PGI synthase overexpression protects against bleomycin-induced mortality and is associated with increased Nqo 1 expression

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 301, Issue 4, 2011, Pages

  Zhou, Weisong ^a   Dowell, Dustin R ^a   Geraci, Mark W ^b   Blackwell, Timothy S ^a   Collins, Robert D ^a   Polosukhin, Vasiliy V ^a   Lawson, William E ^a   Wu, Pingsheng ^a   Sussan, Thomas ^c   Biswal, Shyam ^c   Goleniewska, Kasia ^a   O'Neal, Jamye ^a   Newcomb, Dawn C ^a   Toki, Shinji ^a   Morrow, Jason D ^a   Stokes Peebles, Jr ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF COLORADO   (United States)

^c JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

Epithelial cells; Lung; NAD(P)H: Quinoneoxidoreductase 1; Prostaglandin I

Indexed keywords

BLEOMYCIN; ISOPROSTANE DERIVATIVE; NITRITE REDUCTASE [NAD(P)H]; PROSTACYCLIN RECEPTOR; PROSTAGLANDIN SYNTHASE; REACTIVE OXYGEN METABOLITE;

ACUTE LUNG INJURY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; FEMALE; IN VITRO STUDY; IN VIVO STUDY; LUNG PARENCHYMA; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RESPIRATORY EPITHELIUM; WILD TYPE;

ACUTE LUNG INJURY; ANIMALS; APOPTOSIS; BLEOMYCIN; BRONCHOALVEOLAR LAVAGE FLUID; EPOPROSTENOL; F2-ISOPROSTANES; FEMALE; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; GENE EXPRESSION; HUMANS; IMMUNOHISTOCHEMISTRY; LUNG; MICE; MICE, TRANSGENIC; NAD(P)H DEHYDROGENASE (QUINONE); POLYMERASE CHAIN REACTION; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; REACTIVE OXYGEN SPECIES; RECEPTORS, EPOPROSTENOL; RESPIRATORY FUNCTION TESTS; RESPIRATORY MUCOSA; SIGNAL TRANSDUCTION; SURVIVAL RATE;

EID: 80053358354     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.00224.2010     Document Type: Article

References (29)

1. Chen CH, Lin H, Hsu YH, Sue YM, Cheng TH, Chan P, Chen TH. The protective effect of prostacyclin on adriamycin-induced apoptosis in rat renal tubular cells. Eur J Pharmacol 529: 8-15, 2006.
2. Chen Y, Hanaoka M, Chen P, Droma Y, Voelkel NF, Kubo K. Protective effect of beraprost sodium, a stable prostacyclin analog, in the development of cigarette smoke extract-induced emphysema. Am J Physiol Lung Cell Mol Physiol 296: L648-L656, 2009.
3. Daniel VC, Minton TA, Brown NJ, Nadeau JH, Morrow JD. Simplified assay for the quantification of 2,3-dinor-6-keto- prostaglandin F1 alpha by gas chromatography-mass spectrometry. J Chromatogr B Biomed Appl 653: 117-122, 1994.
4. Dworski R, Murray JJ, Roberts LJ, Oates JA, Morrow JD, Fisher L, Sheller JR. Allergen-induced synthesis of F(2)-isoprostanes in atopic asthmatics. Evidence for oxidant stress. Am J Respir Crit Care Med 160: 1947-1951, 1999.
5. Fam SS, Morrow JD. The isoprostanes: unique products of arachidonic acid oxidation-a review. Curr Med Chem 10: 1723-1740, 2003.
6. Geraci MW, Gao B, Shepherd DC, Moore MD, Westcott JY, Fagan KA, Alger LA, Tuder RM, Voelkel NF. Pulmonary prostacyclin synthase overexpression in transgenic mice protects against development of hypoxic pulmonary hypertension. J Clin Invest 103: 1509-1515, 1999.
7. Howell DC, Johns RH, Lasky JA, Shan B, Scotton CJ, Laurent GJ, Chambers RC. Absence of proteinase-activated receptor-1 signaling affords protection from bleomycin-induced lung inflammation and fibrosis. Am J Pathol 166: 1353-1365, 2005.
8. Hsu YH, Chen CH, Hou CC, Sue YM, Cheng CY, Cheng TH, Lin H, Tsai WL, Chan P, Chen TH. Prostacyclin protects renal tubular cells from gentamicin-induced apoptosis via a PPARalpha-dependent pathway. Kidney Int 73: 578-587, 2008.
9. Iskander K, Jaiswal AK. Quinone oxidoreductases in protection against myelogenous hyperplasia and benzene toxicity. Chem Biol Interact 153-154: 147-157, 2005.
10. Jenkins RG, Su X, Su G, Scotton CJ, Camerer E, Laurent GJ, Davis GE, Chambers RC, Matthay MA, Sheppard D. Ligation of proteaseactivated receptor 1 enhances alpha(v)beta6 integrin-dependent TGF-beta activation and promotes acute lung injury. J Clin Invest 116: 1606-1614, 2006.
11. Lovgren AK, Jania LA, Hartney JM, Parsons KK, Audoly LP, Fitzgerald GA, Tilley SL, Koller BH. COX-2-derived prostacyclin protects against bleomycin-induced pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol 291: L144-L156, 2006.
12. Mercer PF, Johns RH, Scotton CJ, Krupiczojc MA, Konigshoff M, Howell DC, McAnulty RJ, Das A, Thorley AJ, Tetley TD, Eickelberg O, Chambers RC. Pulmonary epithelium is a prominent source of proteinase-activated receptor-1-inducible CCL2 in pulmonary fibrosis. Am J Respir Crit Care Med 179: 414-425, 2009.
13. Murakami S, Nagaya N, Itoh T, Kataoka M, Iwase T, Horio T, Miyahara Y, Sakai Y, Kangawa K, Kimura H. Prostacyclin agonist with thromboxane synthase inhibitory activity (ONO-1301) attenuates bleomycin-induced pulmonary fibrosis in mice. Am J Physiol Lung Cell Mol Physiol 290: L59-L65, 2006.
14. Muzaffar S, Shukla N, Lobo C, Angelini GD, Jeremy JY. Iloprost inhibits superoxide formation and gp91phox expression induced by the thromboxane A2 analog U46619, 8-isoprostane F2alpha, prostaglandin F2alpha, cytokines and endotoxin in the pig pulmonary artery. Br J Pharmacol 141: 488-496, 2004.
15. Nana-Sinkam SP, Lee JD, Sotto-Santiago S, Stearman RS, Keith RL, Choudhury Q, Cool C, Parr J, Moore MD, Bull TM, Voelkel NF, Geraci MW. Prostacyclin prevents pulmonary endothelial cell apoptosis induced by cigarette smoke. Am J Respir Crit Care Med 175: 676-685, 2007.
16. Oury TD, Thakker K, Menache M, Chang LY, Crapo JD, Day BJ. Attenuation of bleomycin-induced pulmonary fibrosis by a catalytic antioxidant metalloporphyrin. Am J Respir Cell Mol Biol 25: 164-169, 2001.
17. Pakrasi PL, Jain AK. Cyclooxygenase-2-derived endogenous prostacyclin reduces apoptosis and enhances embryo viability in mouse. Prostaglandins Leukot Essent Fatty Acids 79: 27-33, 2008.
18. Robbins IM, Morrow JD, Christman BW. Oxidant stress but not thromboxane decreases with epoprostenol therapy. Free Radic Biol Med 38: 568-574, 2005.
19. Ross D, Siegel D. NAD(P)H:quinone oxidoreductase 1 (Nqo 1, DTdiaphorase), functions and pharmacogenetics. Methods Enzymol 382: 115-144, 2004.
20. Rubenfeld GD, Herridge MS. Epidemiology and outcomes of acute lung injury. Chest 131: 554-562, 2007.
21. Scotton CJ, Krupiczojc MA, Konigshoff M, Mercer PF, Lee YC, Kaminski N, Morser J, Post JM, Maher TM, Nicholson AG, Moffatt JD, Laurent GJ, Derian CK, Eickelberg O, Chambers RC. Increased local expression of coagulation factor X contributes to the fibrotic response in human and murine lung injury. J Clin Invest 119: 2550-2563, 2009.
22. Siegel D, Gustafson DL, Dehn DL, Han JY, Boonchoong P, Berliner LJ, Ross D. NAD(P)H:quinone oxidoreductase 1: role as a superoxide scavenger. Mol Pharmacol 65: 1238-1247, 2004.
23. Tanjore H, Xu XC, Polosukhin VV, Degryse AL, Li B, Han W, Sherrill TP, Plieth D, Neilson EG, Blackwell TS, Lawson WE. Contribution of epithelial-derived fibroblasts to bleomycin-induced lung fibrosis. Am J Respir Crit Care Med 180: 657-665, 2009.
24. Voynow JA, Fischer BM, Zheng S, Potts EN, Grover AR, Jaiswal AK, Ghio AJ, Foster WM. NAD(P)H quinone oxidoreductase 1 is essential for ozone-induced oxidative stress in mice and humans. Am J Respir Cell Mol Biol 41: 107-113, 2009.
25. Ware LB. Pathophysiology of acute lung injury and the acute respiratory distress syndrome. Semin Respir Crit Care Med 27: 337-349, 2006.
26. Yamagishi S, Amano S, Inagaki Y, Okamoto T, Takeuchi M, Makita Z. Beraprost sodium, a prostaglandin I2 analog, protects against advanced gycation end products-induced injury in cultured retinal pericytes. Mol Med 8: 546-550, 2002.
27. Yano T, Itoh Y, Kubota T, Sendo T, Koyama T, Fujita T, Saeki K, Yuo A, Oishi R. A prostacyclin analog prevents radiocontrast nephropathy via phosphorylation of cyclic AMP response element binding protein. Am J Pathol 166: 1333-1342, 2005.
28. Zhou W, Blackwell TS, Goleniewska K, O'Neal JF, Fitzgerald GA, Lucitt M, Breyer RM, Peebles RS Jr. Prostaglandin I2 analogs inhibit Th1 and Th2 effector cytokine production by CD4 T cells. J Leukoc Biol 81: 809-817, 2007.
29. Zhou W, Hashimoto K, Goleniewska K, O'Neal JF, Ji S, Blackwell TS, Fitzgerald GA, Egan KM, Geraci MW, Peebles RS Jr. Prostaglandin I2 analogs inhibit proinflammatory cytokine production and T cell stimulatory function of dendritic cells. J Immunol 178: 702-710, 2007.