Impact of the K24N mutation on the transactivation domain of p53 and its binding to murine double-minute clone 2

Proteins: Structure, Function and Bioinformatics

Volumn 81, Issue 10, 2013, Pages 1738-1747

  Zhan, Yingqian Ada ^a   Wu, Hongwei ^b   Powell, Anne T ^b   Daughdrill, Gary W ^b   Ytreberg, F Marty ^a  

^a UNIVERSITY OF IDAHO   (United States)

^b UNIVERSITY OF SOUTH FLORIDA   (United States)

Author keywords

Binding mechanism; Intrinsically disordered protein; Isothermal titration calorimetry; Molecular dynamics; Nuclear magnetic resonance spectroscopy

Indexed keywords

ASPARAGINE; INTRINSICALLY DISORDERED PROTEIN; LYSINE; PROTEIN MDM2; PROTEIN P53; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CHORIOCARCINOMA; CLONE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; COW; DYNAMICS; ELECTRIC POTENTIAL; ENERGY; ENTROPY; GENE EXPRESSION; GENE MUTATION; ISOTHERMAL TITRATION CALORIMETRY; MOLECULAR DYNAMICS; NUCLEAR MAGNETIC RESONANCE; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN INTERACTION; PROTEIN SECONDARY STRUCTURE; PROTEIN STRUCTURE; SIMULATION; STATIC ELECTRICITY; THERMODYNAMICS; TRANSACTIVATION; WILD TYPE;

BOVINAE; EUKARYOTA; MURINAE;

BINDING MECHANISM; INTRINSICALLY DISORDERED PROTEIN; ISOTHERMAL TITRATION CALORIMETRY; MOLECULAR DYNAMICS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY;

AMINO ACID SEQUENCE; CALORIMETRY; HUMANS; MOLECULAR DYNAMICS SIMULATION; MOLECULAR SEQUENCE DATA; MUTATION; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS C-MDM2; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84884205525     PISSN: 08873585     EISSN: 10970134     Source Type: Journal    
DOI: 10.1002/prot.24310     Document Type: Article

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