Nuclear Survivin and Its Relationship to DNA Damage Repair Genes in Non-Small Cell Lung Cancer Investigated Using Tissue Array

PLoS ONE

Volumn 8, Issue 9, 2013, Pages

  Hu, Songliu ^a   Qu, Yuanyuan ^a   Xu, Xiangying ^a   Xu, Qingyong ^a   Geng, Jingshu ^a   Xu, Jianyu ^a  

^a HARBIN MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ATM PROTEIN; CISPLATIN; DNA DEPENDENT PROTEIN KINASE; DOUBLE STRANDED DNA; HETERODIMER; KU ANTIGEN; NUCLEAR PROTEIN; SURVIVIN;

ADJUVANT THERAPY; ADULT; ANTIGEN EXPRESSION; ARTICLE; CANCER GENETICS; CANCER PATIENT; CANCER PROGNOSIS; CANCER RADIOTHERAPY; CANCER STAGING; CANCER SURGERY; CANCER SURVIVAL; CONTROLLED STUDY; DISEASE FREE SURVIVAL; DNA DOUBLE STRAND BREAKS REPAIR GENE; FEMALE; GENE; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; LUNG NON SMALL CELL CANCER; LUNG RESECTION; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; OVERALL SURVIVAL; PROTEIN DNA INTERACTION; PROTEIN EXPRESSION;

ANTIGENS, NUCLEAR; ATAXIA TELANGIECTASIA MUTATED PROTEINS; CARCINOMA, NON-SMALL-CELL LUNG; DNA REPAIR; DNA-BINDING PROTEINS; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; INHIBITOR OF APOPTOSIS PROTEINS; MALE; MIDDLE AGED; TISSUE ARRAY ANALYSIS;

EID: 84884194843     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0074161     Document Type: Article

References (35)

1. Hanahan D, Weinberg RA, (2000) The hallmarks of cancer. Cell 100: 57-70.
2. Fesik SW, (2005) Promoting apoptosis as a strategy for cancer drug discovery. Nat Rev Cancer 5: 876-885.
3. Altieri DC, (2008) Survivin, cancer networks and pathway-directed drug discovery. Nat Rev Cancer 8: 61-70.
4. Dohi T, Xia F, Altieri DC, (2007) Compartmentalized phosphorylation of IAP by protein kinase A regulates cytoprotection. Mol Cell 27: 17-28.
5. Fortugno P, Wall NR, Giodini A, O'Connor DS, Plescia J, et al. (2002) Survivin exists in immunochemically distinct subcellular pools and is involved in spindle microtubule function. J Cell Sci 115: 575-585.
6. Dohi T, Beltrami E, Wall NR, Plescia J, Altieri DC, (2004) Mitochondrial survivin inhibits apoptosis and promotes tumorigenesis. J Clin Invest 114: 1117-1127.
7. Stauber RH, Mann W, Knauer SK, (2007) Nuclear and cytoplasmic survivin: molecular mechanism, prognostic, and therapeutic potential. Cancer Res 67: 5999-6002.
8. Connell CM, Colnaghi R, Wheatley SP, (2008) Nuclear survivin has reduced stability and is not cytoprotective. J Biol Chem 283: 3289-3296.
9. Valerie K, Povirk LF, (2003) Regulation and mechanisms of mammalian double-strand break repair. Oncogene 22: 5792-5812.
10. Lieber MR, Ma Y, Pannicke U, Schwarz K, (2003) Mechanism and regulation of human non-homologous DNA end-joining. Nat Rev Mol Cell Biol 4: 712-720.
11. Shiloh Y, (2003) ATM and related protein kinases: safeguarding genome integrity. Nat Rev Cancer 3: 155-168.
12. Rodel F, Hoffmann J, Distel L, Herrmann M, Noisternig T, et al. (2005) Survivin as a radioresistance factor, and prognostic and therapeutic target for radiotherapy in rectal cancer. Cancer Res 65: 4881-4887.
13. Iwasa T, Okamoto I, Suzuki M, Nakahara T, Yamanaka K, et al. (2008) Radiosensitizing effect of YM155, a novel small-molecule survivin suppressant, in non-small cell lung cancer cell lines. Clin Cancer Res 14: 6496-6504.
14. Capalbo G, Dittmann K, Weiss C, Reichert S, Hausmann E, et al. (2010) Radiation-induced survivin nuclear accumulation is linked to DNA damage repair. Int J Radiat Oncol Biol Phys 77: 226-234.
15. Mountain CF, (1997) Revisions in the International System for Staging Lung Cancer. Chest 111: 1710-1717.
16. Xing J, Wu X, Vaporciyan AA, Spitz MR, Gu J, (2008) Prognostic significance of ataxia-telangiectasia mutated, DNA-dependent protein kinase catalytic subunit, and Ku heterodimeric regulatory complex 86-kD subunit expression in patients with nonsmall cell lung cancer. Cancer 112: 2756-2764.
17. Vischioni B, van der Valk P, Span SW, Kruyt FA, Rodriguez JA, et al. (2004) Nuclear localization of survivin is a positive prognostic factor for survival in advanced non-small-cell lung cancer. Ann Oncol 15: 1654-1660.
18. Dai CH, Li J, Shi SB, Yu LC, Ge LP, et al. (2010) Survivin and Smac gene expressions but not livin are predictors of prognosis in non-small cell lung cancer patients treated with adjuvant chemotherapy following surgery. Jpn J Clin Oncol 40: 327-335.
19. Lu B, Gonzalez A, Massion PP, Shyr Y, Shaktour B, et al. (2004) Nuclear survivin as a biomarker for non-small-cell lung cancer. Br J Cancer 91: 537-540.
20. Atikcan S, Unsal E, Demirag F, Koksal D, Yilmaz A, (2006) Correlation between survivin expression and prognosis in non-small cell lung cancer. Respir Med 100: 2220-2226.
21. Bria E, Visca P, Novelli F, Casini B, Diodoro MG, et al. (2008) Nuclear and cytoplasmic cellular distribution of survivin as survival predictor in resected non-small-cell lung cancer. Eur J Surg Oncol 34: 593-598.
22. Shinohara ET, Gonzalez A, Massion PP, Chen H, Li M, et al. (2005) Nuclear survivin predicts recurrence and poor survival in patients with resected nonsmall cell lung carcinoma. Cancer 103: 1685-1692.
23. Fan J, Wang L, Jiang GN, He WX, Ding JA, (2008) The role of survivin on overall survival of non-small cell lung cancer, a meta-analysis of published literatures. Lung Cancer 61: 91-96.
24. Mohamed S, Yasufuku K, Nakajima T, Hiroshima K, Chiyo M, et al. (2009) Nuclear survivin in pN2 nonsmall cell lung cancer: prognostic and clinical implications. Eur Respir J 33: 127-133.
25. Xu P, Xu XL, Huang Q, Zhang ZH, Zhang YB, (2012) CIP2A with survivin protein expressions in human non-small-cell lung cancer correlates with prognosis. Med Oncol 29: 1643-1647.
26. Roos WP, Kaina B (2012) DNA damage-induced apoptosis: From specific DNA lesions to the DNA damage response and apoptosis. Cancer Lett.
27. Friesland S, Kanter-Lewensohn L, Tell R, Munck-Wikland E, Lewensohn R, et al. (2003) Expression of Ku86 confers favorable outcome of tonsillar carcinoma treated with radiotherapy. Head Neck 25: 313-321.
28. Colnaghi R, Connell CM, Barrett RM, Wheatley SP, (2006) Separating the anti-apoptotic and mitotic roles of survivin. J Biol Chem 281: 33450-33456.
29. Knauer SK, Bier C, Habtemichael N, Stauber RH, (2006) The Survivin-Crm1 interaction is essential for chromosomal passenger complex localization and function.EMBO Rep. 7: 1259-1265.
30. Ghosh JC, Dohi T, Raskett CM, Kowalik TF, Altieri DC, (2006) Activated checkpoint kinase 2 provides a survival signal for tumor cells. Cancer Res 66: 11576-11579.
31. Reichert S, Rodel C, Mirsch J, Harter PN, Tomicic MT, et al. (2011) Survivin inhibition and DNA double-strand break repair: a molecular mechanism to overcome radioresistance in glioblastoma. Radiother Oncol 101: 51-58.
32. Soderlund Leifler K, Queseth S, Fornander T, Askmalm MS, (2010) Low expression of Ku70/80, but high expression of DNA-PKcs, predict good response to radiotherapy in early breast cancer. Int J Oncol 37: 1547-1554.
33. Beskow C, Skikuniene J, Holgersson A, Nilsson B, Lewensohn R, et al. (2009) Radioresistant cervical cancer shows upregulation of the NHEJ proteins DNA-PKcs, Ku70 and Ku86. Br J Cancer 101: 816-821.
34. Bouchaert P, Guerif S, Debiais C, Irani J, Fromont G (2012) DNA-PKcs Expression Predicts Response to Radiotherapy in Prostate Cancer. Int J Radiat Oncol Biol Phys.
35. Noguchi T, Shibata T, Fumoto S, Uchida Y, Mueller W, et al. (2002) DNA-PKcs expression in esophageal cancer as a predictor for chemoradiation therapeutic sensitivity. Ann Surg Oncol 9: 1017-1022.