Computational analysis of open loop handwriting movements in Parkinson's disease: A rapid method to detect dopamimetic effects

Movement Disorders

Volumn 11, Issue 3, 1996, Pages 289-297

  Eichhorn, T E ^a,c   Gasser, T ^a   Mai, N ^a,b   Marquardt, C ^b   Arnold, G ^a   Schwarz, J ^a   Oertel, W H ^a  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^b Munich Municipal Hospital   (Germany)

^c Neurologische Klinik   (Germany)

Author keywords

Apomorphine; Computational analysis; Handwriting movements; Parkinson's disease; Unified Parkinson's Disease Rating Scale

Indexed keywords

APOMORPHINE; DOPAMINE RECEPTOR STIMULATING AGENT; LEVODOPA;

ACCELERATION; ADULT; AGED; ARTICLE; CLINICAL ARTICLE; COMPUTER ANALYSIS; CONTROLLED STUDY; FEMALE; HANDWRITING; HUMAN; MALE; PARKINSON DISEASE; PARKINSONISM; PRIORITY JOURNAL; RATING SCALE; SUBCUTANEOUS DRUG ADMINISTRATION; VELOCITY;

ADULT; AGED; ANTIPARKINSON AGENTS; APOMORPHINE; BRAIN; CARBIDOPA; DRUG THERAPY, COMBINATION; FEMALE; HANDWRITING; HUMANS; LEVODOPA; MALE; MICROCOMPUTERS; MIDDLE AGED; NEUROLOGIC EXAMINATION; PARKINSON DISEASE; PARKINSON DISEASE, SECONDARY; SIGNAL PROCESSING, COMPUTER-ASSISTED; TREATMENT OUTCOME;

EID: 0030009659     PISSN: 08853185     EISSN: None     Source Type: Journal    
DOI: 10.1002/mds.870110313     Document Type: Article

References (32)

1. Gibb WRG, Lees AJ. The significance of the Lewy body in the diagnosis of idiopathic Parkinson's disease. J Neuropathol Appl Neurobiol 1990;15:27-44.
2. Ward CD, Gibb WRG. Research diagnostic criteria for Parkinson's disease. Adv Neurol 1990;53:245-249.
3. Fahn S, Elton RL and members of the UPDRS Development Committee. Unified Parkinson's Disease Rating Scale. In: Fahn S, Marsden CD, Goldstein M, Calne DB, eds. Recent developments in Parkinson's disease, vol. II. Florham Park, NJ: Macmillan Healthcare Information, 1987:153-163.
4. Hughes AJ, Lees AJ, Stern GM. Apomorphine tests to predict dopaminergic responsiveness in parkinsonian syndromes. Lancet 1990;336;32-34.
5. Oertel WH, Gasser T, Ippisch R, Trenkwalder C. Apomorphine test for dopaminergic responsiveness. Lancet 1989;1: 1262-1263.
6. Hughes AJ, Lees AJ, Stern GM. Challenge test to predict the dopaminergic response in untreated Parkinson's disease. Neurology 1991;41:1723-1725.
7. Gasser T, Schwarz, J, Arnold G, Trenkwalder C, Oertel WH. Apomorphine test to predict the dopaminergic responsiveness in patients with previously untreated Parkinson's disease. Arch Neurol 1992;49:1131-1134.
8. Marsden CD, Schachter M. Assessment of extrapyramidal disorders. Br J Clin Pharmacol 1981;11:129-151.
9. Diamond SG, Markham CH. Evaluating the evaluations: or how to weigh the scales of parkinsonian disability. Neurology 1983;33:1098-1099.
10. Marquardt C, Mai N. Computational procedures for movement analysis in handwriting. J Neurosci Methods 1994;52: 39-45.
11. Morasso P, Mussa Ivaldi FA. Trajectory formation and handwriting: a computational model. Biol Cybern 1982;45: 131-142.
12. Mai N, Marquardt C. Analysis and therapy of disturbed handwriting movements. Psychol Beitr 1995;37:36-70.
13. Hollerbach JM. An oscillation theory of handwriting. Biol Cybern 1981;39:139-156.
14. Stelmach GE, Teulings HL. Force amplitude and force duration in parkinsonian handwriting. In: Requin J, Stelmach GE, eds. Tutorials in motor neuroscience. Dordrecht: Netherlands: Kluver Academic, 1991:149-160.
15. Thomassen AJWM, Teulings HL. Time, size and shape in handwriting, exploring spatiotemporal relationships at different levels. In: Michon JA, Jackson JB, eds. Time, mind and behaviour. Heidelberg: Springer Verlag, 1985:253-263.
16. Margolin DI, Wing AM. Agraphia and micrographia: clinical manifestations of motor programming and performance dis-orders. Acta Psychol 1983;54:263-283.
17. Berardelli A, Dick JPR, Rothwell JC. Scaling of the size of the first agonist EMG burst during rapid wrist movements in patients with Parkinson's disease. J Neurol Neurosurg Psych 1986;49:1273-1279.
18. Johnson MTV, Mendez A, Kipnis AN, Silverstein P, Zwiebel F, Ebner TJ. Acute effects of levodopa on wrist movement in Parkinson's disease. Kinematics, volitional EMG modulation and reflex amplitude modulation. Brain 1994; 117:1409-1422.
19. Hallett M, Khoshbin S. A physiological mechanism of bradykinesia. Brain 1980;103:301-314.
20. Godaux E, Koulischer D, Jacquy J. Parkinsonian bradykinesia is due to depression in the rate of rise of muscle activity. Ann Neurol 1992;31:93-100.
21. Flowers KA. Visual closed loop and open loop characteristics of voluntary movement in patients with Parkinson's disease. Brain 1976;99:269-310.
22. Plamondon R. On the origin of asymmetric bell shaped velocity profiles in rapid aimed movements. In: Requin J, Stelmach GE. eds. Tutorials in motor neuroscience. Dordrecht, Netherlands: Kluver Academic, 1991:283-295.
23. Inzelberg R, Flash T, Korczyn AD. Kinematic properties of upper limb trajectories in Parkinson's disease and idiopathic torsion dystonia. Adv Neurol 1990;53:183-189.
24. Marsden CD. The mysterious function of the basal ganglia: The Robert Wartenberg Lecture. Neurology 1982;32:514-539.
25. LeWitt PA. Micrographia as a focal sign of neurological disease. J Neurol Neurosurg Psych 1983;46:1152-1157.
26. Tertrud JW. Preclinical Parkinson's disease: detection of motor and non motor manifestations. Neurology 1991;41:69-72.
27. Agostino R, Berardelli A, Formica A, Accornero N, Manfredi MTI. Sequential arm movements in patients with Parkinson's disease, Huntington's disease and dystonia. Brain 1992;115:1481-1495
28. Draper IT, Johns RJ. The disordered movement in parkinsonism and the effect of drug treatment. Bull Johns Hopkins Hosp 1964;115:465-480.
29. Steg G, Ingvarsson PE, Johnels B, Valls M, Thorselius M. Objective measurement of motor disability in Parkinson's disease. Acta Neurol Scand 1989;126:67-75.
30. Kraus PH, Klotz P, Fischer A, Przuntek H. Assessment of symptoms of Parkinson's disease by apparative methods. J Neural Transm 1987;25:89-96.
31. Kraus PH, Klotz P, Steinbeck R, Przuntek H. Contribution of motor performance tests to the early diagnosis of Parkinson's disease. In: Riederer P, Przuntek H, eds. Early markers in Parkinson's disease. New York: Springer Verlag, 1990:41-57.
32. Hefter H, Hömberg V, Freund HJ. Quantitative analysis of voluntary and involuntary motor phenomena in Parkinson's disease. In: Riederer P, Przuntek H, eds. Early markers in Parkinson's disease. New York: Springer Verlag, 1990:65-72.