Structural insight into maternal embryonic leucine zipper kinase (MELK) Conformation and inhibition toward structure-based drug design

Biochemistry

Volumn 52, Issue 37, 2013, Pages 6380-6387

  Canevari, Giulia ^a   Re Depaolini, Stefania ^a   Cucchi, Ulisse ^a   Bertrand, Jay A ^a,b   Casale, Elena ^a   Perrera, Claudia ^a   Forte, Barbara ^a   Carpinelli, Patrizia ^a   Felder, Eduard R ^a  

^a NERVIANO MEDICAL SCIENCES   (Italy)

^b VERTEX PHARMACEUTICALS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN TUMORS; CELL SURVIVAL; KEY RESIDUES; MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE; NANOMOLAR INHIBITORS; STRUCTURAL INSIGHTS; STRUCTURE-BASED DRUG DESIGN; THERAPEUTIC AGENTS;

CELL DEATH; CELL PROLIFERATION; DRUG DELIVERY; TRANSCRIPTION FACTORS; TUMORS;

ENZYMES;

ADENOSINE PHOSPHATE; MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE; PHOSPHOTRANSFERASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CHEMICAL STRUCTURE; COMPLEX FORMATION; CRYSTALLIZATION; ENZYME ACTIVE SITE; ENZYME CONFORMATION; ENZYME INHIBITION; ENZYME STRUCTURE; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION;

ADENYLYL IMIDODIPHOSPHATE; ANTINEOPLASTIC AGENTS; CATALYTIC DOMAIN; CELL LINE, TUMOR; DRUG DESIGN; ENZYME INHIBITORS; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; PROTEIN-SERINE-THREONINE KINASES; PYRAZOLES;

EID: 84884252933     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi4005864     Document Type: Article

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