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Volumn 8, Issue 9, 2013, Pages

SCD1 Expression Is Dispensable for Hepatocarcinogenesis Induced by AKT and Ras Oncogenes in Mice

Author keywords

[No Author keywords available]

Indexed keywords

ACYL COENZYME A DESATURASE; ACYL COENZYME A DESATURASE 1; PROTEIN KINASE B; PROTEIN SCD2; RAS PROTEIN; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

EID: 84884402458     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0075104     Document Type: Article
Times cited : (21)

References (34)
  • 1
    • 34250020201 scopus 로고    scopus 로고
    • Hepatocellular carcinoma: epidemiology and molecular carcinogenesis
    • doi:10.1053/j.gastro.2007.04.061
    • El-Serag HB, Rudolph KL, (2007) Hepatocellular carcinoma: epidemiology and molecular carcinogenesis. Gastroenterology 132: 2557-2576. doi:10.1053/j.gastro.2007.04.061. PubMed: 17570226.
    • (2007) Gastroenterology , vol.132 , pp. 2557-2576
    • El-Serag, H.B.1    Rudolph, K.L.2
  • 2
    • 1642544603 scopus 로고    scopus 로고
    • Focus on hepatocellular carcinoma
    • doi:10.1016/S1535-6108(04)00058-3
    • Bruix J, Boix L, Sala M, Llovet JM, (2004) Focus on hepatocellular carcinoma. Cancer Cell 5: 215-219. doi:10.1016/S1535-6108(04)00058-3. PubMed: 15050913.
    • (2004) Cancer Cell , vol.5 , pp. 215-219
    • Bruix, J.1    Boix, L.2    Sala, M.3    Llovet, J.M.4
  • 3
    • 40849124295 scopus 로고    scopus 로고
    • Novel advancements in the management of hepatocellular carcinoma in 2008
    • doi:10.1016/S0168-8278(08)60049-5
    • Llovet JM, Bruix J, (2008) Novel advancements in the management of hepatocellular carcinoma in 2008. J Hepatol 48 (Suppl 1):: S20-S37. doi:10.1016/S0168-8278(08)60049-5. PubMed: 18304676.
    • (2008) J Hepatol , vol.48 , Issue.SUPPL. 1
    • Llovet, J.M.1    Bruix, J.2
  • 4
    • 67650930433 scopus 로고    scopus 로고
    • Targeted therapy for hepatocellular carcinoma
    • doi:10.1038/nrgastro.2009.86
    • Spangenberg HC, Thimme R, Blum HE, (2009) Targeted therapy for hepatocellular carcinoma. Nat. Rev Gastroenterol Hepatol 6: 423-432. doi:10.1038/nrgastro.2009.86.
    • (2009) Nat Rev Gastroenterol Hepatol , vol.6 , pp. 423-432
    • Spangenberg, H.C.1    Thimme, R.2    Blum, H.E.3
  • 5
    • 77649336663 scopus 로고    scopus 로고
    • Metabolic genes in cancer: their roles in tumor progression and clinical implications
    • Furuta E, Okuda H, Kobayashi A, Watabe K, (2010) Metabolic genes in cancer: their roles in tumor progression and clinical implications. Biochim Biophys Acta 1805: 141-152. PubMed: 20122995.
    • (2010) Biochim Biophys Acta , vol.1805 , pp. 141-152
    • Furuta, E.1    Okuda, H.2    Kobayashi, A.3    Watabe, K.4
  • 6
    • 79251517382 scopus 로고    scopus 로고
    • Regulation of cancer cell metabolism
    • doi:10.1038/nrc2981
    • Cairns RA, Harris IS, Mak TW, (2011) Regulation of cancer cell metabolism. Nat Rev Cancer 11: 85-95. doi:10.1038/nrc2981. PubMed: 21258394.
    • (2011) Nat Rev Cancer , vol.11 , pp. 85-95
    • Cairns, R.A.1    Harris, I.S.2    Mak, T.W.3
  • 7
    • 65549096661 scopus 로고    scopus 로고
    • De novo fatty-acid synthesis and related pathways as molecular targets for cancer therapy
    • doi:10.1038/sj.bjc.6605007
    • Mashima T, Seimiya H, Tsuruo T, (2009) De novo fatty-acid synthesis and related pathways as molecular targets for cancer therapy. Br J Cancer 100: 1369-1372. doi:10.1038/sj.bjc.6605007. PubMed: 19352381.
    • (2009) Br J Cancer , vol.100 , pp. 1369-1372
    • Mashima, T.1    Seimiya, H.2    Tsuruo, T.3
  • 8
    • 34748912615 scopus 로고    scopus 로고
    • Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis
    • doi:10.1038/nrc2222
    • Menendez JA, Lupu R, (2007) Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis. Nat Rev Cancer 7: 763-777. doi:10.1038/nrc2222. PubMed: 17882277.
    • (2007) Nat Rev Cancer , vol.7 , pp. 763-777
    • Menendez, J.A.1    Lupu, R.2
  • 9
    • 0037832581 scopus 로고    scopus 로고
    • Recent insights into stearoyl-CoA desaturase-1
    • doi:10.1097/00041433-200306000-00005
    • Ntambi JM, Miyazaki M, (2003) Recent insights into stearoyl-CoA desaturase-1. Curr Opin Lipidol 14: 255-261. doi:10.1097/00041433-200306000-00005. PubMed: 12840656.
    • (2003) Curr Opin Lipidol , vol.14 , pp. 255-261
    • Ntambi, J.M.1    Miyazaki, M.2
  • 10
    • 84867235842 scopus 로고    scopus 로고
    • Stearoyl-CoA desaturase: rogue or innocent bystander?
    • doi:10.1016/j.plipres.2012.08.002
    • Hodson L, Fielding BA, (2013) Stearoyl-CoA desaturase: rogue or innocent bystander? Prog Lipid Res 52: 15-42. doi:10.1016/j.plipres.2012.08.002. PubMed: 23000367.
    • (2013) Prog Lipid Res , vol.52 , pp. 15-42
    • Hodson, L.1    Fielding, B.A.2
  • 11
    • 77956290719 scopus 로고    scopus 로고
    • Stearoyl-CoA desaturase-1: a novel key player in the mechanisms of cell proliferation, programmed cell death and transformation to cancer
    • doi:10.1093/carcin/bgq131
    • Igal RA, (2010) Stearoyl-CoA desaturase-1: a novel key player in the mechanisms of cell proliferation, programmed cell death and transformation to cancer. Carcinogenesis 31: 1509-1515. doi:10.1093/carcin/bgq131. PubMed: 20595235.
    • (2010) Carcinogenesis , vol.31 , pp. 1509-1515
    • Igal, R.A.1
  • 12
    • 77956210076 scopus 로고    scopus 로고
    • Inhibition of stearoylCoA desaturase activity blocks cell cycle progression and induces programmed cell death in lung cancer cells
    • doi:10.1371/journal.pone.0011394
    • Hess D, Chisholm JW, Igal RA, (2010) Inhibition of stearoylCoA desaturase activity blocks cell cycle progression and induces programmed cell death in lung cancer cells. PLOS ONE 5: e11394. doi:10.1371/journal.pone.0011394. PubMed: 20613975.
    • (2010) PLOS ONE , vol.5
    • Hess, D.1    Chisholm, J.W.2    Igal, R.A.3
  • 13
    • 78650725619 scopus 로고    scopus 로고
    • Inhibition of stearoyl-CoA desaturase 1 expression induces CHOP-dependent cell death in human cancer cells
    • doi:10.1371/journal.pone.0014363
    • Minville-Walz M, Pierre AS, Pichon L, Bellenger S, Fèvre C, et al. (2010) Inhibition of stearoyl-CoA desaturase 1 expression induces CHOP-dependent cell death in human cancer cells. PLOS ONE 5: e14363. doi:10.1371/journal.pone.0014363. PubMed: 21179554.
    • (2010) PLOS ONE , vol.5
    • Minville-Walz, M.1    Pierre, A.S.2    Pichon, L.3    Bellenger, S.4    Fèvre, C.5
  • 14
    • 34249285532 scopus 로고    scopus 로고
    • Identification of Ras-related nuclear protein, targeting protein for Xenopus kinesin-like protein 2, and stearoyl-CoA desaturase 1 as promising cancer targets from an RNAi-based screen
    • doi:10.1158/0008-5472.CAN-06-4132
    • Morgan-Lappe SE, Tucker LA, Huang X, Zhang Q, Sarthy AV, et al. (2007) Identification of Ras-related nuclear protein, targeting protein for Xenopus kinesin-like protein 2, and stearoyl-CoA desaturase 1 as promising cancer targets from an RNAi-based screen. Cancer Res 67: 4390-4398. doi:10.1158/0008-5472.CAN-06-4132. PubMed: 17483353.
    • (2007) Cancer Res , vol.67 , pp. 4390-4398
    • Morgan-Lappe, S.E.1    Tucker, L.A.2    Huang, X.3    Zhang, Q.4    Sarthy, A.V.5
  • 15
    • 77950509620 scopus 로고    scopus 로고
    • A transcriptional signature and common gene networks link cancer with lipid metabolism and diverse human diseases
    • doi:10.1016/j.ccr.2010.01.022
    • Hirsch HA, Iliopoulos D, Joshi A, Zhang Y, Jaeger SA, et al. (2010) A transcriptional signature and common gene networks link cancer with lipid metabolism and diverse human diseases. Cancer Cell 17: 348-361. doi:10.1016/j.ccr.2010.01.022. PubMed: 20385360.
    • (2010) Cancer Cell , vol.17 , pp. 348-361
    • Hirsch, H.A.1    Iliopoulos, D.2    Joshi, A.3    Zhang, Y.4    Jaeger, S.A.5
  • 16
    • 77955483125 scopus 로고    scopus 로고
    • Activation of a metabolic gene regulatory network downstream of mTOR complex 1
    • doi:10.1016/j.molcel.2010.06.022
    • Düvel K, Yecies JL, Menon S, Raman P, Lipovsky AI, et al. (2010) Activation of a metabolic gene regulatory network downstream of mTOR complex 1. Mol Cell 39: 171-183. doi:10.1016/j.molcel.2010.06.022. PubMed: 20670887.
    • (2010) Mol Cell , vol.39 , pp. 171-183
    • Düvel, K.1    Yecies, J.L.2    Menon, S.3    Raman, P.4    Lipovsky, A.I.5
  • 17
    • 84863393589 scopus 로고    scopus 로고
    • The Scap/SREBP pathway is essential for developing diabetic fatty liver and carbohydrate-induced hypertriglyceridemia in animals
    • doi:10.1016/j.cmet.2011.12.017
    • Moon YA, Liang G, Xie X, Frank-Kamenetsky M, Fitzgerald K, et al. (2012) The Scap/SREBP pathway is essential for developing diabetic fatty liver and carbohydrate-induced hypertriglyceridemia in animals. Cell Metab 15: 240-246. doi:10.1016/j.cmet.2011.12.017. PubMed: 22326225.
    • (2012) Cell Metab , vol.15 , pp. 240-246
    • Moon, Y.A.1    Liang, G.2    Xie, X.3    Frank-Kamenetsky, M.4    Fitzgerald, K.5
  • 18
    • 50049116472 scopus 로고    scopus 로고
    • SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth
    • doi:10.1016/j.cmet.2008.07.007
    • Porstmann T, Santos CR, Griffiths B, Cully M, Wu M, et al. (2008) SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth. Cell Metab 8: 224-236. doi:10.1016/j.cmet.2008.07.007. PubMed: 18762023.
    • (2008) Cell Metab , vol.8 , pp. 224-236
    • Porstmann, T.1    Santos, C.R.2    Griffiths, B.3    Cully, M.4    Wu, M.5
  • 19
    • 79952312698 scopus 로고    scopus 로고
    • Increased lipogenesis, induced by AKT-mTORC1-RPS6 signaling, promotes development of human hepatocellular carcinoma
    • doi:10.1053/j.gastro.2010.12.006
    • Calvisi DF, Wang C, Ho C, Ladu S, Lee SA, et al. (2011) Increased lipogenesis, induced by AKT-mTORC1-RPS6 signaling, promotes development of human hepatocellular carcinoma. Gastroenterology 140: 1071-1083. doi:10.1053/j.gastro.2010.12.006. PubMed: 21147110.
    • (2011) Gastroenterology , vol.140 , pp. 1071-1083
    • Calvisi, D.F.1    Wang, C.2    Ho, C.3    Ladu, S.4    Lee, S.A.5
  • 20
    • 84857439515 scopus 로고    scopus 로고
    • AKT (v-akt murine thymoma viral oncogene homologue 1) and N-Ras (neuroblastoma ras viral oncogene homolog) coactivation in the mouse liver promotes rapid carcinogenesis by way of mTOR (mammalian target of rapamycin complex 1), FOXM1 (forkhead box M1)/SKP2, and c-Myc pathways
    • doi:10.1002/hep.24736
    • Ho C, Wang C, Mattu S, Destefanis G, Ladu S, et al. (2012) AKT (v-akt murine thymoma viral oncogene homologue 1) and N-Ras (neuroblastoma ras viral oncogene homolog) coactivation in the mouse liver promotes rapid carcinogenesis by way of mTOR (mammalian target of rapamycin complex 1), FOXM1 (forkhead box M1)/SKP2, and c-Myc pathways. Hepatology 55: 833-845. doi:10.1002/hep.24736. PubMed: 21993994.
    • (2012) Hepatology , vol.55 , pp. 833-845
    • Ho, C.1    Wang, C.2    Mattu, S.3    Destefanis, G.4    Ladu, S.5
  • 21
    • 84866981249 scopus 로고    scopus 로고
    • Bmi1 is required for hepatic progenitor cell expansion and liver tumor development
    • doi:10.1371/journal.pone.0046472
    • Fan L, Xu C, Wang C, Tao J, Ho C, et al. (2012) Bmi1 is required for hepatic progenitor cell expansion and liver tumor development. PLOS ONE 7: e46472. doi:10.1371/journal.pone.0046472. PubMed: 23029524.
    • (2012) PLOS ONE , vol.7
    • Fan, L.1    Xu, C.2    Wang, C.3    Tao, J.4    Ho, C.5
  • 22
    • 2342652187 scopus 로고    scopus 로고
    • Stearoyl-CoA desaturase 1 deficiency increases fatty acid oxidation by activating AMP-activated protein kinase in liver
    • doi:10.1073/pnas.0401627101
    • Dobrzyn P, Dobrzyn A, Miyazaki M, Cohen P, Asilmaz E, et al. (2004) Stearoyl-CoA desaturase 1 deficiency increases fatty acid oxidation by activating AMP-activated protein kinase in liver. Proc Natl Acad Sci U S A 101: 6409-6414. doi:10.1073/pnas.0401627101. PubMed: 15096593.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 6409-6414
    • Dobrzyn, P.1    Dobrzyn, A.2    Miyazaki, M.3    Cohen, P.4    Asilmaz, E.5
  • 23
    • 42249098060 scopus 로고    scopus 로고
    • Integration of genomic analysis and in vivo transfection to identify sprouty 2 as a candidate tumor suppressor in liver cancer
    • Lee SA, Ho C, Roy R, Kosinski C, Patil MA, et al. (2008) Integration of genomic analysis and in vivo transfection to identify sprouty 2 as a candidate tumor suppressor in liver cancer. Hepatology 47: 1200-1210. PubMed: 18214995.
    • (2008) Hepatology , vol.47 , pp. 1200-1210
    • Lee, S.A.1    Ho, C.2    Roy, R.3    Kosinski, C.4    Patil, M.A.5
  • 24
    • 28044461707 scopus 로고    scopus 로고
    • Somatic integration of an oncogene-harboring Sleeping Beauty transposon models liver tumor development in the mouse
    • doi:10.1073/pnas.0502974102
    • Carlson CM, Frandsen JL, Kirchhof N, McIvor RS, Largaespada DA, (2005) Somatic integration of an oncogene-harboring Sleeping Beauty transposon models liver tumor development in the mouse. Proc Natl Acad Sci U S A 102: 17059-17064. doi:10.1073/pnas.0502974102. PubMed: 16286660.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 17059-17064
    • Carlson, C.M.1    Frandsen, J.L.2    Kirchhof, N.3    McIvor, R.S.4    Largaespada, D.A.5
  • 25
    • 70449158340 scopus 로고
    • A simple method for the isolation and purification of total lipides from animal tissues
    • Folch J, Lees M, Sloane Stanley GH, (1957) A simple method for the isolation and purification of total lipides from animal tissues. J Biol Chem 226: 497-509. PubMed: 13428781.
    • (1957) J Biol Chem , vol.226 , pp. 497-509
    • Folch, J.1    Lees, M.2    Sloane Stanley, G.H.3
  • 26
    • 4243190715 scopus 로고
    • Preparation of Fatty Acid Methyl Esters and Dimethylacetals from Lipids with Boron Fluoride--Methanol
    • Morrison WR, Smith LM, (1964) Preparation of Fatty Acid Methyl Esters and Dimethylacetals from Lipids with Boron Fluoride--Methanol. J Lipid Res 5: 600-608. PubMed: 14221106.
    • (1964) J Lipid Res , vol.5 , pp. 600-608
    • Morrison, W.R.1    Smith, L.M.2
  • 27
    • 12344266711 scopus 로고    scopus 로고
    • Regulation of stearoyl-CoA desaturase expression
    • doi:10.1007/s11745-004-1331-2
    • Ntambi JM, Miyazaki M, Dobrzyn A, (2004) Regulation of stearoyl-CoA desaturase expression. Lipids 39: 1061-1065. doi:10.1007/s11745-004-1331-2. PubMed: 15726820.
    • (2004) Lipids , vol.39 , pp. 1061-1065
    • Ntambi, J.M.1    Miyazaki, M.2    Dobrzyn, A.3
  • 28
    • 33748655454 scopus 로고    scopus 로고
    • Stearoyl-coenzyme A desaturase 1 deficiency protects against hypertriglyceridemia and increases plasma high-density lipoprotein cholesterol induced by liver X receptor activation
    • doi:10.1128/MCB.00077-06
    • Chu K, Miyazaki M, Man WC, Ntambi JM, (2006) Stearoyl-coenzyme A desaturase 1 deficiency protects against hypertriglyceridemia and increases plasma high-density lipoprotein cholesterol induced by liver X receptor activation. Mol Cell Biol 26: 6786-6798. doi:10.1128/MCB.00077-06. PubMed: 16943421.
    • (2006) Mol Cell Biol , vol.26 , pp. 6786-6798
    • Chu, K.1    Miyazaki, M.2    Man, W.C.3    Ntambi, J.M.4
  • 29
    • 33745294817 scopus 로고    scopus 로고
    • Tamoxifen-induced anorexia is associated with fatty acid synthase inhibition in the ventromedial nucleus of the hypothalamus and accumulation of malonyl-CoA
    • doi:10.2337/db05-1356
    • López M, Lelliott CJ, Tovar S, Kimber W, Gallego R, et al. (2006) Tamoxifen-induced anorexia is associated with fatty acid synthase inhibition in the ventromedial nucleus of the hypothalamus and accumulation of malonyl-CoA. Diabetes 55: 1327-1336. doi:10.2337/db05-1356. PubMed: 16644689.
    • (2006) Diabetes , vol.55 , pp. 1327-1336
    • López, M.1    Lelliott, C.J.2    Tovar, S.3    Kimber, W.4    Gallego, R.5
  • 30
    • 84863388391 scopus 로고    scopus 로고
    • SCD1 inhibition causes cancer cell death by depleting mono-unsaturated fatty acids
    • doi:10.1371/journal.pone.0033823
    • Mason P, Liang B, Li L, Fremgen T, Murphy E, et al. (2012) SCD1 inhibition causes cancer cell death by depleting mono-unsaturated fatty acids. PLOS ONE 7: e33823. doi:10.1371/journal.pone.0033823. PubMed: 22457791.
    • (2012) PLOS ONE , vol.7
    • Mason, P.1    Liang, B.2    Li, L.3    Fremgen, T.4    Murphy, E.5
  • 31
    • 84861043736 scopus 로고    scopus 로고
    • Connecting mTORC1 signaling to SREBP-1 activation
    • doi:10.1097/MOL.0b013e328352dd03
    • Bakan I, Laplante M, (2012) Connecting mTORC1 signaling to SREBP-1 activation. Curr Opin Lipidol 23: 226-234. doi:10.1097/MOL.0b013e328352dd03. PubMed: 22449814.
    • (2012) Curr Opin Lipidol , vol.23 , pp. 226-234
    • Bakan, I.1    Laplante, M.2
  • 32
    • 77958030867 scopus 로고    scopus 로고
    • Rapamycin regulates stearoyl CoA desaturase 1 expression in breast cancer
    • doi:10.1158/1535-7163.MCT-09-0980
    • Luyimbazi D, Akcakanat A, McAuliffe PF, Zhang L, Singh G, et al. (2010) Rapamycin regulates stearoyl CoA desaturase 1 expression in breast cancer. Mol Cancer Ther 9: 2770-2784. doi:10.1158/1535-7163.MCT-09-0980. PubMed: 20876744.
    • (2010) Mol Cancer Ther , vol.9 , pp. 2770-2784
    • Luyimbazi, D.1    Akcakanat, A.2    McAuliffe, P.F.3    Zhang, L.4    Singh, G.5
  • 33
    • 77953471622 scopus 로고    scopus 로고
    • Abrogation of de novo lipogenesis by stearoyl-CoA desaturase 1 inhibition interferes with oncogenic signaling and blocks prostate cancer progression in mice
    • doi:10.1158/1535-7163.MCT-09-1064
    • Fritz V, Benfodda Z, Rodier G, Henriquet C, Iborra F, et al. (2010) Abrogation of de novo lipogenesis by stearoyl-CoA desaturase 1 inhibition interferes with oncogenic signaling and blocks prostate cancer progression in mice. Mol Cancer Ther 9: 1740-1754. doi:10.1158/1535-7163.MCT-09-1064. PubMed: 20530718.
    • (2010) Mol Cancer Ther , vol.9 , pp. 1740-1754
    • Fritz, V.1    Benfodda, Z.2    Rodier, G.3    Henriquet, C.4    Iborra, F.5
  • 34
    • 84876206165 scopus 로고    scopus 로고
    • A Direct in vivo RNAi screen identifies MKK4 as a key regulator of liver regeneration
    • doi:10.1016/j.cell.2013.03.026
    • Wuestefeld T, Pesic M, Rudalska R, Dauch D, Longerich T, et al. (2013) A Direct in vivo RNAi screen identifies MKK4 as a key regulator of liver regeneration. Cell 153: 389-401. doi:10.1016/j.cell.2013.03.026. PubMed: 23582328.
    • (2013) Cell , vol.153 , pp. 389-401
    • Wuestefeld, T.1    Pesic, M.2    Rudalska, R.3    Dauch, D.4    Longerich, T.5


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