Effect of elevated exhaled nitric oxide levels on the risk of respiratory tract illness in preschool-aged children with moderate-to-severe intermittent wheezing

Annals of Allergy, Asthma and Immunology

Volumn 103, Issue 2, 2009, Pages 108-113

  Beigelman, Avraham ^a   Mauger, David T ^b   Phillips, Brenda R ^b   Zeiger, Robert S ^c,d   Taussig, Lynn M ^e   Strunk, Robert C ^a   Bacharier, Leonard B ^a,f  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b PENNSYLVANIA STATE UNIVERSITY   (United States)

^c UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^d KAISER PERMANENTE   (United States)

^e DEPARTMENT OF MEDICINE   (United States)

^f ST LOUIS CHILDREN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLERGEN; NITRIC OXIDE;

ARTICLE; BODY BURDEN; BREATHING; CHILD; CONFIDENCE INTERVAL; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; FOLLOW UP; HUMAN; MAJOR CLINICAL STUDY; MALE; PEDIATRICS; PRESCHOOL CHILD; PRIORITY JOURNAL; PROPORTIONAL HAZARDS MODEL; RESPIRATORY TRACT DISEASE; RISK FACTOR; SENSITIZATION; SKIN TEST; WHEEZING;

AGING; ALLERGENS; BREATH TESTS; CHILD, PRESCHOOL; CONTINENTAL POPULATION GROUPS; FEMALE; FOLLOW-UP STUDIES; HUMANS; HYPERSENSITIVITY, IMMEDIATE; INFANT; KAPLAN-MEIER ESTIMATE; MALE; NITRIC OXIDE; RESPIRATORY SOUNDS; RESPIRATORY TRACT DISEASES; RISK; SEASONS; SEX CHARACTERISTICS; SKIN TESTS;

EID: 68249099920     PISSN: 10811206     EISSN: 15344436     Source Type: Journal    
DOI: 10.1016/S1081-1206(10)60162-7     Document Type: Article

References (32)

1. ATS/ERS recommendations for standardized procedures for the online and offline measurement of exhaled lower respiratory nitric oxide and nasal nitric oxide, 2005. Am J Respir Crit Care Med. 2005;171:912-930.
2. Buchvald F, Bisgaard H. FeNO measured at fixed exhalation flow rate during controlled tidal breathing in children from the age of 2 yr. Am J Respir Crit Care Med. 2001;163:699-704. (Pubitemid 32230832)
3. Strunk RC, Szefler SJ, Phillips BR, et al. Relationship of exhaled nitric oxide to clinical and inflammatory markers of persistent asthma in children. J Allergy Clin Immunol. 2003;112:883-892.
4. Fitzpatrick AM, Gaston BM, Erzurum SC, Teague WG. Features of severe asthma in school-age children: atopy and increased exhaled nitric oxide. J Allergy Clin Immunol. 2006;118:1218-1225. (Pubitemid 44854125)
5. Covar RA, Szefler SJ, Martin RJ, et al. Relations between exhaled nitric oxide and measures of disease activity among children with mild-to-moderate asthma. J Pediatr. 2003;142:469-475.
6. Smith AD, Cowan JO, Brassett KP, Herbison GP, Taylor DR. Use of exhaled nitric oxide measurements to guide treatment in chronic asthma. N Engl J Med. 2005;352:2163-2173.
7. Zacharasiewicz A, Wilson N, Lex C, et al. Clinical use of noninvasive measurements of airway inflammation in steroid reduction in children. Am J Respir Crit Care Med. 2005;171:1077-1082. (Pubitemid 40663717)
8. Pijnenburg MW, Bakker EM, Hop WC, De Jongste JC. Titrating steroids on exhaled nitric oxide in children with asthma: a randomized controlled trial. Am J Respir Crit Care Med. 2005;172:831-836.
9. Shaw DE, Berry MA, Thomas M, et al. The use of exhaled nitric oxide to guide asthma management: a randomized controlled trial. Am J Respir Crit Care Med. 2007;176:231-237. (Pubitemid 47195872)
10. Malmberg LP, Pelkonen AS, Haahtela T, Turpeinen M. Exhaled nitric oxide rather than lung function distinguishes preschool children with probable asthma. Thorax. 2003;58:494-499. (Pubitemid 36714010)
11. Avital A, Uwyyed K, Berkman N, Godfrey S, Bar-Yishay E, Springer C. Exhaled nitric oxide and asthma in young children. Pediatr Pulmonol. 2001;32:308-313. (Pubitemid 32938880)
12. Bacharier LB, Phillips BR, Bloomberg GR, et al. Severe intermittent wheezing in preschool children: a distinct phenotype. J Allergy Clin Immunol. 2007;119:604-610.
13. Varni JW, Burwinkle TM, Rapoff MA, Kamps JL, Olson N. The PedsQL in pediatric asthma: reliability and validity of the Pediatric Quality of Life Inventory generic core scales and asthma module. J Behav Med. 2004;27:297-318. (Pubitemid 39024007)
14. Juniper EF, Guyatt GH, Feeny DH, Ferrie PJ, Griffith LE, Townsend M. Measuring quality of life in the parents of children with asthma. Qual Life Res. 1996;5:27-34. (Pubitemid 26100500)
15. Beck-Ripp J, Griese M, Arenz S, Koring C, Pasqualoni B, Bufler P. Changes of exhaled nitric oxide during steroid treatment of childhood asthma. Eur Respir J. 2002;19:1015-1019. (Pubitemid 34649612)
16. Tsai YG, Lee MY, Yang KD, Chu DM, Yuh YS, Hung CH. A single dose of nebulized budesonide decreases exhaled nitric oxide in children with acute asthma. J Pediatr. 2001;139:433-437. (Pubitemid 32889522)
17. Meyts I, Proesmans M, Van Gerven V, Hoppenbrouwers K, De Boeck K. Tidal off-line exhaled nitric oxide measurements in a pre-school population. Eur J Pediatr. 2003;162:506-510. (Pubitemid 36904276)
18. Guilbert TW, Morgan WJ, Zeiger RS, et al. Long-term inhaled corticosteroids in preschool children at high risk for asthma. N Engl J Med. 2006;354:1985-1997.
19. Nelson KA, Lee P, Yan Y, Hodgdon K, Schootman M, Strunk RC. Effect of peak expiratory flow rate measurement on exhaled nitric oxide levels in children with asthma. J Allergy Clin Immunol. 2007;119: 245-246. (Pubitemid 46037794)
20. Bacharier LB, Phillips BR, Zeiger RS, et al; CARE Network. Episodic use of an inhaled corticosteroid or leukotriene receptor antagonist in preschool children with moderate-to-severe intermittent wheezing. J Allergy Clin Immunol. 2008;122:1127-1135.
21. Baraldi E, Dario C, Ongaro R, et al. Exhaled nitric oxide concentrations during treatment of wheezing exacerbation in infants and young children. Am J Respir Crit Care Med. 1999;159:1284-1288. (Pubitemid 29202568)
22. Daniel PF, Klug B, Valerius NH. Exhaled nitric oxide in healthy young children during tidal breathing through a facemask. Pediatr Allergy Immunol. 2007;18:42-46. (Pubitemid 46232282)
23. Malmberg LP, Petays T, Haahtela T, et al. Exhaled nitric oxide in healthy nonatopic school-age children: determinants and height-adjusted reference values. Pediatr Pulmonol. 2006;41:635-642.
24. Jouaville LF, Annesi-Maesano I, Nguyen LT, Bocage AS, Bedu M, Caillaud D. Interrelationships among asthma, atopy, rhinitis and exhaled nitric oxide in a population-based sample of children. Clin Exp Allergy. 2003;33:1506-1511. (Pubitemid 37421627)
25. Dinakar C, Craff M, Laskowski D. Infants and toddlers without asthma with eczema have elevated exhaled nitric oxide levels. J Allergy Clin Immunol. 2006;117:212-213. (Pubitemid 43017163)
26. Moeller A, Diefenbacher C, Lehmann A, et al. Exhaled nitric oxide distinguishes between subgroups of preschool children with respiratory symptoms. J Allergy Clin Immunol. 2008;121:705-709.
27. Latzin P, Kuehni CE, Baldwin DN, Roiha HL, Casaulta C, Frey U. Elevated exhaled nitric oxide in newborns of atopic mothers precedes respiratory symptoms. Am J Respir Crit Care Med. 2006;174: 1292-1298. (Pubitemid 44913030)
28. Hunninghake GM, Weiss ST, Celedon JC. Asthma in Hispanics. Am J Respir Crit Care Med. 2006;173:143-163.
29. Akinbami LJ, Rhodes JC, Lara M. Racial and ethnic differences in asthma diagnosis among children who wheeze. Pediatrics. 2005;115: 1254-1260. (Pubitemid 43843228)
30. Wong GW, Liu EK, Leung TF, et al. High levels and gender difference of exhaled nitric oxide in Chinese schoolchildren. Clin Exp Allergy. 2005;35:889-893.
31. Kovesi T, Kulka R, Dales R. Exhaled nitric oxide concentration is affected by age, height, and race in healthy 9-to 12-year-old children. Chest. 2008;133:169-175.
32. Leung TF, Liu EK, Tang NL, et al. Nitric oxide synthase polymorphisms and asthma phenotypes in Chinese children. Clin Exp Allergy. 2005;35: 1288-1294. (Pubitemid 43919821)