Keratin 8 Is Required for the Maintenance of Architectural Structure in Thymus Epithelium

PLoS ONE

Volumn 8, Issue 9, 2013, Pages

  Odaka, Chikako ^a   Loranger, Anne ^b   Takizawa, Kazuya ^a   Ouellet, Michel ^b   Tremblay, Michel J ^b   Murata, Shigeo ^c   Inoko, Akihito ^d   Inagaki, Masaki ^d   Marceau, Normand ^b  

^a NATIONAL INSTITUTE OF INFECTIOUS DISEASES   (Japan)

^b University Laval   (Canada)

^c UNIVERSITY OF TOKYO   (Japan)

^d AICHI CANCER CENTER HOSPITAL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; CYTOKERATIN 18; CYTOKERATIN 8; FAS BINDING FACTOR 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL DIFFERENTIATION; CELL MATURATION; CELL STRUCTURE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; EPITHELIUM CELL; FEMALE; GENE; GENE INACTIVATION; INTERMEDIATE FILAMENT; K8 GENE; MALE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; THYMOCYTE; THYMUS; THYMUS EPITHELIUM CELL;

ANIMALS; EPITHELIUM; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; KERATIN-18; KERATIN-8; MICE; MICE, KNOCKOUT; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; STATISTICS, NONPARAMETRIC; THYMUS GLAND;

EID: 84884536461     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0075101     Document Type: Article

References (44)

1. Coulombe PA, Omary MB, (2002) 'Hard' and 'soft' principles defining the structure, function and regulation of keratin intermediate filaments. Curr Opin Cell Biol 14: 110-122.
2. Bragulla HH, Homberger DG, (2009) Structure and functions of keratin proteins in simple, stratified, keratinized and cornified epithelia. J Anat 214: 516-559.
3. Jackson BW, Grund C, Schmid E, Bürki K, Franke WW, et al. (1980) Formation of cytoskeletal elements during mouse embryogenesis. Intermediate filaments of the cytokeratin type and desmosomes in preimplantation embryos. Differentiation 17: 161-179.
4. Brulet P, Babinet C, Kemler R, Jacob F, (1980) Monoclonal antibodies against trophectoderm-specific markers during mouse blastocyst formation. Proc Natl Acad Sci U S A 77: 4113-4117.
5. Moll R, Franke WW, Schiller DL, Geiger B, Krepler R, (1982) The catalog of human cytokeratins: patterns of expression in normal epithelia, tumors and cultured cells. Cell 31: 11-24.
6. Lane EB, Goodman SL, Trejdosiewicz LK, (1982) Disruption of the keratin filament network during epithelial cell division. EMBO J 1: 1365-1372.
7. Oshima RG, Baribault H, Caulín C, (1996) Oncogenic regulation and function of keratins 8 and 18. Cancer Metastasis Rev 15: 445-471.
8. Baribault H, Price J, Miyai K, Oshima RG, (1992) Mid-gestational lethality in mice lacking keratin 8. Genes Dev 7: 1991-2002.
9. Baribault H, Penner J, lozzo RV, Wilson-Heiner M, (1994) Colorectal hyperplasia and inflammation in keratin 8-deficient FVB/N mice. Genes Dev 8: 2964-2973.
10. Marceau N, Gilbert S, Loranger A, (2004) Uncovering the roles of intermediate filaments in apoptosis. Methods Cell Biol 78: 95-129.
11. Loranger A, Duclos S, Grenier A, Price J, Wilson-Heiner M, et al. (1997) Simple epithelium keratins are required for maintenance of hepatocyte integrity. Am J Pathol 151: 1673-83.
12. Caulin CC, Ware F, Magin TM, Oshima RG, (2000) Keratin-dependent, epithelial resistance to tumor necrosis factor-induced apoptosis. J Cell Biol 149: 17-22.
13. Gilbert S, Loranger A, Daigle N, Marceau N, (2001) Simple epithelium keratins 8 and 18 provide resistance to Fas-mediated apoptosis. The protection occurs through a receptor-targeting modulation. J Cell Biol 154: 763-773.
14. Habtezion A, Toivola DM, Asghar MN, Kronmal GS, Brooks JD, et al. (2011) Absence of keratin 8 confers a paradoxicamicroflora-dependent resistance to apoptosis in the colon. Proc Natl Acad Sci U S A 108: 1445-1450.
15. Oriolo AS, Wald FA, Ramsauer VP, Salas PJ, (2007) Intermediate filaments: a role in epithelial polarity. Exp Cell Res 313: 2255-2264.
16. Toivola DM, Tao GZ, Habtezion A, Liao J, Omary MB, (2005) Beyond cellular integrity: organelle-related and protein-targeting functions of intermediate filaments. Trends Cell Biol 15: 608-617.
17. Farr AG, Dooley UL, Erickson M, (2002) Organization of thymic medullary epithelial heterogeneity: implications for mechanisms of epithelial differentiation. Immunol Rev 189: 20-27.
18. Klug DB, Carter C, Crouch E, Roop D, Conti CJ, et al. (1998) Interdependence of cortical thymic epithelial cell differentiation and T-lineage commitment. Proc Natl Acad Sci U S A 95: 11822-11827.
19. Bleul CC, Corbeaux T, Fisch AP, Mönting JS, Boehm T, (2006) Formation of a functional thymus initiated by a postnatal epithelial progenitor cell. Nature 441: 992-996.
20. Rossi SW, Jenkinson WE, Anderson G, Jenkinson EJ, (2006) Clonal analysis reveals a common progenitor for thymic cortical and medullary epithelium. Nature 441: 988-991.
21. Odaka C, Morisada T, Oike Y, Suda T, (2006) Distribution of lymphatic vessels in mouse thymus: immunofluorescence analysis. Cell Tissue Res 325: 13-22.
22. Odaka C, (2009) Localization of mesenchymal cells in adult mouse thymus: their abnormal distribution in mice with disorganization of thymic medullary epithelium. J Histochem Cytochem 57: 373-382.
23. Bravo-Nuevo A, O'Donnell R, Rosendahl A, Chung JH, Benjamin LE, et al. (2011) RhoB deficiency in thymic medullary epithelium leads to early thymic atrophy. Int Immunol 23: 593-600.
24. Murata S, Sasaki K, Kishimoto T, Niwa S, Hayashi H, et al. (2007) Regulation of CD8+ T cell development by thymus-specific proteasomes. Science 316: 1349-1353.
25. Sugimoto M, Inoko A, Shiromizu T, Nakayama M, Zou P, et al. (2008) The keratin-binding protein Albatross regulates polarization of epithelial cells. J Cell Biol 183: 19-28.
26. Odaka C, Mizuochi T, (1999) Role of macrophage lysosomal enzymes in the degradation of nucleosomes of apoptotic cells. J Immunol 163: 5346-5352.
27. Odaka C, Mizuochi T, (2002) Macrophages are involved in DNA degradation of apoptotic cells in murine thymus after administration of hydrocortisone. Cell Death Differ 9: 104-112.
28. Rouse RV, Bolin LM, Bender JR, Kyewski BA, (1998) Monoclonal antibodies reactive with subsets of mouse and humans thymic epithelial cells. J Histochem Cytochem 36: 1511-1519.
29. Jiang W, Swiggard WJ, Heufler C, Peng M, Mirza A, et al. (1995) Nussenzweig MC: The receptor DEC-205 expressed bydendritic cells and thymic epithelial cells is involved in antigen processing. Nature 375: 151-155.
30. Lee MG, Sharrow SO, Farr AG, Singer A, Udey MC, (1994) Expression of the homotypic adhesion molecule E-cadherin by immature murine thymocytes and thymic epithelial cells. J Immunol 152: 5653-5659.
31. Reisner Y, Linker-Israeli M, Sharon N, (1976) Separation of mouse thymocytes into two subpopulations by the use of peanut agglutinin. Cell Immunol 25: 129-134.
32. Schmidt T, Karsunky H, Frass B, Baum W, Denzel A, et al. (2000) A novel protein (Fbf-1) that binds to CD95/APO-1/FAS and shows sequence similarity to trichohyalin and plectin. Biochim Biophys Acta 1493: 249-254.
33. Garrod DR, Tselepis C, Runswick SK, North AJ, Wallis SR, et al. (1999) Desmosomal adhesion. Adv Mol Cell Biol 28: 165-202.
34. Runswick SK, O'Hare MJ, Jones L, Streuli CH, Garrod DR, (2001) Desmosomal adhesion regulates epithelial morphogenesis and cell positioning. Nat Cell Biol 3: 823-830.
35. Vasioukhin V, Bowers E, Bauer C, Degenstein L, Fuchs E, (2001) Desmoplakin is essential in epidermal sheet formation. Nat Cell Biol 3: 1076-1085.
36. Godsel LM, Hsieh SN, Amargo EV, Bass AE, Pascoe-McGillicuddy LT, et al. (2005) Desmoplakin assembly dynamics in four dimensions: multiple phases differentially regulated by intermediate filaments and actin. J Cell Biol 171: 1045-59.
37. Loranger A, Gilbert S, Brouard JS, Magin TM, Marceau N, (2006) Keratin 8 modulation of desmoplakin deposition at desmosomes in hepatocytes. Exp Cell Res 312: 4108-4119.
38. Farr AG, Anderson SK, (1985) Epithelial heterogeneity in the murine thymus: fucose-specific lectins bind medullary epithelial cells. J Immunol 134: 2971-2977.
39. Degermann S, Surh CD, Glimcher LH, Sprent J, Lo D, (1994) B7 expression on thymic medullary epithelium correlates with epithelium-mediated deletion of V beta 5+ thymocytes. J Immunol 152: 3254-3263.
40. Anderson MS, Venanzi ES, Klein L, Chen Z, Berzins SP, et al. (2002) Projection of an immunological self shadow within the thymus by the aire protein. Science 298: 1395-1401.
41. Senoo M, Pinto F, Crum CP, McKeon F, (2007) P63 is essential for the proliferative potential of stem cells in stratified epithelia. Cell 129: 523-536.
42. Candi E, Rufini A, Terrinoni A, Giamboi-Miraglia A, Lena AM, et al. (2007) ΔNp63 regulates thymic development through enhanced expression of FgfR2 and Jag2. Proc Natl Acad Sci U. S. A. 104: 11999-2004.
43. Irla M, Hollander G, Reith W, (2010) Control of central self-tolerance induction by autoreactive CD4+ thymocytes. Trends Immunol 31: 71-79.
44. Starr TK, Jameson SC, Hogquist KA, (2003) Positive and negative selection of T cells. Annu Rev Immunol 21: 139-176.