-
1
-
-
33845921542
-
NAD + metabolism in health and disease
-
doi: 10.1016/j.tibs.2006.11.006
-
Belenky P, Bogan KL, Brenner C (2007) NAD + metabolism in health and disease. Trends Biochem Sci 32(1):12-19. doi: 10.1016/j.tibs.2006.11.006
-
(2007)
Trends Biochem Sci
, vol.32
, Issue.1
, pp. 12-19
-
-
Belenky, P.1
Bogan, K.L.2
Brenner, C.3
-
2
-
-
84865411082
-
The dynamic regulation of NAD metabolism in mitochondria
-
doi: 10.1016/j.tem.2012.06.005
-
Stein LR, Imai S (2012) The dynamic regulation of NAD metabolism in mitochondria. Trends Endocrinol Metab 23(9):420-428. doi: 10.1016/j.tem.2012.06. 005
-
(2012)
Trends Endocrinol Metab
, vol.23
, Issue.9
, pp. 420-428
-
-
Stein, L.R.1
Imai, S.2
-
3
-
-
33846693322
-
The regulation of nicotinamide adenine dinucleotide biosynthesis by Nampt/PBEF/visfatin in mammals
-
doi: 10.1097/MOG.0b013e32801b3c8f
-
Revollo JR, Grimm AA, Imai S (2007) The regulation of nicotinamide adenine dinucleotide biosynthesis by Nampt/PBEF/visfatin in mammals. Curr Opin Gastroenterol 23(2):164-170. doi: 10.1097/MOG.0b013e32801b3c8f
-
(2007)
Curr Opin Gastroenterol
, vol.23
, Issue.2
, pp. 164-170
-
-
Revollo, J.R.1
Grimm, A.A.2
Imai, S.3
-
4
-
-
63149089930
-
The NAD world: A new systemic regulatory network for metabolism and aging-Sirt1, systemic NAD biosynthesis, and their importance
-
doi: 10.1007/s12013-008-9041-4
-
Imai S (2009) The NAD world: a new systemic regulatory network for metabolism and aging-Sirt1, systemic NAD biosynthesis, and their importance. Cell Biochem Biophys 53(2):65-74. doi: 10.1007/s12013-008-9041-4
-
(2009)
Cell Biochem Biophys
, vol.53
, Issue.2
, pp. 65-74
-
-
Imai, S.1
-
5
-
-
2042500141
-
Enzymology of NAD + synthesis
-
Magni G, Amici A, Emanuelli M, Raffaelli N, Ruggieri S (1999) Enzymology of NAD + synthesis. Adv Enzymol Relat Areas Mol Biol 73:135-182
-
(1999)
Adv Enzymol Relat Areas Mol Biol
, vol.73
, pp. 135-182
-
-
Magni, G.1
Amici, A.2
Emanuelli, M.3
Raffaelli, N.4
Ruggieri, S.5
-
6
-
-
50949120914
-
Nicotinic acid, nicotinamide, and nicotinamide riboside: A molecular evaluation of NAD + precursor vitamins in human nutrition
-
doi: 10.1146/annurev. nutr.28.061807.155443
-
Bogan KL, Brenner C (2008) Nicotinic acid, nicotinamide, and nicotinamide riboside: a molecular evaluation of NAD + precursor vitamins in human nutrition. Annu Rev Nutr 28:115-130. doi: 10.1146/annurev. nutr.28.061807.155443
-
(2008)
Annu Rev Nutr
, vol.28
, pp. 115-130
-
-
Bogan, K.L.1
Brenner, C.2
-
7
-
-
10944270187
-
The NAD biosynthesis pathway mediated by nicotinamide phosphoribosyltransferase regulates Sir2 activity in mammalian cells
-
doi: 10.1074/jbc. M408388200
-
Revollo JR, Grimm AA, Imai S (2004) The NAD biosynthesis pathway mediated by nicotinamide phosphoribosyltransferase regulates Sir2 activity in mammalian cells. J Biol Chem 279(49):50754-50763. doi: 10.1074/jbc. M408388200
-
(2004)
J Biol Chem
, vol.279
, Issue.49
, pp. 50754-50763
-
-
Revollo, J.R.1
Grimm, A.A.2
Imai, S.3
-
8
-
-
77954274504
-
The PARP side of the nucleus: Molecular actions, physiological outcomes, and clinical targets
-
doi: 10.1016/j. molcel.2010.06.017
-
Krishnakumar R, Kraus WL (2010) The PARP side of the nucleus: molecular actions, physiological outcomes, and clinical targets. Mol Cell 39(1):8-24. doi: 10.1016/j. molcel.2010.06.017
-
(2010)
Mol Cell
, vol.39
, Issue.1
, pp. 8-24
-
-
Krishnakumar, R.1
Kraus, W.L.2
-
9
-
-
84865731753
-
The role of PARP-1 and PARP-2 enzymes in metabolic regulation and disease
-
doi: 10.1016/j.cmet.2012.06.016
-
Bai P, Canto C (2012) The role of PARP-1 and PARP-2 enzymes in metabolic regulation and disease. Cell Metab 16(3):290-295. doi: 10.1016/j.cmet.2012.06. 016
-
(2012)
Cell Metab
, vol.16
, Issue.3
, pp. 290-295
-
-
Bai, P.1
Canto, C.2
-
10
-
-
0037881920
-
Functional aspects of protein mono-ADP-ribosylation
-
doi: 10.1093/emboj/cdg209
-
Corda D, Di Girolamo M (2003) Functional aspects of protein mono-ADP-ribosylation. EMBO J 22(9):1953-1958. doi: 10.1093/emboj/cdg209
-
(2003)
EMBO J
, vol.22
, Issue.9
, pp. 1953-1958
-
-
Corda, D.1
Di Girolamo, M.2
-
11
-
-
0035033022
-
Physiological functions of cyclic ADP-ribose and NAADP as calcium messengers
-
doi: 10.1146/annurev.pharmtox.41.1.317
-
Lee HC (2001) Physiological functions of cyclic ADP-ribose and NAADP as calcium messengers. Annu Rev Pharmacol Toxicol 41:317-345. doi: 10.1146/annurev.pharmtox.41.1.317
-
(2001)
Annu Rev Pharmacol Toxicol
, vol.41
, pp. 317-345
-
-
Lee, H.C.1
-
12
-
-
77952547233
-
Ten years of NAD dependent SIR2 family deacetylases: Implications for metabolic diseases
-
doi: 10.1016/j.tips.2010.02.003
-
Imai S, Guarente L (2010) Ten years of NAD dependent SIR2 family deacetylases: implications for metabolic diseases. Trends Pharmacol Sci 31(5):212-220. doi: 10.1016/j.tips.2010.02.003
-
(2010)
Trends Pharmacol Sci
, vol.31
, Issue.5
, pp. 212-220
-
-
Imai, S.1
Guarente, L.2
-
13
-
-
79958206937
-
Franklin H. Epstein lecture: Sirtuins, aging, and medicine
-
doi: 10.1056/NEJMra1100831
-
Guarente L (2011) Franklin H. Epstein lecture: sirtuins, aging, and medicine. N Eng J Med 364(23):2235-2244. doi: 10.1056/NEJMra1100831
-
(2011)
N Eng J Med
, vol.364
, Issue.23
, pp. 2235-2244
-
-
Guarente, L.1
-
14
-
-
65549103855
-
Circadian clock feedback cycle through NAMPT-mediated NAD + biosynthesis
-
doi: 10.1126/science.1171641
-
Ramsey KM, Yoshino J, Brace CS, Abrassart D, Kobayashi Y, Marcheva B, Hong HK, Chong JL, Buhr ED, Lee C, Takahashi JS, Imai S, Bass J (2009) Circadian clock feedback cycle through NAMPT-mediated NAD + biosynthesis. Science 324(5927):651-654. doi: 10.1126/science.1171641
-
(2009)
Science
, vol.324
, Issue.5927
, pp. 651-654
-
-
Ramsey, K.M.1
Yoshino, J.2
Brace, C.S.3
Abrassart, D.4
Kobayashi, Y.5
Marcheva, B.6
Hong, H.K.7
Chong, J.L.8
Buhr, E.D.9
Lee, C.10
Takahashi, J.S.11
Imai, S.12
Bass, J.13
-
15
-
-
65549118773
-
Circadian control of the NAD + salvage pathway by CLOCKSIRT1
-
doi: 10.1126/science.1170803
-
Nakahata Y, Sahar S, Astarita G, Kaluzova M, Sassone-Corsi P (2009) Circadian control of the NAD + salvage pathway by CLOCKSIRT1. Science 324(5927):654-657. doi: 10.1126/science.1170803
-
(2009)
Science
, vol.324
, Issue.5927
, pp. 654-657
-
-
Nakahata, Y.1
Sahar, S.2
Astarita, G.3
Kaluzova, M.4
Sassone-Corsi, P.5
-
16
-
-
77953290430
-
Clocks in the NAD world: NAD as a metabolic oscillator for the regulation of metabolism and aging
-
doi: 10.1016/j.bbapap.2009.10.024
-
Imai S (2010) "Clocks" in the NAD world: NAD as a metabolic oscillator for the regulation of metabolism and aging. Biochim Biophys Acta 1804(8):1584-1590. doi: 10.1016/j.bbapap.2009.10.024
-
(2010)
Biochim Biophys Acta
, vol.1804
, Issue.8
, pp. 1584-1590
-
-
Imai, S.1
-
17
-
-
80053920774
-
Nicotinamide mononucleotide, a key NAD(+) intermediate, treats the pathophysiology of diet-and age-induced diabetes in mice
-
doi: 10.1016/j. cmet.2011.08.014
-
Yoshino J, Mills KF, Yoon MJ, Imai S (2011) Nicotinamide mononucleotide, a key NAD(+) intermediate, treats the pathophysiology of diet-and age-induced diabetes in mice. Cell Metab 14(4):528-536. doi: 10.1016/j. cmet.2011.08.014
-
(2011)
Cell Metab
, vol.14
, Issue.4
, pp. 528-536
-
-
Yoshino, J.1
Mills, K.F.2
Yoon, M.J.3
Imai, S.4
-
18
-
-
35549002189
-
Nampt/PBEF/visfatin regulates insulin secretion in beta cells as a systemic NAD biosynthetic enzyme
-
doi: 10.1016/j.cmet.2007.09.003
-
Revollo JR, Korner A, Mills KF, Satoh A, Wang T, Garten A, Dasgupta B, Sasaki Y, Wolberger C, Townsend RR, Milbrandt J, Kiess W, Imai S (2007) Nampt/PBEF/visfatin regulates insulin secretion in beta cells as a systemic NAD biosynthetic enzyme. Cell Metab 6(5):363-375. doi: 10.1016/j.cmet.2007.09.003
-
(2007)
Cell Metab
, vol.6
, Issue.5
, pp. 363-375
-
-
Revollo, J.R.1
Korner, A.2
Mills, K.F.3
Satoh, A.4
Wang, T.5
Garten, A.6
Dasgupta, B.7
Sasaki, Y.8
Wolberger, C.9
Townsend, R.R.10
Milbrandt, J.11
Kiess, W.12
Imai, S.13
-
19
-
-
79953752384
-
PARP-1 inhibition increases mitochondrial metabolism through SIRT1 activation
-
doi: 10.1016/j.cmet.2011.03.004
-
Bai P, Canto C, Oudart H, Brunyanszki A, Cen Y, Thomas C, Yamamoto H, Huber A, Kiss B, Houtkooper RH, Schoonjans K, Schreiber V, Sauve AA, Menissier-de Murcia J, Auwerx J (2011) PARP-1 inhibition increases mitochondrial metabolism through SIRT1 activation. Cell Metab 13(4):461-468. doi: 10.1016/j.cmet.2011.03.004
-
(2011)
Cell Metab
, vol.13
, Issue.4
, pp. 461-468
-
-
Bai, P.1
Canto, C.2
Oudart, H.3
Brunyanszki, A.4
Cen, Y.5
Thomas, C.6
Yamamoto, H.7
Huber, A.8
Kiss, B.9
Houtkooper, R.H.10
Schoonjans, K.11
Schreiber, V.12
Sauve, A.A.13
Menissier-De Murcia, J.14
Auwerx, J.15
-
20
-
-
36049038217
-
The enzyme CD38 (a NAD glycohydrolase, EC 3.2.2.5) is necessary for the development of diet-induced obesity
-
doi: 10.1096/fj.07-8290com
-
Barbosa MT, Soares SM, Novak CM, Sinclair D, Levine JA, Aksoy P, Chini EN (2007) The enzyme CD38 (a NAD glycohydrolase, EC 3.2.2.5) is necessary for the development of diet-induced obesity. FASEB J 21(13):3629-3639. doi: 10.1096/fj.07-8290com
-
(2007)
FASEB J
, vol.21
, Issue.13
, pp. 3629-3639
-
-
Barbosa, M.T.1
Soares, S.M.2
Novak, C.M.3
Sinclair, D.4
Levine, J.A.5
Aksoy, P.6
Chini, E.N.7
-
21
-
-
78650987216
-
Sirtuin-1 regulation of mammalian metabolism
-
doi: 10.1016/j. molmed.2010.09.005
-
Gillum MP, Erion DM, Shulman GI (2010) Sirtuin-1 regulation of mammalian metabolism. Trends Mol Med. doi: 10.1016/j. molmed.2010.09.005
-
(2010)
Trends Mol Med
-
-
Gillum, M.P.1
Erion, D.M.2
Shulman, G.I.3
-
22
-
-
84859429591
-
Sirtuins in cognitive ageing and Alzheimer's disease
-
doi: 10.1097/YCO.0b013e32835112c1
-
Braidy N, Jayasena T, Poljak A, Sachdev PS (2012) Sirtuins in cognitive ageing and Alzheimer's disease. Curr Opin Psychiatry 25(3):226-230. doi: 10.1097/YCO.0b013e32835112c1
-
(2012)
Curr Opin Psychiatry
, vol.25
, Issue.3
, pp. 226-230
-
-
Braidy, N.1
Jayasena, T.2
Poljak, A.3
Sachdev, P.S.4
-
23
-
-
77955046461
-
SIRT1 Suppresses beta-amyloid production by activating the alpha-secretase gene ADAM10
-
doi: 10.1016/j. cell.2010.06.020
-
Donmez G, Wang D, Cohen DE, Guarente L (2010) SIRT1 Suppresses beta-amyloid production by activating the alpha-secretase gene ADAM10. Cell 142(2):320-332. doi: 10.1016/j. cell.2010.06.020
-
(2010)
Cell
, vol.142
, Issue.2
, pp. 320-332
-
-
Donmez, G.1
Wang, D.2
Cohen, D.E.3
Guarente, L.4
-
24
-
-
82355190885
-
Sirt1 is a regulator of bone mass and a repressor of sost encoding for sclerostin, a bone formation inhibitor
-
doi: 10.1210/en.2011-1128
-
Cohen-Kfir E, Artsi H, Levin A, Abramowitz E, Bajayo A, Gurt I, Zhong L, D'Urso A, Toiber D, Mostoslavsky R, Dresner-Pollak R (2011) Sirt1 is a regulator of bone mass and a repressor of sost encoding for sclerostin, a bone formation inhibitor. Endocrinology 152(12):4514-4524. doi: 10.1210/en.2011-1128
-
(2011)
Endocrinology
, vol.152
, Issue.12
, pp. 4514-4524
-
-
Cohen-Kfir, E.1
Artsi, H.2
Levin, A.3
Abramowitz, E.4
Bajayo, A.5
Gurt, I.6
Zhong, L.7
D'Urso, A.8
Toiber, D.9
Mostoslavsky, R.10
Dresner-Pollak, R.11
-
25
-
-
80054979571
-
Nicotinamide phosphoribosyltransferase (Nampt) affects the lineage fate determination of mesenchymal stem cells: A possible cause for reduced osteogenesis and increased adipogenesis in older individuals
-
doi: 10.1002/jbmr.480
-
Li Y, He X, Li Y, He J, Anderstam B, Andersson G, Lindgren U (2011) Nicotinamide phosphoribosyltransferase (Nampt) affects the lineage fate determination of mesenchymal stem cells: a possible cause for reduced osteogenesis and increased adipogenesis in older individuals. J Bone Miner Res 26(11):2656-2664. doi: 10.1002/jbmr.480
-
(2011)
J Bone Miner Res
, vol.26
, Issue.11
, pp. 2656-2664
-
-
Li, Y.1
He, X.2
Li, Y.3
He, J.4
Anderstam, B.5
Andersson, G.6
Lindgren, U.7
-
26
-
-
79952501323
-
SIRT3 opposes reprogramming of cancer cell metabolism through HIF1alpha destabilization
-
doi: 10.1016/j.ccr.2011.02.014
-
Finley LW, Carracedo A, Lee J, Souza A, Egia A, Zhang J, Teruya-Feldstein J, Moreira PI, Cardoso SM, Clish CB, Pandolfi PP, Haigis MC (2011) SIRT3 opposes reprogramming of cancer cell metabolism through HIF1alpha destabilization. Cancer Cell 19(3):416-428. doi: 10.1016/j.ccr.2011.02.014
-
(2011)
Cancer Cell
, vol.19
, Issue.3
, pp. 416-428
-
-
Finley, L.W.1
Carracedo, A.2
Lee, J.3
Souza, A.4
Egia, A.5
Zhang, J.6
Teruya-Feldstein, J.7
Moreira, P.I.8
Cardoso, S.M.9
Clish, C.B.10
Pandolfi, P.P.11
Haigis, M.C.12
-
27
-
-
84870874690
-
The histone deacetylase SIRT6 is a tumor suppressor that controls cancer metabolism
-
doi: 10.1016/j.cell.2012.10.047
-
Sebastian C, Zwaans BM, Silberman DM, Gymrek M, Goren A, Zhong L, Ram O, Truelove J, Guimaraes AR, Toiber D, Cosentino C, Greenson JK, Macdonald AI, McGlynn L, Maxwell F, Edwards J, Giacosa S, Guccione E, Weissleder R, Bernstein BE, Regev A, Shiels PG, Lombard DB, Mostoslavsky R (2012) The histone deacetylase SIRT6 is a tumor suppressor that controls cancer metabolism. Cell 151(6):1185-1199. doi: 10.1016/j.cell.2012.10.047
-
(2012)
Cell
, vol.151
, Issue.6
, pp. 1185-1199
-
-
Sebastian, C.1
Zwaans, B.M.2
Silberman, D.M.3
Gymrek, M.4
Goren, A.5
Zhong, L.6
Ram, O.7
Truelove, J.8
Guimaraes, A.R.9
Toiber, D.10
Cosentino, C.11
Greenson, J.K.12
MacDonald, A.I.13
McGlynn, L.14
Maxwell, F.15
Edwards, J.16
Giacosa, S.17
Guccione, E.18
Weissleder, R.19
Bernstein, B.E.20
Regev, A.21
Shiels, P.G.22
Lombard, D.B.23
Mostoslavsky, R.24
more..
-
28
-
-
84862022077
-
The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat dietinduced obesity
-
doi: 10.1016/j.cmet.2012.04.022
-
Canto C, Houtkooper RH, Pirinen E, Youn DY, Oosterveer MH, Cen Y, Fernandez-Marcos PJ, Yamamoto H, Andreux PA, Cettour-Rose P, Gademann K, Rinsch C, Schoonjans K, Sauve AA, Auwerx J (2012) The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat dietinduced obesity. Cell Metab 15(6):838-847. doi: 10.1016/j.cmet.2012.04.022
-
(2012)
Cell Metab
, vol.15
, Issue.6
, pp. 838-847
-
-
Canto, C.1
Houtkooper, R.H.2
Pirinen, E.3
Youn, D.Y.4
Oosterveer, M.H.5
Cen, Y.6
Fernandez-Marcos, P.J.7
Yamamoto, H.8
Andreux, P.A.9
Cettour-Rose, P.10
Gademann, K.11
Rinsch, C.12
Schoonjans, K.13
Sauve, A.A.14
Auwerx, J.15
-
29
-
-
84875431269
-
Flavonoid apigenin is an inhibitor of the NAD + ase CD38: Implications for cellular NAD + metabolism, protein acetylation, and treatment of metabolic syndrome
-
doi: 10.2337/db12-1139
-
Escande C, Nin V, Price NL, Capellini V, Gomes AP, Barbosa MT, O'Neil L, White TA, Sinclair DA, Chini EN (2012) Flavonoid apigenin is an inhibitor of the NAD + ase CD38: implications for cellular NAD + metabolism, protein acetylation, and treatment of metabolic syndrome. Diabetes. doi: 10.2337/db12-1139
-
(2012)
Diabetes
-
-
Escande, C.1
Nin, V.2
Price, N.L.3
Capellini, V.4
Gomes, A.P.5
Barbosa, M.T.6
O'Neil, L.7
White, T.A.8
Sinclair, D.A.9
Chini, E.N.10
-
30
-
-
77952549055
-
A possibility of nutriceuticals as an anti-aging intervention: Activation of sirtuins by promoting mammalian NAD biosynthesis
-
doi: 10.1016/j.phrs.2010.01.006
-
Imai S (2010) A possibility of nutriceuticals as an anti-aging intervention: activation of sirtuins by promoting mammalian NAD biosynthesis. Pharmacol Res 62(1):42-47. doi: 10.1016/j.phrs.2010.01.006
-
(2010)
Pharmacol Res
, vol.62
, Issue.1
, pp. 42-47
-
-
Imai, S.1
-
31
-
-
0242526050
-
FK866, a highly specific noncompetitive inhibitor of nicotinamide phosphoribosyltransferase, represents a novel mechanism for induction of tumor cell apoptosis
-
Hasmann M, Schemainda I (2003) FK866, a highly specific noncompetitive inhibitor of nicotinamide phosphoribosyltransferase, represents a novel mechanism for induction of tumor cell apoptosis. Cancer Res 63(21): 7436-7442
-
(2003)
Cancer Res
, vol.63
, Issue.21
, pp. 7436-7442
-
-
Hasmann, M.1
Schemainda, I.2
|