메뉴 건너뛰기




Volumn 57, Issue 10, 2013, Pages 4681-4688

Basis for early and preferential selection of the E138K mutation in HIV-1 reverse transcriptase

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; ARGININE; ETRAVIRINE; GLUTAMIC ACID; GLUTAMINE; GLYCINE; LYSINE; RNA DIRECTED DNA POLYMERASE; VALINE;

EID: 84884262354     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.01029-13     Document Type: Article
Times cited : (21)

References (50)
  • 2
    • 83655163698 scopus 로고    scopus 로고
    • Genotypic and phenotypic characterization of HIV-1 isolates obtained from patients on rilpivirine therapy experiencing virologic failure in the phase 3 ECHO and THRIVE studies: 48-week analysis
    • Rimsky L, Vingerhoets J, Van Eygen V, Eron J, Clotet B, Hoogstoel A, Boven K, Picchio G. 2012. Genotypic and phenotypic characterization of HIV-1 isolates obtained from patients on rilpivirine therapy experiencing virologic failure in the phase 3 ECHO and THRIVE studies: 48-week analysis. J. Acquir. Immune Defic. Syndr. 59:39-46.
    • (2012) J. Acquir. Immune Defic. Syndr. , vol.59 , pp. 39-46
    • Rimsky, L.1    Vingerhoets, J.2    Van Eygen, V.3    Eron, J.4    Clotet, B.5    Hoogstoel, A.6    Boven, K.7    Picchio, G.8
  • 3
    • 78649305180 scopus 로고    scopus 로고
    • Characterization of genotypic and phenotypic changes in HIV-1-infected patients with virologic failure on an etravirinecontaining regimen in the DUET-1 and DUET-2 clinical studies
    • Tambuyzer L, Vingerhoets J, Azijn H, Daems B, Nijs S, de Béthune M-P, Picchio G. 2010. Characterization of genotypic and phenotypic changes in HIV-1-infected patients with virologic failure on an etravirinecontaining regimen in the DUET-1 and DUET-2 clinical studies. AIDS Res. Hum. Retrovir. 26:1197-1205.
    • (2010) AIDS Res. Hum. Retrovir. , vol.26 , pp. 1197-1205
    • Tambuyzer, L.1    Vingerhoets, J.2    Azijn, H.3    Daems, B.4    Nijs, S.5    De Béthune, M.-P.6    Picchio, G.7
  • 6
    • 80055110312 scopus 로고    scopus 로고
    • Effect of mutations at position E138 in HIV-1 reverse transcriptase on phenotypic susceptibility and virologic response to etravirine
    • Tambuyzer L, Nijs S, Daems B, Picchio G, Vingerhoets J. 2011. Effect of mutations at position E138 in HIV-1 reverse transcriptase on phenotypic susceptibility and virologic response to etravirine. J. Acquir. Immune Defic. Syndr. 58:18-22.
    • (2011) J. Acquir. Immune Defic. Syndr. , vol.58 , pp. 18-22
    • Tambuyzer, L.1    Nijs, S.2    Daems, B.3    Picchio, G.4    Vingerhoets, J.5
  • 7
    • 78751693611 scopus 로고    scopus 로고
    • Characterization of the E138K resistance mutation in HIV-1 reverse transcriptase conferring susceptibility to etravirine in B and non-B HIV-1 subtypes
    • Asahchop EL, Oliveira M, Wainberg MA, Brenner BG, Moisi D, Toni TD, Tremblay CL. 2011. Characterization of the E138K resistance mutation in HIV-1 reverse transcriptase conferring susceptibility to etravirine in B and non-B HIV-1 subtypes. Antimicrob. Agents Chemother. 55:600-607.
    • (2011) Antimicrob. Agents Chemother. , vol.55 , pp. 600-607
    • Asahchop, E.L.1    Oliveira, M.2    Wainberg, M.A.3    Brenner, B.G.4    Moisi, D.5    Toni, T.D.6    Tremblay, C.L.7
  • 9
    • 84876410269 scopus 로고    scopus 로고
    • Distinct resistance patterns to etravirine and rilpivirine in viruses containing nonnucleoside reverse transcriptase inhibitor mutations at baseline
    • Asahchop EL, Wainberg MA, Oliveira M, Xu H, Brenner BG, Moisi D, Ibanescu IR, Tremblay C. 2013. Distinct resistance patterns to etravirine and rilpivirine in viruses containing nonnucleoside reverse transcriptase inhibitor mutations at baseline. AIDS 27:879-887.
    • (2013) AIDS , vol.27 , pp. 879-887
    • Asahchop, E.L.1    Wainberg, M.A.2    Oliveira, M.3    Xu, H.4    Brenner, B.G.5    Moisi, D.6    Ibanescu, I.R.7    Tremblay, C.8
  • 10
    • 84879012959 scopus 로고    scopus 로고
    • Effect of mutations at position E138 in HIV-1 reverse transcriptase and their interactions with the M184I mutation on defining patterns of resistance to nonnucleoside reverse transcriptase inhibitors rilpivirine and etravirine
    • Xu HT, Colby-Germinario SP, Asahchop EL, Oliveira M, McCallum M, Schader SM, Han Y, Quan Y, Sarafianos SG, Wainberg MA. 2013. Effect of mutations at position E138 in HIV-1 reverse transcriptase and their interactions with the M184I mutation on defining patterns of resistance to nonnucleoside reverse transcriptase inhibitors rilpivirine and etravirine. Antimicrob. Agents Chemother. 57:3100-3109.
    • (2013) Antimicrob. Agents Chemother. , vol.57 , pp. 3100-3109
    • Xu, H.T.1    Colby-Germinario, S.P.2    Asahchop, E.L.3    Oliveira, M.4    McCallum, M.5    Schader, S.M.6    Han, Y.7    Quan, Y.8    Sarafianos, S.G.9    Wainberg, M.A.10
  • 11
    • 0029075130 scopus 로고
    • Lower in vivo mutation rate of human immunodeficiency virus type 1 than that predicted from the fidelity of purified reverse transcriptase
    • Mansky LM, Temin HM. 1995. Lower in vivo mutation rate of human immunodeficiency virus type 1 than that predicted from the fidelity of purified reverse transcriptase. J. Virol. 69:5087-5094.
    • (1995) J. Virol. , vol.69 , pp. 5087-5094
    • Mansky, L.M.1    Temin, H.M.2
  • 12
    • 77956820495 scopus 로고    scopus 로고
    • Nature, position, and frequency of mutations made in a single cycle of HIV-1 replication
    • Abram ME, Ferris AL, Shao W, Alvord WG, Hughes SH. 2010. Nature, position, and frequency of mutations made in a single cycle of HIV-1 replication. J. Virol. 84:9864-9878.
    • (2010) J. Virol. , vol.84 , pp. 9864-9878
    • Abram, M.E.1    Ferris, A.L.2    Shao, W.3    Alvord, W.G.4    Hughes, S.H.5
  • 13
    • 0027946446 scopus 로고
    • Hypermutagenesis of RNA using human immunodeficiency virus type 1 reverse transcriptase and biased dNTP concentrations
    • Martinez MA, Vartanian JP, Wain-Hobson S. 1994. Hypermutagenesis of RNA using human immunodeficiency virus type 1 reverse transcriptase and biased dNTP concentrations. Proc. Natl. Acad. Sci. U. S. A. 91:11787-11791.
    • (1994) Proc. Natl. Acad. Sci. U. S. A. , vol.91 , pp. 11787-11791
    • Martinez, M.A.1    Vartanian, J.P.2    Wain-Hobson, S.3
  • 15
    • 67649888155 scopus 로고    scopus 로고
    • Natural variation in Vif: Differential impact on APOBEC3G/3F and a potential role in HIV-1 diversification
    • doi:10.1371 /journal.ppat.0010006
    • Simon V, Zennou V, Murray D, Huang Y, Ho DD, Bieniasz PD. 2005. Natural variation in Vif: differential impact on APOBEC3G/3F and a potential role in HIV-1 diversification. PLoS Pathog. 1:e6. doi:10.1371 /journal.ppat.0010006.
    • (2005) PLoS Pathog. , vol.1
    • Simon, V.1    Zennou, V.2    Murray, D.3    Huang, Y.4    Ho, D.D.5    Bieniasz, P.D.6
  • 17
    • 25144451296 scopus 로고    scopus 로고
    • Substi-tutions in the reverse transcriptase and protease genes of HIV-1 subtype B in untreated individuals and patients treated with antiretroviral drugs
    • Turner D, Brenner B, Mosis D, Liang C, Wainberg MA. 2005. Substi-tutions in the reverse transcriptase and protease genes of HIV-1 subtype B in untreated individuals and patients treated with antiretroviral drugs. MedGenMed 7:69.
    • (2005) MedGenMed , vol.7 , pp. 69
    • Turner, D.1    Brenner, B.2    Mosis, D.3    Liang, C.4    Wainberg, M.A.5
  • 19
    • 79951485606 scopus 로고    scopus 로고
    • HIV type-1 drug resistance in treatment-naive patients monitored using minority species assays: A systematic review and meta-analysis
    • Buckton AJ, Harris RJ, Pillay D, Cane PA. 2011. HIV type-1 drug resistance in treatment-naive patients monitored using minority species assays: a systematic review and meta-analysis. Antivir. Ther. 16:9-16.
    • (2011) Antivir. Ther. , vol.16 , pp. 9-16
    • Buckton, A.J.1    Harris, R.J.2    Pillay, D.3    Cane, P.A.4
  • 23
    • 85045497108 scopus 로고
    • Mismatch amplification mutation assay (MAMA): Application to the c-H-ras gene
    • Cha RS, Zarbl H, Keohavong P, Thilly WG. 1992. Mismatch amplification mutation assay (MAMA): application to the c-H-ras gene. Genome Res. 2:14-20.
    • (1992) Genome Res. , vol.2 , pp. 14-20
    • Cha, R.S.1    Zarbl, H.2    Keohavong, P.3    Thilly, W.G.4
  • 24
    • 39849098585 scopus 로고    scopus 로고
    • Simple PCR assays improve the sensitivity of HIV-1 subtype B drug resistance testing and allow linking of resistance mutations
    • doi:10.1371/journal.pone .0000638
    • Johnson JA, Li JF, Wei X, Lipscomb J, Bennett D, Brant A, Cong ME, Spira T, Shafer RW, Heneine W. 2007. Simple PCR assays improve the sensitivity of HIV-1 subtype B drug resistance testing and allow linking of resistance mutations. PLoS One 2:e638. doi:10.1371/journal.pone .0000638.
    • (2007) PLoS One , vol.2
    • Johnson, J.A.1    Li, J.F.2    Wei, X.3    Lipscomb, J.4    Bennett, D.5    Brant, A.6    Cong, M.E.7    Spira, T.8    Shafer, R.W.9    Heneine, W.10
  • 25
    • 0022495870 scopus 로고
    • Production of acquired immunodeficiency syndromeassociated retrovirus in human and nonhuman cells transfected with an infectious molecular clone
    • Adachi A, Gendelman HE, Koenig S, Folks T, Willey R, Rabson A, Martin MA. 1986. Production of acquired immunodeficiency syndromeassociated retrovirus in human and nonhuman cells transfected with an infectious molecular clone. J. Virol. 59:284-291.
    • (1986) J. Virol. , vol.59 , pp. 284-291
    • Adachi, A.1    Gendelman, H.E.2    Koenig, S.3    Folks, T.4    Willey, R.5    Rabson, A.6    Martin, M.A.7
  • 26
    • 65649119703 scopus 로고    scopus 로고
    • Apricitabine does not select additional drug resistance mutations in tissue culture in human immunodeficiency virus type 1 variants containing K65R, M184V, or M184V plus thymidine analogue mutations
    • Oliveira M, Moisi D, Spira B, Cox S, Brenner BG, Wainberg MA. 2009. Apricitabine does not select additional drug resistance mutations in tissue culture in human immunodeficiency virus type 1 variants containing K65R, M184V, or M184V plus thymidine analogue mutations. Antimicrob. Agents Chemother. 53:1683-1685.
    • (2009) Antimicrob. Agents Chemother. , vol.53 , pp. 1683-1685
    • Oliveira, M.1    Moisi, D.2    Spira, B.3    Cox, S.4    Brenner, B.G.5    Wainberg, M.A.6
  • 28
    • 34648867190 scopus 로고    scopus 로고
    • Systematic evaluation of allele-specific real-time PCR for the detection of minor HIV-1 variants with pol and env resistance mutations
    • Paredes R, Marconi VC, Campbell TB, Kuritzkes DR. 2007. Systematic evaluation of allele-specific real-time PCR for the detection of minor HIV-1 variants with pol and env resistance mutations. J. Virol. Methods 146:136-146.
    • (2007) J. Virol. Methods , vol.146 , pp. 136-146
    • Paredes, R.1    Marconi, V.C.2    Campbell, T.B.3    Kuritzkes, D.R.4
  • 32
    • 79957613599 scopus 로고    scopus 로고
    • MEGA5: Molecular evolutionary genetics analysis using maximum likelihood, evolutionary distance, and maximum-parsimony methods
    • Tamura K, Peterson D, Peterson N, Stecher G, Nei M, Kumar S. 2011. MEGA5: molecular evolutionary genetics analysis using maximum likelihood, evolutionary distance, and maximum-parsimony methods. Mol. Biol. Evol. 28:2731-2739.
    • (2011) Mol. Biol. Evol. , vol.28 , pp. 2731-2739
    • Tamura, K.1    Peterson, D.2    Peterson, N.3    Stecher, G.4    Nei, M.5    Kumar, S.6
  • 33
    • 77952261538 scopus 로고    scopus 로고
    • VFitness: A web-based computing tool for improving estimation of in vitro HIV-1 fitness experiments
    • doi:10.1186/1471-2105-11-261
    • Ma J, Dykes C, Wu T, Huang Y, Demeter L, Wu H. 2010. vFitness: a web-based computing tool for improving estimation of in vitro HIV-1 fitness experiments. BMC Bioinformatics 11:261. doi:10.1186/1471-2105-11-261.
    • (2010) BMC Bioinformatics , vol.11 , pp. 261
    • Ma, J.1    Dykes, C.2    Wu, T.3    Huang, Y.4    Demeter, L.5    Wu, H.6
  • 34
    • 20244372866 scopus 로고    scopus 로고
    • The N137 and P140 amino acids in the p51 and the P95 amino acid in the p66 subunit of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase are instrumental to maintain catalytic activity and to design new classes of anti-HIV-1 drugs
    • Auwerx J, Van Nieuwenhove J, Rodríguez-Barrios F, de Castro S, Velázquez S, Ceccherini-Silberstein F, De Clercq E, Ma Camarasa J, Perno C-F, Gago F, Balzarini J. 2005. The N137 and P140 amino acids in the p51 and the P95 amino acid in the p66 subunit of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase are instrumental to maintain catalytic activity and to design new classes of anti-HIV-1 drugs. FEBS Lett. 579:2294-2300.
    • (2005) FEBS Lett. , vol.579 , pp. 2294-2300
    • Auwerx, J.1    Van Nieuwenhove, J.2    Rodríguez-Barrios, F.3    De Castro, S.4    Velázquez, S.5    Ceccherini-Silberstein, F.6    De Clercq, E.7    Ma Camarasa, J.8    Perno, C.-F.9    Gago, F.10    Balzarini, J.11
  • 35
    • 33846069355 scopus 로고    scopus 로고
    • Analysis of amino acids in the beta7-beta8 loop of human immunodeficiency virus type 1 reverse transcriptase for their role in virus replication
    • Mulky A, Vu BC, Conway JA, Hughes SH, Kappes JC. 2007. Analysis of amino acids in the beta7-beta8 loop of human immunodeficiency virus type 1 reverse transcriptase for their role in virus replication. J. Mol. Biol. 365:1368-1378.
    • (2007) J. Mol. Biol. , vol.365 , pp. 1368-1378
    • Mulky, A.1    Vu, B.C.2    Conway, J.A.3    Hughes, S.H.4    Kappes, J.C.5
  • 37
    • 54549118264 scopus 로고    scopus 로고
    • Prevalence of etravirine-associated mutations in clinical samples with resistance to nevirapine and efavirenz
    • Llibre JM, Santos JR, Puig T, Molto J, Ruiz L, Paredes R, Clotet B. 2008. Prevalence of etravirine-associated mutations in clinical samples with resistance to nevirapine and efavirenz. J. Antimicrob. Chemother. 62:909-913.
    • (2008) J. Antimicrob. Chemother. , vol.62 , pp. 909-913
    • Llibre, J.M.1    Santos, J.R.2    Puig, T.3    Molto, J.4    Ruiz, L.5    Paredes, R.6    Clotet, B.7
  • 39
    • 84865099478 scopus 로고    scopus 로고
    • Subunit-selective mutational analysis and tissue culture evaluations of the interactions of the E138K and M184I mutations in HIV-1 reverse transcriptase
    • Xu HT, Oliveira M, Quashie PK, McCallum M, Han Y, Quan Y, Brenner BG, Wainberg MA. 2012. Subunit-selective mutational analysis and tissue culture evaluations of the interactions of the E138K and M184I mutations in HIV-1 reverse transcriptase. J. Virol. 86:8422-8431.
    • (2012) J. Virol. , vol.86 , pp. 8422-8431
    • Xu, H.T.1    Oliveira, M.2    Quashie, P.K.3    McCallum, M.4    Han, Y.5    Quan, Y.6    Brenner, B.G.7    Wainberg, M.A.8
  • 40
    • 80055119045 scopus 로고    scopus 로고
    • Compensation by the E138K mutation in HIV-1 reverse transcriptase for deficits in viral replication capacity and enzyme processivity associated with the M184I/V mutations
    • Xu HT, Asahchop EL, Oliveira M, Quashie PK, Quan Y, Brenner BG, Wainberg MA. 2011. Compensation by the E138K mutation in HIV-1 reverse transcriptase for deficits in viral replication capacity and enzyme processivity associated with the M184I/V mutations. J. Virol. 85:11300-11308.
    • (2011) J. Virol. , vol.85 , pp. 11300-11308
    • Xu, H.T.1    Asahchop, E.L.2    Oliveira, M.3    Quashie, P.K.4    Quan, Y.5    Brenner, B.G.6    Wainberg, M.A.7
  • 42
    • 0034990846 scopus 로고    scopus 로고
    • Exploitation of the low fidelity of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase and the nucleotide composition bias in the HIV-1 genome to alter the drug resistance development of HIV
    • Balzarini J, Camarasa MJ, Perez-Perez MJ, San-Felix A, Velazquez S, Perno CF, De Clercq E, Anderson JN, Karlsson A. 2001. Exploitation of the low fidelity of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase and the nucleotide composition bias in the HIV-1 genome to alter the drug resistance development of HIV. J. Virol. 75:5772-5777.
    • (2001) J. Virol. , vol.75 , pp. 5772-5777
    • Balzarini, J.1    Camarasa, M.J.2    Perez-Perez, M.J.3    San-Felix, A.4    Velazquez, S.5    Perno, C.F.6    De Clercq, E.7    Anderson, J.N.8    Karlsson, A.9
  • 43
    • 0032408626 scopus 로고    scopus 로고
    • Contribution of Taq polymeraseinduced errors to the estimation of RNA virus diversity
    • Bracho MA, Moya A, Barrio E. 1998. Contribution of Taq polymeraseinduced errors to the estimation of RNA virus diversity. J. Gen. Virol. 79(Pt 12):2921-2928.
    • (1998) J. Gen. Virol. , vol.79 , Issue.PART. 12 , pp. 2921-2928
    • Bracho, M.A.1    Moya, A.2    Barrio, E.3
  • 44
    • 80052959048 scopus 로고    scopus 로고
    • Prevalence of low-level HIV-1 variants with reverse transcriptase mutation K65R and the effect of antiretroviral drug exposure on variant levels
    • Kozal MJ, Chiarella J, St John EP, Moreno EA, Simen BB, Arnold TE, Lataillade M. 2011. Prevalence of low-level HIV-1 variants with reverse transcriptase mutation K65R and the effect of antiretroviral drug exposure on variant levels. Antivir. Ther. 16:925-929.
    • (2011) Antivir. Ther. , vol.16 , pp. 925-929
    • Kozal, M.J.1    Chiarella, J.2    St John, E.P.3    Moreno, E.A.4    Simen, B.B.5    Arnold, T.E.6    Lataillade, M.7
  • 45
    • 77955402078 scopus 로고    scopus 로고
    • Dynamics of HIV-1 quasispecies during antiviral treatment dissected using ultra-deep pyrosequencing
    • doi:10.1371/journal.pone.0011345
    • Hedskog C, Mild M, Jernberg J, Sherwood E, Bratt G, Leitner T, Lundeberg J, Andersson B, Albert J. 2010. Dynamics of HIV-1 quasispecies during antiviral treatment dissected using ultra-deep pyrosequencing. PLoS One 5:e11345. doi:10.1371/journal.pone.0011345.
    • (2010) PLoS One , vol.5
    • Hedskog, C.1    Mild, M.2    Jernberg, J.3    Sherwood, E.4    Bratt, G.5    Leitner, T.6    Lundeberg, J.7    Andersson, B.8    Albert, J.9
  • 46
    • 0028372046 scopus 로고
    • The ratio of defective HIV-1 particles to replication-competent infectious virions
    • Bourinbaiar AS. 1994. The ratio of defective HIV-1 particles to replication-competent infectious virions. Acta Virol. 38:59-61.
    • (1994) Acta Virol. , vol.38 , pp. 59-61
    • Bourinbaiar, A.S.1
  • 47
    • 0038709669 scopus 로고    scopus 로고
    • Determination of infectious retrovirus concentration from colony-forming assay with quantitative analysis
    • Kwon YJ, Hung G, Anderson WF, Peng CA, Yu H. 2003. Determination of infectious retrovirus concentration from colony-forming assay with quantitative analysis. J. Virol. 77:5712-5720.
    • (2003) J. Virol. , vol.77 , pp. 5712-5720
    • Kwon, Y.J.1    Hung, G.2    Anderson, W.F.3    Peng, C.A.4    Yu, H.5
  • 48
    • 59649120492 scopus 로고    scopus 로고
    • Template usage is responsible for the preferential acquisition of the K65R reverse transcriptase mutation in subtype C variants of human immunodeficiency virus type 1
    • Coutsinos D, Invernizzi CF, Xu H, Moisi D, Oliveira M, Brenner BG, Wainberg MA. 2009. Template usage is responsible for the preferential acquisition of the K65R reverse transcriptase mutation in subtype C variants of human immunodeficiency virus type 1. J. Virol. 83:2029-2033.
    • (2009) J. Virol. , vol.83 , pp. 2029-2033
    • Coutsinos, D.1    Invernizzi, C.F.2    Xu, H.3    Moisi, D.4    Oliveira, M.5    Brenner, B.G.6    Wainberg, M.A.7
  • 49
    • 84865461131 scopus 로고    scopus 로고
    • High rate of K65R for antiretroviral therapy-naive patients with subtype C HIV infection failing a tenofovir-containing first-line regimen
    • Sunpath H, Wu B, Gordon M, Hampton J, Johnson B, Moosa MY, Ordonez C, Kuritzkes DR, Marconi VC. 2012. High rate of K65R for antiretroviral therapy-naive patients with subtype C HIV infection failing a tenofovir-containing first-line regimen. AIDS 26:1679-1684.
    • (2012) AIDS , vol.26 , pp. 1679-1684
    • Sunpath, H.1    Wu, B.2    Gordon, M.3    Hampton, J.4    Johnson, B.5    Moosa, M.Y.6    Ordonez, C.7    Kuritzkes, D.R.8    Marconi, V.C.9


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.