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Volumn 15, Issue 9, 2013, Pages

T-wave alternans as an arrhythmic risk stratifier: State of the art

Author keywords

Arrhythmia prevention; Arrhythmia risk stratification; Repolarization alternans; Sudden cardiac death; T wave alternans

Indexed keywords

ELECTROCARDIOGRAPHY; HEART ARRHYTHMIA; HEART VENTRICLE TACHYCARDIA; HUMAN; METHODOLOGY; PATHOPHYSIOLOGY; REVIEW; RISK ASSESSMENT; SUDDEN CARDIAC DEATH; ARRHYTHMIAS, CARDIAC; DEATH, SUDDEN, CARDIAC; PROCEDURES; TACHYCARDIA, VENTRICULAR;

EID: 84884511193     PISSN: 15233782     EISSN: 15343170     Source Type: Journal    
DOI: 10.1007/s11886-013-0398-7     Document Type: Article
Times cited : (23)

References (91)
  • 1
    • 0009758850 scopus 로고
    • Das Wesen des Herzalternans
    • Hering HE. Das Wesen des Herzalternans. Munchen Med Wchenshr. 1908;4:1417-21.
    • (1908) Munchen Med Wchenshr , vol.4 , pp. 1417-1421
    • Hering, H.E.1
  • 2
    • 0021236875 scopus 로고
    • Period multupling-evidence for nonlinear behaviour of the canine heart
    • Ritzenberg AL, Adam DR, Cohen RJ. Period multiplying-evidence for nonlinear behavior of the canine heart. Nature. 1984;307:159-61. (Pubitemid 14132899)
    • (1984) Nature , vol.307 , Issue.5947 , pp. 159-161
    • Ritzenberg, A.L.1    Adam, D.R.2    Cohen, R.J.3
  • 5
    • 14844349561 scopus 로고    scopus 로고
    • Action potential duration restitution and alternans in rabbit ventricular myocytes: The key role of intracellular calcium cycling
    • DOI 10.1161/01.RES.0000156891.66893.83
    • Goldhaber JI, Xie LH, Duong T, Motter C, Khuu K, Weiss JN. Action potential duration restitution and alternans in rabbit ventricular myocytes: the key role of intracellular calcium cycling. Circ Res. 2005;96:459-66. (Pubitemid 40354540)
    • (2005) Circulation Research , vol.96 , Issue.4 , pp. 459-466
    • Goldhaber, J.I.1    Xie, L.-H.2    Duong, T.3    Motter, C.4    Khuu, K.5    Weiss, J.N.6
  • 6
    • 0037020006 scopus 로고    scopus 로고
    • Depressed ryanodine receptor activity increases variability and duration of the systolic Ca2+ transient in rat ventricular myocytes
    • 12364386 10.1161/01.RES.0000035527.53514.C2 1:CAS:528: DC%2BD38Xntl2is7k%3D
    • Diaz ME, Eisner DA, O'Neill SC. Depressed ryanodine receptor activity increases variability and duration of the systolic Ca2+ transient in rat ventricular myocytes. Circ Res. 2002;91:585-93.
    • (2002) Circ Res , vol.91 , pp. 585-593
    • Diaz, M.E.1    Eisner, D.A.2    O'Neill, S.C.3
  • 7
    • 0032763731 scopus 로고    scopus 로고
    • Intracellular Ca(2+) dynamics and the stability of ventricular tachycardia
    • 10585917 10.1016/S0006-3495(99)77126-2 1:CAS:528:DyaK1MXotVGhs7o%3D
    • Chudin E, Goldhaber J, Garfinkel A, Weiss J, Kogan B. Intracellular Ca(2+) dynamics and the stability of ventricular tachycardia. Biophys J. 1999;77:2930-41.
    • (1999) Biophys J , vol.77 , pp. 2930-2941
    • Chudin, E.1    Goldhaber, J.2    Garfinkel, A.3    Weiss, J.4    Kogan, B.5
  • 8
    • 33646185379 scopus 로고    scopus 로고
    • Action potential morphology influences intracellular calcium handling stability and the occurrence of alternans
    • 16239324 10.1529/biophysj.105.071340 1:CAS:528:DC%2BD28XktlKrtA%3D%3D
    • Jordan PN, Christini DJ. Action potential morphology influences intracellular calcium handling stability and the occurrence of alternans. Biophys J. 2006;90:672-80.
    • (2006) Biophys J , vol.90 , pp. 672-680
    • Jordan, P.N.1    Christini, D.J.2
  • 9
    • 18944375264 scopus 로고    scopus 로고
    • 2+ release by glycolysis in cat atrial myocytes
    • DOI 10.1113/jphysiol.2004.078782
    • Kockskamper J, Zima AV, Blatter LA. Modulation of sarcoplasmic reticulum Ca2+ release by glycolysis in cat atrial myocytes. J Physiol. 2005;564(Pt 3):697-714. (Pubitemid 40704138)
    • (2005) Journal of Physiology , vol.564 , Issue.3 , pp. 697-714
    • Kockskamper, J.1    Zima, A.V.2    Blatter, L.A.3
  • 10
    • 0343963165 scopus 로고    scopus 로고
    • Functional coupling between glycolysis and excitation-contraction coupling underlies alternans in cat heart cells
    • Hüser J, Wang YG, Sheehan KA, Cifuentes F, Lipsius SL, Blatter LA. Functional coupling between glycolysis and excitation-contraction coupling underlies alternans in cat heart cells. J Physiol. 2000;524(Pt 3):795-806. (Pubitemid 30303626)
    • (2000) Journal of Physiology , vol.524 , Issue.3 , pp. 795-806
    • Huser, J.1    Wang, Y.G.2    Sheehan, K.A.3    Cifuentes, F.4    Lipsius, S.L.5    Blatter, L.A.6
  • 11
    • 0033574271 scopus 로고    scopus 로고
    • Mechanism linking T-wave alternans to the genesis of cardiac fibrillation
    • Pastore JM, Girouard SD, Laurita KR, Akar FG, Rosenbaum DS. Mechanism linking T-wave alternans to the genesis of cardiac fibrillation. Circulation. 1999;99:1385-94. (Pubitemid 29129926)
    • (1999) Circulation , vol.99 , Issue.10 , pp. 1385-1394
    • Pastore, J.M.1    Girouard, S.D.2    Laurita, K.R.3    Akar, F.G.4    Rosenbaum, D.S.5
  • 12
    • 0034623825 scopus 로고    scopus 로고
    • Role of structural barriers in the mechanism of alternans-induced reentry
    • 11110773 10.1161/01.RES.87.12.1157 1:CAS:528:DC%2BD3cXoslyntbg%3D
    • Pastore JM, Rosenbaum DS. Role of structural barriers in the mechanism of alternans-induced reentry. Circ Res. 2000;87:1157-63.
    • (2000) Circ Res , vol.87 , pp. 1157-1163
    • Pastore, J.M.1    Rosenbaum, D.S.2
  • 13
    • 0005911582 scopus 로고    scopus 로고
    • How restitution, repolarization, and alternans form arrhythmogenic substrates: Insights from high-resolution optical mapping
    • D. Zipes J. Jalife (eds) 2 W.B. Saunders Philadelphia, PA
    • Laurita KR, Pastore JM, Rosenbaum DS. How restitution, repolarization, and alternans form arrhythmogenic substrates: insights from high-resolution optical mapping. In: Zipes DP, Jalife J, editors. Cardiac Electrophysiology: From Cell to Bedside. 2nd ed. Philadelphia, PA: W.B. Saunders; 1999. p. 239-48.
    • (1999) Cardiac Electrophysiology: From Cell to Bedside , pp. 239-248
    • Laurita, K.R.1    Pastore, J.M.2    Rosenbaum, D.S.3
  • 16
    • 0026280409 scopus 로고
    • Abnormal Cai2+ handling is the primary cause of mechanical alternans: Study in ferret ventricular muscles
    • 1750531 1:CAS:528:DyaK38XotFektQ%3D%3D
    • Kihara Y, Morgan JP. Abnormal Cai2+ handling is the primary cause of mechanical alternans: study in ferret ventricular muscles. Am J Physiol. 1991;261(6 Pt 2):H1746-55.
    • (1991) Am J Physiol , vol.261 , Issue.6 PART 2 , pp. 1746-1755
    • Kihara, Y.1    Morgan, J.P.2
  • 17
    • 0025259586 scopus 로고
    • Changes in intracellular calcium during mechanical alternans in isolated ferret ventricular muscle
    • Lab MJ, Lee JA. Changes in intracellular calcium during mechanical alternans in isolated ferret ventricular muscle. Circ Res. 1990;66:585-95. (Pubitemid 20086900)
    • (1990) Circulation Research , vol.66 , Issue.3 , pp. 585-595
    • Lab, M.J.1    Lee, J.A.2
  • 18
    • 0015081152 scopus 로고
    • A comparison of alternation in myocardial action potentials and contractility
    • 5087820 1:STN:280:DyaE3M3hs1OqtA%3D%3D
    • Spear JF, Moore EN. A comparison of alternation in myocardial action potentials and contractility. Am J Physiol. 1971;220:1708-16.
    • (1971) Am J Physiol , vol.220 , pp. 1708-1716
    • Spear, J.F.1    Moore, E.N.2
  • 19
    • 38349042115 scopus 로고    scopus 로고
    • Modifying L-type calcium current kinetics: Consequences for cardiac excitation and arrhythmia dynamics
    • 18160661 10.1529/biophysj.106.98590 1:CAS:528:DC%2BD1cXnsVOntg%3D%3D
    • Mahajan A, Sato D, Shiferaw Y, Baher A, Xie LH, Peralta R, et al. Modifying L-type calcium current kinetics: consequences for cardiac excitation and arrhythmia dynamics. Biophys J. 2008;94:411-23.
    • (2008) Biophys J , vol.94 , pp. 411-423
    • Mahajan, A.1    Sato, D.2    Shiferaw, Y.3    Baher, A.4    Xie, L.H.5    Peralta, R.6
  • 21
    • 0023280509 scopus 로고
    • Myocardial contractile function during ischemia and hypoxia
    • Allen DG, Orchard CH. Myocardial contractile function during ischemia and hypoxia. Circ Res. 1987;60:153-68. (Pubitemid 17078830)
    • (1987) Circulation Research , vol.60 , Issue.2 , pp. 153-168
    • Allen, D.G.1    Orchard, C.H.2
  • 22
    • 63849172706 scopus 로고    scopus 로고
    • Mechanism of abnormal sarcoplasmic reticulum calcium release in canine left-ventricular myocytes results in cellular alternans
    • 19272939 10.1109/TBME.2008.2003283
    • Armoundas AA. Mechanism of abnormal sarcoplasmic reticulum calcium release in canine left-ventricular myocytes results in cellular alternans. IEEE Trans Biomed Eng. 2009;56:220-8.
    • (2009) IEEE Trans Biomed Eng , vol.56 , pp. 220-228
    • Armoundas, A.A.1
  • 23
    • 33745000775 scopus 로고    scopus 로고
    • From pulsus to pulseless: The saga of cardiac alternans
    • DOI 10.1161/01.RES.0000224540.97431.f0, PII 0000301220060526000006
    • Weiss JN, Karma A, Shiferaw Y, Chen PS, Garfinkel A, Qu Z. From pulsus to pulseless: the saga of cardiac alternans. Circ Res. 2006;98:1244-53. (Pubitemid 43948079)
    • (2006) Circulation Research , vol.98 , Issue.10 , pp. 1244-1253
    • Weiss, J.N.1    Karma, A.2    Shiferaw, Y.3    Chen, P.-S.4    Garfinkel, A.5    Qu, Z.6
  • 24
    • 55949136438 scopus 로고    scopus 로고
    • Action potential dynamics explain arrhythmic vulnerability in human heart failure: A clinical and modeling study implicating abnormal calcium handling
    • 19022157 10.1016/j.jacc.2008.08.037
    • Narayan SM, Bayer JD, Lalani G, Trayanova NA. Action potential dynamics explain arrhythmic vulnerability in human heart failure: a clinical and modeling study implicating abnormal calcium handling. J Am Coll Cardiol. 2008;52:1782-92.
    • (2008) J Am Coll Cardiol , vol.52 , pp. 1782-1792
    • Narayan, S.M.1    Bayer, J.D.2    Lalani, G.3    Trayanova, N.A.4
  • 25
    • 1942441076 scopus 로고    scopus 로고
    • Role of Calcium Cycling Versus Restitution in the Mechanism of Repolarization Alternans
    • DOI 10.1161/01.RES.0000125629.72053.95
    • Pruvot EJ, Katra RP, Rosenbaum DS, Laurita KR. Role of calcium cycling vs restitution in the mechanism of repolarization alternans. Circ Res. 2004;94:1083-10. (Pubitemid 38579703)
    • (2004) Circulation Research , vol.94 , Issue.8 , pp. 1083-1090
    • Pruvot, E.J.1    Katra, R.P.2    Rosenbaum, D.S.3    Laurita, K.R.4
  • 26
    • 84856428812 scopus 로고    scopus 로고
    • Role of substrate and triggers in the genesis of cardiac alternans, from the myocyte to the whole heart: Implications for therapy
    • 22271847 10.1161/CIRCULATIONAHA.111.033563
    • Merchant FM, Armoundas AA. Role of substrate and triggers in the genesis of cardiac alternans, from the myocyte to the whole heart: implications for therapy. Circulation. 2012;125:539-49.
    • (2012) Circulation , vol.125 , pp. 539-549
    • Merchant, F.M.1    Armoundas, A.A.2
  • 27
    • 0034668923 scopus 로고    scopus 로고
    • Simultaneous maps of optical action potentials and calcium transients in guinea-pig hearts: Mechanisms underlying concordant alternans
    • 11080260 10.1111/j.1469-7793.2000.00171.x 1:CAS:528:DC%2BD3cXovVajs70%3D
    • Choi BR, Salama G. Simultaneous maps of optical action potentials and calcium transients in guinea-pig hearts: mechanisms underlying concordant alternans. J Physiol. 2000;529(Pt 1):171-88.
    • (2000) J Physiol , vol.529 , Issue.PART 1 , pp. 171-188
    • Choi, B.R.1    Salama, G.2
  • 28
    • 0032534508 scopus 로고    scopus 로고
    • Modulated dispersion explains changes in arrhythmia vulnerability during premature stimulation of the heart
    • Laurita KR, Girouard SD, Akar FG, Rosenbaum DS. Modulated dispersion explains changes in arrhythmia vulnerability during premature stimulation of the heart. Circulation. 1998;98:2774-80. (Pubitemid 28564015)
    • (1998) Circulation , vol.98 , Issue.24 , pp. 2774-2780
    • Laurita, K.R.1    Girouard, S.D.2    Akar, F.G.3    Rosenbaum, D.S.4
  • 29
    • 0031468958 scopus 로고    scopus 로고
    • Implications of ion channel diversity to ventricular repolarization and arrhythmogenesis: Insights from high resolution optical mapping
    • Laurita KR, Rosenbaum DS. Implications of ion channel diversity to ventricular repolarization and arrhythmogenesis: insights from high resolution optical mapping. Can J Cardiol. 1997;13:1069-76. (Pubitemid 28004548)
    • (1997) Canadian Journal of Cardiology , vol.13 , Issue.11 , pp. 1069-1076
    • Laurita, K.R.1    Rosenbaum, D.S.2
  • 30
    • 0023802275 scopus 로고
    • Effect of ischemia on calcium-dependent fluorescence transients in rabbit hearts containing indo 1. Correlation with monophasic action potentials and contraction
    • 2844438 10.1161/01.CIR.78.4.1047 1:STN:280:DyaL1M%2FgtlCrtQ%3D%3D
    • Lee HC, Mohabir R, Smith N, Franz MR, Clusin WT. Effect of ischemia on calcium-dependent fluorescence transients in rabbit hearts containing indo 1. Correlation with monophasic action potentials and contraction. Circulation. 1988;78:1047-59.
    • (1988) Circulation , vol.78 , pp. 1047-1059
    • Lee, H.C.1    Mohabir, R.2    Smith, N.3    Franz, M.R.4    Clusin, W.T.5
  • 31
    • 0035940395 scopus 로고    scopus 로고
    • Spatial heterogeneity of calcium transient alternans during the early phase of myocardial ischemia in the blood-perfused rabbit heart
    • Qian YW, Clusin WT, Lin SF, Han J, Sung RJ. Spatial heterogeneity of calcium transient alternans during the early phase of myocardial ischemia in the blood-perfused rabbit heart. Circulation. 2001;104:2082-7. (Pubitemid 33027050)
    • (2001) Circulation , vol.104 , Issue.17 , pp. 2082-2087
    • Qian, Y.-W.1    Clusin, W.T.2    Lin, S.-F.3    Han, J.4    Sung, R.J.5
  • 32
    • 33745416009 scopus 로고    scopus 로고
    • Calcium transient alternans in blood-perfused ischemic hearts: Observations with fluorescent indicator fura red
    • 9374749 1:CAS:528:DyaK2sXnsVCksb4%3D
    • Wu Y, Clusin WT. Calcium transient alternans in blood-perfused ischemic hearts: observations with fluorescent indicator fura red. Am J Physiol. 1997;273(5 Pt 2):H2161-9.
    • (1997) Am J Physiol , vol.273 , Issue.5 PART 2 , pp. 2161-2169
    • Wu, Y.1    Clusin, W.T.2
  • 33
    • 63849172706 scopus 로고    scopus 로고
    • Mechanism of abnormal sarcoplasmic reticulum calcium release in canine left ventricular myocytes results in cellular alternans
    • In press
    • Armoundas AA. Mechanism of abnormal sarcoplasmic reticulum calcium release in canine left ventricular myocytes results in cellular alternans. IEEE Trans Biomed Eng. 2009:In press.
    • (2009) IEEE Trans Biomed Eng
    • Armoundas, A.A.1
  • 34
    • 85047675278 scopus 로고
    • Dispersion of monophasic action potential durations and activation times during atrial pacing, ventricular pacing, and ventricular premature stimulation in canine ventricles
    • Kuo CS, Amlie JP, Munakata K, Reddy CP, Surawicz B. Dispersion of monophasic action potential durations and activation times during atrial pacing, ventricular pacing, and ventricular premature stimulation in canine ventricles. Cardiovasc Res. 1983;17:152-61. (Pubitemid 13113951)
    • (1983) Cardiovascular Research , vol.17 , Issue.3 , pp. 152-161
    • Kuo, C.S.1    Amlie, J.P.2    Munakata, K.3
  • 35
    • 0032556025 scopus 로고    scopus 로고
    • Electrophysiological basis of arrhythmogenicity of QT/T alternans in the long-QT syndrome: Tridimensional analysis of the kinetics of cardiac repolarization
    • Chinushi M, Restivo M, Caref EB, El-Sherif N. Electrophysiological basis of arrhythmogenicity of QT/T alternans in the long-QT syndrome: tridimensional analysis of the kinetics of cardiac repolarization. Circ Res. 1998;83:614-28. (Pubitemid 28427745)
    • (1998) Circulation Research , vol.83 , Issue.6 , pp. 614-628
    • Chinushi, M.1    Restivo, M.2    Caref, E.B.3    El-Sherif, N.4
  • 37
    • 58849098155 scopus 로고    scopus 로고
    • Heart failure enhances susceptibility to arrhythmogenic cardiac alternans
    • 10.1016/j.hrthm.2008.11.008
    • Wilson LD, Jeyaraj D, Wan X, Hoeker GS, Said TH, Gittinger M, et al. Heart failure enhances susceptibility to arrhythmogenic cardiac alternans. Hear Rhythm. 2009;6:251-9.
    • (2009) Hear Rhythm , vol.6 , pp. 251-259
    • Wilson, L.D.1    Jeyaraj, D.2    Wan, X.3    Hoeker, G.S.4    Said, T.H.5    Gittinger, M.6
  • 39
    • 84867764589 scopus 로고    scopus 로고
    • Targeted sarcoplasmic reticulum Ca2+ ATPase 2a gene delivery to restore electrical stability in the failing heart
    • 23019291 10.1161/CIRCULATIONAHA.111.071480 1:CAS:528:DC%2BC38XhsFGqsbrN This paper highlights the close relationship between contractile dysfunction and arrhythmogenesis in pre-clinical models
    • •• Cutler MJ, Wan X, Plummer BN, Liu H, Deschenes I, Laurita KR, et al. Targeted sarcoplasmic reticulum Ca2+ ATPase 2a gene delivery to restore electrical stability in the failing heart. Circulation. 2012;126:2095-104. This paper highlights the close relationship between contractile dysfunction and arrhythmogenesis in pre-clinical models.
    • (2012) Circulation , vol.126 , pp. 2095-2104
    • Cutler, M.J.1    Wan, X.2    Plummer, B.N.3    Liu, H.4    Deschenes, I.5    Laurita, K.R.6
  • 43
    • 33846890687 scopus 로고    scopus 로고
    • Autonomic modulation of electrical restitution, alternans and ventricular fibrillation initiation in the isolated heart
    • DOI 10.1016/j.cardiores.2006.12.001, PII S0008636306005645
    • Ng GA, Brack KE, Patel VH, Coote JH. Autonomic modulation of electrical restitution, alternans and ventricular fibrillation initiation in the isolated heart. Cardiovasc Res. 2007;73:750-60. (Pubitemid 46227349)
    • (2007) Cardiovascular Research , vol.73 , Issue.4 , pp. 750-760
    • Ng, G.A.1    Brack, K.E.2    Patel, V.H.3    Coote, J.H.4
  • 44
    • 0030296540 scopus 로고    scopus 로고
    • Sympathetic influences on electrical and mechanical alternans in the canine heat
    • DOI 10.1016/0008-6363(96)00151-4
    • Euler DE, Guo H, Olshansky B. Sympathetic influences on electrical and mechanical alternans in the canine heart. Cardiovasc Res. 1996;32:854-60. (Pubitemid 26342650)
    • (1996) Cardiovascular Research , vol.32 , Issue.5 , pp. 854-860
    • Euler, D.E.1    Guo, G.2    Olshansky, B.3
  • 45
    • 0001589399 scopus 로고
    • Mechanisms controlling cardiac autonomic function and their relationships to arrhythmogenesis
    • H.A. Fozzard E. Haber R.B. Jennings (eds) et al. Raven Press New York
    • Corr PB, Yamada KA, Witkowski FX. Mechanisms controlling cardiac autonomic function and their relationships to arrhythmogenesis. In: Fozzard HA, Haber E, Jennings RB, et al., editors. The Heart and Cardiovascular System. New York: Raven Press; 1986. p. 1343-404.
    • (1986) The Heart and Cardiovascular System , pp. 1343-1404
    • Corr, P.B.1    Yamada, K.A.2    Witkowski, F.X.3
  • 46
    • 24644524532 scopus 로고    scopus 로고
    • Mechanisms of sudden cardiac death
    • DOI 10.1172/JCI26381
    • Rubart M, Zipes DP. Mechanisms of sudden cardiac death. J Clin Invest. 2005;115:2305-15. (Pubitemid 41266189)
    • (2005) Journal of Clinical Investigation , vol.115 , Issue.9 , pp. 2305-2315
    • Rubart, M.1    Zipes, D.P.2
  • 48
    • 0021932249 scopus 로고
    • Effects of unilateral stellate ganglion stimulation and ablation on electrophysiologic changes induced by acute myocardial ischemia in dogs
    • Janse MJ, Schwartz PJ, Wilms-Schopman F, Peters RJ, Durrer D. Effects of unilateral stellate ganglion stimulation and ablation on electrophysiologic changes induced by acute myocardial ischemia in dogs. Circulation. 1985;72:585-95. (Pubitemid 15242253)
    • (1985) Circulation , vol.72 , Issue.3 , pp. 585-595
    • Janse, M.J.1    Schwartz, P.J.2    Wilms-Schopman, F.3
  • 49
    • 33746751481 scopus 로고    scopus 로고
    • A comprehensive review and analysis of 25 years of data from an in vivo canine model of sudden cardiac death: Implications for future anti-arrhythmic drug development
    • DOI 10.1016/j.pharmthera.2006.01.002, PII S0163725806000052
    • Billman GE. A comprehensive review and analysis of 25 years of data from an in vivo canine model of sudden cardiac death: implications for future anti-arrhythmic drug development. Pharmacol Ther. 2006;111:808-35. (Pubitemid 44160523)
    • (2006) Pharmacology and Therapeutics , vol.111 , Issue.3 , pp. 808-835
    • Billman, G.E.1
  • 51
    • 21344474383 scopus 로고    scopus 로고
    • Microvolt T-wave alternans for the risk stratification of ventricular tachyarrhythmic events: A meta-analysis
    • DOI 10.1016/j.jacc.2005.03.059, PII S0735109705008715
    • Gehi AK, Stein RH, Metz LD, Gomes JA. Microvolt T-wave alternans for the risk stratification of ventricular tachyarrhythmic events: a meta-analysis. J Am Coll Cardiol. 2005;46:75-82. (Pubitemid 40905133)
    • (2005) Journal of the American College of Cardiology , vol.46 , Issue.1 , pp. 75-82
    • Gehi, A.K.1    Stein, R.H.2    Metz, L.D.3    Gomes, J.A.4
  • 52
    • 78650158253 scopus 로고    scopus 로고
    • Sudden cardiac death prediction and prevention: Report from a National Heart, Lung, and Blood Institute and Heart Rhythm Society Workshop
    • 21147730 10.1161/CIRCULATIONAHA.110.976092
    • Fishman GI, Chugh SS, Dimarco JP, Albert CM, Anderson ME, Bonow RO, et al. Sudden cardiac death prediction and prevention: report from a National Heart, Lung, and Blood Institute and Heart Rhythm Society Workshop. Circulation. 2010;122:2335-48.
    • (2010) Circulation , vol.122 , pp. 2335-2348
    • Fishman, G.I.1    Chugh, S.S.2    Dimarco, J.P.3    Albert, C.M.4    Anderson, M.E.5    Bonow, R.O.6
  • 53
    • 33644903761 scopus 로고    scopus 로고
    • Population-based analysis of sudden cardiac death with and without left ventricular systolic dysfunction: 2-year findings from the Oregon Sudden Unexpected Death Study
    • 16545646 10.1016/j.jacc.2005.11.045
    • Stecker EC, Vickers C, Waltz J, Socoteanu C, John BT, Mariani R, et al. Population-based analysis of sudden cardiac death with and without left ventricular systolic dysfunction: 2-year findings from the Oregon Sudden Unexpected Death Study. J Am Coll Cardiol. 2006;47:1161-6.
    • (2006) J Am Coll Cardiol , vol.47 , pp. 1161-1166
    • Stecker, E.C.1    Vickers, C.2    Waltz, J.3    Socoteanu, C.4    John, B.T.5    Mariani, R.6
  • 54
    • 61649091384 scopus 로고    scopus 로고
    • AHA/ACCF/HRS recommendations for the standardization and interpretation of the electrocardiogram: Part IV: The ST segment, T and U waves, and the QT interval: A scientific statement from the American Heart Association Electrocardiography and Arrhythmias Committee
    • 19281931 10.1016/j.jacc.2008.12.014 Council on Clinical Cardiology; The American College of Cardiology Foundation; And the Heart Rhythm Society. Endorsed by the International Society for Computerized Electrocardiology
    • Rautaharju PM, Surawicz B, Gettes LS, Bailey JJ, Childers R, Deal BJ, et al. AHA/ACCF/HRS recommendations for the standardization and interpretation of the electrocardiogram: part IV: the ST segment, T and U waves, and the QT interval: a scientific statement from the American Heart Association Electrocardiography and Arrhythmias Committee, Council on Clinical Cardiology; the American College of Cardiology Foundation; and the Heart Rhythm Society. Endorsed by the International Society for Computerized Electrocardiology. J Am Coll Cardiol. 2009;53:982-91.
    • (2009) J Am Coll Cardiol , vol.53 , pp. 982-991
    • Rautaharju, P.M.1    Surawicz, B.2    Gettes, L.S.3    Bailey, J.J.4    Childers, R.5    Deal, B.J.6
  • 55
    • 55049088260 scopus 로고    scopus 로고
    • Does microvolt T-wave alternans testing predict ventricular tachyarrhythmias in patients with ischemic cardiomyopathy and prophylactic defibrillators? The MASTER (Microvolt T Wave Alternans Testing for Risk Stratification of Post-Myocardial Infarction Patients) trial
    • 18992649 10.1016/j.jacc.2008.08.018
    • Chow T, Kereiakes DJ, Onufer J, Woelfel A, Gursoy S, Peterson BJ, et al. Does microvolt T-wave alternans testing predict ventricular tachyarrhythmias in patients with ischemic cardiomyopathy and prophylactic defibrillators? The MASTER (Microvolt T Wave Alternans Testing for Risk Stratification of Post-Myocardial Infarction Patients) trial. J Am Coll Cardiol. 2008;52:1607-15.
    • (2008) J Am Coll Cardiol , vol.52 , pp. 1607-1615
    • Chow, T.1    Kereiakes, D.J.2    Onufer, J.3    Woelfel, A.4    Gursoy, S.5    Peterson, B.J.6
  • 57
    • 57149125829 scopus 로고    scopus 로고
    • Role of microvolt T-wave alternans in assessment of arrhythmia vulnerability among patients with heart failure and systolic dysfunction: Primary results from the T-wave alternans sudden cardiac death in heart failure trial substudy
    • 18955671 10.1161/CIRCULATIONAHA.107.748962
    • Gold MR, Ip JH, Costantini O, Poole JE, McNulty S, Mark DB, et al. Role of microvolt T-wave alternans in assessment of arrhythmia vulnerability among patients with heart failure and systolic dysfunction: primary results from the T-wave alternans sudden cardiac death in heart failure trial substudy. Circulation. 2008;118:2022-8.
    • (2008) Circulation , vol.118 , pp. 2022-2028
    • Gold, M.R.1    Ip, J.H.2    Costantini, O.3    Poole, J.E.4    McNulty, S.5    Mark, D.B.6
  • 58
    • 60949106951 scopus 로고    scopus 로고
    • Evidence regarding clinical use of microvolt T-wave alternans
    • 10.1016/j.hrthm.2008.10.011 This paper elucidates the confounding role that including ICD therapies as an endpoint in risk stratification trials may have on defining the utility of T-wave alternans testing
    • • Hohnloser SH, Ikeda T, Cohen RJ. Evidence regarding clinical use of microvolt T-wave alternans. Hear Rhythm. 2009;6(3):S36-44. This paper elucidates the confounding role that including ICD therapies as an endpoint in risk stratification trials may have on defining the utility of T-wave alternans testing.
    • (2009) Hear Rhythm , vol.6 , Issue.3 , pp. 36-44
    • Hohnloser, S.H.1    Ikeda, T.2    Cohen, R.J.3
  • 59
    • 33644870367 scopus 로고    scopus 로고
    • Are implantable cardioverter defibrillator shocks a surrogate for sudden cardiac death in patients with nonischemic cardiomyopathy?
    • 16461817 10.1161/CIRCULATIONAHA.105.561571
    • Ellenbogen KA, Levine JH, Berger RD, Daubert JP, Winters SL, Greenstein E, et al. Are implantable cardioverter defibrillator shocks a surrogate for sudden cardiac death in patients with nonischemic cardiomyopathy? Circulation. 2006;113:776-82.
    • (2006) Circulation , vol.113 , pp. 776-782
    • Ellenbogen, K.A.1    Levine, J.H.2    Berger, R.D.3    Daubert, J.P.4    Winters, S.L.5    Greenstein, E.6
  • 60
    • 33645739897 scopus 로고    scopus 로고
    • Frequency and causes of implantable cardioverter-defibrillator therapies: Is device therapy proarrhythmic?
    • 16616037 10.1016/j.amjcard.2005.11.048
    • Germano JJ, Reynolds M, Essebag V, Josephson ME. Frequency and causes of implantable cardioverter-defibrillator therapies: is device therapy proarrhythmic? Am J Cardiol. 2006;97:1255-61.
    • (2006) Am J Cardiol , vol.97 , pp. 1255-1261
    • Germano, J.J.1    Reynolds, M.2    Essebag, V.3    Josephson, M.E.4
  • 61
    • 84864446744 scopus 로고    scopus 로고
    • Clinical utility of microvolt T-wave alternans testing in identifying patients at high or low risk of sudden cardiac death
    • 10.1016/j.hrthm.2012.03.014 e1252. This paper highlights the robust role of T-wave alternans testing in clinical risk stratification among patients without ICDs
    • •• Merchant FM, Ikeda T, Pedretti RF, Salerno-Uriarte JA, Chow T, Chan PS, et al. Clinical utility of microvolt T-wave alternans testing in identifying patients at high or low risk of sudden cardiac death. Hear Rhythm. 2012;9:1256-64. This paper highlights the robust role of T-wave alternans testing in clinical risk stratification among patients without ICDs.
    • (2012) Hear Rhythm , vol.9 , pp. 1256-1264
    • Merchant, F.M.1    Ikeda, T.2    Pedretti, R.F.3    Salerno-Uriarte, J.A.4    Chow, T.5    Chan, P.S.6
  • 63
    • 80052318889 scopus 로고    scopus 로고
    • A novel lead configuration for optimal spatio-temporal detection of intracardiac repolarization alternans
    • This paper describes a novel intra-cardiac system to optimize detection of repolarization alternans. Optimized detection is an important step in the ability to deliver upstream anti-arrhythmic therapies.
    • • Weiss EH, Merchant FM, d'Avila A, Foley L, Reddy VY, Singh JP, et al. A novel lead configuration for optimal spatio-temporal detection of intracardiac repolarization alternans. Circ Arrhythm Electrophysiol. 2011:407-17. This paper describes a novel intra-cardiac system to optimize detection of repolarization alternans. Optimized detection is an important step in the ability to deliver upstream anti-arrhythmic therapies.
    • (2011) Circ Arrhythm Electrophysiol , pp. 407-417
    • Weiss, E.H.1    Merchant, F.M.2    D'Avila, A.3    Foley, L.4    Reddy, V.Y.5    Singh, J.P.6
  • 64
    • 58949086983 scopus 로고    scopus 로고
    • The ABCD (Alternans before Cardioverter Defibrillator) Trial: Strategies using T-wave alternans to improve efficiency of sudden cardiac death prevention
    • 19195603 10.1016/j.jacc.2008.08.077
    • Costantini O, Hohnloser SH, Kirk MM, Lerman BB, Baker II JH, Sethuraman B, et al. The ABCD (Alternans Before Cardioverter Defibrillator) Trial: strategies using T-wave alternans to improve efficiency of sudden cardiac death prevention. J Am Coll Cardiol. 2009;53:471-9.
    • (2009) J Am Coll Cardiol , vol.53 , pp. 471-479
    • Costantini, O.1    Hohnloser, S.H.2    Kirk, M.M.3    Lerman, B.B.4    Baker, I.I.J.H.5    Sethuraman, B.6
  • 66
    • 20844456962 scopus 로고    scopus 로고
    • Microvolt T-wave alternans distinguishes between patients likely and patients not likely to benefit from implanted cardiac defibrillator therapy: A solution to the Multicenter Automatic Defibrillator Implantation Trial (MADIT) II conundrum
    • DOI 10.1161/01.CIR.0000143160.14610.53
    • Bloomfield DM, Steinman RC, Namerow PB, Parides M, Davidenko J, Kaufman ES, et al. Microvolt T-wave alternans distinguishes between patients likely and patients not likely to benefit from implanted cardiac defibrillator therapy: a solution to the Multicenter Automatic Defibrillator Implantation Trial (MADIT) II conundrum. Circulation. 2004;110:1885-9. (Pubitemid 39331896)
    • (2004) Circulation , vol.110 , Issue.14 , pp. 1885-1889
    • Bloomfield, D.M.1    Steinman, R.C.2    Namerow, P.B.3    Parides, M.4    Davidenko, J.5    Kaufman, E.S.6    Shinn, T.7    Curtis, A.8    Fontaine, J.9    Holmes, D.10    Russo, A.11    Tang, C.12    Bigger Jr., J.T.13
  • 67
  • 69
    • 0025801015 scopus 로고
    • Dynamic tracking of cardiac vulnerability by complex demodulation of the T wave
    • Nearing BD, Huang AH, Verrier RL. Dynamic tracking of cardiac vulnerability by complex demodulation of the T wave. Science. 1991;252:437-40. (Pubitemid 21916981)
    • (1991) Science , vol.252 , Issue.5004 , pp. 437-440
    • Nearing, B.D.1    Huang, A.H.2    Verrier, R.L.3
  • 70
    • 0028786001 scopus 로고
    • Risk of cardiac events in family members of patients with long QT syndrome
    • 7594104 10.1016/0735-1097(95)60383-2 1:STN:280:DyaK28%2FotlGnsQ%3D%3D
    • Zareba W, Moss AJ, le Cessie S, Locati EH, Robinson JL, Hall WJ, et al. Risk of cardiac events in family members of patients with long QT syndrome. J Am Coll Cardiol. 1995;26:1685-91.
    • (1995) J Am Coll Cardiol , vol.26 , pp. 1685-1691
    • Zareba, W.1    Moss, A.J.2    Le Cessie, S.3    Locati, E.H.4    Robinson, J.L.5    Hall, W.J.6
  • 71
    • 84878622917 scopus 로고    scopus 로고
    • Elevated T-Wave Alternans Predicts Nonsustained Ventricular Tachycardia in Association with Percutaneous Coronary Intervention in ST-Segment Elevation Myocardial Infarction (STEMI) Patients
    • Verrier RL, Nearing BD, Ghanem RN, Olson RE, Garberich RF, Katsiyiannis WT, et al. Elevated T-Wave Alternans Predicts Nonsustained Ventricular Tachycardia in Association with Percutaneous Coronary Intervention in ST-Segment Elevation Myocardial Infarction (STEMI) Patients. J Cardiovasc Electrophysiol. 2012;24:658-63.
    • (2012) J Cardiovasc Electrophysiol , vol.24 , pp. 658-663
    • Verrier, R.L.1    Nearing, B.D.2    Ghanem, R.N.3    Olson, R.E.4    Garberich, R.F.5    Katsiyiannis, W.T.6
  • 72
    • 79955383687 scopus 로고    scopus 로고
    • Continuous T-wave alternans monitoring to predict impending life-threatening cardiac arrhythmias during emergent coronary reperfusion therapy in patients with acute coronary syndrome
    • 10.1093/europace/euq512
    • Takasugi N, Kubota T, Nishigaki K, Verrier RL, Kawasaki M, Takasugi M, et al. Continuous T-wave alternans monitoring to predict impending life-threatening cardiac arrhythmias during emergent coronary reperfusion therapy in patients with acute coronary syndrome. Europace. 2012;13:708-15.
    • (2012) Europace , vol.13 , pp. 708-715
    • Takasugi, N.1    Kubota, T.2    Nishigaki, K.3    Verrier, R.L.4    Kawasaki, M.5    Takasugi, M.6
  • 73
    • 79953234505 scopus 로고    scopus 로고
    • Antifibrillatory effect of ranolazine during severe coronary stenosis in the intact porcine model
    • 10.1016/j.hrthm.2010.11.029
    • Nieminen T, Nanbu DY, Datti IP, Vaz GR, Tavares CA, Pegler JR, et al. Antifibrillatory effect of ranolazine during severe coronary stenosis in the intact porcine model. Hear Rhythm. 2011;8:608-14.
    • (2011) Hear Rhythm , vol.8 , pp. 608-614
    • Nieminen, T.1    Nanbu, D.Y.2    Datti, I.P.3    Vaz, G.R.4    Tavares, C.A.5    Pegler, J.R.6
  • 74
    • 33750852496 scopus 로고    scopus 로고
    • Discordant S-T alternans contributes to formation of reentry: A possible mechanism of reperfusion arrhythmia
    • 9688903 1:CAS:528:DyaK1cXkvFarurg%3D
    • Tachibana H, Kubota I, Yamaki M, Watanabe T, Tomoike H. Discordant S-T alternans contributes to formation of reentry: a possible mechanism of reperfusion arrhythmia. Am J Physiol. 1998;275(1 Pt 2):H116-21.
    • (1998) Am J Physiol , vol.275 , Issue.1 PART 2 , pp. 116-121
    • Tachibana, H.1    Kubota, I.2    Yamaki, M.3    Watanabe, T.4    Tomoike, H.5
  • 75
    • 0033596974 scopus 로고    scopus 로고
    • Cellular and ionic basis for T-wave alternans under long-QT conditions
    • Shimizu W, Antzelevitch C. Cellular and ionic basis for T-wave alternans under long-QT conditions. Circulation. 1999;99:1499-507. (Pubitemid 29140918)
    • (1999) Circulation , vol.99 , Issue.11 , pp. 1499-1507
    • Shimizu, W.1    Antzelevitch, C.2
  • 77
    • 0034601749 scopus 로고    scopus 로고
    • Mechanisms of discordant alternans and induction of reentry in simulated cardiac tissue
    • 11015345 10.1161/01.CIR.102.14.1664 1:STN:280:DC%2BD3cvmslarug%3D%3D
    • Qu Z, Garfinkel A, Chen PS, Weiss JN. Mechanisms of discordant alternans and induction of reentry in simulated cardiac tissue. Circulation. 2000;102:1664-70.
    • (2000) Circulation , vol.102 , pp. 1664-1670
    • Qu, Z.1    Garfinkel, A.2    Chen, P.S.3    Weiss, J.N.4
  • 79
    • 33747143137 scopus 로고    scopus 로고
    • Upsurge in T-wave alternans and nonalternating repolarization instability precedes spontaneous initiation of ventricular tachyarrhythmias in humans
    • DOI 10.1161/CIRCULATIONAHA.105.607895, PII 0000301720060627000007
    • Shusterman V, Goldberg A, London B. Upsurge in T-wave alternans and nonalternating repolarization instability precedes spontaneous initiation of ventricular tachyarrhythmias in humans. Circulation. 2006;113:2880-7. (Pubitemid 44297228)
    • (2006) Circulation , vol.113 , Issue.25 , pp. 2880-2887
    • Shusterman, V.1    Goldberg, A.2    London, B.3
  • 80
    • 84858304943 scopus 로고    scopus 로고
    • Crescendo in depolarization and repolarization heterogeneity heralds development of ventricular tachycardia in hospitalized patients with decompensated heart failure
    • 22157521 10.1161/CIRCEP.111.965434
    • Nearing BD, Wellenius GA, Mittleman MA, Josephson ME, Burger AJ, Verrier RL. Crescendo in depolarization and repolarization heterogeneity heralds development of ventricular tachycardia in hospitalized patients with decompensated heart failure. Circ Arrhythm Electrophysiol. 2012;5:84-90.
    • (2012) Circ Arrhythm Electrophysiol , vol.5 , pp. 84-90
    • Nearing, B.D.1    Wellenius, G.A.2    Mittleman, M.A.3    Josephson, M.E.4    Burger, A.J.5    Verrier, R.L.6
  • 81
    • 58549089506 scopus 로고    scopus 로고
    • Defibrillator electrogram T wave alternans as a predictor of spontaneous ventricular tachyarrhythmias in defibrillator recipients
    • 19039191 10.1253/circj.CJ-08-0311
    • Kim JW, Pak HN, Park JH, Nam GB, Kim SK, Lee HS, et al. Defibrillator electrogram T wave alternans as a predictor of spontaneous ventricular tachyarrhythmias in defibrillator recipients. Circ J. 2009;73:55-62.
    • (2009) Circ J , vol.73 , pp. 55-62
    • Kim, J.W.1    Pak, H.N.2    Park, J.H.3    Nam, G.B.4    Kim, S.K.5    Lee, H.S.6
  • 82
    • 2442606540 scopus 로고    scopus 로고
    • Utility of implantable cardioverter defibrillator electrograms to estimate repolarization alternans preceding a tachyarrhythmic event
    • Armoundas AA, Albert CM, Cohen RJ, Mela T. Utility of implantable cardioverter defibrillator electrograms to estimate repolarization alternans preceding a tachyarrhythmic event. J Cardiovasc Electrophysiol. 2004;15:594-7. (Pubitemid 38621913)
    • (2004) Journal of Cardiovascular Electrophysiology , vol.15 , Issue.5 , pp. 594-597
    • Armoundas, A.A.1    Albert, C.M.2    Cohen, R.J.3    Mela, T.4
  • 83
    • 42649083305 scopus 로고    scopus 로고
    • High amplitude T-wave alternans precedes spontaneous ventricular tachycardia or fibrillation in ICD electrograms
    • 10.1016/j.hrthm.2008.02.018
    • Swerdlow CD, Zhou X, Voroshilovsky O, Abeyratne A, Gillberg J. High amplitude T-wave alternans precedes spontaneous ventricular tachycardia or fibrillation in ICD electrograms. Hear Rhythm. 2008;5:670-6.
    • (2008) Hear Rhythm , vol.5 , pp. 670-676
    • Swerdlow, C.D.1    Zhou, X.2    Voroshilovsky, O.3    Abeyratne, A.4    Gillberg, J.5
  • 84
    • 79953066360 scopus 로고    scopus 로고
    • Intracardiac electrogram T-wave alternans/variability increases before spontaneous ventricular tachyarrhythmias in implantable cardioverter- defibrillator patients: A prospective, multi-center study
    • 21357826 10.1161/CIRCULATIONAHA.110.986364 This paper demonstrates the feasibility of intra-cardiac detection of repolarization alternans in predicting ICD therapy and opens the door to delivery of upstream, abortive anti-arrhythmic therapies
    • •• Swerdlow C, Chow T, Das M, Gillis AM, Zhou X, Abeyratne A, et al. Intracardiac electrogram T-wave alternans/variability increases before spontaneous ventricular tachyarrhythmias in implantable cardioverter- defibrillator patients: a prospective, multi-center study. Circulation. 2011;123:1052-60. This paper demonstrates the feasibility of intra-cardiac detection of repolarization alternans in predicting ICD therapy and opens the door to delivery of upstream, abortive anti-arrhythmic therapies.
    • (2011) Circulation , vol.123 , pp. 1052-1060
    • Swerdlow, C.1    Chow, T.2    Das, M.3    Gillis, A.M.4    Zhou, X.5    Abeyratne, A.6
  • 85
    • 33745490029 scopus 로고    scopus 로고
    • Detection of T-wave alternans using an implantable cardioverter- defibrillator
    • DOI 10.1016/j.hrthm.2006.03.022, PII S1547527106013245
    • Paz O, Zhou X, Gillberg J, Tseng HJ, Gang E, Swerdlow C. Detection of T-wave alternans using an implantable cardioverter-defibrillator. Hear Rhythm. 2006;3:791-7. (Pubitemid 43960543)
    • (2006) Heart Rhythm , vol.3 , Issue.7 , pp. 791-797
    • Paz, O.1    Zhou, X.2    Gillberg, J.3    Tseng, H.-J.4    Gang, E.5    Swerdlow, C.6
  • 86
    • 29444449745 scopus 로고    scopus 로고
    • Cardiac contractility modulation by non-excitatory currents: Studies in isolated cardiac muscle
    • DOI 10.1016/j.ejheart.2005.05.011, PII S1388984205001340
    • Brunckhorst CB, Shemer I, Mika Y, Ben-Haim SA, Burkhoff D. Cardiac contractility modulation by nonexcitatory currents: studies in isolated cardiac muscle. Eur J Heart Fail. 2006;8:7-15. (Pubitemid 43012095)
    • (2006) European Journal of Heart Failure , vol.8 , Issue.1 , pp. 7-15
    • Brunckhorst, C.B.1    Shemer, I.2    Mika, Y.3    Ben-Haim, S.A.4    Burkhoff, D.5
  • 87
    • 79959507250 scopus 로고    scopus 로고
    • The acute inotropic effects of cardiac contractility modulation (CCM) are associated with action potential duration shortening and mediated by beta1-adrenoceptor signalling
    • 21557948 10.1016/j.yjmcc.2011.04.010 1:CAS:528:DC%2BC3MXotVeis78%3D
    • Winter J, Brack KE, Ng GA. The acute inotropic effects of cardiac contractility modulation (CCM) are associated with action potential duration shortening and mediated by beta1-adrenoceptor signalling. J Mol Cell Cardiol. 2011;51:252-62.
    • (2011) J Mol Cell Cardiol , vol.51 , pp. 252-262
    • Winter, J.1    Brack, K.E.2    Ng, G.A.3
  • 88
    • 84875742069 scopus 로고    scopus 로고
    • A novel pacing method to suppress repolarization alternans in vivo: Implications for arrhythmia prevention
    • Armoundas AA, Weiss EH, Sayadi O, Laferriere S, Sajja N, Mela T, et al. A novel pacing method to suppress repolarization alternans in vivo: implications for arrhythmia prevention. Heart Rhythm. 2013;10:564-72.
    • (2013) Heart Rhythm , vol.10 , pp. 564-572
    • Armoundas, A.A.1    Weiss, E.H.2    Sayadi, O.3    Laferriere, S.4    Sajja, N.5    Mela, T.6
  • 90
    • 0037044421 scopus 로고    scopus 로고
    • Alternans of atrial action potentials during atrial flutter as a precursor to atrial fibrillation
    • DOI 10.1161/01.CIR.0000037062.35762.B4
    • Narayan SM, Bode F, Karasik PL, Franz MR. Alternans of atrial action potentials during atrial flutter as a precursor to atrial fibrillation. Circulation. 2002;106:1968-73. (Pubitemid 35176303)
    • (2002) Circulation , vol.106 , Issue.15 , pp. 1968-1973
    • Narayan, S.M.1    Bode, F.2    Karasik, P.L.3    Franz, M.R.4
  • 91
    • 79959960476 scopus 로고    scopus 로고
    • Repolarization alternans reveals vulnerability to human atrial fibrillation
    • 21646498 10.1161/CIRCULATIONAHA.110.977827
    • Narayan SM, Franz MR, Clopton P, Pruvot EJ, Krummen DE. Repolarization alternans reveals vulnerability to human atrial fibrillation. Circulation. 2011;123:2922-30.
    • (2011) Circulation , vol.123 , pp. 2922-2930
    • Narayan, S.M.1    Franz, M.R.2    Clopton, P.3    Pruvot, E.J.4    Krummen, D.E.5


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