The role of hepatocyte nuclear factor 4alpha in metastatic tumor formation of hepatocellular carcinoma and its close relationship with the mesenchymal-epithelial transition markers

BMC Cancer

Volumn 13, Issue , 2013, Pages

  Yao, Dianbo ^a   Peng, Songlin ^a   Dai, Chaoliu ^a  

^a CHINA MEDICAL UNIVERSITY   (China)

Author keywords

E cadherin; Hepatocellular carcinoma; Hepatocyte nuclear factor 4alpha; Mesenchymal epithelial transition; Metastasis

Indexed keywords

FIBRONECTIN; HEPATOCYTE NUCLEAR FACTOR 4ALPHA; NERVE CELL ADHESION MOLECULE; TRANSCRIPTION FACTOR SLUG; TRANSCRIPTION FACTOR SNAIL; TUMOR MARKER; UVOMORULIN; VIMENTIN;

ARTICLE; CANCER PATIENT; CARCINOMA CELL; CELL STRAIN; CELL STRAIN BEL 7402; CELL STRAIN HEP3B; CELL STRAIN HUH 7; CELL STRAIN K HEP 1; CLINICAL ARTICLE; CONTROLLED STUDY; EPITHELIAL MESENCHYMAL TRANSITION; EXPRESSION VECTOR; GENETIC TRANSFECTION; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; LIVER CARCINOGENESIS; LIVER CELL CARCINOMA; METASTASIS POTENTIAL; PRIMARY TUMOR; PROTEIN EXPRESSION; REGULATORY MECHANISM; UNIVERSITY HOSPITAL;

BIOLOGICAL MARKERS; CADHERINS; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; EPITHELIAL-MESENCHYMAL TRANSITION; GENE EXPRESSION; HEPATOCYTE NUCLEAR FACTOR 4; HUMANS; LIVER NEOPLASMS; NEOPLASM METASTASIS; TRANSCRIPTION FACTORS;

EID: 84884364028     PISSN: None     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/1471-2407-13-432     Document Type: Article

References (34)

1. Herszényi L, Tulassay Z. Epidemiology of gastrointestinal and liver tumors. Eur Rev Med Pharmacol Sci 2010, 14:249-258.
2. Forner A, Llovet JM, Bruix J. Hepatocellular carcinoma. Lancet 2012, 379:1245-1255. 10.1016/S0140-6736(11)61347-0, 22353262.
3. Tung-Ping Poon R, Fan ST, Wong J. Risk factors, prevention, and management of postoperative recurrence after resection of hepatocellular carcinoma. Ann Surg 2000, 232:10-24. 10.1097/00000658-200007000-00003, 1421103, 10862190.
4. Yao D, Dai C, Peng S. Mechanism of the mesenchymal-epithelial transition and its relationship with metastatic tumor formation. Mol Cancer Res 2011, 9:1608-1620. 10.1158/1541-7786.MCR-10-0568, 21840933.
5. Osada T, Sakamoto M, Ino Y, Iwamatsu A, Matsuno Y, Muto T, Hirohashi S. E-cadherin is involved in the intrahepatic metastasis of hepatocellular carcinoma. Hepatology 1996, 24:1460-1467. 10.1002/hep.510240627, 8938181.
6. Asayama Y, Taguchi Ki K, Aishima Si S, Nishi H, Masuda K, Tsuneyoshi M. The mode of tumour progression in combined hepatocellular carcinoma and cholangiocarcinoma: an immunohistochemical analysis of E-cadherin, alpha-catenin and beta-catenin. Liver 2002, 22:43-50.
7. Wells A, Yates C, Shepard CR. E-cadherin as an indicator of mesenchymal to epithelial reverting transitions during the metastatic seeding of disseminated carcinomas. Clin Exp Metastasis 2008, 25:621-628. 10.1007/s10585-008-9167-1, 2929356, 18600305.
8. Odom DT, Zizlsperger N, Gordon DB, Bell GW, Rinaldi NJ, Murray HL, Volkert TL, Schreiber J, Rolfe PA, Gifford DK, Fraenkel E, Bell GI, Young RA. Control of pancreas and liver gene expression by HNF transcription factors. Science 2004, 303:1378-1381. 10.1126/science.1089769, 3012624, 14988562.
9. Parviz F, Matullo C, Garrison WD, Savatski L, Adamson JW, Ning G, Kaestner KH, Rossi JM, Zaret KS, Duncan SA. Hepatocyte nuclear factor 4alpha controls the development of a hepatic epithelium and liver morphogenesis. Nat Genet 2003, 34:292-296. 10.1038/ng1175, 12808453.
10. Battle MA, Konopka G, Parviz F, Gaggl AL, Yang C, Sladek FM, Duncan SA. Hepatocyte nuclear factor 4alpha orchestrates expression of cell adhesion proteins during the epithelial transformation of the developing liver. Proc Natl Acad Sci USA 2006, 103:8419-8424. 10.1073/pnas.0600246103, 1482507, 16714383.
11. Späth GF, Weiss MC. Hepatocyte nuclear factor 4 provokes expression of epithelial marker genes, acting as a morphogen in dedifferentiated hepatoma cells. J Cell Biol 1998, 140:935-946. 10.1083/jcb.140.4.935, 2141753, 9472044.
12. Lazarevich NL, Al'pern DV. Hepatocyte nuclear factor 4 (HNF4) in epithelial development and carcinogenesis. Mol Biol (Mosk) 2008, 42:786-797.
13. Santangelo L, Marchetti A, Cicchini C, Conigliaro A, Conti B, Mancone C, Bonzo JA, Gonzalez FJ, Alonzi T, Amicone L, Tripodi M. The stable repression of mesenchymal program is required for hepatocyte identity: a novel role for hepatocyte nuclear factor 4alpha. Hepatology 2011, 53:2063-2074. 10.1002/hep.24280, 21384409.
14. Iwazaki N, Kobayashi K, Morimoto K, Hirano M, Kawashima S, Furihata T, Chiba K. Involvement of hepatocyte nuclear factor 4 alpha in transcriptional regulation of the human pregnane X receptor gene in the human liver. Drug Metab Pharmacokinet 2008, 23:59-66. 10.2133/dmpk.23.59, 18305375.
15. Chao Y, Wu Q, Acquafondata M, Dhir R, Wells A. Partial mesenchymal to epithelial reverting transition in breast and prostate cancer metastases. Cancer Microenviron 2012, 5:19-28. 10.1007/s12307-011-0085-4, 3343195, 21892699.
16. Chao YL, Shepard CR, Wells A. Breast carcinoma cells re-express E-cadherin during mesenchymal to epithelial reverting transition. Mol Cancer 2010, 9:179. 10.1186/1476-4598-9-179, 2907333, 20609236.
17. Chellappa K, Jankova L, Schnabl JM, Pan S, Brelivet Y, Fung CL, Chan C, Dent OF, Clarke SJ, Robertson GR, Sladek FM. Src tyrosine kinase phosphorylation of nuclear receptor HNF4α correlates with isoform-specific loss of HNF4α in human colon cancer. Proc Natl Acad Sci USA 2012, 109:2302-2307. 10.1073/pnas.1106799109, 3289305, 22308320.
18. Kalluri R, Weinberg RA. The basics of epithelial-mesenchymal transition. J Clin Invest 2009, 119:1420-1428. 10.1172/JCI39104, 2689101, 19487818.
19. Thiery JP, Acloque H, Huang RY, Nieto MA. Epithelial-mesenchymal transitions in development and disease. Cell 2009, 139:871-890. 10.1016/j.cell.2009.11.007, 19945376.
20. Wells A, Chao YL, Grahovac J, Wu Q, Lauffenburger DA. Epithelial and mesenchymal phenotypic switchings modulate cell motility in metastasis. Front Biosci 2011, 16:815-837.
21. Thiery JP, Sleeman JP. Complex networks orchestrate epithelial mesenchymal transitions. Nat Rev Mol Cell Biol 2006, 7:131-142. 10.1038/nrm1835, 16493418.
22. Chaffer CL, Thompson EW, Williams ED. Mesenchymal to epithelial transition in development and disease. Cells Tissues Organs 2007, 185:7-19. 10.1159/000101298, 17587803.
23. Hugo H, Ackland ML, Blick T, Lawrence MG, Clements JA, Williams ED, Thompson EW. Epithelial-mesenchymal and mesenchymal-epithelial transitions in carcinoma progression. J Cell Physiol 2007, 213:374-383. 10.1002/jcp.21223, 17680632.
24. Brabletz T. To differentiate or not - routes towards metastasis. Nat Rev Cancer 2012, 12:425-436. 10.1038/nrc3265, 22576165.
25. Yates CC, Shepard CR, Stolz DB, Wells A. Co-culturing human prostate carcinoma cells with hepatocytes leads to increased expression of E-cadherin. Br J Cancer 2007, 96:1246-1252. 10.1038/sj.bjc.6603700, 2360137, 17406365.
26. Reddy P, Liu L, Ren C, Lindgren P, Boman K, Shen Y, Lundin E, Ottander U, Rytinki M, Liu K. Formation of E-cadherin-mediated cell-cell adhesion activates AKT and mitogen activated protein kinase via phosphatidylinositol 3 kinase and ligand-independent activation of epidermal growth factor receptor in ovarian cancer cells. Mol Endocrinol 2005, 19:2564-2578. 10.1210/me.2004-0342, 15928314.
27. Yin C, Lin Y, Zhang X, Chen YX, Zeng X, Yue HY, Hou JL, Deng X, Zhang JP, Han ZG, Xie WF. Differentiation therapy of hepatocellular carcinoma in mice with recombinant adenovirus carrying hepatocyte nuclear factor-4alpha gene. Hepatology 2008, 48:1528-1539. 10.1002/hep.22510, 18925631.
28. Lazarevich NL, Fleishman DI. Tissue-specific transcription factors in progression of epithelial tumors. Biochemistry (Mosc) 2008, 73:573-591. 10.1134/S0006297908050106, 18605982.
29. Bolos V, Peinado H, Perez-Moreno MA, Frga M, Esteller M, Cano A. The transcription factor Slug represses E-cadherin expression and induces epithelial to mesenchymal transitions: a comparison with Snail and E47 repressors. J Cell Sci 2002, 116:499-511.
30. Cicchini C, Filippini D, Coen S, Marchetti A, Cavallari C, Laudadio I, Spagnoli FM, Alonzi T, Tripodi M. Snail controls differentiation of hepatocytes by repressing HNF4alpha expression. J Cell Physiol 2006, 209:230-238. 10.1002/jcp.20730, 16826572.
31. Tanaka T, Jiang S, Hotta H, Takano K, Iwanari H, Sumi K, Daigo K, Ohashi R, Sugai M, Ikegame C, Umezu H, Hirayama Y, Midorikawa Y, Hippo Y, Watanabe A, Uchiyama Y, Hasegawa G, Reid P, Aburatani H, Hamakubo T, Sakai J, Naito M, Kodama T. Dysregulated expression of P1 and P2 promoter-driven hepatocyte nuclear factor-4alpha in the pathogenesis of human cancer. J Pathol 2006, 208:662-672. 10.1002/path.1928, 16400631.
32. Ning BF, Ding J, Yin C, Zhong W, Wu K, Zeng X, Yang W, Chen YX, Zhang JP, Zhang X, Wang HY, Xie WF. Hepatocyte nuclear factor 4 alpha suppresses the development of hepatocellular carcinoma. Cancer Res 2010, 70:7640-7651. 10.1158/0008-5472.CAN-10-0824, 20876809.
33. Lazarevich NL, Cheremnova OA, Varga EV, Ovchinnikov DA, Kudrjavtseva EI, Morozova OV, Fleishman DI, Engelhardt NV, Duncan SA. Progression of HCC in mice is associated with a downregulation in the expression of hepatocyte nuclear factors. Hepatology 2004, 39:1038-1047. 10.1002/hep.20155, 15057908.
34. Fidler IJ, Poste G. The " seed and soil" hypothesis revisited. Lancet Oncol 2008, 9:808. 10.1016/S1470-2045(08)70201-8, 18672217.