Gender- and age-related distinctions for the in vivo prooxidant state in Fanconi anaemia patients

Carcinogenesis

Volumn 25, Issue 10, 2004, Pages 1899-1909

  Pagano, Giovanni ^a   Degan, Paolo ^a   d'Ischia, Marco ^b   Kelly, Frank J ^c   Pallardó, Federico V ^d   Zatterale, Adriana ^e   Anak, S Sema ^f   Akişik, Ebru E ^f   Beneduce, Gerardo ^a   Calzone, Rita ^e   De Nicola, Elena ^a   Dunster, Christina ^c   Lloret, Ana ^d   Manini, Paola ^b   Nobili, Bruno ^g   Saviano, Anna ^h   Vuttariello, Emilia ^a   Warnau, Michel ⁱ  

^a NATIONAL CANCER INSTITUTE   (Italy)

^b UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^c KING'S COLLEGE LONDON   (United Kingdom)

^d UNIVERSITY OF VALENCIA   (Spain)

^e Elena d'Aosta Hospital   (Italy)

^f ISTANBUL UNIVERSITY   (Turkey)

^g SECOND UNIVERSITY OF NAPLES   (Italy)

^h CARDARELLI HOSPITAL   (Italy)

ⁱ Intl Atomic Energy Agency MEL   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; ALPHA TOCOPHEROL; ASCORBIC ACID; DNA BASE; GLUTATHIONE; GLUTATHIONE DISULFIDE; METHYLGLYOXAL; URIC ACID;

ADOLESCENT; ADULT; AGE; ARTICLE; BLOOD LEVEL; BONE MARROW TRANSPLANTATION; CELL LEVEL; CHILD; CHROMOSOME BREAKAGE; CONTROLLED STUDY; CORRELATION ANALYSIS; FANCONI ANEMIA; FEMALE; GENDER; GROUPS BY AGE; HETEROZYGOSITY; HUMAN; HUMAN CELL; IN VIVO STUDY; LEUKOCYTE; MAJOR CLINICAL STUDY; MALE; MEASUREMENT; OXIDATIVE STRESS; PARENT; PRIORITY JOURNAL; SEX DIFFERENCE; STATISTICAL SIGNIFICANCE; URIC ACID BLOOD LEVEL; URINE LEVEL; VITAMIN BLOOD LEVEL;

ADOLESCENT; ADULT; AGE FACTORS; ASCORBIC ACID; CASE-CONTROL STUDIES; CHILD; CHILD, PRESCHOOL; CHROMOSOME BREAKAGE; CHROMOSOMES, HUMAN; DEOXYGUANOSINE; DNA; FANCONI ANEMIA; FEMALE; GLUTATHIONE; GLUTATHIONE DISULFIDE; HETEROZYGOTE; HUMANS; INFANT; LEUKOCYTES; MALE; OXIDATION-REDUCTION; OXIDATIVE STRESS; PYRUVALDEHYDE; REACTIVE OXYGEN SPECIES; RESPIRATORY BURST; SEX FACTORS; TRANSPLANTS; URIC ACID; VITAMIN E;

EID: 6444220011     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/bgh194     Document Type: Article

References (68)

1. Auerbach,A.D., Buchwald,M. and Joenje,H. (1998) Fanconi anemia. In Vogelstein,B. and Kinzier,K.W. (eds) The Genetic Basis of Human Cancer. McGraw-Hill, New York, NY, pp. 317-322.
2. Alter,B.P. (1996) Fanconi's anemia and malignancies. Am. J. Hematol., 53, 99-110.
3. Ahmad,S.I., Hanaoka,F. and Kirk,S.H. (2002) Molecular biology of Fanconi anaemia - an old problem, a new insight. Bioessays, 24, 439-448.
4. Pagano,G. and Youssoufian,H. (2003) Fanconi's anaemia proteins: concurrent roles in cell protection against oxidative damage. Bioessays, 25, 589-595.
5. Taniguchi,T. and D'Andrea,A.D. (2002) Molecular pathogenesis of Fanconi anemia. Int. J. Hematol., 75, 123-128.
6. Levitus,M., Rooimans,M.A., Steltenpool,J. et al. (2004) Genetic heterogeneity in Fanconi anemia: evidence for two new genetic subtypes. Blood, 103, 2498-2503.
7. Meetei,A.R., de Winter,J.P., Medhurst,A.L. et al. (2003) A novel ubiquitin ligase is deficient in Fanconi anemia. Nature Genet., 35, 165-170.
8. Nordenson,I. (1977) Effect of superoxide dismutase and catalase on spontaneously occurring chromosome breaks in patients with Fanconi's anemia. Hereditas, 86, 147-150.
9. Nagasawa,H. and Little,J.B. (1983) Suppression of cytotoxic effect of mitomycin-C by superoxide dismutase in Fanconi's anemia and dyskeratosis congenita fibroblasts. Carcinogenesis, 4, 795-798.
10. Hoehn,K., Kubbies,M., Poot,M. and Rabinovitch,P.S. (1989) BrdU-Hoechst flow cytometry links the cell kinetic defect of Fanconi's anemia to oxygen hypersensitivity. In Schroeder-Kurt,T.M., Auerbach,A.D. and Obe,G. (eds) Fanconi Anemia: Clinical, Cytogenetic and Experimental Aspects. Springer-Verlag, Berlin, pp. 161-173.
11. Joenje,H., Arwert,F., Eriksson,A.W., de Koning,H. and Oostra,A.B. (1981) Oxygen-dependence of chromosomal aberrations in Fanconi's anaemia. Nature, 290, 142-143.
12. Dallapiccola,B., Porfirio,B., Mokini,V., Alimena,G., Isacchi,G. and Gandini,E. (1985) Effect of oxidants and antioxidants on chromosomal breakage in Fanconi's anemia lymphocytes. Hum. Genet., 69, 62-65.
13. Korkina,L.G., Samochatova,E.V., Maschan,A.A., Suslova,T.B., Cheremisina,Z.P. and Afanas'ev,I.B. (1992) Release of active oxygen radicals by leukocytes of Fanconi's anemia patients. J. Leukoc. Biol. 52, 357-362.
14. Takeuchi,T. and Morimoto,K. (1993) Increased formation of 8-hydroxydeoxyguanosine, an oxidative DNA damage, in lymphoblasts from Fanconi's anemia patients due to possible catalase deficiency. Carcinogenesis, 14, 1115-1120.
15. Degan,P., Bonassi,S., De Caterina,M., Korkina,L.G., Pinto,L., Scopacasa,F., Zatterale,A., Calzone,R. and Pagano,G. (1995) In vivo accumulation of 8-hydroxy-2′-deoxyguanosine in DNA correlates with release of reactive oxygen species in Fanconi's anaemia families. Carcinogenesis, 16, 735-742.
16. Poot,M., Gross,O., Epe,B., Pflaum,M. and Hoehn,H. (1996) Cell cycle defect in connection with oxygen and iron sensitivity in Fanconi anemia lymphoblastoid cells. Exp. Cell, Res., 222, 262-268.
17. Emerit,I., Levy,A., Pagano,G., Pinto,L., Calzone,R. and Zatterale,A. (1995) Transferable clastogenic activity in plasma from patients with FA. Hum. Genet., 96, 14-20.
18. Schulz,J.C. and Shahidi,N.T. (1993) Tumor necrosis factor-α over-production in Fanconi's anemia. Am. J. Hematol., 42, 196-201.
19. Ruppitsch,W., Meisslitzer,C., Hirsch-Kauffmann,M. and Schweiger,M. (1998) Overexpression of thioredoxin in Fanconi anemia fibroblasts prevents the cytotoxic and DNA damaging effect of mitomycin C and diepoxybutane. FEBS Lett., 422, 99-102.
20. Kontou,M., Adelfalk,C., Ramirez,M.H., Ruppitsch,W., Hirsch-Kauffmann,M. and Schweiger,M. (2002) Overexpressed thioredoxin compensates Fanconi anemia related chromosomal instability. Oncogene 21, 2406-2412.
21. Malorni,W., Straface,E., Pagano,G. et al. (2000) Cytoskeleton alterations of erythrocytes from patients with Fanconi's anemia. FEBS Lett., 468, 125-128.
22. Saadatzadeh,M.R., Bijangi-Vishehsaraei,K., Hong,P., Bergmann,H. and Haneline,L.S. (2004) Oxidant hypersensitivity of Fanconi anemia type C deficient cells is dependent on a redox-regulated apoptotic pathway. J. Biol. Chem., 279, 16805-16812.
23. Clarke,A.A., Philpott,N.J., Gordon-Smith,E.C. and Rutherford,T.R. (1997) The sensitivity of Fanconi anaemia group C cells to apoptosis induced by mitomycin C is due to oxygen radical generation, not DNA crosslinking. Br. J. Haematol., 96, 240-247.
24. Futaki,M., Igarashi,T., Watanabe,S., Kajigaya,S., Tatsuguchi,A., Wang,J. and Liu,J.M. (2002) The FANCG Fanconi anemia protein interacts with CYP2E1: possible role in protection against oxidative DNA damage. Carcinogenesis, 23, 67-72.
25. Zanier,R., Briot,D., Villard,J.A., Sarasin,A. and Rosselli,F. (2004) Fanconi anemia C gene product regulates expression of genes involved in differentiation and inflammation. Oncogene, doi:10.1038/sj. onc. 1207677.
26. Reuter,T.Y., Medhurst,A.L., Waisfisz,Q. et al. (2003) Yeast two-hybrid screens imply involvement of Fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism and cellular transport. Exp. Cell Res., 289, 211-221.
27. Pagano,G., Korkina,L.G., Brunk,U.T. et al. (1998) Congenital disorders sharing oxidative stress and cancer proneness as phenotypic hallmarks: prospects for joint research in pharmacology. Med. Hypotheses, 51, 253-266.
28. Pagano,G. and Korkina,L.G. (2000) Prospects for nutritional interventions in the clinical management of Fanconi anemia. Cancer Causes Control, 11, 881-889.
29. Kruyt,F.A., Hoshino,T., Liu,J.M., Joseph,P., Jaiswal,A.K. and Youssoufian,H. (1998) Abnormal microsomal detoxification implicated in Fanconi anemia group C by interaction of the FAC protein with NADPH cytochrome P450 reductase. Blood, 92, 3050-3056.
30. Cumming,R.C., Lightfoot,J., Beard,K., Youssoufian,H., O'Brien,P.J. and Buchwald,M. (2001) Fanconi anemia group C protein prevents apoptosis in hematopoietic cells through redox regulation of GSTP1. Nature Med., 7, 814-820.
31. Dusre,L., Rajagopalan,S., Eliot,H.M., Covey,J.M. and Sinha,B.K. (1990) DNA interstrand cross-link and free radical formation in a human multidrug resistant cell line from mitomycin C and its analogues. Cancer Res., 50, 648-652.
32. Pritsos,C.A. and Sartorelli,A.C. (1986) Generation of reactive oxygen radicals through bioactivation of mitomycin antibiotics. Cancer Res., 46, 3528-3532.
33. Batcabe,J.P., MacGill,R.S., Zaman,K., Ahmad,S. and Pardini,R.S. (1994) Mitomycin C induced alterations in antioxidant enzyme levels in a model insect species, Spodoptera eridania. Gen. Pharmacol. 25, 569-574.
34. Yokomizo,A., Ono,M., Nanri,H. et al. (1995) Cellular levels of thioredoxin associated with drug sensitivity to cisplatin, mitomycin C, doxorubicin and etoposide. Cancer Res., 55, 4293-4296.
35. Korkina,L.G., Deeva,I.B., Iaccarino,M., De Biase,A., Oral,R., Warnau,M. and Pagano,G. (2000) Redox-dependent toxicity of diepoxybutane and mitomycin C in sea urchin embryogenesis. Carcinogenesis, 21 213-220.
36. Look,M.P. and Musch,E. (1994) Lipid peroxides in the polychemotherapy of cancer patients. Chemotherapy, 40, 8-15.
37. Pagano,G., Degan,P., De Biase,A., Iaccarino,M. and Warnau,M. (2001) Diepoxybutane and mitomycin C toxicity is associated with the induction of oxidative DNA damage in sea urchin embryos. Hum. Exp. Toxicol., 20, 651-655.
38. Pagano,G., Manini,P. and Bagchi,D. (2003) Oxidative stress-related mechanisms are associated with xenobiotics exerting excess toxicity to Fanconi anemia cells. Environ. Health Perspect., 111 1699-1703.
39. Kim,H.J., Kim,K.W., Yu,B.P. and Chung,H.Y. (2000) The effect of age on cyclooxygenase-2 gene expression: NF-kappaB activation and IkappaBalpha degradation. Free Radic. Biol. Med., 28, 683-692.
40. Degan,P., Shigenaga,M.K., Park,E.-M., Alperin,P.E. and Ames,B.N. (1991) Immunoaffinity isolation of urinary 8-hydroxy-2′-deoxyguanosine and 8-hydroxyguanine and quantitation of 8-hydroxyguanosine in DNA by polyclonal antibodies. Carcinogenesis, 12, 865-871.
41. Akhand,A.A., Hossain,K., Mitsui,H. et al. (2001) Glyoxal and methylglyoxal trigger distinct signals for map family kinases and caspase activation in human endothelial cells. Free Radic. Biol. Med., 31, 20-30.
42. Du,J., Suzuki,H., Nagase,F., Akhand,A.A., Ma,X.Y., Yokoyama,T., Miyata,T. and Nakashima,I. (2001) Superoxide-mediated early oxidation and activation of ASK1 are important for initiating methylglyoxal-induced apoptosis process. Free Radic. Biol. Med., 31, 469-478.
43. Asensi,M., Sastre,J., Pallardó,F.V., Estrela,J.M. and Viña,J. (1994) High performance liquid chromatography determination of oxidized glutathione in blood. Methods Enzymol., 234, 367-371.
44. Kelly,F.J., Rodgers,W., Handel,J., Smith,S. and Hall,M.A. (1990) Time course of vitamin E repletion in the preterm infant. Br. J. Nutr., 63, 631-638.
45. Wajnrajch,M.P., Gertner,J.M., Huma,Z. et al. (2001) Evaluation of growth and hormonal status in patients referred to the International Fanconi Anemia Registry. Pediatrics, 107, 744-754.
46. Morrell,D., Chase,C.L., Kupper,L.L. and Swift,M. (1986) Diabetes mellitus in ataxia-telangiectasia. Fanconi anemia, xeroderma pigmentosum, common variable immune deficiency and severe combined immune deficiency families. Diabetes, 35, 143-147.
47. Srivastava,S.K. and Beutler,E. (1968) Oxidised glutathione levels in erythrocytes of glucose-6-phosphate-dehydrogenase-deficient subjects. Lancet, ii (7558), 23-24.
48. Espinosa-Mansilla,A., Duràn-Merzàs,I. and Salinas,F. (1998) High-performance liquid chromatographic-fluorometric determination of glyoxal, methylglyoxal and diacetyl in urine by prederivatization to pteridinic rings. Anal. Biochem., 255, 263-273.
49. Iriyama,K., Teranishi,T., Mori,H., Nishiwaki,H. and Kusaka,N. (1984) Simultaneous determination of uric and ascorbic acids in human serum by reversed-phase high-performance liquid chromatography with electrochemical detection. Anal. Biochem., 141, 238-243.
50. Kornberg,A. and Horecker,B.L. (1955) Glucose-6-phosphate dehydrogenase. Methods Enzymol., 1, 323-327.
51. Hutchinson,E.B. (1960) The measurement of methemoglobin. Am. J. Med. Technol., 26, 75-83.
52. Kunst,A., Draeger,B. and Ziegenhorn,J. (1983) UV-methods with hexokinase and glucose-6-phosphate dehydrogenase. In Bergmeyer,H.U. (ed.) Methods of Enzymatic Analysis. Verlag Chemie, Deerfield, FL, Vol. 6, pp. 163-172.
53. Zar,J.H. (1996) Biostatistical Analysis, 3rd Edn. Prentice-Hall, Upper Saddle River, NJ.
54. Wells-Knecht,K.J., Zyzak,D.V., Lichtfield,J.E., Thorpe,S.R. and Baynes,J.W. (1995) Mechanism of autoxidative glycosylation: identification of glyoxal and arabinose as intermediates in the autoxidative modification of proteins by glucose. Biochemistry, 34, 3702-3709.
55. Vlassara,H. and Palace,M.R. (2002) Diabetes and advanced glycation endproducts. J. Intern. Med., 251, 87-101.
56. Sheader,E.A., Benson,R.S. and Best,L. (2001) Cytotoxic action of methylglyoxal on insulin-secreting cells. Biochem. Pharmacol., 61, 1381-1386.
57. Verzijl,N., DeGroot,J., Ben,Z.C. et al. (2002) Crosslinking by advanced glycation end products increases the stiffness of the collagen network in human articular cartilage: a possible mechanism through which age is a risk factor for osteoarthritis. Arthritis Rheum., 46, 114-123.
58. O'Byrne,D., Devaraj,S., Islam,K.N., Collazo,R., McDonald,L., Grundy,S. and Jialal,I. (2001) Low-density lipoprotein (LDL)-induced monocyte-endothelial cell adhesion, soluble cell adhesion molecules and autoantibodies to oxidized-LDL in chronic renal failure patients on dialysis therapy. Metabolism, 50, 207-215.
59. Murata-Kamiya,N. and Kamiya,H. (2001) Methylglyoxal, an endogenous aldehyde, crosslinks DNA polymerase and the substrate DNA. Nucleic Acids Res., 29, 3433-3438.
60. Wolff,S.P. (1993) Diabetes mellitus and free radicals. Free radicals, transition metals and oxidative stress in the aetiology of diabetes mellitus and complications. Br. Med. Bull., 49, 642-652.
61. Floyd,R.A. (1990) The role of 8-hydroxyguanine in carcinogenesis. Carcinogenesis, 9, 1447-1450.
62. Jones,D.P., Mody,V.C.,Jr, Carlson,J.L., Lynn,M.J. and Sternberg,P.,Jr (2002) Redox analysis of human plasma allows separation of pro-oxidant events of aging from decline in antioxidant defenses. Free Radic. Biol. Med., 33, 1290-1300.
63. Weimann,A., Belling,D. and Poulsen,H.E. (2002) Quantification of 8-oxoguanine and guanine as the nucleobase, nucleoside and deoxynucleoside forms in human urine by high-performance liquid chromatography-electrospray tandem mass spectrometry. Nucleic Acids Res., 30, e7.
64. Schmidt,A.J., Krieg,J.C. and Vedder,H. (2002) Differential effects of glucocorticoids and gonadal steroids on glutathione levels in neuronal and glial cell systems. J. Neurosci. Res., 67, 544-550.
65. Aragno,M., Parola,S., Brignardello,E., Mauro,A., Tamagno,E., Manti,R., Danni,O. and Boccuzzi,G. (2000) Dehydroepiandrosterone prevents oxidative injury induced by transient ischemia/reperfusion in the brain of diabetic rats. Diabetes, 49, 1924-1931.
66. Ginsburg,G.S., O'Toole,M., Rimm,E., Douglas,P.S. and Rifai,N. (2001) Gender differences in exercise-induced changes in sex hormone levels and lipid peroxidation in athletes participating in the Hawaii Ironman triathlon. Clin. Chim. Acta, 305, 131-139.
67. Giannattasio,A., Girotti,M., Williams,K., Hall,L. and Bellastella A. (1997) Puberty influences expression of phospholipid hydroperoxide glutathione peroxidase (GPX4) in rat testis: probable hypophysis regulation of the enzyme in male reproductive tract. J. Endocrinol. Invest., 20, 439-444.
68. Bai,J. and Cederbaum,A.I. (2003) Catalase protects HepG2 cells from apoptosis induced by DNA-damaging agents by accelerating the degradation of p53. J. Biol. Chem., 278, 4660-4667.