Liver Glucagon Receptors (GluR): Effect of Exercise and Fasting on Binding Characteristics, GluR-mRNA, and GluR Protein Content in Rats

Hormone and Metabolic Research

Volumn 45, Issue 10, 2013, Pages 716-721

  Melancon A ^a,b   Gagnon, V ^a,c   Milot, M ^a   Charest, E ^a,c   Foucher, D ^a,c   Peronnet F ^a   Unson O'Brien, C G ^b   Asselin, E ^a,c   Lavoie, C ^a,c  

^a UNIVERSITÉ DE MONTRÉAL   (Canada)

^b ROCKEFELLER UNIVERSITY   (United States)

^c UNIVERSITÉ DU QUÉBEC À TROIS RIVIÈRES   (Canada)

Author keywords

de novo synthesis; externalization; glucagon insulin ratio; glycogen; swimming

Indexed keywords

3 HYDROXYBUTYRIC ACID; GLUCAGON; GLUCAGON RECEPTOR; GLYCOGEN; INSULIN; LACTIC ACID; MESSENGER RNA;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL MEMBRANE; CONTROLLED STUDY; DIET RESTRICTION; EXERCISE; GLUCAGON BLOOD LEVEL; GLYCOGEN LIVER LEVEL; INSULIN BLOOD LEVEL; LACTATE BLOOD LEVEL; LIVER; LIVER HOMOGENATE; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN CONTENT; RAT; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

RATTUS;

ANIMALS; FASTING; LIVER; MALE; PHYSICAL CONDITIONING, ANIMAL; PROTEIN BINDING; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GLUCAGON; RNA, MESSENGER; SWIMMING;

EID: 84884416880     PISSN: 00185043     EISSN: 14394286     Source Type: Journal    
DOI: 10.1055/s-0033-1349853     Document Type: Article

References (34)

1. Wasserman D. H. Four grams of glucose. Am J Physiol Endocrinol Metab: 2009; 296 E11 E21
2. Cherrington A. D., Stevenson R. W., Steiner K. E. Glucagon as a regulator of hepatic glucose production in vivo. Biochem Soc Trans: 1987; 15 1023 1027 (Pubitemid 18036263)
3. Ramnanan C. J., Edgerton D. S., Kraft G., Cherrington A. D. Physiologic action of glucagon on liver glucose metabolism. Diabetes Obes Metab: 2011; 13 01 118 125
4. Brand C. L., Jorgensen P. N., Knigge U., Warberg J., Svendsen I., Kristensen J. S., Holst J. J. Role of glucagon in maintenance of euglycemia in fed and fasted rats. Am J Physiol: 1995; 269 E469 E477
5. Hendrick G. K., Wasserman D. H., Frizzell R. T., Williams P. E., Lacy D. B., Jaspan J. B., Cherrington A. D. Importance of basal glucagon in maintaining hepatic glucose production during a prolonged fast in conscious dogs. Am J Physiol: 1992; 263 E541 E549
6. Bonjorn V. M., Latour M. G., Belanger P., Lavoie J. M. Influence of prior exercise and liver glycogen content on the sensitivity of the liver to glucagon. J Appl Physiol: 2002; 92 188 194 (Pubitemid 34670005)
7. Wagle S. R. Studies on the differential response to glucagon concentration on gluconeogenesis in isolated hepatocytes containing high and low glycogen. Biochem Biophy Res Commun: 1974; 59 1366 1372
8. Caro J. F., Amatruda J. M. The effects of fasting on glucagon binding and action in isolated rat hepatocytes. Metabolism: 1980; 29 732 738 (Pubitemid 10035081)
9. Charbonneau A., Melancon A., Lavoie C., Lavoie J. M. Alterations in hepatic glucagon receptor density and in Gsalpha and Gialpha2 protein content with diet-induced hepatic steatosis: effects of acute exercise. Am J Physiol Endocrinol Metab: 2005; 289 E8 E14 (Pubitemid 40874928)
10. Charbonneau A., Unson C. G., Lavoie J. M. High-fat diet-induced hepatic steatosis reduces glucagon receptor content in rat hepatocytes: potential interaction with acute exercise. J Physiol: 2007; 579 255 267
11. Burcelin R., Mrejen C., Decaux J. F., De Mouzon S. H., Girard J., Charron M. J. In vivo and in vitro regulation of hepatic glucagon receptor mRNA concentration by glucose metabolism. J Biol Chem: 1998; 273 8088 8093 (Pubitemid 28168861)
12. Fouchereau-Peron M., Rancon F., Freychet P., Rosselin G. Effect of feeding and fasting on the early steps of glucagon action in isolated rat liver cells. Endocrinology: 1976; 98 755 760
13. Broer Y., Freychet P., Rosselin G. Insulin and glucagon-receptor interactions in the genetically obese Zucker rat: studies of hormone binding and glucagon-stimulated cyclic AMP levels in isolated hepatocytes. Endocrinology: 1977; 101 236 249 (Pubitemid 8141327)
14. Kregel K. C., Allen D. L., Booth F. W., Fleshner M. R., Henriksen E. J., Musch T. I., O'Leary D. S., Parks C. M., Poole D. C., Ra'anan A. W., Sheriff D. D., Sturek M. S., Toth L. A. Resource Book for the Design of Animal Exercise Protocols. Bethesda, MD American Physiological Society: 2006; 35 41
15. Baar K., Wende A. R., Jones T. E., Marison M., Nolte L. A., Chen M., Kelly D. P., Holloszy J. O. Adaptations of skeletal muscle to exercise: rapid increase in the transcriptional coactivator PGC-1. Faseb J: 2002; 16 1879 1886 (Pubitemid 35462607)
16. Passonneau J. V., Lauderdale V. R. A comparison of three methods of glycogen measurement in tissues. Anal Biochem: 1974; 60 405 412
17. Persson A., Jergil B. Purification of plasma membranes by aqueous two-phase affinity partitioning. Anal Biochem: 1992; 204 131 136
18. Legare A., Drouin R., Milot M., Massicotte D., Peronnet F., Massicotte G., Lavoie C. Increased density of glucagon receptors in liver from endurance-trained rats. Am J Physiol Endocrinol Metab: 2001; 280 E193 E196
19. Frandsen E. K., Thim L., Moody A. J., Markussen J. Structure-function relationships in glucagon. Re-evaluation of glucagon-(1-21). J Biol Chem: 1985; 260 7581 7584 (Pubitemid 15063040)
20. Cadrin M., Hovington H., Marceau N., McFarlane-Anderson N. Early perturbations in keratin and actin gene expression and fibrillar organisation in griseofulvin-fed mouse liver. J Hepatol: 2000; 33 199 207 (Pubitemid 30485223)
21. Unson C. G., Cypess A. M., Wu C. R., Goldsmith P. K., Merrifield R. B., Sakmar T. P. Antibodies against specific extracellular epitopes of the glucagon receptor block glucagon binding. Proc Natl Acad Sci USA: 1996; 93 310 315 (Pubitemid 26038149)
22. Carruthers C. J., Unson C. G., Kim H. N., Sakmar T. P. Synthesis and expression of a gene for the rat glucagon receptor. Replacement of an aspartic acid in the extracellular domain prevents glucagon binding. J Biol Chem: 1994; 269 29321 29328
23. Jelinek L. J., Lok S., Rosenberg G. B., Smith R. A., Grant F. J., Biggs S., Bensch P. A., Kuijper J. L., Sheppard P. O., Sprecher C. A. Expression cloning and signaling properties of the rat glucagon receptor. Science: 1993; 259 1614 1616 (Pubitemid 23114641)
24. Authier F., Desbuquois B. Glucagon receptors. Cell Mol Life Sci: 2008; 65 1880 1899
25. Authier F., Desbuquois B., De Galle B. Ligand-mediated internalization of glucagon receptors in intact rat liver. Endocrinology: 1992; 131 447 457
26. Authier F., Janicot M., Lederer F., Desbuquois B. Fate of injected glucagon taken up by rat liver in vivo. Degradation of internalized ligand in the endosomal compartment. Biochem J: 1990; 272 703 712
27. Krilov L., Nguyen A., Miyazaki T., Unson C. G., Bouscarel B. Glucagon receptor recycling: role of carboxyl terminus, beta-arrestins, and cytoskeleton. Am J Physiol Cell Physiol: 2008; 295 C1230 C1237 (Pubitemid 352790332)
28. Krilov L., Nguyen A., Miyazaki T., Unson C. G., Williams R., Lee N. H., Ceryak S., Bouscarel B. Dual Mode of glucagon receptor internalization: Role of PKCalpha, GRKs and beta-arrestins. Exp Cell Res: 2011; 317 2981 2994
29. Merlen C., Fabrega S., Desbuquois B., Unson C. G., Authier F. Glucagon-mediated internalization of serine-phosphorylated glucagon receptor and Gsalpha in rat liver. FEBS Lett: 2006; 580 5697 5704 (Pubitemid 44515091)
30. Premont R. T., Iyengar R. Glucagon-induced desensitization of adenylyl cyclase in primary cultures of chick hepatocytes. Evidence for multiple pathways. J Biol Chem: 1988; 263 16087 16095 (Pubitemid 18262022)
31. Cahill G. F. Glucagon action in isolated perfused liver. Adv Enzyme Regul: 1965; 3 195 201
32. Abrahamsen N., Lundgren K., Nishimura E. Regulation of glucagon receptor mRNA in cultured primary rat hepatocytes by glucose and cAMP. J Biol Chem: 1995; 270 15853 15857
33. Balks H. J., Jungermann K. Regulation of peripheral insulin/glucagon levels by rat liver. Eur J Biochem: 1984; 141 645 650 (Pubitemid 14082363)
34. Wasserman D. H., Lacy D. B., Bracy D. P. Relationship between arterial and portal vein immunoreactive glucagon during exercise. J Appl Physiol: 1993; 75 724 729 (Pubitemid 23260214)