Epidural application of spinal instrumentation particulate wear debris: A comprehensive evaluation of neurotoxicity using an in vivo animal model Laboratory investigation

Journal of Neurosurgery: Spine

Volumn 19, Issue 3, 2013, Pages 336-350

  Cunningham, Bryan W ^a   Hallab, Nadim J ^b   Hu, Nianbin ^a   Mcafee, Paul C ^a  

^a UNIVERSITY OF MARYLAND   (United States)

^b RUSH UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Animal model; Epidural application; Epidural fibrosis; Neurotoxicity; Proinflammatory cytokines; Spinal cord; Wear particulate

Indexed keywords

CHROMIUM; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 6; POLITEF; POLYCARBONATE; POLYESTER; POLYETHERETHERKETONE; POLYETHYLENE TEREPHTHALATE; SILICONE; STAINLESS STEEL; TITANIUM; TUMOR NECROSIS FACTOR ALPHA; ULTRA HIGH MOLECULAR WEIGHT POLYETHYLENE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CERAMICS; CONTROLLED STUDY; CYTOKINE PRODUCTION; DURA MATER; EPIDURAL SPACE; HISTOPATHOLOGY; IMMUNOCYTOCHEMISTRY; IN VIVO STUDY; LIGAMENTUM FLAVUM; MACROPHAGE; MEDICAL DEVICE COMPLICATION; NEUROTOXICITY; NONHUMAN; PARTICLE SIZE; PARTICULATE WEAR DEBRIS; RABBIT MODEL; SCANNING ELECTRON MICROSCOPY; SPINE IMPLANT;

ANIMALS; CYTOKINES; ENDOTOXINS; EPIDURAL SPACE; FIBROSIS; LUMBAR VERTEBRAE; MACROPHAGE ACTIVATION; MODELS, ANIMAL; NEUROTOXINS; ORTHOPEDIC PROCEDURES; PARTICULATE MATTER; PROSTHESES AND IMPLANTS; RABBITS; RANDOM ALLOCATION; SPINAL CORD;

EID: 84884479888     PISSN: 15475654     EISSN: 15475646     Source Type: Journal    
DOI: 10.3171/2013.5.SPINE13166     Document Type: Article

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