-
1
-
-
84859603846
-
New oral anticoagulants in atrial fibrillation and acute coronary syndromes: ESC Working Group on Thrombosis-Task Force on Anticoagulants in Heart Disease position paper
-
De Caterina R, Husted S, Wallentin L, et al. New oral anticoagulants in atrial fibrillation and acute coronary syndromes: ESC Working Group on Thrombosis-Task Force on Anticoagulants in Heart Disease position paper. J Am Coll Cardiol 2012;59(16):1413-25.
-
(2012)
J Am Coll Cardiol
, vol.59
, Issue.16
, pp. 1413-1425
-
-
De Caterina, R.1
Husted, S.2
Wallentin, L.3
-
2
-
-
84866866045
-
Phase III studies on novel oral anticoagulants for stroke prevention in atrial fibrillation: A look beyond the excellent results
-
Pengo V, Crippa L, Falanga A, et al. Phase III studies on novel oral anticoagulants for stroke prevention in atrial fibrillation: a look beyond the excellent results. J Thromb Haemost 2012;10(10):1979-87
-
(2012)
J Thromb Haemost
, vol.10
, Issue.10
, pp. 1979-1987
-
-
Pengo, V.1
Crippa, L.2
Falanga, A.3
-
4
-
-
84856804647
-
American college of chest p parenteral anticoagulants: Antithrombotic therapy and prevention of thrombosis
-
9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines
-
Garcia DA, Baglin TP, Weitz JI, Samama MM; American College of Chest P. Parenteral anticoagulants: antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest 2012;141(2 Suppl):e24S-43S
-
(2012)
Chest
, Issue.2 SUPPL.
-
-
Garcia, D.A.1
Baglin, T.P.2
Weitz, J.I.3
Samama, M.M.4
-
5
-
-
0034971291
-
A cell-based model of hemostasis
-
Hoffman M, Monroe DM III. A cell-based model of hemostasis. Thromb Haemost 2001;85(6):958-65
-
(2001)
Thromb Haemost
, vol.85
, Issue.6
, pp. 958-965
-
-
Hoffman, M.1
Monroe, D.M.2
-
7
-
-
34247201717
-
Factor IXa inhibitors as novel anticoagulants
-
Howard EL, Becker KC, Rusconi CP, Becker RC. Factor IXa inhibitors as novel anticoagulants. Arterioscler Thromb Vasc Biol 2007;27(4):722-7
-
(2007)
Arterioscler Thromb Vasc Biol
, vol.27
, Issue.4
, pp. 722-727
-
-
Howard, E.L.1
Becker, K.C.2
Rusconi, C.P.3
Becker, R.C.4
-
8
-
-
78149254900
-
Coagulation factor XI as a novel target for antithrombotic treatment
-
Lowenberg EC, Meijers JC, Monia BP, Levi M. Coagulation factor XI as a novel target for antithrombotic treatment. J Thromb Haemost 2010;8(11):2349-57
-
(2010)
J Thromb Haemost
, vol.8
, Issue.11
, pp. 2349-2357
-
-
Lowenberg, E.C.1
Meijers, J.C.2
Monia, B.P.3
Levi, M.4
-
9
-
-
84861750668
-
Monocytes, neutrophils, and platelets cooperate to initiate and propagate venous thrombosis in mice in vivo
-
von Bruhl ML, Stark K, Steinhart A, et al. Monocytes, neutrophils, and platelets cooperate to initiate and propagate venous thrombosis in mice in vivo. J Exp Med 2012;209(4):819-35.1
-
(2012)
J Exp Med
, vol.209
, Issue.4
, pp. 819-835
-
-
Von Bruhl, M.L.1
Stark, K.2
Steinhart, A.3
-
10
-
-
78650792758
-
And thrombin as targets for new oral anticoagulants
-
Weitz JI. Factor Xa and thrombin as targets for new oral anticoagulants. Thromb Res 2011;127(Suppl 2):S5-S12
-
(2011)
Thromb Res
, vol.127
, Issue.SUPPL. 2
-
-
Weitz, J.I.1
-
11
-
-
67049155338
-
Biochemical and pharmacological effects of the direct thrombin inhibitor AR-H067637
-
Deinum J, Mattsson C, Inghardt T, Elg M. Biochemical and pharmacological effects of the direct thrombin inhibitor AR-H067637. Thromb Haemost 2009;101(6):1051-9
-
(2009)
Thromb Haemost
, vol.101
, Issue.6
, pp. 1051-1059
-
-
Deinum, J.1
Mattsson, C.2
Inghardt, T.3
Elg, M.4
-
12
-
-
79955976183
-
Single-dose pharmacokinetics, pharmacodynamics and safety of AZD0837, a novel oral direct thrombin inhibitor, in young healthy male subjects
-
Johansson S, Cullberg M, Eriksson UG, et al. Single-dose pharmacokinetics, pharmacodynamics and safety of AZD0837, a novel oral direct thrombin inhibitor, in young healthy male subjects. Int J Clin Pharmacol Ther 2011;49(4):258-67
-
(2011)
Int J Clin Pharmacol Ther
, vol.49
, Issue.4
, pp. 258-267
-
-
Johansson, S.1
Cullberg, M.2
Eriksson, U.G.3
-
13
-
-
77749298350
-
Safety and tolerability of an immediate-release formulation of theoral direct thrombin inhibitor AZD0837 in the prevention of stroke and systemic embolism in patients with atrial fibrillation
-
Olsson SB, Rasmussen LH, Tveit A, et al. Safety and tolerability of an immediate-release formulation of theoral direct thrombin inhibitor AZD0837 in the prevention of stroke and systemic embolism in patients with atrial fibrillation. Thromb Haemost 2010;103(3):604-12
-
(2010)
Thromb Haemost
, vol.103
, Issue.3
, pp. 604-612
-
-
Olsson, S.B.1
Rasmussen, L.H.2
Tveit, A.3
-
14
-
-
71649109346
-
Oral direct thrombin inhibitor AZD0837 for the prevention of stroke and systemic embolism in patients with non-valvular atrial fibrillation: A randomized dose-guiding, safety, and tolerability study of four doses of AZD0837 vs. vitamin K antagonists
-
Lip GY, Rasmussen LH, Olsson SB, et al. Oral direct thrombin inhibitor AZD0837 for the prevention of stroke and systemic embolism in patients with non-valvular atrial fibrillation: a randomized dose-guiding, safety, and tolerability study of four doses of AZD0837 vs. vitamin K antagonists. Eur Heart J 2009;30(23):2897-907
-
(2009)
Eur Heart J
, vol.30
, Issue.23
, pp. 2897-2907
-
-
Lip, G.Y.1
Rasmussen, L.H.2
Olsson, S.B.3
-
15
-
-
79151471916
-
Oral direct thrombin inhibitor AZD0837 for the prevention of stroke and systemic embolism in patients with non-valvular atrial fibrillation: A Phase II study of AZD0837 in patients who are appropriate for but unable or unwilling to take vitamin K antagonist therapy
-
Lip GY, Rasmussen LH, Olsson SB, et al. Oral direct thrombin inhibitor AZD0837 for the prevention of stroke and systemic embolism in patients with non-valvular atrial fibrillation: a Phase II study of AZD0837 in patients who are appropriate for but unable or unwilling to take vitamin K antagonist therapy. Thromb Res 2011;127(2):91-9
-
(2011)
Thromb Res
, vol.127
, Issue.2
, pp. 91-99
-
-
Lip, G.Y.1
Rasmussen, L.H.2
Olsson, S.B.3
-
17
-
-
63149141508
-
Discovery of betrixaban (PRT054021), N-(5-chloropyridin-2-yl)-2-(4-(N, Ndimethylcarbamimidoyl) benzamido)-5-methoxybenz amide, a highly potent, selective, and orally efficacious factor Xa inhibitor
-
Zhang P, Huang W, Wang L, et al. Discovery of betrixaban (PRT054021), N-(5-chloropyridin-2-yl)-2-(4-(N,Ndimethylcarbamimidoyl) benzamido)-5- methoxybenz amide, a highly potent, selective, and orally efficacious factor Xa inhibitor. Bioorg Med Chem Lett 2009;19(8):2179-85
-
(2009)
Bioorg Med Chem Lett
, vol.19
, Issue.8
, pp. 2179-2185
-
-
Zhang, P.1
Huang, W.2
Wang, L.3
-
18
-
-
60849097858
-
A randomized evaluation of betrixaban, an oral factor Xa inhibitor, for prevention of thromboembolic events after total knee replacement (EXPERT)
-
Turpie AG, Bauer KA, Davidson BL, et al. A randomized evaluation of betrixaban, an oral factor Xa inhibitor, for prevention of thromboembolic events after total knee replacement (EXPERT). Thromb Haemost 2009;101(1):68-76
-
(2009)
Thromb Haemost
, vol.101
, Issue.1
, pp. 68-76
-
-
Turpie, A.G.1
Bauer, K.A.2
Davidson, B.L.3
-
19
-
-
84878290471
-
Betrixaban compared with warfarin in patients with atrial fibrillation: Results of a phase 2, randomized, dose-ranging study (Explore-Xa)
-
Connolly SJ, Eikelboom J, Dorian P, et al. Betrixaban compared with warfarin in patients with atrial fibrillation: results of a phase 2, randomized, dose-ranging study (Explore-Xa). Eur Heart J 2013;34(20):1498-505
-
(2013)
Eur Heart J
, vol.34
, Issue.20
, pp. 1498-1505
-
-
Connolly, S.J.1
Eikelboom, J.2
Dorian, P.3
-
20
-
-
81855164650
-
Biochemical and pharmacological profile of darexaban, an oral direct factor Xa inhibitor
-
Iwatsuki Y, Sato T, Moritani Y, et al. Biochemical and pharmacological profile of darexaban, an oral direct factor Xa inhibitor. Eur J Pharmacol 2011;673(1-3):49-55
-
(2011)
Eur J Pharmacol
, vol.673
, Issue.1-3
, pp. 49-55
-
-
Iwatsuki, Y.1
Sato, T.2
Moritani, Y.3
-
21
-
-
84872252194
-
The pharmacokinetics of darexaban are not affected to a clinically relevant degree by rifampicin, a strong inducer of P-glycoprotein and CYP3A4
-
Groenendaal D, Strabach G, Garcia-Hernandez A, et al. The pharmacokinetics of darexaban are not affected to a clinically relevant degree by rifampicin, a strong inducer of P-glycoprotein and CYP3A4. Br J Clin Pharmacol 2013;75(2):440-9
-
(2013)
Br J Clin Pharmacol
, vol.75
, Issue.2
, pp. 440-449
-
-
Groenendaal, D.1
Strabach, G.2
Garcia-Hernandez, A.3
-
22
-
-
84862276529
-
Novel oral anticoagulants: Focus on the direct factor Xa inhibitor darexaban
-
Apostolakis S, Lip GY. Novel oral anticoagulants: focus on the direct factor Xa inhibitor darexaban. Expert Opin Investig Drugs 2012;21(7):1057-64
-
(2012)
Expert Opin Investig Drugs
, vol.21
, Issue.7
, pp. 1057-1064
-
-
Apostolakis, S.1
Lip, G.Y.2
-
23
-
-
80054775296
-
Safety and tolerability of YM150 in subjects with non-valvular atrial fibrillation: A phase II study
-
[abstract 1194]
-
Turpie AGG, Lip GYH, Minematsu K, et al. Safety and tolerability of YM150 in subjects with non-valvular atrial fibrillation: a phase II study [abstract 1194]. Eur Heart J 2010;31(Abstr Suppl):173
-
(2010)
Eur Heart J
, vol.31
, Issue.SUPPL.
, pp. 173
-
-
Agg, T.1
Gyh, L.2
Minematsu, K.3
-
24
-
-
84884241915
-
-
Astellas Pharma Inc. Astellas Pharma Inc. [press release] 28 Sep 2011
-
Astellas Pharma, Inc. Astellas Pharma, Inc. Discontinues Development of Darexaban (YM150), an Oral Direct Factor Xa Inhibitor. [press release] 28 Sep. 2011. Available from: http://www.astellas.com/en/corporate/news/detail/astellas- pharma-incdiscontinu. html
-
Iscontinues Development of Darexaban (YM150), An Oral Direct Factor Xa Inhibitor
-
-
-
25
-
-
77956640230
-
Differential effects of TAK-442 a novel orally active direct factor Xa inhibitor and ximelagatran a thrombin inhibitor on factor V-mediated feedback on coagulation cascade and bleeding
-
Konishi N, Hiroe K, Kawamura M. Differential effects of TAK-442, a novel orally active direct factor Xa inhibitor, and ximelagatran, a thrombin inhibitor, on factor V-mediated feedback on coagulation cascade and bleeding. Thromb Haemost 2010;104(3):504-13
-
(2010)
Thromb Haemost
, vol.104
, Issue.3
, pp. 504-513
-
-
Konishi, N.1
Hiroe, K.2
Kawamura, M.3
-
26
-
-
78649720309
-
A dose-finding study with TAK-442 an oral factor Xa inhibitor in patients undergoing elective total knee replacement surgery
-
Weitz JI, Cao C, Eriksson BI, et al. A dose-finding study with TAK-442, an oral factor Xa inhibitor, in patients undergoing elective total knee replacement surgery. Thromb Haemost 2010;104(6):1150-7
-
(2010)
Thromb Haemost
, vol.104
, Issue.6
, pp. 1150-1157
-
-
Weitz, J.I.1
Cao, C.2
Eriksson, B.I.3
-
27
-
-
84862893520
-
Safety evaluation of the factor Xa inhibitor TAK-442 in subjects with acute coronary syndromes: Phase 2 AXIOM-ACS trial results
-
abstract #2430
-
Goldstein S, Bates E, Bhatt D, et al. Safety evaluation of the factor Xa inhibitor TAK-442 in subjects with acute coronary syndromes: phase 2 AXIOM-ACS trial results. Eur Heart J 2011;32(Suppl): abstract #2430
-
(2011)
Eur Heart J
, Issue.SUPPL.
, pp. 32
-
-
Goldstein, S.1
Bates, E.2
Bhatt, D.3
-
28
-
-
34147141000
-
A phase II study of the oral factor Xa inhibitor LY517717 for the prevention of venous thromboembolism after hip or knee replacement
-
Agnelli G, Haas S, Ginsberg JS, et al. A phase II study of the oral factor Xa inhibitor LY517717 for the prevention of venous thromboembolism after hip or knee replacement. J Thromb Haemost 2007;5(4):746-53
-
(2007)
J Thromb Haemost
, vol.5
, Issue.4
, pp. 746-753
-
-
Agnelli, G.1
Haas, S.2
Ginsberg, J.S.3
-
29
-
-
33845536606
-
Direct and rapid inhibition of factor Xa by otamixaban: A pharmacokinetic and pharmacodynamic investigation in patients with coronary artery disease
-
Hinder M, Frick A, Jordaan P, et al. Direct and rapid inhibition of factor Xa by otamixaban: a pharmacokinetic and pharmacodynamic investigation in patients with coronary artery disease. Clin Pharmacol Ther 2006;80(6):691-702
-
(2006)
Clin Pharmacol Ther
, vol.80
, Issue.6
, pp. 691-702
-
-
Hinder, M.1
Frick, A.2
Jordaan, P.3
-
30
-
-
34249025394
-
Randomized, double-blind, dose-ranging study of otamixaban, a novel, parenteral, short-acting direct factor Xa inhibitor, in percutaneous coronary intervention: The SEPIA-PCI trial
-
Cohen M, Bhatt DL, Alexander JH, et al. Randomized, double-blind, dose-ranging study of otamixaban, a novel, parenteral, short-acting direct factor Xa inhibitor, in percutaneous coronary intervention: the SEPIA-PCI trial. Circulation 2007;115(20):2642-51
-
(2007)
Circulation
, vol.115
, Issue.20
, pp. 2642-2651
-
-
Cohen, M.1
Bhatt, D.L.2
Alexander, J.H.3
-
31
-
-
69949096467
-
Otamixaban for the treatment of patients with non-ST-elevation acute coronary syndromes (SEPIA-ACS1 TIMI 42): A randomised, double-blind, active-controlled, phase 2 trial
-
Sabatine MS, Antman EM, Widimsky P, et al. Otamixaban for the treatment of patients with non-ST-elevation acute coronary syndromes (SEPIA-ACS1 TIMI 42): a randomised, double-blind, active-controlled, phase 2 trial. Lancet 2009;374(9692):787-95
-
(2009)
Lancet
, vol.374
, Issue.9692
, pp. 787-795
-
-
Sabatine, M.S.1
Antman, E.M.2
Widimsky, P.3
-
32
-
-
84870298498
-
Design and rationale of the treatment of acute coronary syndromes with otamixaban trial: A double-blind triple-dummy 2-stage randomized trial comparing otamixaban to unfractionated heparin and eptifibatide in non-ST-segment elevation acute coronary syndromes with a planned early invasive strategy
-
e13
-
Steg PG, Mehta SR, Pollack CV Jr., et al. Design and rationale of the treatment of acute coronary syndromes with otamixaban trial: a double-blind triple-dummy 2-stage randomized trial comparing otamixaban to unfractionated heparin and eptifibatide in non-ST-segment elevation acute coronary syndromes with a planned early invasive strategy. Am Heart J 2012;164(6):817-24; e13
-
(2012)
Am Heart J
, vol.164
, Issue.6
, pp. 817-824
-
-
Steg, P.G.1
Mehta, S.R.2
Pollack Jr., C.V.3
-
34
-
-
80053109628
-
Identification of the site of binding of sulfated low molecular weight lignins on thrombin
-
Abdel Aziz MH, Mosier PD, Desai UR. Identification of the site of binding of sulfated, low molecular weight lignins on thrombin. Biochem Biophys Res Commun 2011;413(2):348-52
-
(2011)
Biochem Biophys Res Commun
, vol.413
, Issue.2
, pp. 348-352
-
-
Abdel Aziz, M.H.1
Mosier, P.D.2
Desai, U.R.3
-
35
-
-
84855781095
-
Sulfated low molecular weight lignins inhibit a select group of heparin-binding serine proteases
-
Henry BL, Thakkar JN, Liang A, Desai UR. Sulfated, low molecular weight lignins inhibit a select group of heparin-binding serine proteases. Biochem Biophys Res Commun 2012;417(1):382-6
-
(2012)
Biochem Biophys Res Commun
, vol.417
, Issue.1
, pp. 382-386
-
-
Henry, B.L.1
Thakkar, J.N.2
Liang, A.3
Desai, U.R.4
-
36
-
-
19744372264
-
Synthetic heparin derivatives as new anticoagulant drugs
-
de Kort M, Buijsman RC, van Boeckel CA. Synthetic heparin derivatives as new anticoagulant drugs. Drug Discov Today 2005;10(11):769-79
-
(2005)
Drug Discov Today
, vol.10
, Issue.11
, pp. 769-779
-
-
De Kort, M.1
Buijsman, R.C.2
Van Boeckel, C.A.3
-
37
-
-
84858016010
-
Specificity and selectivity profile of EP217609: A new neutralizable dual-action anticoagulant that targets thrombin and factor Xa
-
Olson ST, Swanson R, Petitou M. Specificity and selectivity profile of EP217609: a new neutralizable dual-action anticoagulant that targets thrombin and factor Xa. Blood 2012;119(10):2187-95
-
(2012)
Blood
, vol.119
, Issue.10
, pp. 2187-2195
-
-
Olson, S.T.1
Swanson, R.2
Petitou, M.3
-
38
-
-
2442561673
-
Antithrombotic properties of a direct thrombin inhibitor with a prolonged half-life and AT-mediated factor Xa inhibitory activity
-
Vogel GM, Meuleman DG, Van Dinther TG, et al. Antithrombotic properties of a direct thrombin inhibitor with a prolonged half-life and AT-mediated factor Xa inhibitory activity. J Thromb Haemost 2003;1(9):1945-54
-
(2003)
J Thromb Haemost
, vol.1
, Issue.9
, pp. 1945-1954
-
-
Vogel, G.M.1
Meuleman, D.G.2
Van Dinther, T.G.3
-
39
-
-
70449598272
-
From heparin to EP217609: The long way to a new pentasaccharide-based neutralisable anticoagulant with an unprecedented pharmacological profile
-
Petitou M, Nancy-Portebois V, Dubreucq G, et al. From heparin to EP217609: the long way to a new pentasaccharide-based neutralisable anticoagulant with an unprecedented pharmacological profile. Thromb Haemost 2009;102(5):804-10
-
(2009)
Thromb Haemost
, vol.102
, Issue.5
, pp. 804-810
-
-
Petitou, M.1
Nancy-Portebois, V.2
Dubreucq, G.3
-
40
-
-
84884229825
-
Endotis Pharma presents Phase i clinical trial results for a first-in-class synthetic parenteral neutralizable anticoagulant EP217609
-
[press release] 8 Jul 2010
-
Endotis Pharma. Endotis Pharma presents Phase I clinical trial results for a first-in-class synthetic parenteral neutralizable anticoagulant EP217609 at the 21st International Congress on Thrombosis. [press release] 8 Jul. 2010. Available from: http://www.endotis.com/news/document-1279012503596.pdf
-
21st International Congress on Thrombosis
-
-
Pharma, E.1
-
41
-
-
33745246311
-
Pharmacokinetics and pharmacodynamics of BIBT 986, a novel small molecule dual inhibitor of thrombin and factor Xa
-
Graefe-Mody EU, Schuhly U, Rathgen K, et al. Pharmacokinetics and pharmacodynamics of BIBT 986, a novel small molecule dual inhibitor of thrombin and factor Xa. J Thromb Haemost 2006;4(7):1502-9
-
(2006)
J Thromb Haemost
, vol.4
, Issue.7
, pp. 1502-1509
-
-
Graefe-Mody, E.U.1
Schuhly, U.2
Rathgen, K.3
-
42
-
-
34249004639
-
Pharmacokinetics and pharmacodynamics of the dual FII/FX inhibitor BIBT 986 in endotoxin-induced coagulation
-
Leitner JM, Jilma B, Mayr FB, et al. Pharmacokinetics and pharmacodynamics of the dual FII/FX inhibitor BIBT 986 in endotoxin-induced coagulation. Clin Pharmacol Ther 2007;81(6):858-66
-
(2007)
Clin Pharmacol Ther
, vol.81
, Issue.6
, pp. 858-866
-
-
Leitner, J.M.1
Jilma, B.2
Mayr, F.B.3
-
44
-
-
0028627767
-
Recombinant E coli-derived tissue factor pathway inhibitor reduces coagulopathic and lethal effects in the baboon gram-negative model of septic shock
-
Carr C, Bild GS, Chang AC, et al. Recombinant E. coli-derived tissue factor pathway inhibitor reduces coagulopathic and lethal effects in the baboon gram-negative model of septic shock. Circ Shock 1994;44(3):126-37
-
(1994)
Circ Shock
, vol.44
, Issue.3
, pp. 126-137
-
-
Carr, C.1
Bild, G.S.2
Chang, A.C.3
-
45
-
-
79957948640
-
Recombinant tissue factor pathway inhibitor in severe community-acquired pneumonia: A randomized trial
-
Wunderink RG, Laterre PF, Francois B, et al. Recombinant tissue factor pathway inhibitor in severe community-acquired pneumonia: a randomized trial. Am J Respir Crit Care Med 2011;183(11):1561-8
-
(2011)
Am J Respir Crit Care Med
, vol.183
, Issue.11
, pp. 1561-1568
-
-
Wunderink, R.G.1
Laterre, P.F.2
Francois, B.3
-
46
-
-
0035800075
-
Dose-response study of recombinant factor VIIa/tissue factor inhibitor recombinant nematode anticoagulant protein c2 in prevention of postoperative venous thromboembolism in patients undergoing total knee replacement
-
Lee A, Agnelli G, Buller H, et al. Dose-response study of recombinant factor VIIa/tissue factor inhibitor recombinant nematode anticoagulant protein c2 in prevention of postoperative venous thromboembolism in patients undergoing total knee replacement. Circulation 2001;104(1):74-8
-
(2001)
Circulation
, vol.104
, Issue.1
, pp. 74-78
-
-
Lee, A.1
Agnelli, G.2
Buller, H.3
-
47
-
-
34250775488
-
Recombinant nematode anticoagulant protein c2 in patients with non-ST-segment elevation acute coronary syndrome: The ANTHEM-TIMI-32 trial
-
Giugliano RP, Wiviott SD, Stone PH, et al. Recombinant nematode anticoagulant protein c2 in patients with non-ST-segment elevation acute coronary syndrome: the ANTHEM-TIMI-32 trial. J Am Coll Cardiol 2007;49(25):2398-407
-
(2007)
J Am Coll Cardiol
, vol.49
, Issue.25
, pp. 2398-2407
-
-
Giugliano, R.P.1
Wiviott, S.D.2
Stone, P.H.3
-
48
-
-
77955458657
-
BMS-593214 an active site-directed factor VIIa inhibitor: Enzyme kinetics antithrombotic and antihaemostatic studies
-
Wong PC, Luettgen JM, Rendina AR, et al. BMS-593214, an active site-directed factor VIIa inhibitor: enzyme kinetics, antithrombotic and antihaemostatic studies. Thromb Haemost 2010;104(2):261-9
-
(2010)
Thromb Haemost
, vol.104
, Issue.2
, pp. 261-269
-
-
Wong, P.C.1
Luettgen, J.M.2
Rendina, A.R.3
-
49
-
-
80051794851
-
Factor XI and XII as antithrombotic targets
-
Muller F, Gailani D, Renne T. Factor XI and XII as antithrombotic targets. Curr Opin Hematol 2011;18(5):349-55
-
(2011)
Curr Opin Hematol
, vol.18
, Issue.5
, pp. 349-355
-
-
Muller, F.1
Gailani, D.2
Renne, T.3
-
50
-
-
80052467986
-
A small-molecule factor XIa inhibitor produces antithrombotic efficacy with minimal bleeding time prolongation in rabbits
-
Wong PC, Crain EJ, Watson CA, Schumacher WA. A small-molecule factor XIa inhibitor produces antithrombotic efficacy with minimal bleeding time prolongation in rabbits. J Thromb Thrombolysis 2011;32(2):129-37
-
(2011)
J Thromb Thrombolysis
, vol.32
, Issue.2
, pp. 129-137
-
-
Wong, P.C.1
Crain, E.J.2
Watson, C.A.3
Schumacher, W.A.4
-
51
-
-
34547828204
-
Antithrombotic and hemostatic effects of a small molecule factor XIa inhibitor in rats
-
Schumacher WA, Seiler SE, Steinbacher TE, et al. Antithrombotic and hemostatic effects of a small molecule factor XIa inhibitor in rats. Eur J Pharmacol 2007;570(1-3):167-74
-
(2007)
Eur J Pharmacol
, vol.570
, Issue.1-3
, pp. 167-174
-
-
Schumacher, W.A.1
Seiler, S.E.2
Steinbacher, T.E.3
-
52
-
-
77955451612
-
Apixaban a direct factor Xa inhibitor inhibits tissue-factor induced human platelet aggregation in vitro: Comparison with direct inhibitors of factor VIIa XIa and thrombin
-
Wong PC, Jiang X. Apixaban, a direct factor Xa inhibitor, inhibits tissue-factor induced human platelet aggregation in vitro: comparison with direct inhibitors of factor VIIa, XIa and thrombin. Thromb Haemost 2010;104(2):302-10
-
(2010)
Thromb Haemost
, vol.104
, Issue.2
, pp. 302-310
-
-
Wong, P.C.1
Jiang, X.2
-
53
-
-
77950899732
-
Factor XIIa inhibitor recombinant human albumin Infestin-4 abolishes occlusive arterial thrombus formation without affecting bleeding
-
Hagedorn I, Schmidbauer S, Pleines I, et al. Factor XIIa inhibitor recombinant human albumin Infestin-4 abolishes occlusive arterial thrombus formation without affecting bleeding. Circulation 2010;121(13):1510-17
-
(2010)
Circulation
, vol.121
, Issue.13
, pp. 1510-1517
-
-
Hagedorn, I.1
Schmidbauer, S.2
Pleines, I.3
-
54
-
-
70449698361
-
Ir-CPI, a coagulation contact phase inhibitor from the tick Ixodes ricinus, inhibits thrombus formation without impairing hemostasis
-
Decrem Y, Rath G, Blasioli V, et al. Ir-CPI, a coagulation contact phase inhibitor from the tick Ixodes ricinus, inhibits thrombus formation without impairing hemostasis. J Exp Med 2009;206(11):2381-95
-
(2009)
J Exp Med
, vol.206
, Issue.11
, pp. 2381-2395
-
-
Decrem, Y.1
Rath, G.2
Blasioli, V.3
-
55
-
-
77649125820
-
Coagulation factor IXa as a target for treatment and prophylaxis of venous thromboembolism
-
Eikelboom JW, Zelenkofske SL, Rusconi CP. Coagulation factor IXa as a target for treatment and prophylaxis of venous thromboembolism. Arterioscler Thromb Vasc Biol 2010;30(3):382-7
-
(2010)
Arterioscler Thromb Vasc Biol
, vol.30
, Issue.3
, pp. 382-387
-
-
Eikelboom, J.W.1
Zelenkofske, S.L.2
Rusconi, C.P.3
-
56
-
-
39549104685
-
Partial factor IXa inhibition with TTP889 for prevention of venous thromboembolism: An exploratory study
-
Eriksson BI, Dahl OE, Lassen MR, et al. Partial factor IXa inhibition with TTP889 for prevention of venous thromboembolism: an exploratory study. J Thromb Haemost 2008;6(3):457-63
-
(2008)
J Thromb Haemost
, vol.6
, Issue.3
, pp. 457-463
-
-
Eriksson, B.I.1
Dahl, O.E.2
Lassen, M.R.3
-
57
-
-
78649471947
-
Inhibition of the intrinsic coagulation pathway factor XI by antisense oligonucleotides: A novel antithrombotic strategy with lowered bleeding risk
-
Zhang H, Lowenberg EC, Crosby JR, et al. Inhibition of the intrinsic coagulation pathway factor XI by antisense oligonucleotides: a novel antithrombotic strategy with lowered bleeding risk. Blood 2010;116(22):4684-92
-
(2010)
Blood
, vol.116
, Issue.22
, pp. 4684-4692
-
-
Zhang, H.1
Lowenberg, E.C.2
Crosby, J.R.3
-
58
-
-
0000015743
-
Antisense oligonucleotides: Basic concepts and mechanisms
-
Dias N, Stein CA. Antisense oligonucleotides: basic concepts and mechanisms. Mol Cancer Ther 2002;1(5):347-55
-
(2002)
Mol Cancer Ther
, vol.1
, Issue.5
, pp. 347-355
-
-
Dias, N.1
Stein, C.A.2
-
59
-
-
84879117604
-
Isis-fxirx, a novel and specific antisense inhibitor of factor XI, significantly reduces fXI antigen and activity and increases aPTT without causing bleeding in healthy volunteers
-
Liu Q, Bethune C, Dessouki E, et al. Isis-fxirx, a novel and specific antisense inhibitor of factor XI, significantly reduces fXI antigen and activity and increases aPTT without causing bleeding in healthy volunteers. Blood 2011;118:209
-
(2011)
Blood
, vol.118
, pp. 209
-
-
Liu, Q.1
Bethune, C.2
Dessouki, E.3
-
60
-
-
81155133305
-
Selective depletion of plasma prekallikrein or coagulation factor XII inhibits thrombosis in mice without increased risk of bleeding
-
Revenko AS, Gao D, Crosby JR, et al. Selective depletion of plasma prekallikrein or coagulation factor XII inhibits thrombosis in mice without increased risk of bleeding. Blood 2011;118(19):5302-11
-
(2011)
Blood
, vol.118
, Issue.19
, pp. 5302-5311
-
-
Revenko, A.S.1
Gao, D.2
Crosby, J.R.3
-
61
-
-
84869854718
-
In vivo roles of factor XII
-
Renne T, Schmaier AH, Nickel KF, et al. In vivo roles of factor XII. Blood 2012;120(22):4296-303
-
(2012)
Blood
, vol.120
, Issue.22
, pp. 4296-4303
-
-
Renne, T.1
Schmaier, A.H.2
Nickel, K.F.3
-
63
-
-
8344221992
-
Antidote-mediated control of an anticoagulant aptamer in vivo
-
Rusconi CP, Roberts JD, Pitoc GA, et al. Antidote-mediated control of an anticoagulant aptamer in vivo. Nat Biotechnol 2004;22(11):1423-8
-
(2004)
Nat Biotechnol
, vol.22
, Issue.11
, pp. 1423-1428
-
-
Rusconi, C.P.1
Roberts, J.D.2
Pitoc, G.A.3
-
65
-
-
56749092148
-
Anticoagulant characteristics of HD1-22, a bivalent aptamer that specifically inhibits thrombin and prothrombinase
-
Muller J, Freitag D, Mayer G, Potzsch B. Anticoagulant characteristics of HD1-22, a bivalent aptamer that specifically inhibits thrombin and prothrombinase. J Thromb Haemost 2008;6(12):2105-12
-
(2008)
J Thromb Haemost
, vol.6
, Issue.12
, pp. 2105-2112
-
-
Muller, J.1
Freitag, D.2
Mayer, G.3
Potzsch, B.4
-
66
-
-
33845988051
-
HD1, a thrombin-directed aptamer, binds exosite 1 on prothrombin with high affinity and inhibits its activation by prothrombinase
-
Kretz CA, Stafford AR, Fredenburgh JC, Weitz JI. HD1, a thrombin-directed aptamer, binds exosite 1 on prothrombin with high affinity and inhibits its activation by prothrombinase. J Biol Chem 2006;281(49):37477-85
-
(2006)
J Biol Chem
, vol.281
, Issue.49
, pp. 37477-37485
-
-
Kretz, C.A.1
Stafford, A.R.2
Fredenburgh, J.C.3
Weitz, J.I.4
-
67
-
-
33845388596
-
First-in-human experience of an antidote-controlled anticoagulant using RNA aptamer technology: A phase 1a pharmacodynamic evaluation of a drug-antidote pair for the controlled regulation of factor IXa activity
-
Dyke CK, Steinhubl SR, Kleiman NS, et al. First-in-human experience of an antidote-controlled anticoagulant using RNA aptamer technology: a phase 1a pharmacodynamic evaluation of a drug-antidote pair for the controlled regulation of factor IXa activity. Circulation 2006;114(23):2490-7
-
(2006)
Circulation
, vol.114
, Issue.23
, pp. 2490-2497
-
-
Dyke, C.K.1
Steinhubl, S.R.2
Kleiman, N.S.3
-
68
-
-
80054052562
-
Pegnivacogin results in near complete FIX inhibition in acute coronary syndrome patients: RADAR pharmacokinetic and pharmacodynamic substudy
-
Povsic TJ, Wargin WA, Alexander JH, et al. Pegnivacogin results in near complete FIX inhibition in acute coronary syndrome patients: RADAR pharmacokinetic and pharmacodynamic substudy. Eur Heart J 2011;32(19):2412-19
-
(2011)
Eur Heart J
, vol.32
, Issue.19
, pp. 2412-2419
-
-
Povsic, T.J.1
Wargin, W.A.2
Alexander, J.H.3
-
69
-
-
44649163943
-
Phase 1b randomized study of antidote-controlled modulation of factor IXa activity in patients with stable coronary artery disease
-
Chan MY, Cohen MG, Dyke CK, et al. Phase 1b randomized study of antidote-controlled modulation of factor IXa activity in patients with stable coronary artery disease. Circulation 2008;117(22):2865-74
-
(2008)
Circulation
, vol.117
, Issue.22
, pp. 2865-2874
-
-
Chan, M.Y.1
Cohen, M.G.2
Dyke, C.K.3
-
70
-
-
77955468444
-
First clinical application of an actively reversible direct factor IXa inhibitor as an anticoagulation strategy in patients undergoing percutaneous coronary intervention
-
Cohen MG, Purdy DA, Rossi JS, et al. First clinical application of an actively reversible direct factor IXa inhibitor as an anticoagulation strategy in patients undergoing percutaneous coronary intervention. Circulation 2010;122(6):614-22
-
(2010)
Circulation
, vol.122
, Issue.6
, pp. 614-622
-
-
Cohen, M.G.1
Purdy, D.A.2
Rossi, J.S.3
-
71
-
-
84884269173
-
A Phase 2, randomized, partially blinded, active-controlled study assessing the efficacy and safety of variable anticoagulation reversal using the REG1 system in patients with acute coronary syndromes: Results of the RADAR trial
-
[Epub ahead of print]
-
Povsic TJ, Vavalle JP, Aberle LH, et al. A Phase 2, randomized, partially blinded, active-controlled study assessing the efficacy and safety of variable anticoagulation reversal using the REG1 system in patients with acute coronary syndromes: results of the RADAR trial. Eur Heart J 2012. [Epub ahead of print]
-
(2012)
Eur Heart J
-
-
Povsic, T.J.1
Vavalle, J.P.2
Aberle, L.H.3
-
72
-
-
84884255141
-
Reg1, a Novel RNA-Aptamer Direct Factor IXa-inhibitor (pegnivacogin) Reduces Platelet Activation in Healthy Volunteers and Residual Platelet Aggregation in Patients with ACS
-
Ahrens I, Putz V, Zelenkofske SL, et al. Reg1, a Novel RNA-Aptamer Direct Factor IXa-inhibitor (pegnivacogin) Reduces Platelet Activation in Healthy Volunteers and Residual Platelet Aggregation in Patients with ACS. A Radar Substudy. Circulation 2011;124:A9771
-
(2011)
A Radar Substudy. Circulation
, vol.124
-
-
Ahrens, I.1
Putz, V.2
Zelenkofske, S.L.3
-
73
-
-
84863465362
-
A phase 1 ascending dose study of a subcutaneously administered factor IXa inhibitor and its active control agent
-
Vavalle JP, Rusconi CP, Zelenkofske S, et al. A phase 1 ascending dose study of a subcutaneously administered factor IXa inhibitor and its active control agent. J Thromb Haemost 2012;10(7):1303-11
-
(2012)
J Thromb Haemost
, vol.10
, Issue.7
, pp. 1303-1311
-
-
Vavalle, J.P.1
Rusconi, C.P.2
Zelenkofske, S.3
-
74
-
-
84884261101
-
-
Regado Biosciences Inc. Regado Biosciences Inc. to Present at the [press release] 8 Aug 2012
-
Regado Biosciences, Inc. Regado Biosciences, Inc. to Present at the Canaccord Genuity 32nd Annual Growth Conference in Boston, MA. [press release] 8 Aug. 2012. Available from: http://www.regadobio.com/index.php/2012/08/ regadobiosciences-inc-to-present-at-thecanaccord-genuity-32nd-annual- growthconference-in-boston-ma-2/
-
Canaccord Genuity 32nd Annual Growth Conference in Boston MA
-
-
-
75
-
-
59849087682
-
A human monoclonal antibody inhibiting partially factor VIII activity reduces thrombus growth in baboons
-
Jacquemin M, Stassen JM, Saint-Remy JM, et al. A human monoclonal antibody inhibiting partially factor VIII activity reduces thrombus growth in baboons. J Thromb Haemost 2009;7(3):429-37
-
(2009)
J Thromb Haemost
, vol.7
, Issue.3
, pp. 429-437
-
-
Jacquemin, M.1
Stassen, J.M.2
Saint-Remy, J.M.3
-
76
-
-
77954655748
-
Tolerability and pharmacokinetics of TB-402 in healthy male volunteers
-
Verhamme P, Pakola S, Jensen TJ, et al. Tolerability and pharmacokinetics of TB-402 in healthy male volunteers. Clin Ther 2010;32(6):1205-20
-
(2010)
Clin Ther
, vol.32
, Issue.6
, pp. 1205-1220
-
-
Verhamme, P.1
Pakola, S.2
Jensen, T.J.3
-
77
-
-
84863458846
-
Antidote strategies to reverse anticoagulation with TB-402, a long-acting partial inhibitor of factor VIII
-
Tangelder M, Long C, Emmerechts J, et al. Antidote strategies to reverse anticoagulation with TB-402, a long-acting partial inhibitor of factor VIII. J Thromb Haemost 2012;10(7):1371-8
-
(2012)
J Thromb Haemost
, vol.10
, Issue.7
, pp. 1371-1378
-
-
Tangelder, M.1
Long, C.2
Emmerechts, J.3
-
78
-
-
79953330537
-
Single intravenous administration of TB-402 for the prophylaxis of venous thromboembolism after total knee replacement: A dose-escalating, randomized, controlled trial
-
Verhamme P, Tangelder M, Verhaeghe R, et al. Single intravenous administration of TB-402 for the prophylaxis of venous thromboembolism after total knee replacement: a dose-escalating, randomized, controlled trial. J Thromb Haemost 2011;9(4):664-71
-
(2011)
J Thromb Haemost
, vol.9
, Issue.4
, pp. 664-671
-
-
Verhamme, P.1
Tangelder, M.2
Verhaeghe, R.3
-
79
-
-
84861665800
-
Drotrecogin alfa (activated) in adults with septic shock
-
Ranieri VM, Thompson BT, Barie PS, et al. Drotrecogin alfa (activated) in adults with septic shock. N Engl J Med 2012;366(22):2055-64
-
(2012)
N Engl J Med
, vol.366
, Issue.22
, pp. 2055-2064
-
-
Ranieri, V.M.1
Thompson, B.T.2
Barie, P.S.3
-
80
-
-
84865743203
-
Preclinical safety and pharmacokinetic profile of 3K3A-APC a novel modified activated protein C for ischemic stroke
-
Williams PD, Zlokovic BV, Griffin JH, et al. Preclinical safety and pharmacokinetic profile of 3K3A-APC, a novel, modified activated protein C for ischemic stroke. Curr Pharm Des 2012;18(27):4215-22
-
(2012)
Curr Pharm des
, vol.18
, Issue.27
, pp. 4215-4222
-
-
Williams, P.D.1
Zlokovic, B.V.2
Griffin, J.H.3
-
82
-
-
60849087332
-
Protease-activated receptors as targets for antiplatelet therapy
-
Hamilton JR. Protease-activated receptors as targets for antiplatelet therapy. Blood Rev 2009;23(2):61-5
-
(2009)
Blood Rev
, vol.23
, Issue.2
, pp. 61-65
-
-
Hamilton, J.R.1
-
83
-
-
0141498162
-
Specificity of coagulation factor signaling
-
Ruf W, Dorfleutner A, Riewald M. Specificity of coagulation factor signaling. J Thromb Haemost 2003;1(7):1495-503
-
(2003)
J Thromb Haemost
, vol.1
, Issue.7
, pp. 1495-1503
-
-
Ruf, W.1
Dorfleutner, A.2
Riewald, M.3
-
84
-
-
83655177669
-
Thrombin-receptor antagonist vorapaxar in acute coronary syndromes
-
Tricoci P, Huang Z, Held C, et al. Thrombin-receptor antagonist vorapaxar in acute coronary syndromes. N Engl J Med 2012;366(1):20-33
-
(2012)
N Engl J Med
, vol.366
, Issue.1
, pp. 20-33
-
-
Tricoci, P.1
Huang, Z.2
Held, C.3
-
85
-
-
84867336413
-
Vorapaxar for secondary prevention of thrombotic events for patients with previous myocardial infarction: A prespecified subgroup analysis of the TRA 2 degrees P-TIMI 50 trial
-
Scirica BM, Bonaca MP, Braunwald E, et al. Vorapaxar for secondary prevention of thrombotic events for patients with previous myocardial infarction: a prespecified subgroup analysis of the TRA 2 degrees P-TIMI 50 trial. Lancet 2012;380(9850):1317-24
-
(2012)
Lancet
, vol.380
, Issue.9850
, pp. 1317-1324
-
-
Scirica, B.M.1
Bonaca, M.P.2
Braunwald, E.3
-
86
-
-
84859555815
-
Vorapaxar in the secondary prevention of atherothrombotic events
-
Morrow DA, Braunwald E, Bonaca MP, et al. Vorapaxar in the secondary prevention of atherothrombotic events. N Engl J Med 2012;366(15):1404-13
-
(2012)
N Engl J Med
, vol.366
, Issue.15
, pp. 1404-1413
-
-
Morrow, D.A.1
Braunwald, E.2
Bonaca, M.P.3
-
87
-
-
84876110526
-
Vorapaxar in patients with peripheral artery disease: Results from TRA2oP-TIMI 50
-
Bonaca MP, Scirica BM, Creager MA, et al. Vorapaxar in Patients With Peripheral Artery Disease: results From TRA2oP-TIMI 50. Circulation 2013;127(14):1522-9
-
(2013)
Circulation
, vol.127
, Issue.14
, pp. 1522-1529
-
-
Bonaca, M.P.1
Scirica, B.M.2
Creager, M.A.3
-
88
-
-
84876282305
-
Efficacy and safety of vorapaxar in patients with prior ischemic stroke
-
Morrow DA, Alberts MJ, Mohr JP, et al. Efficacy and safety of vorapaxar in patients with prior ischemic stroke. Stroke 2013;44(3):691-8
-
(2013)
Stroke
, vol.44
, Issue.3
, pp. 691-698
-
-
Morrow, D.A.1
Alberts, M.J.2
Mohr, J.P.3
-
89
-
-
84879099064
-
Effect of vorapaxar on myocardial infarction in the thrombin receptor antagonist for clinical event reduction in acute coronary syndrome (TRAoCER) trial
-
Leonardi S, Tricoci P, White HD, et al. Effect of vorapaxar on myocardial infarction in the thrombin receptor antagonist for clinical event reduction in acute coronary syndrome (TRAoCER) trial. Eur Heart J 2013;34(23):1723-31
-
(2013)
Eur Heart J
, vol.34
, Issue.23
, pp. 1723-1731
-
-
Leonardi, S.1
Tricoci, P.2
White, H.D.3
-
90
-
-
84884225650
-
-
Merck [press release] 26 Aug 2012
-
Merck. Merck Provides Update on Cardiovascular Development Programs. [press release] 26 Aug. 2012. Available from: http://www.mercknewsroom.com/ press-release/research-and-development-news/merckprovides-update- cardiovasculardevelopment-program
-
Merck Provides Update on Cardiovascular Development Programs
-
-
-
91
-
-
85027946204
-
Safety and tolerability of atopaxar in the treatment of patients with acute coronary syndromes: The lessons from antagonizing the cellular effects of Thrombin-Acute Coronary Syndromes Trial
-
O'Donoghue ML, Bhatt DL, Wiviott SD, et al. Safety and tolerability of atopaxar in the treatment of patients with acute coronary syndromes: the lessons from antagonizing the cellular effects of Thrombin-Acute Coronary Syndromes Trial. Circulation 2011;123(17):1843-53
-
(2011)
Circulation
, vol.123
, Issue.17
, pp. 1843-1853
-
-
O'donoghue, M.L.1
Bhatt, D.L.2
Wiviott, S.D.3
-
92
-
-
84862764516
-
Atopaxar and its effects on markers of platelet activation and inflammation: Results from the LANCELOT CAD program
-
O'Donoghue ML, Bhatt DL, Flather MD, et al. Atopaxar and its effects on markers of platelet activation and inflammation: results from the LANCELOT CAD program. J Thromb Thrombolysis 2012;34(1):36-43
-
(2012)
J Thromb Thrombolysis
, vol.34
, Issue.1
, pp. 36-43
-
-
O'donoghue, M.L.1
Bhatt, D.L.2
Flather, M.D.3
-
93
-
-
84877301336
-
European Heart Rhythm Association Practical Guide on the use of new oral anticoagulants in patients with non-valvular atrial fibrillation
-
Heidbuchel H, Verhamme P, Alings M, et al. European Heart Rhythm Association Practical Guide on the use of new oral anticoagulants in patients with non-valvular atrial fibrillation. Europace 2013;15(5):625-51
-
(2013)
Europace
, vol.15
, Issue.5
, pp. 625-651
-
-
Heidbuchel, H.1
Verhamme, P.2
Alings, M.3
-
94
-
-
84857438475
-
New oral anticoagulants should not be used as first-line agents to prevent thromboembolism in patients with atrial fibrillation
-
discussion 70
-
Ansell J. New oral anticoagulants should not be used as first-line agents to prevent thromboembolism in patients with atrial fibrillation. Circulation 2012;125(1):165-70; discussion 70
-
(2012)
Circulation
, vol.125
, Issue.1
, pp. 165-170
-
-
Ansell, J.1
|