메뉴 건너뛰기




Volumn 300, Issue 5, 2011, Pages

Fenofibrate, a PPARα agonist, decreases atrogenes and myostatin expression and improves arthritis-induced skeletal muscle atrophy

Author keywords

Atrogin 1; Muscle RING finger 1; Peroxisome proliferator activated receptor a

Indexed keywords

ATROGIN 1; CYCLINE; FENOFIBRATE; MUSCLE RING FINGER 1 PROTEIN; MYOD PROTEIN; MYOGENIN; MYOSTATIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PROTEASOME; PROTEIN KINASE B; TRANSCRIPTION FACTOR FKHRL1; TUMOR NECROSIS FACTOR ALPHA; UBIQUITIN;

EID: 79955569162     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00590.2010     Document Type: Article
Times cited : (50)

References (58)
  • 2
    • 77957124969 scopus 로고    scopus 로고
    • Myostatin expression is increased by food deprivation in a muscle-specific manner and contributes to muscle atrophy during prolonged food deprivation in mice
    • Allen DL, Cleary AS, Lindsay SF, Loh AS, Reed JM. Myostatin expression is increased by food deprivation in a muscle-specific manner and contributes to muscle atrophy during prolonged food deprivation in mice. J Appl Physiol 109: 692-701, 2010.
    • (2010) J Appl Physiol , vol.109 , pp. 692-701
    • Allen, D.L.1    Cleary, A.S.2    Lindsay, S.F.3    Loh, A.S.4    Reed, J.M.5
  • 3
    • 0029040739 scopus 로고
    • Activation of the ATP-ubiquitin-proteasome pathway in skeletal muscle of cachectic rats bearing a hepatoma
    • Baracos VE, DeVivo C, Hoyle DH, Goldberg AL. Activation of the ATP-ubiquitin-proteasome pathway in skeletal muscle of cachectic rats bearing a hepatoma. Am J Physiol Endocrinol Metab 268: E996-E1006, 1995.
    • (1995) Am J Physiol Endocrinol Metab , vol.268
    • Baracos, V.E.1    DeVivo, C.2    Hoyle, D.H.3    Goldberg, A.L.4
  • 4
    • 77951912082 scopus 로고    scopus 로고
    • Targeting apoptosis in the heart of streptozotocin- induced diabetic rats
    • Baraka A, Abdel Gawad H. Targeting apoptosis in the heart of streptozotocin- induced diabetic rats. J Cardiovasc Pharmacol Ther 15: 175-181, 2010.
    • (2010) J Cardiovasc Pharmacol Ther , vol.15 , pp. 175-181
    • Baraka, A.1    Abdel Gawad, H.2
  • 5
    • 69249232300 scopus 로고    scopus 로고
    • Changes in postnatal skeletal muscle development induced by alternative immobilization model in female rat
    • Benedini-Elias PC, Morgan MC, Gomes AR, Mattiello-Sverzut AC. Changes in postnatal skeletal muscle development induced by alternative immobilization model in female rat. Anat Sci Int 84: 218-225, 2009.
    • (2009) Anat Sci Int , vol.84 , pp. 218-225
    • Benedini-Elias, P.C.1    Morgan, M.C.2    Gomes, A.R.3    Mattiello-Sverzut, A.C.4
  • 6
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantification of microgram quantities of proteins utilizing the principle of protein-dye binding
    • Bradford MM. A rapid and sensitive method for the quantification of microgram quantities of proteins utilizing the principle of protein-dye binding. Anal Biochem 72: 248-254, 1976.
    • (1976) Anal Biochem , vol.72 , pp. 248-254
    • Bradford, M.M.1
  • 7
    • 4444305799 scopus 로고    scopus 로고
    • Histological parameters for the quantitative assessment of muscular dystrophy in the mdx-mouse
    • Briguet A, Courdier-Fruh I, Foster M, Meier T, Magyar JP. Histological parameters for the quantitative assessment of muscular dystrophy in the mdx-mouse. Neuromuscul Disord 10: 675-682, 2004.
    • (2004) Neuromuscul Disord , vol.10 , pp. 675-682
    • Briguet, A.1    Courdier-Fruh, I.2    Foster, M.3    Meier, T.4    Magyar, J.P.5
  • 8
    • 0028807357 scopus 로고
    • Human satellite cell proliferation in vitro is regulated by autocrine secretion of IL-6 stimulated by a soluble factor(s) released by activated monocytes
    • Cantini M, Massimino ML, Rapizzi E, Rossini K, Catani C, Dalla Libera L, Carraro U. Human satellite cell proliferation in vitro is regulated by autocrine secretion of IL-6 stimulated by a soluble factor(s) released by activated monocytes. Biochem Biophys Res Commun 216: 49-53, 1995.
    • (1995) Biochem Biophys Res Commun , vol.216 , pp. 49-53
    • Cantini, M.1    Massimino, M.L.2    Rapizzi, E.3    Rossini, K.4    Catani, C.5    Dalla Libera, L.6    Carraro, U.7
  • 12
    • 34250669605 scopus 로고    scopus 로고
    • TNF-_ regulates myogenesis and muscle regeneration by activating p38 MAPK
    • Chen SE, Jin B, Li YP. TNF-_ regulates myogenesis and muscle regeneration by activating p38 MAPK. Am J Physiol Cell Physiol 292: C1660-C1671, 2007.
    • (2007) Am J Physiol Cell Physiol , vol.292
    • Chen, S.E.1    Jin, B.2    Li, Y.P.3
  • 14
    • 56449103294 scopus 로고    scopus 로고
    • A potential role for Akt/FOXO signalling in both protein loss and the impairment of muscle carbohydrate oxidation during sepsis in rodent skeletal muscle
    • Crossland H, Constantin-Teodosiu D, Gardiner SM, Constantin D, Greenhaff PL. A potential role for Akt/FOXO signalling in both protein loss and the impairment of muscle carbohydrate oxidation during sepsis in rodent skeletal muscle. J Physiol 586: 5589-5600, 2008.
    • (2008) J Physiol , vol.586 , pp. 5589-5600
    • Crossland, H.1    Constantin-Teodosiu, D.2    Gardiner, S.M.3    Constantin, D.4    Greenhaff, P.L.5
  • 15
    • 0034711185 scopus 로고    scopus 로고
    • Induction of IkappaBalpha expression as a mechanism contributing to the anti-inflammatory activities of peroxisome proliferator-activated receptor-alpha activators
    • Delerive P, Gervois P, Fruchart JC, Staels B. Induction of IkappaBalpha expression as a mechanism contributing to the anti-inflammatory activities of peroxisome proliferator-activated receptor-alpha activators. J Biol Chem 275: 36703-36707, 2000.
    • (2000) J Biol Chem , vol.275 , pp. 36703-36707
    • Delerive, P.1    Gervois, P.2    Fruchart, J.C.3    Staels, B.4
  • 18
    • 0027098040 scopus 로고
    • Endotoxin rapidly induces changes in lipid metabolism that produce hypertriglyceridemia: Low doses stimulate hepatic triglyceride production while high doses inhibit clearance
    • Feingold KR, Staprans I, Memon RA, Moser AH, Shigenaga JK, Doerrler W, Dinarello CA, Grunfeld C. Endotoxin rapidly induces changes in lipid metabolism that produce hypertriglyceridemia: low doses stimulate hepatic triglyceride production while high doses inhibit clearance. J Lipid Res 33: 1765-1776, 1992.
    • (1992) J Lipid Res , vol.33 , pp. 1765-1776
    • Feingold, K.R.1    Staprans, I.2    Memon, R.A.3    Moser, A.H.4    Shigenaga, J.K.5    Doerrler, W.6    Dinarello, C.A.7    Grunfeld, C.8
  • 19
    • 0942287345 scopus 로고    scopus 로고
    • Altered expression of nuclear hormone receptors and coactivators in mouse heart during the acute-phase response
    • Feingold K, Kim MS, Shigenaga J, Moser A, Grunfeld C. Altered expression of nuclear hormone receptors and coactivators in mouse heart during the acute-phase response. Am J Physiol Endocrinol Metab 286: E201-E207, 2004.
    • (2004) Am J Physiol Endocrinol Metab , vol.286
    • Feingold, K.1    Kim, M.S.2    Shigenaga, J.3    Moser, A.4    Grunfeld, C.5
  • 20
    • 67649814105 scopus 로고    scopus 로고
    • LPS decreases fatty acid oxidation and nuclear hormone receptors in the kidney
    • Feingold KR, Wang Y, Moser A, Shigenaga JK, Grunfeld C. LPS decreases fatty acid oxidation and nuclear hormone receptors in the kidney. J Lipid Res 49: 2179-2187, 2008.
    • (2008) J Lipid Res , vol.49 , pp. 2179-2187
    • Feingold, K.R.1    Wang, Y.2    Moser, A.3    Shigenaga, J.K.4    Grunfeld, C.5
  • 21
    • 53149090164 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors in the modulation of the immune/inflammatory response in atherosclerosis
    • Fernandez AZ. Peroxisome proliferator-activated receptors in the modulation of the immune/inflammatory response in atherosclerosis. PPAR Res 2008: 285842, 2008.
    • (2008) PPAR Res , vol.2008 , pp. 285842
    • Fernandez, A.Z.1
  • 23
    • 77956637898 scopus 로고    scopus 로고
    • A comparative study of anti-inflammatory and antidyslipidemic effects of fenofibrate and statins on rheumatoid arthritis
    • Goto M. A comparative study of anti-inflammatory and antidyslipidemic effects of fenofibrate and statins on rheumatoid arthritis. Mod Rheumatol 20: 238-243, 2010.
    • (2010) Mod Rheumatol , vol.20 , pp. 238-243
    • Goto, M.1
  • 24
    • 33644669037 scopus 로고    scopus 로고
    • Ghrelin receptor agonist GHRP-2 prevents arthritis-induced increase in E3 ubiquitin-ligating enzymes MuRF1 and MAFbx gene expression in skeletal muscle
    • Granado M, Priego T, Martín AI, Villanúa MA, López-Calderón A. Ghrelin receptor agonist GHRP-2 prevents arthritis-induced increase in E3 ubiquitin-ligating enzymes MuRF1 and MAFbx gene expression in skeletal muscle. Am J Physiol Endocrinol Metab 289: E1007-E1014, 2005.
    • (2005) Am J Physiol Endocrinol Metab , vol.289
    • Granado, M.1    Priego, T.2    Martín, A.I.3    Villanúa, M.A.4    López-Calderón, A.5
  • 25
    • 34447556834 scopus 로고    scopus 로고
    • Experimental arthritis inhibits the insulin-like growth factor-I axis and induces muscle wasting through cyclooxygenase-2 activation
    • Granado M, Martín AI, Villanúa MA, López-Calderón A. Experimental arthritis inhibits the insulin-like growth factor-I axis and induces muscle wasting through cyclooxygenase-2 activation. Am J Physiol Endocrinol Metab 292: E1656-E1665, 2007.
    • (2007) Am J Physiol Endocrinol Metab , vol.292
    • Granado, M.1    Martín, A.I.2    Villanúa, M.A.3    López-Calderón, A.4
  • 26
    • 0033957165 scopus 로고    scopus 로고
    • Dietary polyunsaturated fatty acids and inflammatory mediator production
    • James MJ, Gibson RA, Cleland LG. Dietary polyunsaturated fatty acids and inflammatory mediator production. Am J Clin Nutr 71: 343S-348S, 2000.
    • (2000) Am J Clin Nutr , vol.71
    • James, M.J.1    Gibson, R.A.2    Cleland, L.G.3
  • 27
    • 77952967106 scopus 로고    scopus 로고
    • Modulation of LPS-mediated inflammation by fenofibrate via the TRIF-dependent TLR4 signaling pathway in vascular smooth muscle cells
    • Ji Y, Wang Z, Li Z, Liu J. Modulation of LPS-mediated inflammation by fenofibrate via the TRIF-dependent TLR4 signaling pathway in vascular smooth muscle cells. Cell Physiol Biochem 25: 631-640, 2010.
    • (2010) Cell Physiol Biochem , vol.25 , pp. 631-640
    • Ji, Y.1    Wang, Z.2    Li, Z.3    Liu, J.4
  • 28
    • 3042606551 scopus 로고    scopus 로고
    • Effects of infection and inflammation on lipid and lipoprotein metabolism: Mechanisms and consequences to the host
    • Khovidhunkit W, Kim MS, Memon RA, Shigenaga JK, Moser AH, Feingold KR, Grunfeld C. Effects of infection and inflammation on lipid and lipoprotein metabolism: mechanisms and consequences to the host. J Lipid Res 45: 1169-1196, 2004.
    • (2004) J Lipid Res , vol.45 , pp. 1169-1196
    • Khovidhunkit, W.1    Kim, M.S.2    Memon, R.A.3    Shigenaga, J.K.4    Moser, A.H.5    Feingold, K.R.6    Grunfeld, C.7
  • 34
    • 42449118936 scopus 로고    scopus 로고
    • Adipose tissue loss in adjuvant arthritis is associated with a decrease in lipogenesis, but not with an increase in lipolysis
    • Martín AI, Castillero E, Granado M, López-Menduiña M, Villanúa MA, López-Calderón A. Adipose tissue loss in adjuvant arthritis is associated with a decrease in lipogenesis, but not with an increase in lipolysis. J Endocrinol 197: 111-119, 2008.
    • (2008) J Endocrinol , vol.197 , pp. 111-119
    • Martín, A.I.1    Castillero, E.2    Granado, M.3    López-Menduiña, M.4    Villanúa, M.A.5    López-Calderón, A.6
  • 36
    • 34948899219 scopus 로고    scopus 로고
    • The transcriptional coactivator peroxisome proliferator activated receptor (PPAR)gamma coactivator-1 alpha and the nuclear receptor PPAR alpha control the expression of glycerol kinase and metabolism genes independently of PPAR gamma activation in human white adipocytes
    • Mazzucotelli A, Viguerie N, Tiraby C, Annicotte JS, Mairal A, Klimcakova E, Lepin E, Delmar P, Dejean S, Tavernier G, Lefort C, Hidalgo J, Pineau T, Fajas L, Clément K, Langin D. The transcriptional coactivator peroxisome proliferator activated receptor (PPAR)gamma coactivator-1 alpha and the nuclear receptor PPAR alpha control the expression of glycerol kinase and metabolism genes independently of PPAR gamma activation in human white adipocytes. Diabetes 56: 2467-2475, 2007.
    • (2007) Diabetes , vol.56 , pp. 2467-2475
    • Mazzucotelli, A.1    Viguerie, N.2    Tiraby, C.3    Annicotte, J.S.4    Mairal, A.5    Klimcakova, E.6    Lepin, E.7    Delmar, P.8    Dejean, S.9    Tavernier, G.10    Lefort, C.11    Hidalgo, J.12    Pineau, T.13    Fajas, L.14    Clément, K.15    Langin, D.16
  • 37
    • 33749254273 scopus 로고    scopus 로고
    • Myostatin induces cachexia by activating the ubiquitin proteolytic system through an NF-kappaB-independent, FoxO1-dependent mechanism
    • McFarlane C, Plummer E, Thomas M, Hennebry A, Ashby M, Ling N, Smith H, Sharma M, Kambadur R. Myostatin induces cachexia by activating the ubiquitin proteolytic system through an NF-kappaB-independent, FoxO1-dependent mechanism. J Cell Physiol 209: 501-514, 2006.
    • (2006) J Cell Physiol , vol.209 , pp. 501-514
    • McFarlane, C.1    Plummer, E.2    Thomas, M.3    Hennebry, A.4    Ashby, M.5    Ling, N.6    Smith, H.7    Sharma, M.8    Kambadur, R.9
  • 38
    • 0036200822 scopus 로고    scopus 로고
    • Suppression of body fat accumulation in myostatin-deficient mice
    • McPherron AC, Lee SJ. Suppression of body fat accumulation in myostatin-deficient mice. J Clin Invest 109: 595-601, 2002.
    • (2002) J Clin Invest , vol.109 , pp. 595-601
    • McPherron, A.C.1    Lee, S.J.2
  • 39
    • 58149466606 scopus 로고    scopus 로고
    • PPARs Mediate Lipid Signaling in Inflammation and Cancer
    • Michalik L, Wahli W. PPARs Mediate Lipid Signaling in Inflammation and Cancer. PPAR Res 2008: 134059, 2008.
    • (2008) PPAR Res , vol.2008 , pp. 134059
    • Michalik, L.1    Wahli, W.2
  • 43
    • 3242685953 scopus 로고    scopus 로고
    • Successful treatment with fenofibrate, a peroxisome proliferator activated receptor alpha ligand, for a patient with rheumatoid arthritis
    • Okamoto H, Kamatani N. Successful treatment with fenofibrate, a peroxisome proliferator activated receptor alpha ligand, for a patient with rheumatoid arthritis. Ann Rheum Dis 63: 1002-1003, 2004.
    • (2004) Ann Rheum Dis , vol.63 , pp. 1002-1003
    • Okamoto, H.1    Kamatani, N.2
  • 44
    • 20444440328 scopus 로고    scopus 로고
    • Inhibition of NF-kappaB signaling by fenofibrate, a peroxisome proliferator-activated receptor-alpha ligand, presents a therapeutic strategy for rheumatoid arthritis
    • Okamoto H, Iwamoto T, Kotake S, Momohara S, Yamanaka H, Kamatani N. Inhibition of NF-kappaB signaling by fenofibrate, a peroxisome proliferator-activated receptor-alpha ligand, presents a therapeutic strategy for rheumatoid arthritis. Clin Exp Rheumatol 23: 323-330, 2005.
    • (2005) Clin Exp Rheumatol , vol.23 , pp. 323-330
    • Okamoto, H.1    Iwamoto, T.2    Kotake, S.3    Momohara, S.4    Yamanaka, H.5    Kamatani, N.6
  • 45
    • 49849086021 scopus 로고    scopus 로고
    • The peroxisome proliferator-activated receptorgamma agonist pioglitazone represses inflammation in a peroxisome proliferator-activated receptor-alpha-dependent manner in vitro and in vivo in mice
    • Orasanu G, Ziouzenkova O, Devchand PR, Nehra V, Hamdy O, Horton ES, Plutzky J. The peroxisome proliferator-activated receptorgamma agonist pioglitazone represses inflammation in a peroxisome proliferator-activated receptor-alpha-dependent manner in vitro and in vivo in mice. J Am Coll Cardiol 52: 869-881, 2008.
    • (2008) J Am Coll Cardiol , vol.52 , pp. 869-881
    • Orasanu, G.1    Ziouzenkova, O.2    Devchand, P.R.3    Nehra, V.4    Hamdy, O.5    Horton, E.S.6    Plutzky, J.7
  • 46
    • 77957682037 scopus 로고    scopus 로고
    • Signalling and the control of skeletal muscle size
    • Otto A, Patel K. Signalling and the control of skeletal muscle size. Exp Cell Res 316: 3059-3066, 2010.
    • (2010) Exp Cell Res , vol.316 , pp. 3059-3066
    • Otto, A.1    Patel, K.2
  • 49
    • 0034749771 scopus 로고    scopus 로고
    • Cyclosporin a treatment is able to revert the decrease in circulating GH and IGF-I and the increase in IGFBPs induced by adjuvant arthritis
    • Soto L, Martín AI, Vara E, López-Calderón A. Cyclosporin a treatment is able to revert the decrease in circulating GH and IGF-I and the increase in IGFBPs induced by adjuvant arthritis. Horm Metab Res 33: 590-595, 2001.
    • (2001) Horm Metab Res , vol.33 , pp. 590-595
    • Soto, L.1    Martín, A.I.2    Vara, E.3    López-Calderón, A.4
  • 50
    • 0036931477 scopus 로고    scopus 로고
    • Omega-3 fatty acids in inflammation and autoimmune diseases
    • Simopoulos AP. Omega-3 fatty acids in inflammation and autoimmune diseases. J Am Coll Nutr 21: 495-505, 2002.
    • (2002) J Am Coll Nutr , vol.21 , pp. 495-505
    • Simopoulos, A.P.1
  • 51
    • 78049258823 scopus 로고    scopus 로고
    • Sepsis downregulates myostatin mRNA levels without altering myostatin protein levels in skeletal muscle
    • Smith IJ, Aversa Z, Alamdari N, Petkova V, Hasselgren PO. Sepsis downregulates myostatin mRNA levels without altering myostatin protein levels in skeletal muscle. J Cell Biochem 111: 1059-1073, 2010.
    • (2010) J Cell Biochem , vol.111 , pp. 1059-1073
    • Smith, I.J.1    Aversa, Z.2    Alamdari, N.3    Petkova, V.4    Hasselgren, P.O.5
  • 53
    • 40849086138 scopus 로고    scopus 로고
    • Enhanced muscle by myostatin propeptide increases adipose tissue adiponectin, PPAR-alpha, and PPAR-gamma expressions
    • Suzuki ST, Zhao B, Yang J. Enhanced muscle by myostatin propeptide increases adipose tissue adiponectin, PPAR-alpha, and PPAR-gamma expressions. Biochem Biophys Res Commun 369: 767-773, 2008.
    • (2008) Biochem Biophys Res Commun , vol.369 , pp. 767-773
    • Suzuki, S.T.1    Zhao, B.2    Yang, J.3
  • 55
    • 0030951073 scopus 로고    scopus 로고
    • Intracellular regulation of protein degradation during sepsis is different in fast- and slow-twitch muscle
    • Tiao G, Lieberman M, Fischer JE, Hasselgren PO. Intracellular regulation of protein degradation during sepsis is different in fast- and slow-twitch muscle. Am J Physiol Regul Integr Comp Physiol 272: R849-R856, 1997.
    • (1997) Am J Physiol Regul Integr Comp Physiol , vol.272
    • Tiao, G.1    Lieberman, M.2    Fischer, J.E.3    Hasselgren, P.O.4
  • 56
    • 0033977890 scopus 로고    scopus 로고
    • The coactivator PGC-1 cooperates with peroxisome proliferator-activated receptor alpha in transcriptional control of nuclear genes encoding mitochondrial fatty acid oxidation enzymes
    • Vega RB, Huss JM, Kelly DP. The coactivator PGC-1 cooperates with peroxisome proliferator-activated receptor alpha in transcriptional control of nuclear genes encoding mitochondrial fatty acid oxidation enzymes. Mol Cell Biol 20: 1868-1876, 2000.
    • (2000) Mol Cell Biol , vol.20 , pp. 1868-1876
    • Vega, R.B.1    Huss, J.M.2    Kelly, D.P.3
  • 57
    • 77955816283 scopus 로고    scopus 로고
    • FOXO3a mediates signaling crosstalk that coordinates ubiquitin and atrogin-1/ MAFbx expression during glucocorticoid-induced skeletal muscle atrophy
    • Zheng B, Ohkawa S, Li H, Roberts-Wilson TK, Price SR. FOXO3a mediates signaling crosstalk that coordinates ubiquitin and atrogin-1/ MAFbx expression during glucocorticoid-induced skeletal muscle atrophy. FASEB J 24: 2660-2669, 2010.
    • (2010) FASEB J , vol.24 , pp. 2660-2669
    • Zheng, B.1    Ohkawa, S.2    Li, H.3    Roberts-Wilson, T.K.4    Price, S.R.5
  • 58
    • 0034716993 scopus 로고    scopus 로고
    • Dominant negative myostatin produces hypertrophy without hyperplasia in muscle
    • Zhu X, Hadhazy M, Wehling M, Tidball JG, McNally EM. Dominant negative myostatin produces hypertrophy without hyperplasia in muscle. FEBS Lett 474: 71-75, 2000.
    • (2000) FEBS Lett , vol.474 , pp. 71-75
    • Zhu, X.1    Hadhazy, M.2    Wehling, M.3    Tidball, J.G.4    McNally, E.M.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.