Guideline-recommended fractional exhaled nitric oxide is a poor predictor of health-care use among inner-city children and adolescents receiving usual asthma care

Chest

Volumn 144, Issue 3, 2013, Pages 923-929

  McCormack, Meredith C ^a   Aloe, Charles ^b   Curtin Brosnan, Jean ^b   Diette, Gregory B ^a   Breysse, Patrick N ^c   Matsui, Elizabeth C ^b  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^c The Johns Hopkins University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FRACTIONAL EXHALED NITRIC OXIDE; NITRIC OXIDE; UNCLASSIFIED DRUG;

ADOLESCENT; ARTICLE; ASTHMA; CHILD; CHILD HEALTH CARE; COHORT ANALYSIS; EMERGENCY CARE; FEMALE; FORCED EXPIRATORY VOLUME; FORCED VITAL CAPACITY; HEALTH CARE UTILIZATION; HOSPITALIZATION; HUMAN; MAJOR CLINICAL STUDY; MALE; MINORITY GROUP; OBSERVATIONAL STUDY; PRACTICE GUIDELINE; PREDICTIVE VALUE; PRESCHOOL CHILD; PRIORITY JOURNAL; PROSPECTIVE STUDY; SCHOOL CHILD; URBAN POPULATION;

EID: 84884344169     PISSN: 00123692     EISSN: 19313543     Source Type: Journal    
DOI: 10.1378/chest.12-3098     Document Type: Article

References (35)

1. Szefl er SJ, Mitchell H, Sorkness CA, et al. Management of asthma based on exhaled nitric oxide in addition to guideline-based treatment for inner-city adolescents and young adults: a randomised controlled trial. Lancet. 2008 ; 372 (9643): 1065-1072.
2. Dweik RA, Boggs PB, Erzurum SC, et al ; American Thoracic Society Committee on Interpretation of Exhaled Nitric Oxide Levels (FENO) for Clinical Applications. An offi cial ATS clini cal practice guideline: interpretation of exhaled nitric oxide levels (FENO) for clinical applications. Am J Respir Crit Care Med. 2011 ; 184 (5): 602-615.
3. Hankinson JL, Odencrantz JR, Fedan KB. Spirometric reference values from a sample of the general U.S. population. Am J Respir Crit Care Med. 1999 ; 159 (1): 179-187.
4. Miller MR, Hankinson J, Brusasco V, et al ; ATS/ERS Task Force. Standardisation of spirometry. Eur Respir J. 2005 ; 26 (2): 319-338.
5. American Thoracic Society ; European Respiratory Society. ATS/ERS recommendations for standardized procedures for the online and offl ine measurement of exhaled lower respiratory nitric oxide and nasal nitric oxide, 2005. Am J Respir Crit Care Med. 2005 ; 171 (8): 912-930.
6. American Thoracic Society. Recommendations for standardized procedures for the on-line and off-line measurement of exhaled lower respiratory nitric oxide and nasal nitric oxide in adults and children-1999. This offi cial statement of the American Thoracic Society was adopted by the ATS Board of Directors, July 1999. Am J Respir Crit Care Med. 1999 ; 160 (6): 2104-2117.
7. Morgan WJ, Crain EF, Gruchalla RS, et al; Inner-City Asthma Study Group. Results of a home-based environmental intervention among urban children with asthma. N Engl J Med. 2004 ; 351 (11): 1068-1080.
8. Kharitonov SA, Barnes PJ. Does exhaled nitric oxide refl ect asthma control? Yes, it does! Am J Respir Crit Care Med. 2001 ; 164 (5): 727-728.
9. Jatakanon A, Lim S, Kharitonov SA, Chung KF, Barnes PJ. Correlation between exhaled nitric oxide, sputum eosinophils, and methacholine responsiveness in patients with mild asthma. Thorax. 1998 ; 53 (2): 91-95.
10. Jones SL, Kittelson J, Cowan JO, et al. The predictive value of exhaled nitric oxide measurements in assessing changes in asthma control. Am J Respir Crit Care Med. 2001 ; 164 (5): 738-743.
11. Mattes J, Storm van's Gravesande K, Reining U, et al. NO in exhaled air is correlated with markers of eosinophilic airway infl ammation in corticosteroid-dependent childhood asthma. Eur Respir J. 1999 ; 13 (6): 1391-1395.
12. Zacharasiewicz A, Wilson N, Lex C, et al. Clinical use of noninvasive measurements of airway infl ammation in steroid reduction in children. Am J Respir Crit Care Med. 2005 ; 171 (10): 1077-1082.
13. Warke TJ, Fitch PS, Brown V, et al. Exhaled nitric oxide correlates with airway eosinophils in childhood asthma. Thorax. 2002 ; 57 (5): 383-387.
14. Piacentini GL, Bodini A, Costella S, et al. Exhaled nitric oxide and sputum eosinophil markers of infl ammation in asthmatic children. Eur Respir J. 1999 ; 13 (6): 1386-1390.
15. Piacentini GL, Bodini A, Costella S, et al. Exhaled nitric oxide, serum ECP and airway responsiveness in mild asthmatic children. Eur Respir J. 2000 ; 15 (5): 839-843.
16. Payne DN, Adcock IM, Wilson NM, Oates T, Scallan M, Bush A. Relationship between exhaled nitric oxide and mucosal eosinophilic infl ammation in children with diffi cult asthma, after treatment with oral prednisolone. Am J Respir Crit Care Med. 2001 ; 164 (8 pt 1): 1376-1381.
17. Berlyne GS, Parameswaran K, Kamada D, Efthimiadis A, Hargreave FE. A comparison of exhaled nitric oxide and induced sputum as markers of airway infl ammation. J Allergy Clin Immunol. 2000 ; 106 (4): 638-644.
18. Shaw DE, Berry MA, Thomas M, et al. The use of exhaled nitric oxide to guide asthma management: a randomized controlled trial. Am J Respir Crit Care Med. 2007; 176(3): 231-237.
19. Smith AD, Cowan JO, Brassett KP, Herbison GP, Taylor DR. Use of exhaled nitric oxide measurements to guide treatment in chronic asthma. N Engl J Med. 2005 ; 352 (21): 2163-2173.
20. de Jongste JC, Carraro S, Hop WC, Baraldi E ; CHARISM Study Group. Daily telemonitoring of exhaled nitric oxide and symptoms in the treatment of childhood asthma. Am J Respir Crit Care Med. 2009 ; 179 (2): 93-97.
21. Pijnenburg MW, Bakker EM, Lever S, Hop WC, De Jongste JC. High fractional concentration of nitric oxide in exhaled air despite steroid treatment in asthmatic children. Clin Exp Allergy. 2005 ; 35 (7): 920-925.
22. Fritsch M, Uxa S, Horak F Jr, et al. Exhaled nitric oxide in the management of childhood asthma: a prospective 6-months study. Pediatr Pulmonol. 2006 ; 41 (9): 855-862.
23. Gibson PG. Using fractional exhaled nitric oxide to guide asthma therapy: design and methodological issues for ASthma TReat ment ALgorithm studies. Clin Exp Allergy. 2009; 39(4): 478-490.
24. Petsky HL, Cates CJ, Li A, Kynaston JA, Turner C, Chang AB. Tailored interventions based on exhaled nitric oxide versus clinical symptoms for asthma in children and adults. Cochrane Database Syst Rev. 2009 ;(4): CD006340.
25. Caudri D, Wijga AH, Hoekstra MO, et al. Prediction of asthma in symptomatic preschool children using exhaled nitric oxide, Rint and specifi c IgE. Thorax. 2010 ; 65 (9): 801-807.
26. Debley JS, Stamey DC, Cochrane ES, Gama KL, Redding GJ. Exhaled nitric oxide, lung function, and exacerbations in wheezy infants and toddlers. J Allergy Clin Immunol. 2010 ; 125 (6): 1228-1234.
27. Malmberg LP, Pelkonen AS, Haahtela T, Turpeinen M. Exhaled nitric oxide rather than lung function distinguishes preschool children with probable asthma. Thorax. 2003 ; 58 (6): 494-499.
28. Moeller A, Diefenbacher C, Lehmann A, et al. Exhaled nitric oxide distinguishes between subgroups of preschool children with respiratory symptoms. J Allergy Clin Immunol. 2008 ; 121 (3): 705-709.
29. Beigelman A, Mauger DT, Phillips BR, et al ; Childhood Asthma Research and Education (CARE) Network ; National Heart, Lung and Blood Institute. Effect of elevated exhaled nitric oxide levels on the risk of respiratory tract illness in preschool-aged children with moderate-to-severe intermittent wheezing. Ann Allergy Asthma Immunol. 2009 ; 103 (2): 108-113.
30. Pérez-de-Llano LA, Carballada F, Castro Añón O, et al. Exhaled nitric oxide predicts control in patients with diffi cultto-treat asthma. Eur Respir J. 2010 ; 35 (6): 1221-1227.
31. Cabral AL, Vollmer WM, Barbirotto RM, Martins MA. Exhaled nitric oxide as a predictor of exacerbation in children with moderate-to-severe asthma: a prospective, 5-month study. Ann Allergy Asthma Immunol. 2009 ; 103 (3): 206-211.
32. Carrà S, Gagliardi L, Zanconato S, et al. Budesonide but not nedocromil sodium reduces exhaled nitric oxide levels in asthmatic children. Respir Med. 2001 ; 95 (9): 734-739.
33. Paro-Heitor ML, Bussamra MH, Saraiva-Romanholo BM, Martins MA, Okay TS, Rodrigues JC. Exhaled nitric oxide for monitoring childhood asthma infl ammation compared to sputum analysis, serum interleukins and pulmonary function. Pediatr Pulmonol. 2008 ; 43 (2): 134-141.
34. Napier E, Turner SW. Methodological issues related to exhaled nitric oxide measurement in children aged four to six years. Pediatr Pulmonol. 2005 ; 40 (2): 97-104.
35. Schiller B, Hammer J, Barben J, Trachsel D. Comparability of a hand-held nitric oxide analyser with online and offl ine chemiluminescence-based nitric oxide measurement. Pediatr Allergy Immunol. 2009 ; 20 (7): 679-685.