Downregulation of NOX4 expression by roflumilast N-oxide reduces markers of fibrosis in lung fibroblasts

Mediators of Inflammation

Volumn 2013, Issue , 2013, Pages

  Vecchio, Daniela ^a   Acquaviva, Alessandra ^b   Arezzini, Beatrice ^b   Tenor, Hermann ^c   Martorana, Piero A ^b   Gardi, Concetta ^b  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b UNIVERSITY OF SIENA   (Italy)

^c Takeda Pharmaceuticals International GmbH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ISOPROSTANE DERIVATIVE; MESSENGER RNA; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 4; ROFLUMILAST; 8-EPI-PROSTAGLANDIN F2ALPHA; AMINOPYRIDINE DERIVATIVE; BENZAMIDE DERIVATIVE; COLLAGEN; CYCLOPROPANE DERIVATIVE; DNA; ENZYME INHIBITOR; NOX4 PROTEIN, HUMAN; OXYGEN; PROSTAGLANDIN F2 ALPHA; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; ROFLUMILAST N-OXIDE; 8 EPI PROSTAGLANDIN F2ALPHA; DRUG DERIVATIVE; ROFLUMILAST N OXIDE;

ARTICLE; CELL PROLIFERATION; COLLAGEN METABOLISM; COLLAGEN SYNTHESIS; CONTROLLED STUDY; CYTOTOXICITY; DNA SYNTHESIS; DOWN REGULATION; EXTRACELLULAR MATRIX; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IN VITRO STUDY; IN VIVO STUDY; INCUBATION TIME; LIPID PEROXIDATION; LUNG FIBROBLAST; LUNG FIBROSIS; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; ANALOGS AND DERIVATIVES; CELL CULTURE; CHEMISTRY; CYTOLOGY; DRUG EFFECTS; FIBROBLAST; FIBROSIS; GENE EXPRESSION REGULATION; LUNG; METABOLISM; PATHOLOGY; DRUG EFFECT;

AMINOPYRIDINES; BENZAMIDES; CELL PROLIFERATION; CELLS, CULTURED; COLLAGEN; CYCLOPROPANES; DINOPROST; DNA; DOWN-REGULATION; ENZYME INHIBITORS; FIBROBLASTS; FIBROSIS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; LUNG; NADPH OXIDASE; OXIDATIVE STRESS; OXYGEN; REACTIVE OXYGEN SPECIES;

EID: 84884263053     PISSN: 09629351     EISSN: 14661861     Source Type: Journal    
DOI: 10.1155/2013/745984     Document Type: Article

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