Effects of Adult Exposure to Bisphenol A on Genes Involved in the Physiopathology of Rat Prefrontal Cortex

PLoS ONE

Volumn 8, Issue 9, 2013, Pages

  Castro, Beatriz ^a   Sánchez, Pilar ^a   Torres, Jesús M ^a   Ortega, Esperanza ^a  

^a UNIVERSITY OF GRANADA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; 4,4' ISOPROPYLIDENEDIPHENOL; AROMATASE; MESSENGER RNA; SEROTONIN; STEROID 5ALPHA REDUCTASE; TRYPTOPHAN HYDROXYLASE; TRYPTOPHAN HYDROXYLASE 2;

5ALPHA R1 GENE; 5ALPHA R2 GENE; 5ALPHA R3 GENE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN DYSFUNCTION; CONTROLLED STUDY; FEMALE; GABAERGIC SYSTEM; GENE; GENE EXPRESSION; LONG TERM EXPOSURE; MALE; NERVE CELL PLASTICITY; NEUROPATHOLOGY; NEUROTOXICITY; NONHUMAN; NUCLEOTIDE SEQUENCE; P450AROM GENE; POLYMERASE CHAIN REACTION; PREFRONTAL CORTEX; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; RAT; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEROTONIN METABOLISM; SEROTONINERGIC SYSTEM; SEX DIFFERENCE; TPH1 GENE; TPH2 GENE; WESTERN BLOTTING;

ANIMALS; AROMATASE; BENZHYDRYL COMPOUNDS; BLOTTING, WESTERN; CHOLESTENONE 5 ALPHA-REDUCTASE; FEMALE; MALE; PHENOLS; PREFRONTAL CORTEX; RATS; REAL-TIME POLYMERASE CHAIN REACTION; TRYPTOPHAN HYDROXYLASE;

EID: 84884169498     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0073584     Document Type: Article

References (61)

1. Vandenberg LN, Hauser R, Marcus M, Olea N, Welshons WV, (2007) Human exposure to bisphenol A (BPA). Reprod Toxicol 24: 139-177.
2. Pulgar R, Olea-Serrano MF, Novillo-Fertrell A, Rivas A, Pazos P, et al. (2000) Determination of bisphenol A and related aromatic compounds released from bis-GMA-based composites and sealants by high performance liquid chromatography. Environ Health Perspect 108: 21-27.
3. Nadal A, (2013) Obesity: Fat from plastics? Linking bisphenol A exposure and obesity. Nat Rev Endocrinol 9: 9-10.
4. Cabaton NJ, Wadia PR, Rubin BS, Zalko D, Schaeberle CM, et al. (2011) Perinatal exposure to environmentally relevant levels of bisphenol A decreases fertility and fecundity in CD-1 mice. Environ Health Perspect 119: 547-552.
5. Castro B, Sánchez P, Torres JM, Preda O, Del Moral RG, et al. (2013) Bisphenol A Exposure during Adulthood Alters Expression of Aromatase and 5α-Reductase Isozymes in Rat Prostate. PLoS One 8: e55905.
6. Batista TM, Alonso-Magdalena P, Vieira E, Amaral ME, Cederroth CR, et al. (2012) Short-term treatment with bisphenol-A leads to metabolic abnormalities in adult male mice. PLoS One 7: e33814.
7. Richter CA, Birnbaum LS, Farabollini F, Newbold RR, Rubin BS, et al. (2007) In vivo effects of bisphenol A in laboratory rodent studies. Reprod Toxicol 24: 199-224.
8. Brown JS Jr, (2009) Effects of bisphenol-A and other endocrine disruptors compared with abnormalities of schizophrenia: an endocrine-disruption theory of schizophrenia. Schizophr Bull 35: 256-278.
9. Wolstenholme JT, Rissman EF, Connelly JJ, (2011) The role of Bisphenol A in shaping the brain, epigenome and behavior. Horm Behav 59: 296-305.
10. Inagaki T, Frankfurt M, Luine V, (2012) Estrogen-induced memory enhancements are blocked by acute bisphenol A in adult female rats: role of dendritic spines. Endocrinology 153: 3357-3367.
11. Eilam-Stock T, Serrano P, Frankfurt M, Luine V, (2012) Bisphenol-A impairs memory and reduces dendritic spine density in adult male rats. Behav Neurosci 126: 175-185.
12. Barbaccia ML, Serra M, Purdy RH, Biggio G, (2001) Stress and neuroactive steroids. Int Rev Neurobiol 46: 243-272.
13. Paul SM, Purdy RH, (1992) Neuroactive steroids. FASEB J 6: 2311-2322.
14. Mahendroo MS, Cala KM, Landrum DP, Russell DW, (1997) Fetal death in mice lacking 5alpha-Reductase type 1 caused by estrogen excess. Mol Endocrinol 11: 917-927.
15. Torres JM, Ortega E, (2003) Differential regulation of steroid 5alpha-reductase isozymes expression by androgens in the adult rat brain. FASEB J 17: 1428-1433.
16. Torres JM, Ortega E, (2006) Steroid 5α-Reductase isozymes in the adult female rat brain. Central role of dihydrotestosterone. J Mol Endocrinol 36: 239-245.
17. Calza A, Sogliano C, Santoru F, Marra C, Angioni MM, et al. (2010) Neonatal exposure to estradiol in rats influences neuroactive steroid concentrations, GABAA receptor expression, and behavioral sensitivity to anxiolytic drugs. J Neurochem 113: 1285-1295.
18. Waider J, Proft F, Langlhofer G, Asan E, Lesch KP, et al. (2013) GABA concentration and GABAergic neuron populations in limbic areas are differentially altered by brain serotonin deficiency in Tph2 knockout mice. Histochem Cell Biol 139: 267-281.
19. Fuster JM, (2001) The Prefrontal Cortex-An Update: Review Time Is of the Essence. Neuron 30: 319-333.
20. Geyer MA, Vollenweider FX, (2008) Serotonin research: contributions to understanding psychoses. Trends in Pharmacological Sciences 29: 445-453.
21. Snyder SH, (2011) Serotonin, cytokines, p11, and depression. Proc Natl Acad Sci USA 108: 8923-8924.
22. Pjevac M, Pregelj P, (2012) Neurobiology of suicidal behaviour. Psychiatr Danub 24: S336-341.
23. Chen GL, Miller GM, (2012) Advances in tryptophan hydroxylase-2 gene expression regulation: new insights into serotonin-stress interaction and clinical implications. Am J Med Genet B Neuropsychiatr Genet 159B: 152-171.
24. Walther DJ, Bader M, (2003) A unique central tryptophan hydroxylase isoform. Biochem Pharmacol 66: 1673-1680.
25. Paxinos G, Watson C (1986) The Rat Brain in Stereotaxic Coordinates, Second Edition. Academic Press, New York.
26. Prins GS, Ye SH, Birch L, Ho SM, Kannan K, (2011) Serum bisphenol A pharmacokinetics and prostate neoplastic responses following oral and subcutaneous exposures in neonatal Sprague-Dawley rats. Reprod Toxicol 31: 1-9.
27. Fronhoffs S, Totzke G, Stier S, Wernert N, Rothe M, et al. (2002) A method for the rapid construction of cRNA standard curves in quantitative real-time reverse transcription polymerase chain reaction. Mol Cell Probes 16: 99-110.
28. Bradford MN, (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein dye-binding. Anal Biochem 72: 248-254.
29. Torres JM, Ruiz E, Ortega E, (2001) Effects of CRH and ACTH administration on plasma and brain neurosteroid levels. Neurochem Res 26: 555-558.
30. Turkmen S, Backstrom T, Wahlstrom G, Andreen L, Johansson IM, (2011) Tolerance to allopregnanolone with focus on the GABA-A receptor. Br J Pharmacol 162: 311-327.
31. Birzniece V, Bäckström T, Johansson IM, Lindblad C, Lundgren P, et al. (2006) Neuroactive steroid effects on cognitive functions with a focus on the serotonin and GABA systems. Brain Res Rev 51: 212-239.
32. Chung E, Genco MC, Megrelis L, Ruderman JV, (2011) Effects of bisphenol A and triclocarban on brain-specific expression of aromatase in early zebrafish embryos. Proc Natl Acad Sci USA 108: 17732-17737.
33. Xu XH, Wang YM, Zhang J, Luo QQ, Ye YP, et al. (2010) Perinatal exposure to bisphenol-A changes N-methyl-D-aspartate receptor expression in the hippocampus of male rat offspring. Environ Toxicol Chem 29: 176-181.
34. Murphy DD, Cole NB, Greenberger V, Segal M, (1998) Estradiol increases dendritic spine density by reducing GABA neurotransmission in hippocampal neurons. J Neurosci 18: 2550-2559.
35. Puig MV, Gulledge AT, (2011) Serotonin and prefrontal cortex function: neurons, networks, and circuits. Mol Neurobiol 44: 449-464.
36. Matsuda S, Saika S, Amano K, Shimizu E, Sajiki J, (2010) Changes in brain monoamine levels in neonatal rats exposed to bisphenol A at low doses. Chemosphere 78: 894-906.
37. Nakamura K, Itoh K, Yoshimoto K, Sugimoto T, Fushiki S, (2010) Prenatal and lactational exposure to low-doses of bisphenol A alters brain monoamine concentration in adult mice. Neurosci Lett 484: 66-70.
38. Xu X, Liu X, Zhang Q, Zhang G, Lu Y, et al. (2013) Sex-specific effects of bisphenol-A on memory and synaptic structural modification in hippocampus of adult mice. Horm Behav 63: 766-775.
39. Hiroi R, McDevitt RA, Neumaier JF, (2006) Estrogen selectively increases tryptophan hydroxylase-2 mRNA expression in distinct subregions of rat midbrain raphe nucleus: association between gene expression and anxiety behavior in the open field. Biol Psychiatry 60: 288-295.
40. Emery AC, Pshenichkin S, Takoudjou GR, Grajkowska E, Wolfe BB, et al. (2010) The protective signaling of metabotropic glutamate receptor 1 is mediated by sustained, beta-arrestin-1-dependent ERK phosphorylation. J Biol Chem 285: 26041-26048.
41. Avissar S, Matuzany-Ruban A, Tzukert K, Schreiber G, (2004) Beta-arrestin-1 levels: reduced in leukocytes of patients with depression and elevated by antidepressants in rat brain. Am J Psychiatry 161: 2066-2072.
42. Lisman J, Yasuda R, Raghavachari S, (2012) Mechanisms of CaMKII action in long-term potentiation. Nat Rev Neurosci 13: 169-182.
43. Liu XB, Murray KD, (2012) Neuronal excitability and calcium/calmodulin-dependent protein kinase type II: location, location, location. Epilepsia 1: 45-52.
44. Viberg H, Lee I, (2012) A single exposure to bisphenol A alters the levels of important neuroproteins in adult male and female mice. Neurotoxicology 33: 1390-1395.
45. Meffert MK, Chang JM, Wiltgen BJ, Fanselow MS, Baltimore D, (2003) NF-kappa B functions in synaptic signaling and behavior. Nat Neurosci 6: 1072-1078.
46. Igarashi A, Ohtsu S, Muroi M, Tanamoto K, (2006) Effects of possible endocrine disrupting chemicals on bacterial component-induced activation of NF-kappaB. Biol Pharm Bull 29: 2120-2122.
47. Fang M, Jaffrey SR, Sawa A, Ye K, Luo X, et al. (2000) Dexras1: a G protein specifically coupled to neuronal nitric oxide synthase via CAPON. Neuron 28: 183-193.
48. Zhou L, Zhu DY, (2009) Neuronal nitric oxide synthase: structure, subcellular localization, regulation, and clinical implications. Nitric Oxide 20: 223-230.
49. Jaffrey SR, Snyder SH, (1996) PIN: an associated protein inhibitor of neuronal nitric oxide synthase. Science 274: 774-777.
50. Martini M, Miceli D, Gotti S, Viglietti-Panzica C, Fissore E, et al. (2010) Effects of perinatal administration of Bisphenol A on the neuronal nitric oxide synthase expressing system in the hypothalamus and limbic system of CD1 mice. J Neuroendocrinol 22: 1004-1012.
51. Katafuchi T, Li AJ, Hirota S, Kitamura Y, Hori T, (2000) Impairment of spatial learning and hippocampal synaptic potentiation in c-kit mutant rats. Learn Mem 7: 383-392.
52. St OngeJR, Abhari H, Floresco SB, (2011) Dissociable contributions by prefrontal D1 and D2 receptors to risk-based decision making. J Neurosci 31: 8625-8633.
53. Zhang Y, Bertolino A, Fazio L, Blasi G, Rampino A, et al. (2007) Polymorphisms in human dopamine D2 receptor gene affect gene expression, splicing, and neuronal activity during working memory. Proc Natl Acad Sci USA 104: 20552-20557.
54. Zhou R, Zhang Z, Zhu Y, Chen L, Sokabe M, et al. (2009) Deficits in development of synaptic plasticity in rat dorsal striatum following prenatal and neonatal exposure to low-dose bisphenol A. Neuroscience. 159: 161-171.
55. Woo RS, Li XM, Tao Y, Carpenter-Hyland E, Huang YZ, et al. (2007) Neuregulin-1 enhances depolarization-induced GABA release. Neuron 54: 599-610.
56. Chen Y, Fu AK, Ip NY, (2008) Bidirectional signaling of ErbB and Eph receptors at synapses. Neuron Glia Biol 4: 211-221.
57. Conover CA, Bale LK, Overgaard MT, Johnstone EW, Laursen UH, et al. (2004) Metalloproteinase pregnancy-associated plasma protein A is a critical growth regulatory factor during fetal development. Development 131: 1187-1194.
58. Lupien SB, Bluhm EJ, Ishii DN, (2003) Systemic insulin-like growth factor-I administration prevents cognitive impairment in diabetic rats, and brain IGF regulates learning/memory in normal adult rats. J Neurosci Res 74: 512-523.
59. O'Kusky J, Ye P, (2012) Neurodevelopmental effects of insulin-like growth factor signaling. Front Neuroendocrinol 33: 230-251.
60. Klotz DM, Hewitt SC, Korach KS, Diaugustine RP, (2000) Activation of a uterine insulin-like growth factor I signaling pathway by clinical and environmental estrogens: requirement of estrogen receptor-alpha. Endocrinology 141: 3430-3439.
61. Derijck AA, Van Erp S, Pasterkamp RJ, (2010) Semaphorin signaling: molecular switches at the midline. Trends Cell Biol 20: 568-576.