Effects of pharmaceutical excipients on membrane permeability in rat small intestine

International Journal of Pharmaceutics

Volumn 453, Issue 2, 2013, Pages 363-370

  Takizawa, Yusuke ^a   Kishimoto, Hisanao ^a   Nakagawa, Minami ^a   Sakamoto, Nasa ^a   Tobe, Yoshifusa ^a   Furuya, Takahito ^a   Tomita, Mikio ^b   Hayashi, Masahiro ^c  

^a TOKYO UNIVERSITY OF PHARMACY AND LIFE SCIENCES   (Japan)

^b TOHOKU PHARMACEUTICAL UNIVERSITY   (Japan)

^c TAKASAKI UNIVERSITY OF HEALTH AND WELFARE   (Japan)

Author keywords

Membrane permeability; Paracellular route; Pharmaceutical excipient; Small intestine

Indexed keywords

6 CARBOXYFLUORESCEIN; BETA CYCLODEXTRIN; CROSCARMELLOSE SODIUM; DILUENT; DISINTEGRATING AGENT; ETHYL CELLULOSE; EXCIPIENT; GLYCEROL STEARATE; HYDROXYPROPYLCELLULOSE; HYDROXYPROPYLMETHYLCELLULOSE; LUBRICATING AGENT; MAGNESIUM STEARATE; METHYLCELLULOSE; MICROCRYSTALLINE CELLULOSE; POVIDONE; PULLULAN; SILICIC ACID; STARCH; STEARIC ACID; TALC;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG FORMULATION; ILEUM; IN VITRO STUDY; INTESTINE MUCOSA PERMEABILITY; JEJUNUM; MEMBRANE TRANSPORT; NONHUMAN; PRIORITY JOURNAL; RAT; SMALL INTESTINE; SMALL INTESTINE ABSORPTION; SUSTAINED DRUG RELEASE;

EID: 84884167024     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2013.05.055     Document Type: Article

References (25)

1. Alvarez-Lorenzo, C., Concheiro, A., 2006. Molecularly imprinted materials as advanced excipients for drug delivery systems. Biotechnol. Annu. Rev. 12, 225-268. (Pubitemid 44509802)
2. Boulmedarat, L., Bochot, A., Lesieur, S., Fattal, E., 2005. Evaluation of buccal methyl-beta-cyclodextrine toxicity on human oral epithelial cell culture model. J. Pharm. Sci. 94, 1300-1309. (Pubitemid 40904193)
3. Cornaire, G., Woodley, J., Hermann, P., Cloarec, A., Arellano, C., Houin, G., 2005. Impact of excipients on the absorption of P-glycoprotein substrates in vitro and in vivo. Int. J. Pharm. 278, 119-131.
4. Doi, N., Tomita, M., Hayashi, M., 2011. Absorption enhancement effect of acylcarnitines through changes in tight junction protein in Caco-2 cell monolayers. Drug Metab. Pharmacokinet. 26, 162-170.
5. Dorkoosh, F.A., Broekhuizen, C.A., Borchard, G., Rafiee-Tehrani, M., Verhoef, J.C., Junginger, H.E., 2004. Transport of octreotide and evaluation of mechanism of opening the paracellular tight junctions using superporous hydrogel polymers in Caco-2 cell monolayers. J. Pharm. Sci. 93, 743-752. (Pubitemid 38332306)
6. Fenyvesi, F., Kiss, T., Fenyvesi, E., Szente, L., Veszelka, S., Deli, M.A., Váradi, J., Fehér, P., Ujhelyi, Z., Tósaki, A., Vecsernyés, M., Bácskay, I., 2011. Randomly methylated-β- cyclodextrin derivatives enhance taxol permeability through human intestinal epithelial Caco-2 cell monolayer. J. Pharm. Sci. 100, 4734-4744.
7. Fujimura, S., Fuse, K., Takane, H., Nakano, Y., Gomi, K., Kikuchi, T., Watanabe, A., 2011. Antibacterial effects of brand-name teicoplanin and generic products against clinical isolates of methicillin-resistant Staphylococcus aureus. J. Infect. Chemother. 17, 30-33.
8. Hayashi, M., Sakai, T., Hasegawa, Y., Nishikawahara, T., Tomioka, H., Iida, A., Shimizu, N., Tomita, M., Awazu, S., 1999. Physiological mechanism for enhancement of paracellular drug transport. J. Control. Release 62, 141-148. (Pubitemid 29486492)
9. Ishizawa, T., Hayashi, M., Awazu, S., 1987. Enhancement of jejunal and colonic absorption of fosfomycin by promoters in the rat. J. Pharm. Pharmacol. 39, 892-895. (Pubitemid 18048638)
10. Lee, V.H., Yamamoto, A., 1990. Penetration and enzymatic barriers to peptide and protein. Adv. Drug Deliv. Rev. 4, 171-207.
11. Lee, V.H., Yamamoto, A., Kompella, U.B., 1991. Mucosal penetration enhancers for facilitation of peptide and protein drug absorption. Crit. Rev. Ther. Drug Carrier Syst. 8, 91-192.
12. Markov, A.G., Veshnyakova, A., Fromm, M., Amasheh, M., Amasheh, S., 2010. Segmental expression of claudin proteins correlates with tight junction barrier properties in rat intestine. J. Comp. Physiol. B 180, 591-598.
13. Maruyama, M., Ishida, K., Watanabe, Y., Nishikawa, M., Takakura, Y., 2009. Effects of methyl-beta-cyclodextrin treatment on secretion profile of interferon-beta and zonula occuludin-1 architecture in Madin-Darby canine kidney cell monolayers. Biol. Pharm. Bull. 35, 910-915.
14. Merzlikine, A., Rotter, C., Rago, B., Poe, J., Christoffersen, C., Thomas, V.H., Troutman, M., El-Kattan, A., 2009. Effect of chitosan glutamate, carbomer 974P, and EDTA on the in vitro Caco-2 permeability and oral pharmacokinetic profile of acyclovir in rats. Drug Dev. Ind. Pharm. 35, 1082-1091.
15. Mudra, D.R., Borchardt, R.T., 2010. Absorption barriers in the rat intestinal mucosa. 3: Effects of polyethoxylated solubilizing agents on drug permeation and metabolism. J. Pharm. Sci. 99, 1016-1027.
16. Pathak, S.M., Musmade, P., Dengle, S., Karthik, A., Bhat, K., Udupa, N., 2010. Enhanced oral absorption of saquinavir with methly-beta-cyclodextrine- preparation and in vitro and in vivo evaluation. Eur. J. Pharm. Sci. 41, 440-451.
17. Salama, N.N., Fasano, A., Thakar, M., Eddington, N.D., 2004. The effect of delta G on the transport and oral absorption of macromolecules. J. Pharm. Sci. 93, 1310-1319. (Pubitemid 38529704)
18. Sawada, T., Sako, K., Fukui, M., Yokohama, S., Hayashi, M., 2003. A new index, the core erosion ratio, of compression-coated timed-release tablets predicts the bioavailability of acetaminophen. Int. J. Pharm. 265, 55-63. (Pubitemid 37176946)
19. Sugibayashi, K., Onuki, Y., Takayama, K., 2009. Displacement of tight junction proteins from detergent-resistant membrane domains by treatment with sodium caprate. Eur. J. Pharm. Sci. 36, 246-253.
20. Takahashi, Y., Kondo, H., Yasuda, T., Watanabe, T., Kobayashi, S., Yokohama, S., 2004. Common solubilizers to estimate the Caco-2 transport of poorly water-soluble drugs. Int. J. Pharm. 246, 85-94. (Pubitemid 35247981)
21. Takahashi, T., Yamada, Y., Kataoka, K., Nagasaki, Y., 2005. Preparation of a novel PEG-clay hybrid as a DDS material: dispersion stability and sustained release profiles. J. Control. Release 107, 408-416. (Pubitemid 41398068)
22. Tomita, M., Hayashi, M., Awazu, S., 1995. Absorption-enhancing mechanism of sodium caprate and decanoylcarnitine in Caco-2 cells. J. Pharmacol. Exp. Ther. 272, 739-743.
23. Tran, H.T., Tran, P.H., Lee, B.J., 2009. New findings on melatonin absorption and alterations by pharmaceuticalexcipients using the Ussing chamber technique with mounted rat gastrointestinal segments. Int. J. Pharm. 378, 9-16.
24. Uekama, K., 2004. Pharamaceutical application of cyclodextrins as multi-functional drug carriers. YAKUGAKU ZASSI 124, 909-935. (Pubitemid 41359094)
25. Wang, K.L., Yang, Y.C., Lai, J.C., Tsai, T.H., Lin, C.P., Wu, Y.T., Chen, Y.Y., Wang, S.C., Chen, Y.J., 2010. Comparison in purity and antitumor effect of brand and generic paclitaxel against human ovarian cancer cells by an in vitro experimental model. Drug Dev. Ind. Pharm. 36, 1253-1258.