwasa, Y.3
Branford, S.4
Shah, N.P.5
Sawyers, C.L.6
Nowak, M.A.7
-
15
-
-
84881476503
-
High intratumor genetic heterogeneity is related to worse outcome in patients with head and neck squamous cell carcinoma
-
Mroz EA, Tward AD, Pickering CR, Myers JN, Ferris RL, Rocco JW (2013) High intratumor genetic heterogeneity is related to worse outcome in patients with head and neck squamous cell carcinoma. Cancer 119(16): 3034-3042.
-
(2013)
Cancer
, vol.119
, Issue.16
, pp. 3034-3042
-
-
Mroz, E.A.1
Tward, A.D.2
Pickering, C.R.3
Myers, J.N.4
Ferris, R.L.5
Rocco, J.W.6
-
16
-
-
84877579861
-
Non-invasive analysis of acquired resistance to cancer therapy by sequencing of plasma DNA
-
Murtaza M, Dawson S-J, Tsui DWY, Gale D, Forshew T, Piskorz AM, Parkinson C, Chin S-F, Kinsbury Z, Wong ASC, Marass F, Humphray S, Hadfield J, Bentley D, Chin TM, Brenton JD, Caldas C, Rosenfeld N (2013) Non-invasive analysis of acquired resistance to cancer therapy by sequencing of plasma DNA. Nature 497: 108-112.
-
(2013)
Nature
, vol.497
, pp. 108-112
-
-
Murtaza, M.1
Dawson, S.-J.2
Tsui, D.W.Y.3
Gale, D.4
Forshew, T.5
Piskorz, A.M.6
Parkinson, C.7
Chin, S.-F.8
Kinsbury, Z.9
Wong, A.S.C.10
Marass, F.11
Humphray, S.12
Hadfield, J.13
Bentley, D.14
Chin, T.M.15
Brenton, J.D.16
Caldas, C.17
Rosenfeld, N.18
-
17
-
-
84860819704
-
Rac2-MRC-clll-generated ROS cause genomic instability in chronic myeloid leukemia stem cells and primitive progenitors
-
Nieborowska-Skorska M, Kopinski PK, Ray R, Hoser G, Ngaba D, Flis S, Cramer K, Reddy MM, Koptyra M, Penserga T, Glodkowska-Mrowka E, Bolton E, Holyoake TL, Eaves CJ, Cerny-Reiterer S, Valent P, Hochhaus A, Hughes TP, van der Kuip H, Sattler M, Wiktor-Jedrzejczak W, Richardson C, Dorrance A, Stoklosa T, Williams DA, Skorski T (2012) Rac2-MRC-clll-generated ROS cause genomic instability in chronic myeloid leukemia stem cells and primitive progenitors. Blood 119: 4253-4263.
-
(2012)
Blood
, vol.119
, pp. 4253-4263
-
-
Nieborowska-Skorska, M.1
Kopinski, P.K.2
Ray, R.3
Hoser, G.4
Ngaba, D.5
Flis, S.6
Cramer, K.7
Reddy, M.M.8
Koptyra, M.9
Penserga, T.10
Glodkowska-Mrowka, E.11
Bolton, E.12
Holyoake, T.L.13
Eaves, C.J.14
Cerny-Reiterer, S.15
Valent, P.16
Hochhaus, A.17
Hughes, T.P.18
Van Der Kuip, H.19
Sattler, M.20
Wiktor-Jedrzejczak, W.21
Richardson, C.22
Dorrance, A.23
Stoklosa, T.24
Williams, D.A.25
Skorski, T.26
more..
-
18
-
-
21144451094
-
In vitro activity of Bcr-Abl inhibitors AMN107 and BMS-354825 against clinically relevant imatinib-resistant Abl kinase domain mutants
-
O'Hare T, Walters DK, Stoffregen EP, Jia T, Manley PW, Mestan J, Cowan- Jacob SW, Lee FY, Heinrich MC, Deininger MWN, Druker BJ (2005) In vitro activity of Bcr-Abl inhibitors AMN107 and BMS-354825 against clinically relevant imatinib-resistant Abl kinase domain mutants. Cancer Res 65: 4500-4505.
-
(2005)
Cancer Res
, vol.65
, pp. 4500-4505
-
-
O'Hare, T.1
Walters, D.K.2
Stoffregen, E.P.3
Jia, T.4
Manley, P.W.5
Mestan, J.6
Cowan- Jacob, S.W.7
Lee, F.Y.8
Heinrich, M.C.9
Deininger, M.W.N.10
Druker, B.J.11
-
19
-
-
84884575020
-
BCR-ABL1 kinase domain mutations may persist at very low levels for many years and lead to subsequent TKI resistance
-
e-pub ahead of print 25 June 2013; doi:10.1038/bjc.2013.318
-
Parker WT, Yeoman AL, Jamison BA, Yeung DT, Scott HS, Hughes TP, Branford S (2013) BCR-ABL1 kinase domain mutations may persist at very low levels for many years and lead to subsequent TKI resistance. Br J Cancer 109: E-pub ahead of print 25 June 2013; doi:10.1038/bjc.2013.318.
-
(2013)
Br J Cancer
, vol.109
-
-
Parker, W.T.1
Yeoman, A.L.2
Jamison, B.A.3
Yeung, D.T.4
Scott, H.S.5
Hughes, T.P.6
Branford, S.7
-
20
-
-
34547221085
-
Kinase domain mutations of BCR-ABL frequently precede imatinib-based therapy and give rise to relapse in patients with de novo Philadelphia-positive acute lymphoblastic leukemia (Ph+ ALL)
-
Pfeifer H, Wassmann B, Pavlova A, Wunderle L, Oldenburg J, Binckebanck A, Lange T, Hochhaus A, Wystub S, Brück P, Hoelzer D, Ottmann OG (2007) Kinase domain mutations of BCR-ABL frequently precede imatinib-based therapy and give rise to relapse in patients with de novo Philadelphia-positive acute lymphoblastic leukemia (Ph+ ALL). Blood 110: 727-734.
-
(2007)
Blood
, vol.110
, pp. 727-734
-
-
Pfeifer, H.1
Wassmann, B.2
Pavlova, A.3
Wunderle, L.4
Oldenburg, J.5
Binckebanck, A.6
Lange, T.7
Hochhaus, A.8
Wystub, S.9
Brück, P.10
Hoelzer, D.11
Ottmann, O.G.12
-
21
-
-
84863230465
-
Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR
-
Prahallad A, Sun C, Huang S, Di Nicolantonio F, Salazar R, Zecchin D, Beijersbergen RL, Bardelli A, Bernards R (2012) Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR. Nature 483: 100-103.
-
(2012)
Nature
, vol.483
, pp. 100-103
-
-
Prahallad, A.1
Sun, C.2
Huang, S.3
Di Nicolantonio, F.4
Salazar, R.5
Zecchin, D.6
Beijersbergen, R.L.7
Bardelli, A.8
Bernards, R.9
-
23
-
-
0036682481
-
Several types of mutations of the Abl gene can be found in chronic myeloid leukemia patients resistant to STI571, and they can pre-exist to the onset of treatment
-
Roche-Lestienne C, Soenen-Cornu V, Grardel-Duflos N, Lai J-L, Philippe N, Facon T, Fenaux P, Preudhomme C (2002) Several types of mutations of the Abl gene can be found in chronic myeloid leukemia patients resistant to STI571, and they can pre-exist to the onset of treatment. Blood 100: 1014-1018.
-
(2002)
Blood
, vol.100
, pp. 1014-1018
-
-
Roche-Lestienne, C.1
Soenen-Cornu, V.2
Grardel-Duflos, N.3
Lai, J.-L.4
Philippe, N.5
Facon, T.6
Fenaux, P.7
Preudhomme, C.8
-
24
-
-
77749317560
-
Induction of cell cycle entry eliminates human leukemia stem cells in a mouse model of AML
-
Saito Y, Uchida N, Tanaka S, Suzuki N, Tomizawa-Murasawa M, Sone A, Najima Y, Takagi S, Aoki Y, Wake A, Taniguchi S, Shultz LD, Ishikawa F (2010) Induction of cell cycle entry eliminates human leukemia stem cells in a mouse model of AML. Nat Biotech 28: 275-280.
-
(2010)
Nat Biotech
, vol.28
, pp. 275-280
-
-
Saito, Y.1
Uchida, N.2
Tanaka, S.3
Suzuki, N.4
Tomizawa-Murasawa, M.5
Sone, A.6
Najima, Y.7
Takagi, S.8
Aoki, Y.9
Wake, A.10
Taniguchi, S.11
Shultz, L.D.12
Ishikawa, F.13
-
25
-
-
0033891416
-
Increase in mutant frequencies in mice expressing the BCR-ABL activated tyrosine kinase
-
Salloukh HF, Laneuville P (2000) Increase in mutant frequencies in mice expressing the BCR-ABL activated tyrosine kinase. Leukemia 14: 1401-1404.
-
(2000)
Leukemia
, vol.14
, pp. 1401-1404
-
-
Salloukh, H.F.1
Laneuville, P.2
-
26
-
-
0034665713
-
Structural mechanism for STI-571 inhibition of abelson tyrosine kinase
-
Schindler T, Bornmann W, Pellicena P, Miller WT, Clarkson B, Kuriyan J (2000) Structural mechanism for STI-571 inhibition of abelson tyrosine kinase. Science 289: 1938-1942.
-
(2000)
Science
, vol.289
, pp. 1938-1942
-
-
Schindler, T.1
Bornmann, W.2
Pellicena, P.3
Miller, W.T.4
Clarkson, B.5
Kuriyan, J.6
-
27
-
-
0001686739
-
Multiple BCR-ABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in chronic phase and blast crisis chronic myeloid leukemia
-
Shah NP, Nicoll JM, Nagar B, Gorre ME, Paquette RL, Kuriyan J, Sawyers CL (2002) Multiple BCR-ABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in chronic phase and blast crisis chronic myeloid leukemia. Cancer Cell 2: 117-125.
-
(2002)
Cancer Cell
, vol.2
, pp. 117-125
-
-
Shah, N.P.1
Nicoll, J.M.2
Nagar, B.3
Gorre, M.E.4
Paquette, R.L.5
Kuriyan, J.6
Sawyers, C.L.7
-
28
-
-
34848911943
-
Sequential ABL kinase inhibitor therapy selects for compound drug-resistant BCR-ABL mutations with altered oncogenic potency
-
Shah NP, Skaggs BJ, Branford S, Hughes TP, Nicoll JM, Paquette RL, Sawyers CL (2007) Sequential ABL kinase inhibitor therapy selects for compound drug-resistant BCR-ABL mutations with altered oncogenic potency. J Clin Invest 117: 2562-2569.
-
(2007)
J Clin Invest
, vol.117
, pp. 2562-2569
-
-
Shah, N.P.1
Skaggs, B.J.2
Branford, S.3
Hughes, T.P.4
Nicoll, J.M.5
Paquette, R.L.6
Sawyers, C.L.7
-
29
-
-
77950809059
-
A chromatinmediated reversible drug-tolerant state in cancer cell subpopulations
-
Sharma SV, Lee DY, Li B, Quinlan MP, Takahashi F, Maheswaran S, McDermott U, Azizian N, Zou L, Fischbach MA, Wong K-K, Brandstetter K, Wittner B, Ramaswamy S, Classon M, Settleman J (2010) A chromatinmediated reversible drug-tolerant state in cancer cell subpopulations. Cell 141: 69-80.
-
(2010)
Cell
, vol.141
, pp. 69-80
-
-
Sharma, S.V.1
Lee, D.Y.2
Li, B.3
Quinlan, M.P.4
Takahashi, F.5
Maheswaran, S.6
McDermott, U.7
Azizian, N.8
Zou, L.9
Fischbach, M.A.10
Wong, K.-K.11
Brandstetter, K.12
Wittner, B.13
Ramaswamy, S.14
Classon, M.15
Settleman, J.16
-
30
-
-
84864286442
-
Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors
-
Wilson TR, Fridlyand J, Yan Y, Penuel E, Burton L, Chan E, Peng J, Lin E, Wang Y, Sosman J, Ribas A, Li J, Moffat J, Sutherlin DP, Koeppen H, Merchant M, Neve R, Settleman J (2012) Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors. Nature 487: 505-509.
-
(2012)
Nature
, vol.487
, pp. 505-509
-
-
Wilson, T.R.1
Fridlyand, J.2
Yan, Y.3
Penuel, E.4
Burton, L.5
Chan, E.6
Peng, J.7
Lin, E.8
Wang, Y.9
Sosman, J.10
Ribas, A.11
Li, J.12
Moffat, J.13
Sutherlin, D.P.14
Koeppen, H.15
Merchant, M.16
Neve, R.17
Settleman, J.18
-
31
-
-
79953760380
-
Resisting targeted therapy: Fifty ways to leave your EGFR
-
Workman P, Clarke PA (2011) Resisting targeted therapy: Fifty ways to leave your EGFR. Cancer Cell 19: 437-440.
-
(2011)
Cancer Cell
, vol.19
, pp. 437-440
-
-
Workman, P.1
Clarke, P.A.2
|