The role of calcium, NF-κB and NFAT in the regulation of CXCL8 and IL-6 expression in Jurkat T-cells

International Journal of Biochemistry and Molecular Biology

Volumn 4, Issue 3, 2013, Pages 150-156

  Khalaf, Hazem ^a   Jass, Jana ^a   Olsson, Per Erik ^a  

^a ÖREBRO UNIVERSITY   (Sweden)

Author keywords

E. coli.; Gene expression; Inflammation; PMA

Indexed keywords

CALCIUM ION; CALCIUM IONOPHORE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; INTERLEUKIN 8; PHORBOL 13 ACETATE 12 MYRISTATE; TRANSCRIPTION FACTOR NFAT;

ARTICLE; CALCIUM CELL LEVEL; CELLULAR DISTRIBUTION; CELLULAR IMMUNITY; COMPLEX FORMATION; CONTROLLED STUDY; HUMAN; HUMAN CELL; IMMUNOREGULATION; LEUKEMIA CELL LINE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION; T LYMPHOCYTE; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION;

EID: 84884266912     PISSN: None     EISSN: 21524114     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Ginn-Pease ME and Whisler RL. Optimal NF kappa B mediated transcriptional responses in Jurkat T cells exposed to oxidative stress are dependent on intracellular glutathione and costimulatory signals. Biochem Biophys Res Commun 1996; 226: 695-702.
2. Aifantis I, Gounari F, Scorrano L, Borowski C and von Boehmer H. Constitutive pre-TCR signaling promotes differentiation through Ca2+ mobilization and activation of NF-kappaB and NFAT. Nat Immunol 2001; 2: 403-409.
3. Scharschmidt E, Wegener E, Heissmeyer V, Rao A and Krappmann D. Degradation of Bcl10 induced by T-cell activation negatively regulates NF-kappa B signaling. Mol Cell Biol 2004; 24: 3860-3873.
4. Narayan P, Holt B, Tosti R and Kane LP. CARMA1 is required for Akt-mediated NF-kappaB activation in T cells. Mol Cell Biol 2006; 26: 2327-2336.
5. Ebinu JO, Stang SL, Teixeira C, Bottorff DA, Hooton J, Blumberg PM, Barry M, Bleakley RC, Ostergaard HL and Stone JC. RasGRP links T-cell receptor signaling to Ras. Blood 2000; 95: 3199-3203.
6. Berry N and Nishizuka Y. Protein kinase C and T cell activation. Eur J Biochem 1990; 189: 205-214.
7. Manicassamy S, Sadim M, Ye RD and Sun Z. Differential roles of PKC-theta in the regulation of intracellular calcium concentration in primary T cells. J Mol Biol 2006; 355: 347-359.
8. Horsley V and Pavlath GK. NFAT: ubiquitous regulator of cell differentiation and adaptation. J Cell Biol 2002; 156: 771-774.
9. Jain J, McCaffrey PG, Miner Z, Kerppola TK, Lambert JN, Verdine GL, Curran T and Rao A. The T-cell transcription factor NFATp is a substrate for calcineurin and interacts with Fos and Jun. Nature 1993; 365: 352-355.
10. Khalaf H, Jass J and Olsson PE. Differential cytokine regulation by NF-kappaB and AP-1 in Jurkat T-cells. BMC Immunol 2010; 11: 26.
11. Hogan PG, Chen L, Nardone J and Rao A. Transcriptional regulation by calcium, calcineurin, and NFAT. Genes Dev 2003; 17: 2205-2232.
12. Park KA, Byun HS, Won M, Yang KJ, Shin S, Piao L, Kim JM, Yoon WH, Junn E, Park J, Seok JH and Hur GM. Sustained activation of protein kinase C downregulates nuclear factor-kappaB signaling by dissociation of IKK-gamma and Hsp90 complex in human colonic epithelial cells. Carcinogenesis 2007; 28: 71-80.
13. Tergaonkar V. NFkappaB pathway: a good signaling paradigm and therapeutic target. Int J Biochem Cell Biol 2006; 38: 1647-1653.
14. Brown K, Park S, Kanno T, Franzoso G and Siebenlist U. Mutual regulation of the transcriptional activator NF-kappa B and its inhibitor, I kappa B-alpha. Proc Natl Acad Sci U S A 1993; 90: 2532-2536.
15. Barnes P and Adcock I. NF-kappa B: a pivotal role in asthma and a new target for therapy. Trends Pharmacol Sci 1997; 18: 46-50.
16. Brand K, Page S, Walli AK, Neumeier D and Baeuerle PA. Role of nuclear factor-kappa B in atherogenesis. Exp Physiol 1997; 82: 297-304.
17. Mattson MP and Meffert MK. Roles for NF-kappaB in nerve cell survival, plasticity, and disease. Cell Death Differ 2006; 13: 852-860.
18. Christman JW, Lancaster LH and Blackwell TS. Nuclear factor kappa B: a pivotal role in the systemic inflammatory response syndrome and new target for therapy. Intensive Care Med 1998; 24: 1131-1138.
19. Renard P and Raes M. The proinflammatory transcription factor NFkappaB: a potential target for novel therapeutical strategies. Cell Biol Toxicol 1999; 15: 341-344.
20. Sanchez-Perez I, Benitah SA, Martinez-Gomariz M, Lacal JC and Perona R. Cell stress and MEKK1-mediated c-Jun activation modulate NFkappaB activity and cell viability. Mol Biol Cell 2002; 13: 2933-2945.
21. Dolmetsch RE, Lewis RS, Goodnow CC and Healy JI. Differential activation of transcription factors induced by Ca2+ response amplitude and duration. Nature 1997; 386: 855-858.
22. Antonsson A, Hughes K, Edin S and Grundstrom T. Regulation of c-Rel nuclear localization by binding of Ca2+/calmodulin. Mol Cell Biol 2003; 23: 1418-1427.
23. Chen X, Kandasamy K and Srivastava RK. Differential roles of RelA (p65) and c-Rel subunits of nuclear factor kappa B in tumor necrosis factor-related apoptosis-inducing ligand signaling. Cancer Res 2003; 63: 1059-1066.
24. Freund A, Jolivel V, Durand S, Kersual N, Chalbos D, Chavey C, Vignon F and Lazennec G. Mechanisms underlying differential expression of interleukin-8 in breast cancer cells. Oncogene 2004; 23: 6105-6114.
25. Macian F, Lopez-Rodriguez C and Rao A. Partners in transcription: NFAT and AP-1. Oncogene 2001; 20: 2476-2489.