Deletions within its subcellular targeting domain enhance the axon protective capacity of Nmnat2 in vivo

Scientific Reports

Volumn 3, Issue , 2013, Pages

  Milde, Stefan ^a   Fox, A Nicole ^b   Freeman, Marc R ^b   Coleman, Michael P ^a  

^a BABRAHAM INSTITUTE   (United Kingdom)

^b UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NICOTINAMIDE NUCLEOTIDE ADENYLYLTRANSFERASE; NMNAT2 PROTEIN, MOUSE;

ANIMAL; C57BL MOUSE; CELL CULTURE; CELL FRACTIONATION; GENE DELETION; GENETICS; KNOCKOUT MOUSE; METABOLISM; MOUSE; NERVE FIBER; PATHOLOGY; PATHOPHYSIOLOGY; STRUCTURE ACTIVITY RELATION; TRANSGENIC MOUSE; ULTRASTRUCTURE; WALLERIAN DEGENERATION; ARTICLE;

ANIMALS; AXONS; CELLS, CULTURED; GENE DELETION; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; NICOTINAMIDE-NUCLEOTIDE ADENYLYLTRANSFERASE; STRUCTURE-ACTIVITY RELATIONSHIP; SUBCELLULAR FRACTIONS; WALLERIAN DEGENERATION;

EID: 84884266070     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep02567     Document Type: Article

References (29)

1. Gilley, J. & Coleman, M. P. Endogenous Nmnat2 Is an Essential Survival Factor for Maintenance of Healthy Axons. PLoS Biol 8, e1000300 (2010).
2. Gilley, J., Adalbert, R., Yu, G. & Coleman, M. P. Rescue of Peripheral and CNS Axon Defects in Mice Lacking NMNAT2. J Neurosci 33, 13410-13424 (2013).
3. Mack, T. G. et al.Wallerian degeneration of injured axons and synapses is delayed by a Ube4b/Nmnat chimeric gene. Nat Neurosci 4, 1199-206 (2001).
4. Babetto, E. et al. Targeting NMNAT1 to axons and synapses transforms its neuroprotective potency in vivo. J Neurosci 30, 13291-304 (2010).
5. Sasaki, Y., Vohra, B. P. S., Baloh, R.H. & Milbrandt, J. Transgenic mice expressing the Nmnat1 protein manifest robust delay in axonal degeneration in vivo. J Neurosci 29, 6526-34 (2009).
6. Feng, Y. et al. Overexpression of Wld(S) or Nmnat2 in mauthner cells by singlecell electroporation delays axon degeneration in live zebrafish. J Neurosci Res 88, 3319-27 (2010).
7. Yan, T. et al. Nmnat2 delays axon degeneration in superior cervical ganglia dependent on its NAD synthesis activity. Neurochem Int 56, 1-6 (2009).
8. Ljungberg, M. C. et al. CREB-activity and nmnat2 transcription are downregulated prior to neurodegeneration, while NMNAT2 over-expression is neuroprotective, in a mouse model of human tauopathy. Hum Mol Genet 21, 251-67 (2012).
9. Milde, S., Gilley, J. & Coleman, M. P. Subcellular Localization Determines the Stability and Axon Protective Capacity of Axon Survival Factor Nmnat2. PLoS Biol 11, e1001539 (2013).
10. Zhai, Q. et al. Involvement of the ubiquitin-proteasome system in the early stages of wallerian degeneration. Neuron 39, 217-25 (2003). (Pubitemid 36897545)
11. Xiong, X. et al. The Highwire Ubiquitin Ligase Promotes Axonal Degeneration by Tuning Levels of Nmnat Protein. PLoS Biol 10, e1001440 (2012).
12. Babetto, E., Beirowski, B., Russler, E. V., Milbrandt, J. & DiAntonio, A. The Phr1 ubiquitin ligase promotes injury-induced axon self-destruction. Cell Rep 3, 1422-9 (2013).
13. Lau, C. et al. Isoform-specific targeting and interaction domains (ISTIDs) in human nicotinamide mononucleotide adenylyltransferases (NMNATs). J Biol Chem 3, 18868-18876 (2010).
14. Araki, T., Sasaki, Y. & Milbrandt, J. Increased nuclear NAD biosynthesis and SIRT1 activation prevent axonal degeneration. Science 305, 1010-3 (2004). (Pubitemid 39071777)
15. Conforti, L. et al. NAD(1) and axon degeneration revisited: Nmnat1 cannot substitute for Wld(S) to delay Wallerian degeneration. Cell Death Differ 14, 116-27 (2007). (Pubitemid 44911899)
16. Yahata, N., Yuasa, S. & Araki, T. Nicotinamide mononucleotide adenylyltransferase expression in mitochondrial matrix delays Wallerian degeneration. J Neurosci 29, 6276-84 (2009).
17. Beirowski, B. et al. The progressive nature of Wallerian degeneration in wild-type and slow Wallerian degeneration (WldS) nerves. BMC Neurosci 6, 6 (2005).
18. Caroni, P. Overexpression of growth-associated proteins in the neurons of adult transgenic mice. J Neurosci Methods 71, 3-9 (1997). (Pubitemid 27145767)
19. Misgeld, T., Kerschensteiner, M., Bareyre, F. M., Burgess, R. W. & Lichtman, J. W. Imaging axonal transport of mitochondria in vivo. NatMethods 4, 559-61 (2007). (Pubitemid 47214773)
20. Feng, G. et al. Imaging neuronal subsets in transgenic mice expressing multiple spectral variants of GFP. Neuron 28, 41-51 (2000).
21. Brunetti, L., Di Stefano, M., Ruggieri, S., Cimadamore, F. &Magni, G. Homology modeling and deletion mutants of human nicotinamide mononucleotide adenylyltransferase isozyme 2: new insights on structure and function relationship. Protein Sci 19, 2440-50 (2010).
22. Dobritsa, A. A., Van der Goes van Naters, W., Warr, C. G., Steinbrecht, R. A. & Carlson, J. R. Integrating the molecular and cellular basis of odor coding in the Drosophila antenna. Neuron 37, 827-41 (2003). (Pubitemid 36288555)
23. MacDonald, J. M. et al. The Drosophila cell corpse engulfment receptor Draper mediates glial clearance of severed axons. Neuron 50, 869-81 (2006). (Pubitemid 43850686)
24. Avery, M. A., Sheehan, A. E., Kerr, K. S., Wang, J.&Freeman,M. R.Wld S requires Nmnat1 enzymatic activity and N16-VCP interactions to suppress Wallerian degeneration. J Cell Biol 184, 501-13 (2009).
25. Fang, Y., Soares, L., Teng, X., Geary, M. & Bonini, N. M. A Novel Drosophila Model of Nerve Injury Reveals an Essential Role of Nmnat inMaintaining Axonal Integrity. Curr Biol 22, 590-595 (2012).
26. Scott, D. A., Das, U., Tang, Y. & Roy, S. Mechanistic logic underlying the axonal transport of cytosolic proteins. Neuron 70, 441-54 (2011).
27. Nagai, T. et al. A variant of yellow fluorescent protein with fast and efficient maturation for cell-biological applications. Nat Biotechnol 20, 87-90 (2002). (Pubitemid 34044921)
28. Gilley, J. et al. Age-dependent axonal transport and locomotor changes and tau hypophosphorylation in a "P301L" tau knockin mouse. Neurobiol Aging 33, 621.e1-621.e15 (2012).
29. Adalbert, R. et al. A rat model of slow Wallerian degeneration (WldS) with improved preservation of neuromuscular synapses. Eur J Neurosci 21, 271-7 (2005). (Pubitemid 40193896)