Beyond symmetry-breaking: Competition and negative feedback in GTPase regulation

Trends in Cell Biology

Volumn 23, Issue 10, 2013, Pages 476-483

  Wu, Chi Fang ^a   Lew, Daniel J ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Cdc42; GAP; GEF; Rac; Rop

Indexed keywords

GUANOSINE TRIPHOSPHATASE;

ACTIN FILAMENT; CELL DIVISION; CELL FUNCTION; CELL GROWTH; CELL MEMBRANE; CELL POLARITY; CYTOLOGY; ENZYME REGULATION; FUNGAL CELL; MICROTUBULE; NEGATIVE FEEDBACK; NONHUMAN; OSCILLATION; PERIODICITY; PLANT CELL; POSITIVE FEEDBACK; PRIORITY JOURNAL; PROTEIN DOMAIN; REVIEW; SCHIZOSACCHAROMYCES POMBE; SECRETORY VESICLE; VEGETATIVE GROWTH;

CDC42; GAP; GEF; RAC; ROP;

ACTINS; CDC42 GTP-BINDING PROTEIN; CELL POLARITY; FEEDBACK, PHYSIOLOGICAL; GTP PHOSPHOHYDROLASES; GTPASE-ACTIVATING PROTEINS; GUANINE NUCLEOTIDE EXCHANGE FACTORS; PLANT CELLS; SACCHAROMYCES CEREVISIAE;

EID: 84884417598     PISSN: 09628924     EISSN: 18793088     Source Type: Journal    
DOI: 10.1016/j.tcb.2013.05.003     Document Type: Review

References (50)

1. Johnson J.M., et al. Symmetry breaking and the establishment of cell polarity in budding yeast. Curr. Opin. Genet. Dev. 2011, 21:740-746.
2. Yang Z., Lavagi I. Spatial control of plasma membrane domains: ROP GTPase-based symmetry breaking. Curr. Opin. Plant Biol. 2012, 15:601-607.
3. Fu Y., et al. Arabidopsis interdigitating cell growth requires two antagonistic pathways with opposing action on cell morphogenesis. Cell 2005, 120:687-700.
4. Liu W., et al. Yeast formin Bni1p has multiple localization regions that function in polarized growth and spindle orientation. Mol. Biol. Cell 2012, 23:412-422.
5. Chen H., et al. Cdc42p regulation of the yeast formin Bni1p mediated by the effector Gic2p. Mol. Biol. Cell 2012, 23:3814-3826.
6. Wu H., et al. The Exo70 subunit of the exocyst is an effector for both Cdc42 and Rho3 function in polarized exocytosis. Mol. Biol. Cell 2010, 21:430-442.
7. Baek K., et al. Structure-function study of the N-terminal domain of exocyst subunit Sec3. J. Biol. Chem. 2010, 285:10424-10433.
8. Turing A. The chemical basis of morphogenesis. Philos. Trans. R. Soc. Lond. B: Biol. Sci. 1952, 237:37-72.
9. Gierer A., Meinhardt H. A theory of biological pattern formation. Kybernetik 1972, 12:30-39.
10. Kozubowski L., et al. Symmetry-breaking polarization driven by a Cdc42p GEF-PAK complex. Curr. Biol. 2008, 18:1719-1726.
11. Endo M., et al. The Cdc42 binding and scaffolding activities of the fission yeast adaptor protein Scd2. J. Biol. Chem. 2003, 278:843-852.
12. Feng Q., et al. Regulation of the Cool/Pix proteins: key binding partners of the Cdc42/Rac targets, the p21-activated kinases. J. Biol. Chem. 2002, 277:5644-5650.
13. Papadaki P., et al. Two ras pathways in fission yeast are differentially regulated by two ras guanine nucleotide exchange factors. Mol. Cell. Biol. 2002, 22:4598-4606.
14. Meinhardt H., Gierer A. Pattern formation by local self-activation and lateral inhibition. Bioessays 2000, 22:753-760.
15. Meinhardt H., Gierer A. Applications of a theory of biological pattern formation based on lateral inhibition. J. Cell Sci. 1974, 15:321-346.
16. Goryachev A.B., Pokhilko A.V. Dynamics of Cdc42 network embodies a Turing-type mechanism of yeast cell polarity. FEBS Lett. 2008, 582:1437-1443.
17. Semplice M., et al. A bistable model of cell polarity. PLoS ONE 2012, 7:e30977.
18. Howell A.S., et al. Negative feedback enhances robustness in the yeast polarity establishment circuit. Cell 2012, 149:322-333.
19. Howell A.S., et al. Singularity in polarization: rewiring yeast cells to make two buds. Cell 2009, 139:731-743.
20. Kelly F.D., Nurse P. De novo growth zone formation from fission yeast spheroplasts. PLoS ONE 2011, 6:e27977.
21. Mitchison J.M., Nurse P. Growth in cell length in the fission yeast Schizosaccharomyces pombe. J. Cell Sci. 1985, 75:357-376.
22. Das M., et al. Regulation of cell diameter, For3p localization, and cell symmetry by fission yeast Rho-GAP Rga4p. Mol. Biol. Cell 2007, 18:2090-2101.
23. Feierbach B., Chang F. Roles of the fission yeast formin for3p in cell polarity, actin cable formation and symmetric cell division. Curr. Biol. 2001, 11:1656-1665.
24. Csikász-Nagy A., et al. Spatial controls for growth zone formation during the fission yeast cell cycle. Yeast 2008, 25:59-69.
25. Cerone L., et al. Mathematical model for growth regulation of fission yeast Schizosaccharomyces pombe. PLoS ONE 2012, 7:e49675.
26. Das M., et al. Oscillatory dynamics of Cdc42 GTPase in the control of polarized growth. Science 2012, 337:239-243.
27. Knechtle P., et al. Maximal polar growth potential depends on the polarisome component AgSpa2 in the filamentous fungus Ashbya gossypii. Mol. Biol. Cell 2003, 14:4140-4154.
28. Oda Y., Fukuda H. Initiation of cell wall pattern by a Rho- and microtubule-driven symmetry breaking. Science 2012, 337:1333-1336.
29. Xu T., et al. Cell surface- and rho GTPase-based auxin signaling controls cellular interdigitation in Arabidopsis. Cell 2010, 143:99-110.
30. Hwang J.U., et al. Oscillatory ROP GTPase activation leads the oscillatory polarized growth of pollen tubes. Mol. Biol. Cell 2005, 16:5385-5399.
31. Novak B., Tyson J.J. Design principles of biochemical oscillators. Nat. Rev. Mol. Cell Biol. 2008, 9:981-991.
32. Holdaway-Clarke T.L., et al. Effect of extracellular calcium, pH and borate on growth oscillations in Lilium formosanum pollen tubes. J. Exp. Bot. 2003, 54:65-72.
33. Feijo J.A., et al. Cellular oscillations and the regulation of growth: the pollen tube paradigm. Bioessays 2001, 23:86-94.
34. Ziman M., Johnson D.I. Genetic evidence for a functional interaction between Saccharomyces cerevisiae CDC24 and CDC42. Yeast 1994, 10:463-474.
35. Kelly F.D., Nurse P. Spatial control of Cdc42 activation determines cell width in fission yeast. Mol. Biol. Cell 2011, 22:3801-3811.
36. Dyer J.M., et al. Tracking shallow chemical gradients by actin-driven wandering of the polarization site. Curr. Biol. 2013, 23:32-41.
37. Bendezu F.O., Martin S.G. Cdc42 explores the cell periphery for mate selection in fission yeast. Curr. Biol. 2013, 23:42-47.
38. Kohli M., et al. Growth-speed-correlated localization of exocyst and polarisome components in growth zones of Ashbya gossypii hyphal tips. J. Cell Sci. 2008, 121:3878-3889.
39. Hwang J.U., et al. A tip-localized RhoGAP controls cell polarity by globally inhibiting Rho GTPase at the cell apex. Curr. Biol. 2008, 18:1907-1916.
40. Araujo-Palomares C.L., et al. Functional characterization and cellular dynamics of the CDC-42-RAC-CDC-24 module in Neurospora crassa. PLoS ONE 2011, 6:e27148.
41. Layton A.T., et al. Modeling vesicle traffic reveals unexpected consequences for Cdc42p-mediated polarity establishment. Curr. Biol. 2011, 21:184-194.
42. Savage N.S., et al. Mechanistic mathematical model of polarity in yeast. Mol. Biol. Cell 2012, 23:1998-2013.
43. Ozbudak E.M., et al. A system of counteracting feedback loops regulates Cdc42p activity during spontaneous cell polarization. Dev. Cell 2005, 9:565-571.
44. Qin Y., Yang Z. Rapid tip growth: insights from pollen tubes. Semin. Cell Dev. Biol. 2011, 22:816-824.
45. Frieser S.H., et al. Cla4 kinase triggers destruction of the Rac1-GEF Cdc24 during polarized growth in Ustilago maydis. Mol. Biol. Cell 2011, 22:3253-3262.
46. Gulli M.P., et al. Phosphorylation of the Cdc42 exchange factor Cdc24 by the PAK-like kinase Cla4 may regulate polarized growth in yeast. Mol. Cell 2000, 6:1155-1167.
47. Bose I., et al. Assembly of scaffold-mediated complexes containing Cdc42p, the exchange factor Cdc24p, and the effector Cla4p required for cell cycle-regulated phosphorylation of Cdc24p. J. Biol. Chem. 2001, 276:7176-7186.
48. Wai S.C., et al. Multisite phosphorylation of the guanine nucleotide exchange factor Cdc24 during yeast cell polarization. PLoS ONE 2009, 4:e6563.
49. Xu J., et al. Divergent signals and cytoskeletal assemblies regulate self-organizing polarity in neutrophils. Cell 2003, 114:201-214.
50. Carlin L.M., et al. A targeted siRNA screen identifies regulators of Cdc42 activity at the natural killer cell immunological synapse. Sci. Signal. 2011, 4:ra81.