A polybromodiphenyl ether from an Indonesian marine sponge Lamellodysidea herbacea and its chemical derivatives inhibit protein tyrosine phosphatase 1B, an important target for diabetes treatment

Journal of Natural Medicines

Volumn 67, Issue 4, 2013, Pages 730-735

  Yamazaki, Hiroyuki ^a   Sumilat, Deiske A ^a,b   Kanno, Syu Ichi ^a   Ukai, Kazuyo ^a   Rotinsulu, Henki ^a,c   Wewengkang, Defny S ^b   Ishikawa, Masaaki ^a   Mangindaan, Remy E P ^b   Namikoshi, Michio ^a  

^a TOHOKU PHARMACEUTICAL UNIVERSITY   (Japan)

^b SAM RATULANGI UNIVERSITY   (Indonesia)

^c Faculty of Agriculture   (Indonesia)

Author keywords

Indonesian marine sponge; Inhibitor; Lamellodysidea herbacea; Polybrominated diphenyl ether; Protein tyrosine phosphatase 1B (PTP1B); Type 2 diabetes mellitus (T2DM)

Indexed keywords

3,5 DIBROMO 2 (3',5' DIBROMO 2' METHOXYPHENOXY) 1 METHOXYBENZENE; 3,5 DIBROMO 2 (3',5' DIBROMO 2' METHOXYPHENOXY)PHENYL BENZOATE; 3,5 DIBROMO 2 (3',5' DIBROMO 2' METHOXYPHENOXY)PHENYL BUTANOATE; 3,5 DIBROMO 2 (3',5' DIBROMO 2' METHOXYPHENOXY)PHENYL ETHANOATE; 3,5 DIBROMO 2 (3',5' DIBROMO 2' METHOXYPHENOXY)PHENYL HEXANOATE; ETHER DERIVATIVE; LAMELLODYSIDEA HERBACEA EXTRACT; NATURAL PRODUCT; POLYBROMODIPHENYL ETHER; PROTEIN TYROSINE PHOSPHATASE 1B; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; DIABETES MELLITUS; DRUG ACTIVITY; DRUG CYTOTOXICITY; DRUG EFFICACY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; ENZYME INHIBITION; HUMAN; HUMAN CELL; IC 50; INDONESIA; LAMELLODYSIDEA HERBACEA; LEUKEMIA CELL LINE; LIVER CELL; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; SOLVENT EXTRACTION; SPECTROSCOPY; SPONGE (PORIFERA); STRUCTURE ACTIVITY RELATION;

ANIMALS; CELL LINE, TUMOR; CELL PROLIFERATION; ENZYME INHIBITORS; HALOGENATED DIPHENYL ETHERS; HUMANS; INDONESIA; PORIFERA; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 1; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84884210252     PISSN: 13403443     EISSN: 18610293     Source Type: Journal    
DOI: 10.1007/s11418-012-0735-y     Document Type: Article

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