No association of 9p21 with arterial elasticity and retinal microvascular findings

Atherosclerosis

Volumn 230, Issue 2, 2013, Pages 301-303

  Folsom, Aaron R ^a   Pankow, James S ^a   Li, Xiaohui ^b   Duprez, Daniel A ^c   Jacobs, David R ^a   Klein, Ronald ^d   Klein, Barbara ^d   Tang, Weihong ^a   Wong, Tien Yin ^e   Cotch, Mary Frances ^f   Taylor, Kent D ^b   Rich, Stephen S ^g   Hall, Jennifer L ^c   Post, Wendy S ^h,i   Rotter, Jerome I ^b  

^a UNIVERSITY OF MINNESOTA   (United States)

^b LOS ANGELES BIOMEDICAL RESEARCH INSTITUTE   (United States)

^c UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^d UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^e NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^f NATIONAL EYE INSTITUTE   (United States)

^g UNIVERSITY OF VIRGINIA   (United States)

^h JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

ⁱ JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

9p21 SNP; Arterial elasticity; Prospective study; Retinal microvascular abnormalities

Indexed keywords

ADULT; AGED; ARTERIAL STIFFNESS; ARTICLE; CAROTID ARTERY; COHORT ANALYSIS; CONTROLLED STUDY; FEMALE; GENETIC ASSOCIATION; GENETIC MODEL; GENETIC VARIABILITY; HUMAN; MAJOR CLINICAL STUDY; MALE; PHENOTYPE; PRIORITY JOURNAL; RETINA ARTERY; SINGLE NUCLEOTIDE POLYMORPHISM; YOUNG MODULUS;

9P21 SNP; ARTERIAL ELASTICITY; PROSPECTIVE STUDY; RETINAL MICROVASCULAR ABNORMALITIES;

AGED; AGED, 80 AND OVER; ALLELES; ARTERIES; ATHEROSCLEROSIS; CAROTID ARTERIES; CHROMOSOMES, HUMAN, PAIR 9; ELASTICITY; ENDOTHELIUM, VASCULAR; ETHNIC GROUPS; FEMALE; HUMANS; LINEAR MODELS; MALE; MICROCIRCULATION; MIDDLE AGED; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE; PROSPECTIVE STUDIES; RETINAL ARTERY; RETINAL VEIN; RISK; VASCULAR STIFFNESS;

EID: 84884513464     PISSN: 00219150     EISSN: 18791484     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2013.07.049     Document Type: Article

References (27)

1. Holdt L.M., Teupser D. Recent studies of the human chromosome 9p21 locus, which is associated with atherosclerosis in human populations. Arterioscler Thromb Vasc Biol 2012, 32(2):196-206.
2. Johnson A.D., Hwang S.-J., Vorman A., et al. Resquencing and clinical associations of the 9p21.3 region: a comprehensive investigation in the Framingham Heart Study. Circulation 2013, 127(7):799-810.
3. Harismendy O., Notani D., Song X., et al. 9p21 DNA variants associated with coronary artery disease impair interferon-γ signaling response. Nature 2011, 470(7333):264-268.
4. Chan K., Patel R.S., Newcombe P., et al. Association between the chromosome 9p21 locus and angiographic coronary artery disease burden: a collaborative meta-analysis. JAm Coll Cardiol 2013, 61(9):957-970.
5. Leeper N.J., Raiesdana A., Kojima Y., et al. Loss of CDKN2B promotes p53-dependent smooth muscle cell apoptosis and aneurysm formation. Arterioscler Thromb Vasc Biol 2013, 33(1):e1-e10.
6. Wong T.Y., Islam F.M., Klein R., et al. Retinal vascular caliber, cardiovascular risk factors, and inflammation: the Multi-Ethnic Study of Atherosclerosis (MESA). Invest Ophthalmol Vis Sci 2006, 47(6):2341-2350.
7. Duprez D.A., Jacobs D.R., Lutsey P.L., et al. Association of small artery elasticity with incident cardiovascular disease in older adults: the Multi-Ethnic Study of Atherosclerosis. Am J Epidemiol 2011, 174(5):528-536.
8. Peralta C.A., Adeney K.L., Shlipak M.G., et al. Structural and functional vascular alterations and incident hypertension in normotensive adults: the Multi-Ethnic Study of Atherosclerosis. Am J Epidemiol 2010, 171(1):63-71.
9. Kawasaki R., Xie J., Cheung N., et al. Retinal microvascular signs and risk of stroke: the Multi-Ethnic Study of Atherosclerosis (MESA). Stroke 2012, 43(12):3245-3251.
10. McGeechan K., Liew G., Macaskill P., et al. Meta-analysis: retinal vessel caliber and risk for coronary heart disease. Ann Intern Med 2009, 151(6):404-413.
11. Wong T.Y., Kamineni A., Klein R., et al. Quantitative retinal venular caliber and risk of cardiovascular disease in older persons: the cardiovascular health study. Arch Intern Med 2006, 166(21):2388-2394.
12. Wong T.Y., Klein R., Sharrett A.R., et al. Retinal arteriolar narrowing and risk of coronary heart disease in men and women. The Atherosclerosis Risk in Communities Study. JAMA 2002, 287(9):1153-1159.
13. Cesana F., Nava S., Menni C., et al. Does the 9p region affect arterial stiffness? Results from a cohort of hypertensive individuals. Blood Press 2013, [epub ahead of print]. 10.3109/08037051.2013.765627.
14. Björck H.M., Länne T., Alehagen U., et al. Association of genetic variation on chromosome 9p21.3 and arterial stiffness. JIntern Med 2009, 265(3):373-381.
15. Ikram M.K., Sim X., Jensen R.A., Cotch M.F., Hewitt A.W., Ikram M.A., et al. Four novel Loci (19q13, 6q24, 12q24, and 5q14) influence the microcirculation invivo. PLoS Genet 2010, 6(10):e1001184.
16. Xing C., Klein B.E., Klein R., Jun G., Lee K.E., Iyengar S.K. Genome-wide linkage study of retinal vessel diameters in the Beaver Dam Eye Study. Hypertension 2006, 47(4):797-802.
17. Bild D.E., Bluemke D.A., Burke G.L., et al. Multi-ethnic study of atherosclerosis: objectives and design. Am J Epidemiol 2002, 156(9):871-881.
18. Wassel C.L., Jacobs D.R., Duprez D.A., et al. Association of self-reported race/ethnicity and genetic ancestry with arterial elasticity: the Multi-Ethnic Study of Atherosclerosis (MESA). JAm Soc Hypertens 2011, 5(6):463-472.
19. Fernandes V.R., Polak J.F., Cheng S., et al. Arterial stiffness is associated with regional ventricular systolic and diastolic dysfunction: the Multi-Ethnic Study of Atherosclerosis. Arterioscler Thromb Vasc Biol 2008, 28(1):194-201.
20. Hubbard L.D., Brothers R.J., King W.N., et al. Methods for evaluation of retinal microvascular abnormalities associated with hypertension/sclerosis in the Atherosclerotic Risk in Communities Study. Ophthalmology 1999, 106(12):2269-2280.
21. Knudtson M.D., Lee K.E., Hubbard L.D., Wong T.Y., Klein R., Klein B.E. Revised formulas for summarizing retinal vessel diameters. Curr Eye Res 2003, 27(3):143-149.
22. Liew G., Sharrett A.R., Wang J.J., et al. Relative importance of systemic determinants of retinal arteriolar and venular caliber: the Atherosclerosis Risk in Communities Study. Arch Ophthalmol 2008, 126(10):1404-1410.
23. Keating B.J., Tischfield S., Murray S.S., Bhangale T., Price T.S., Glessner J.T., et al. Concept, design and implementation of a cardiovascular gene-centric 50 k SNP array for large-scale genomic association studies. PLoS One 2008, 3(10):e3583.
24. Howie B.N., Donnelly P., Marchini J. Aflexible and accurate genotype imputation method for the next generation of genome-wide association studies. PLoS Genet 2009, 5(6):e1000529.
25. Silander K., Tang H., Myles S., et al. Worldwide patterns of haplotype diversity at 9p21.3, a locus associated with type 2 diabetes and coronary heart disease. Genome Med 2009, 1(5):51.
26. Wang L., Wong T.Y., Sharrett A.R., Klein R., Folsom A.R., Jerosch-Herold M. Relationship between retinal arteriolar narrowing and myocardial perfusion: Multi-Ethnic Study of Atherosclerosis. Hypertension 2008, 51(1):119-126.
27. Wang J.J., Liew G., Klein R., et al. Retinal vessel diameter and cardiovascular mortality: pooled data analysis from two older populations. Eur Heart J 2007, 28(16):1984-1992.