Handwriting as an objective tool for Parkinson's disease diagnosis

Journal of Neurology

Volumn 260, Issue 9, 2013, Pages 2357-2361

  Rosenblum, Sara ^a   Samuel, Margalit ^b   Zlotnik, Sharon ^b   Erikh, Ilana ^c   Schlesinger, Ilana ^c  

^a UNIVERSITY OF HAIFA   (Israel)

^b Rambam Health Care Campus ^*  (Israel)

^c TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

Author keywords

Biomarker; Diagnosis; Digitizer; Handwriting; Non motor; Parkinson's disease

Indexed keywords

ADULT; AGED; ANALOG DIGITAL CONVERTER; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DIAGNOSTIC TEST ACCURACY STUDY; FEMALE; GOLD STANDARD; HANDWRITING; HUMAN; KINEMATICS; MALE; OUTCOME ASSESSMENT; PARKINSON DISEASE; PILOT STUDY; PRESSURE; PRIORITY JOURNAL; TASK PERFORMANCE; VELOCITY;

ADULT; AGED; AGED, 80 AND OVER; BIOMECHANICAL PHENOMENA; FEMALE; HANDWRITING; HUMANS; MALE; MIDDLE AGED; PARKINSON DISEASE;

EID: 84884354650     PISSN: 03405354     EISSN: 14321459     Source Type: Journal    
DOI: 10.1007/s00415-013-6996-x     Document Type: Article

References (24)

1. Marek K, Jennings D, Lasch S (2011) The Parkinson progression marker Initiative (PPMI). Prog Neurobiol 95:629-663
2. Ravina B, Tanner C, Dieuliis D, Eberly S, Flagg E, Galpern WR, Fahn S, Goetz CG, Grate S, Kurlan R, Lang AE, Marek K, Kieburtz K, Oakes D, Elliott R, Shoulson I; Parkinson Study Group LABS-PD Investigators (2009) A longitudinal program for biomarker development in Parkinson's disease: a feasibility study. Mov Disord 24:2081-2090
3. Tisch U, Schlesinger I, Ionescu R, Nassar M, Axelrod N, Robertman D, Tessler Y, Azar F, Marmur A, Aharon-Peretz J, Haick H (2013) Detection of Alzheimer's and Parkinson's disease from exhaled breath using nanomaterial-based sensors. Nanomedicine (Lond) 8:43-56
4. Wu Y, Le W, Jankovic J (2011) Preclinical biomarkers of Parkinson disease. Arch Neurol 68:22-30
5. Chahine LM, Stern MB (2011) Diagnostic markers for Parkinson's disease. Curr Opin Neurol 24:309-317
6. de la Fuente-Fernández R (2012) Role of DaTSCAN and clinical diagnosis in Parkinson disease. Neurology 78:696-701
7. Carmeli E, Patish H, Colman R (2003) The aging hand. J Gerontol A Biol Sci Med Sci 58:146-152
8. Horowski R, Horowski L, Vogel S, Poewe W, Kielhorn FW (1995) An essay on Wilhelm von Humboldt and the shaking palsy: first comprehensive description of Parkinson's disease by a patient. Neurology 45:565-568
9. Eichhorn TE, Gasser T, Mai N, Marquardt C, Arnold G, Schwarz J, Oertel WH (1996) Computational analysis of open loop handwriting movements in Parkinson's disease: a rapid method to detect dopamimetic effects. Mov Disord 11:289-297
10. Poluha PC, Teulings HL, Brookshire RH (1998) Handwriting and speech changes across the levodopa cycle in Parkinson's disease. Acta psycho (Amst) 100:71-84
11. Teulings HL, Contreras-Vidal JL, Stelmach GE, Adler CH (2002) Adaptation of handwriting size under distorted visual feedback in patients with Parkinson's disease and elderly and young controls. J Neurol Neurosurg Psychiatry 72:315-324
12. Tucha O, Mecklinger L, Thome J, Reiter A, Alders GL, Sartor H, Naumann M, Lange KW (2006) Kinematic analysis of dopaminergic effects on skilled handwriting movements in Parkinson's disease. J Neural Transm 113:609-623
13. Oliveira RM, Gurd JM, Nixon P, Marshall JC, Passingham RE (1997) Micrographia in Parkinson's disease: the effect of providing external cues. J Neurol Neurosurg Psychiatry 63:429-433
14. Ondo WG, Satija P (2007) Withdrawal of visual feedback improves micrographia in Parkinson's disease. Mov Disord 22:2130-2131
15. Gibb WR, Lees AJ (1988) The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson's disease. J Neurol Neurosurg Psychiatry 51:745-752
16. Hoehn MM, Yahr MD (1967) Parkinsonism: onset, progression and mortality. Neurology 17:427-442
17. Folstein MF, Folstein SE, McHugh PR (1975) "Mini-mental state": a practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 12:189-198
18. Rosenblum S, Parush S, Weiss PL (2003) Computerized temporal handwriting characteristics of proficient and non-proficient handwriters. Am J Occup Ther 57:129-138
19. Becker G, Müller A, Braune S, Büttner T, Benecke R, Greulich W, Klein W, Mark G, Rieke J, Thümler R (2002) Early diagnosis of Parkinson's disease. J Neurol 249(Suppl 3:III):40-48
20. Rosenblum S, Dvorkin A, Weiss PL (2006) Automatic segmentation as a tool for examining the handwriting process of children with dysgraphic and proficient handwriting. Hum Mov Sci 25:608-621
21. Werner P, Rosenblum S, Bar-On G, Heinik J, Korczyn A (2006) Handwriting process variables discriminating mild Alzheimer's disease and mild cognitive impairment. J Gerontol B Psychol Sci Soc Sci 61:228-236
22. Sesa-Nogueras E, Faundez-Zanuy M, Mekyska J (2012) An Information Analysis of In-Air and On-Surface Trajectoriesin Online Handwriting. Cogn Comput 4:195-205
23. McLennan JE, Nakano K, Taylor HR, Schwab RS (1972) Micrographia in Parkinson's disease. J Neurol Sci 15:141-152
24. Hatzitaki V, Hoshizaki TB (1998) Dynamic joint analysis as a method to document coordination disabilities associated with Parkinson's disease. Clin Biomech 13:182-189