Identification of the mRNA Expression Status of the Dopamine D2 Receptor and Dopamine Transporter in Peripheral Blood Lymphocytes of Schizophrenia Patients

PLoS ONE

Volumn 8, Issue 9, 2013, Pages

  Liu, Liang ^a   Yuan, Guozhen ^a   Cheng, Zaohuo ^a   Zhang, Guofu ^a   Liu, Xiaowei ^a   Zhang, Huifang ^a  

^a NANJING MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CLOZAPINE; DOPAMINE 2 RECEPTOR; DOPAMINE TRANSPORTER; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; MESSENGER RNA;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; GENE OVEREXPRESSION; GENETIC ANALYSIS; GENETIC ASSOCIATION; HUMAN; HUMAN CELL; MALE; PERIPHERAL LYMPHOCYTE; POSITIVE AND NEGATIVE SYNDROME SCALE; POSITIVE SYNDROME; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SCHIZOPHRENIA; SYMPTOM;

ANALYSIS OF VARIANCE; CHINA; DNA PRIMERS; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; GENE EXPRESSION REGULATION; HUMANS; LYMPHOCYTES; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTORS, DOPAMINE D2; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SCHIZOPHRENIA;

EID: 84884579238     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0075259     Document Type: Article

References (38)

1. Lopez AD, Murray CC, (1998) The global burden of disease, 1990-2020. Nat Med 4: 1241-1243.
2. Ohara K, Nagai M, Tani K, Nakamura Y, Ino A, et al. (1998) Functional polymorphism of-141 Ins/Del in the dopamine D2 receptor gene promoter and schizophrenia. Psychiatry Res 81: 117-123.
3. Zvara A, Szekeres G, Janka Z, Kelemen JZ, Cimmer C, et al. (2005) Over-expression of dopamine D2 receptor and inwardly rectifying potassium channel genes in drug-naive schizophrenic peripheral blood lymphocytes as potential diagnostic markers. Dis Markers 21: 61-69.
4. Carlsson A, (2001) A paradigm shift in brain research. Science 294: 1021-1024.
5. Greengard P, (2001) The neurobiology of slow synaptic transmission. Science 294: 1024-1030.
6. Zhan L, Kerr JR, Lafuente MJ, Maclean A, Chibalina MV, et al. (2011) Altered expression and coregulation of dopamine signalling genes in schizophrenia and bipolar disorder. Neuropathol Appl Neurobiol 37: 206-219.
7. Tenn CC, Fletcher PJ, Kapur S, (2003) Amphetamine-sensitized animals show a sensorimotor gating and neurochemical abnormality similar to that of schizophrenia. Schizophr Res 64: 103-114.
8. Peleg-Raibstein D, Knuesel I, Feldon J, (2008) Amphetamine sensitization in rats as an animal model of schizophrenia. Behav Brain Res 191: 190-201.
9. Allen NC, Bagade S, McQueen MB, Ioannidis JP, Kavvoura FK, et al. (2008) Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene data-base. Nat Genet 40: 827-834.
10. Missale C, Nash SR, Robinson SW, Jaber M, Caron MG, (1998) Dopamine receptors: from structure to function. Physiol Rev 78: 189-225.
11. Buttarelli FR, Fanciulli A, Pellicano C, Pontieri FE, (2011) The Dopaminergic System in Peripheral Blood Lymphocytes: From Physiology to Pharmacology and Potential Applications to Neuropsychiatric Disorders. Curr Neuropharmacol 9: 278-288.
12. Ferrari M, Cosentino M, Marino F, Bombelli R, Rasini E, et al. (2004) Dopaminergic D1-like receptor-dependent inhibition of tyrosine hydroxylase mRNA expression and catecholamine production in human lymphocytes. Biochem Pharmacol 67: 865-873.
13. Kirillova GP, Hrutkay RJ, Shurin MR, Shurin GV, Tourkova IL, et al. (2008) Dopamine receptors in human lymphocytes: radioligand binding and quantitative RT-PCR assays. J Neurosci Methods 174: 272-280.
14. McKenna F, McLaughlin PJ, Lewis BJ, Sibbring GC, Cummerson JA, et al. (2002) Dopamine receptor expression on human T- and B-lymphocytes, monocytes, neutrophils, eosinophils and NK cells: a flow cytometric study. J Neuroimmunol 132: 34-40.
15. Nakano K, Higashi T, Hashimoto K, Takagi R, Tanaka Y, et al. (2008) Antagonizing dopamine D1-like receptor inhibits Th17 cell differentiation: preventive and therapeutic effects on experimental autoimmune encephalomyelitis. Biochem Biophys Res Commun 373: 286-291.
16. Nakano K, Higashi T, Takagi R, Hashimoto K, Tanaka Y, et al. (2009) Dopamine released by dendritic cells polarizes Th2 differentiation. Int Immunol 21: 645-654.
17. Amenta F, Bronzetti E, Cantalamessa F, El-Assouad D, Felici L, et al. (2001) Identification of dopamine plasma membrane and vesicular transporters in human peripheral blood lymphocytes. J Neuroimmunol 117: 133-142.
18. Mill J, Asherson P, Browes C, D'Souza U, Craig I, (2002) Expression of the dopamine transporter gene is regulated by the 3′ UTR VNTR: Evidence from brain and lymphocytes using quantitative RT-PCR. Am J Med Genet 114: 975-979.
19. Liu L, Jia F, Yuan G, Chen Z, Yao J, et al. (2010) Tyrosine hydroxylase, interleukin-1β and tumor necrosis factor-α are overexpressed in peripheral blood mononuclear cells from schizophrenia patients as determined by semi-quantitative analysis. Psychiatry Res 176: 1-7.
20. Goodarzi A, Vousooghi N, Sedaghati M, Mokri A, Zarrindast MR, (2009) Dopamine receptors in human peripheral blood lymphocytes: changes in mRNA expression in opioid addiction. Eur J Pharmacol 615: 218-222.
21. Rollins B, Martin MV, Morgan L, Vawter MP, (2010) Analysis of whole genome biomarker expression in blood and brain. Am J Med Genet B Neuropsychiatr Genet 153B: 919-936.
22. Wonodi I, Hong LE, Stine OC, Mitchell BD, Elliott A, et al. (2009) Dopamine transporter polymorphism modulates oculomotor function and DAT1 mRNA expression in schizophrenia. Am J Med Genet B Neuropsychiatr Genet 150B: 282-289.
23. Marazziti D, Catena Dell'osso M, Baroni S, Masala I, Dell'Osso B, et al. (2010) Alterations of the dopamine transporter in resting lymphocytes of patients with different psychotic disorders. Psychiatry Res 175: 54-57.
24. American Psychiatric Association (1994) Diagnostic and statistical manual of mental disorders, ed 4 (DSM-IV). Washington: American Psychiatric Association. 273-296p.
25. Chinese Society of Psychiatry (2001) The Chinese classification and diagnostic criteria of mental disorders version 3 (CCMD-3). Jinan: Chinese Society of Psychiatry. 78p.
26. Basu S, Dasgupta PS, (2000) Dopamine, a neurotransmitter, influences the immune system. J Neuroimmunol 102: 113-124.
27. Ilani T, Ben-Shachar D, Strous RD, Mazor M, Sheinkman A, et al. (2001) A peripheral marker for schizophrenia: increased levels of D3 dopamine receptor mRNA in blood lymphocytes. Proc Natl Acad Sci U S A. 98: 625-628.
28. Ilani T, Strous RD, Fuchs S, (2004) Dopaminergic regulation of immune cells via D3 dopamine receptor: a pathway mediated by activated T cells. FASEB J 18: 1600-1602.
29. Nagai Y, Ueno S, Saeki Y, Soga F, Hirano M, et al. (1996) Decrease of the D3 dopamine receptor mRNA expression in lymphocytes from patients with Parkinson's disease. Neurology 46: 791-795.
30. Sarkar C, Basu B, Chakroborty D, Dasgupta PS, Basu S, (2010) The immunoregulatory role of dopamine: an update. Brain Behav Immun 24: 525-528.
31. Wandinger KP, Hagenah JM, Klüter H, Rothermundt M, Peters M, et al. (1999) Effects of amantadine treatment on in vitro production of interleukin-2 in de-novo patients with idiopathic Parkinson's disease. J Neuroimmunol 98: 214-220.
32. Yao Y, Schröder J, Karlsson H, (2008) Verification of proposed peripheral biomarkers in mononuclear cells of individuals with schizophrenia. J Psychiatry Res 42: 639-643.
33. Tandon R, (2013) Schizophrenia and other Psychotic Disorders in DSM-5. Clin Schizophr Relat Psychoses 7: 16-19.
34. Fusar-Poli P, Meyer-Lindenberg A, (2013) Striatal presynaptic dopamine in schizophrenia, part I: meta-analysis of dopamine active transporter (DAT) density. Schizophr Bull 39: 22-32.
35. Mané A, Gallego J, Lomeña F, Mateos JJ, Fernandez-Egea E, et al. (2011) A 4-year dopamine transporter (DAT) imaging study in neuroleptic-naive first episode schizophrenia patients. Psychiatry Res 194: 79-84.
36. Sjøholm H, Bratlid T, Sundsfjord J, (2004) 123I-beta-CIT SPECT demonstrates increased presynaptic dopamine transporter binding sites in basal ganglia in vivo in schizophrenia. Psychopharmacology (Berl) 173: 27-31.
37. Laakso A, Bergman J, Haaparanta M, Vilkman H, Solin O, et al. (2001) Decreased striatal dopamine transporter binding in vivo in chronic schizophrenia. Schizophr Res 52: 115-120.
38. Gordon J, Barnes NM, (2003) Lymphocytes transport serotonin and dopamine: agony or ecstasy? Trends Immunol 24: 438-443.