PEGylation of cationic, shell-crosslinked-knedel-like nanoparticles modulates inflammation and enhances cellular uptake in the lung

Nanomedicine: Nanotechnology, Biology, and Medicine

Volumn 9, Issue 7, 2013, Pages 912-922

  Ibricevic, Aida ^a   Guntsen, Sean P ^a   Zhang, Ke ^b   Shrestha, Ritu ^d   Liu, Yongjian ^c   Sun, Jing Yi ^a   Welch, Michael J ^c   Wooley, Karen L ^b,d   Brody, Steven L ^a,c  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b WASHINGTON UNIVERSITY   (United States)

^c WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d TEXAS A AND M UNIVERSITY   (United States)

Author keywords

Airway; Alveolar epithelial cells; Macrophage; Poly(ethylene glycol); Surfactant

Indexed keywords

AIRWAY INFLAMMATION; ALVEOLAR EPITHELIAL CELLS; CELLULAR UPTAKE; DOSE-DEPENDENT MANNER; INTRACELLULAR DELIVERY; NANOPARTICLE SURFACE MODIFICATION; PEGYLATED NANOPARTICLE; SHELL CROSS-LINKED KNEDEL-LIKE NANOPARTICLES;

AIR TRANSPORTATION; CELLS; DRUG DELIVERY; MACROPHAGES; MOLECULAR BIOLOGY; NANOPARTICLES; PATHOLOGY; POLYETHYLENE GLYCOLS; SURFACE ACTIVE AGENTS;

BIOLOGICAL ORGANS;

CLATHRIN; LUNG SURFACTANT; MACROGOL; NANOPARTICLE; POLYMER;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELLULAR PARAMETERS; CELLULAR UPTAKE; CHEMICAL MODIFICATION; CHEMICAL REACTION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CROSS LINKING; DRUG DELIVERY SYSTEM; ENDOCYTOSIS; ENDOSOME; FLOW CYTOMETRY; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; INFLAMMATORY CELL; LUNG ALVEOLUS EPITHELIUM; LUNG LAVAGE; LUNG PARENCHYMA; MOLECULAR LIBRARY; MOUSE; NONHUMAN; PEGYLATION; QUANTITATIVE ANALYSIS; RESPIRATORY TRACT INFLAMMATION; SURFACE PROPERTY;

AIRWAY; ALVEOLAR EPITHELIAL CELLS; BAL; BRONCHOALVEOLAR LAVAGE; CATIONIC SHELL CROSSLINKED KNEDEL-LIKE; CHLORPROMAZINE; CPM; CSCK; MACROPHAGE; MDC; METHYL-Β-CYCLODEXTRAN; MONODANSYLCADAVERINE; MΒCD; NANOPARTICLE; NP; PEG; POLY(ETHYLENE GLYCOL); SD; STANDARD DEVIATION; SURFACTANT;

ANIMALS; CATIONS; CELL LINE; CROSS-LINKING REAGENTS; DRUG DELIVERY SYSTEMS; ENDOCYTOSIS; INFLAMMATION; INTRACELLULAR SPACE; LUNG; MICE; MICE, INBRED C57BL; NANOPARTICLES; PNEUMOCYTES; POLYETHYLENE GLYCOLS;

EID: 84884287138     PISSN: 15499634     EISSN: 15499642     Source Type: Journal    
DOI: 10.1016/j.nano.2013.02.006     Document Type: Article

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