Versatile synthesis of disubstituted triazole library for dopamine and serotonin receptor ligands

Bulletin of the Korean Chemical Society

Volumn 32, Issue , 2011, Pages 3101-3104

  Landge, Kamalkishor P ^a   Seo, Yong Wan ^a   Kwak, Jumyung ^a   Park, Woo Kyu ^b   Gong, Jae Yang ^b   Lee, Hee Yoon ^c   Koh, Hun Yeong ^a  

^a Inha University   (South Korea)

^b Korea Research Institute of Chemical Technology   (South Korea)

^c Korea Advanced Institute of Science and Technology (KAIST)   (South Korea)

Author keywords

Arylpiperazine1,2,3 Triazole; Click chemistry; Dopamine receptors; Serotonin receptors

Indexed keywords

EID: 84884563811     PISSN: 02532964     EISSN: 12295949     Source Type: Journal    
DOI: 10.5012/bkcs.2011.32.8.3101     Document Type: Article

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37. Compounds were evaluated in vitro for dopamine D2, D3, D4 receptors binding affinity by measuring their ability to displace radioligand ([3H]Methylspiperone for D2 and D3, [3H]YM-09151- 2 for D4) from the cloned human dopamine receptors D2Long, D3 and D4.2 which were stably expressed in CHO or Sf9 cells, respectively. For serotonin receptors, compounds were biologically evaluated against human recombinant 5-HT1A, 5- HT2A, 5-HT2C, 5-HT6 and 5-HT7 receptors stably expressed by CHO-K1 cell lines through [3H]8-OH-DPAT, [3H]Ketanserin, [3H]Mesulergine and [3H]LSD binding assay, respectively