Radiation-induced stress response in peripheral blood of breast cancer patients differs between patients with severe acute skin reactions and patients with no side effects to radiotherapy

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 756, Issue 1-2, 2013, Pages 152-157

  Skiöld, Sara ^a   Naslund, Ingemar ^b   Brehwens, Karl ^a   Andersson, Arja ^b   Wersall, Peter ^b   Lidbrink, Elisabet ^b   Harms Ringdahl, Mats ^a   Wojcik, Andrzej ^a   Haghdoost, Siamak ^a  

^a STOCKHOLM UNIVERSITY   (Sweden)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

8 Oxo dG; Breast cancer; Oxidative stress; Predictive assay; Radiosensitivity; Radiotherapy

Indexed keywords

ADULT; AGED; ARTICLE; BLOOD; BLOOD SAMPLING; BREAST CANCER; CANCER PATIENT; CANCER RADIOTHERAPY; CLINICAL ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; HUMAN CELL; IONIZING RADIATION; OXIDATIVE STRESS; PRIORITY JOURNAL; RADIATION DOSE; RADIOSENSITIVITY; SKIN MANIFESTATION;

8-OXO-DG; BREAST CANCER; OXIDATIVE STRESS; PREDICTIVE ASSAY; RADIOSENSITIVITY; RADIOTHERAPY;

ACUTE DISEASE; ADULT; AGED; BIOLOGICAL MARKERS; BLOOD CELLS; BREAST NEOPLASMS; COHORT STUDIES; DEOXYGUANOSINE; DOSE-RESPONSE RELATIONSHIP, RADIATION; FEMALE; GAMMA RAYS; HUMANS; MIDDLE AGED; OXIDATIVE STRESS; RADIATION TOLERANCE; SKIN DISEASES;

EID: 84884208258     PISSN: 13835718     EISSN: 18793592     Source Type: Journal    
DOI: 10.1016/j.mrgentox.2013.04.014     Document Type: Article

References (18)

1. Rieger K.E., Hong W.J., Tusher V.G., Tang J., Tibshirani R., Chu G. Toxicity from radiation therapy associated with abnormal transcriptional responses to DNA damage. Proc. Natl. Acad. Sci. U.S.A. 2004, 101:6635-6640.
2. Popanda O., Ebbeler R., Twardella D., Helmbold I., Gotzes F., Schmezer P., Thielmann H.W., von Fournier D., Haase W., Sautter-Bihl M.L., Wenz F., Bartsch H., Chang-Claude J. Radiation-induced DNA damage and repair in lymphocytes from breast cancer patients and their correlation with acute skin reactions to radiotherapy. Int. J. Radiat. Oncol. Biol. Phys. 2003, 55:1216-1225.
3. Crompton N.E., Miralbell R., Rutz H.P., Ersoy F., Sanal O., Wellmann D., Bieri S., Coucke P.A., Emery G.C., Shi Y.Q., Blattmann H., Ozsahin M. Altered apoptotic profiles in irradiated patients with increased toxicity. Int. J. Radiat. Oncol. Biol. Phys. 1999, 45:707-714.
4. Barber J.B., Burrill W., Spreadborough A.R., Levine E., Warren C., Kiltie A.E., Roberts S.A., Scott D. Relationship between in vitro chromosomal radiosensitivity of peripheral blood lymphocytes and the expression of normal tissue damage following radiotherapy for breast cancer. Radiother. Oncol. 2000, 55:179-186.
5. Russell N.S., Begg A.C. Editorial radiotherapy and oncology 2002: predictive assays for normal tissue damage. Radiother. Oncol. 2002, 64:125-129.
6. Reichenbach J., Schubert R., Schindler D., Muller K., Bohles H., Zielen S. Elevated oxidative stress in patients with ataxia telangiectasia. Antioxid. Redox Signal. 2002, 4:465-469.
7. Pagano G., Degan P., d'Ischia M., Kelly F.J., Pallardo F.V., Zatterale A., Anak S.S., Akisik E.E., Beneduce G., Calzone R., De Nicola E., Dunster C., Lloret A., Manini P., Nobili B., Saviano A., Vuttariello E., Warnau M. Gender- and age-related distinctions for the in vivo prooxidant state in Fanconi anaemia patients. Carcinogenesis 2004, 25:1899-1909.
8. Tuo J., Jaruga P., Rodriguez H., Bohr V.A., Dizdaroglu M. Primary fibroblasts of Cockayne syndrome patients are defective in cellular repair of 8-hydroxyguanine and 8-hydroxyadenine resulting from oxidative stress. FASEB J. 2003, 17:668-674.
9. Haghdoost S., Sjolander L., Czene S., Harms-Ringdahl M. The nucleotide pool is a significant target for oxidative stress. Free Radic. Biol. Med. 2006, 41:620-626.
10. Tagesson C., Kallberg M., Klintenberg C., Starkhammar H. Determination of urinary 8-hydroxydeoxyguanosine by automated coupled-column high performance liquid chromatography: a powerful technique for assaying in vivo oxidative DNA damage in cancer patients. Eur. J. Cancer 1995, 31A:934-940.
11. Erhola M., Toyokuni S., Okada K., Tanaka T., Hiai H., Ochi H., Uchida K., Osawa T., Nieminen M.M., Alho H., Kellokumpu-Lehtinen P. Biomarker evidence of DNA oxidation in lung cancer patients: association of urinary 8-hydroxy-2'-deoxyguanosine excretion with radiotherapy, chemotherapy, and response to treatment. FEBS Lett. 1997, 409:287-291.
12. Haghdoost S., Svoboda P., Naslund I., Harms-Ringdahl M., Tilikides A., Skog S. Can 8-oxo-dG be used as a predictor for individual radiosensitivity. Int. J. Radiat. Oncol. Biol. Phys. 2001, 50:405-410.
13. Roszkowski K., Olinski R. Urinary 8-oxoguanine as a predictor of survival in patients undergoing radiotherapy. Cancer Epidemiol. Biomarkers Prev. 2012, 21:629-634.
14. Sangsuwan T., Haghdoost S. The nucleotide pool, a target for low-dose gamma-ray-induced oxidative stress. Radiat. Res. 2008, 170:776-783.
15. Haghdoost S., Czene S., Naslund I., Skog S., Harms-Ringdahl M. Extracellular 8-oxo-dG as a sensitive parameter for oxidative stress in vivo and in vitro. Free Radic. Res. 2005, 39:153-162.
16. Harms-Ringdahl M., Jenssen D., Haghdoost S. Tomato juice intake suppressed serum concentration of 8-oxodG after extensive physical activity. Nutr. J. 2012, 11:29.
17. Fotouhi A., Skiold S., Shakeri-Manesh S., Osterman-Golkar S., Wojcik A., Jenssen D., Harms-Ringdahl M., Haghdoost S. Reduction of 8-oxodGTP in the nucleotide pool by hMTH1 leads to reduction in mutations in the human lymphoblastoid cell line TK6 exposed to UVA. Mutat. Res. 2011, 715:13-18.
18. Droge W. Free radicals in the physiological control of cell function. Physiol. Rev. 2002, 82:47-95.