Anticancer Activities of Brassinosteroids

Brassinosteroids: Practical Applications in Agriculture and Human Health

Volumn , Issue , 2012, Pages 84-93

  Hoffmannová, Lucie ^a   Steigerová, Jana ^b   Strnad, Miroslav ^a  

^a INSTITUTE OF EXPERIMENTAL BOTANY   (Czech Republic)

^b PALACKÝ UNIVERSITY   (Czech Republic)

Author keywords

Antiangiogenic activity; Anticancer drugs; Apoptosis; Breast cancer; Cell cycle arrest; Metastasis development

Indexed keywords

EID: 84883924394     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.2174/978160805298111201010084     Document Type: Chapter

References (46)

1. Khripach VA, Zhabinskii VN, de Groot AE. Brassinosteroids. A new class of plant hormones. San Diego: Academic Press 1999; 456p.
2. Grove MD, Spencer GF, Rohwedder WK, et al. Brassinolide, a plant growth-promoting steroid isolated from Brassica napus pollen. Nature 1979; 281: 216-7.
3. Sakurai A, Fujioka S. Studies on biosynthesis of brassinosteroids. Biosci Biotechnol Biochem 1997; 61: 757-62.
4. Bajguz A, Tretyn A. The chemical characteristic and distribution of brassinosteroids in plants. Phytochemistry 2003; 62: 1027-46.
5. Bajguz A, Hayat S. Effects of brassinosteroids on the plant responses to environmental stresses. Plant Physiol Biochem 2009; 47: 1-8.
6. Clouse SD, Sasse JM. Brassinosteroids: Essential Regulators of Plant Growth and Development. Annu Rev Plant Physiol Plant Mol Biol 1998; 49427-51.
7. Haubrick LL, Assmann SM. Brassinosteroids and plant function: some clues, more puzzles. Plant Cell Environ 2006; 29: 446-57.
8. Nemhauser JL, Chory J. BRing it on: new insights into the mechanism of brassinosteroid action. J Exp Bot 2004; 55: 265-70.
9. Jiang F, Li P, Fornace AJ, Jr., Nicosia SV, Bai W. G2/M arrest by 1,25-dihydroxyvitamin D3 in ovarian cancer cells mediated through the induction of GADD45 via an exonic enhancer. J Biol Chem 2003; 278: 48030-40.
10. Jun DY, Park HS, Kim JS, et al. 17Alpha-estradiol arrests cell cycle progression at G2/M and induces apoptotic cell death in human acute leukemia Jurkat T cells. Toxicol Appl Pharmacol 2008; 231: 401-12.
11. Hu Y, Bao F, Li J. Promotive effect of brassinosteroids on cell division involves a distinct CycD3-induction pathway in Arabidopsis. Plant J 2000; 24: 693-701.
12. Romanutti C, Castilla V, Coto CE, Wachsman MB. Antiviral effect of a synthetic brassinosteroid on the replication of vesicular stomatitis virus in Vero cells. Int J Antimicrob Agents 2007; 29: 311-6.
13. Wachsman MB, Lopez EM, Ramirez JA, Galagovsky LR, Coto CE. Antiviral effect of brassinosteroids against herpes virus and arenaviruses. Antivir Chem Chemother 2000; 11: 71-7.
14. Wachsman MB, Ramirez JA, Galagovsky LR, Coto CE. Antiviral activity of brassinosteroids derivatives against measles virus in cell cultures. Antivir Chem Chemother 2002; 13: 61-6.
15. Franěk F, Eckschlager T, Kohout L. 24-Epibrassinolide at subnanomolar concentrations modulates growth and production characteristic of a mouse hybridoma. Collect Czech Chem Commun 2003; 68: 2190-2200.
16. Malikova J, Swaczynova J, Kolar Z, Strnad M. Anticancer and antiproliferative activity of natural brassinosteroids. Phytochem 2008; 69: 418-26.
17. Oklešťková J, Hoffmannová L, Steigerová J, Kohout L, Kolář Z, Strnad M. Natural brassinosteroids for use for treating hyperproliferation, treating proliferative diseases and reducing adverse effects of steroid dysfunction in mammals, pharmaceutical composition and its use. US Patent 20100204460, 2010.
18. Newman DJ, Cragg GM. Natural products as sources of new drugs over the last 25 years. J Nat Prod 2007; 70: 461-77.
19. Parl FF. Estrogens, Estrogen Receptor and Breast Cancer. Amsterdam: IOS Press 2000; 263p.
20. Kohout L, Fajkoš J, Šorm F. On Steroids CXXI. B-Homosteroids II. Conformation of the Ring B in BHomosteroid Alcohols and Epoxides. Coll Czech Chem Commun 1969; 34: 601.
21. Hoffmannová L, Steigerová J, Oklešťková J, et al. Cholestane derivatives as antiproliferative and antiangiogenic pharmaceuticals and pharmaceutical preparations containing these compounds. CZ patent application CZ PV 2009-725. 2009.
22. Carmeliet P. Angiogenesis in life, disease and medicine. Nature 2005; 438: 932-6.
23. Folkman J. Tumor angiogenesis. Adv Cancer Res 1974; 19: 331-58.
24. Folkman J, Shing Y. Angiogenesis. J Biol Chem 1992; 267: 10931-4.
25. Bhat TA, Singh RP. Tumor angiogenesis--a potential target in cancer chemoprevention. Food Chem Toxicol 2008; 46: 1334-45.
26. Risau W. Mechanisms of angiogenesis. Nature 1997; 386: 671-4.
27. Bagley RG, Walter-Yohrling J, Cao X, et al. Endothelial precursor cells as a model of tumor endothelium: characterization and comparison with mature endothelial cells. Cancer Res 2003; 63: 5866-73.
28. Gourley M, Williamson JS. Angiogenesis: new targets for the development of anticancer chemotherapies. Curr Pharm Des 2000; 6: 417-39.
29. Ranieri G, Gasparini G. Angiogenesis and angiogenesis inhibitors: a new potential anticancer therapeutic strategy. Curr Drug Targets Immune Endocr Metabol Disord 2001; 1: 241-53.
30. Singh RP, Agarwal R. Tumor angiogenesis: a potential target in cancer control by phytochemicals. Curr Cancer Drug Targets 2003; 3: 205-17.
31. Kesisis G, Broxterman H, Giaccone G. Angiogenesis inhibitors. Drug selectivity and target specificity. Curr Pharm Des 2007; 13: 2795-809.
32. Min JK, Han KY, Kim EC, et al. Capsaicin inhibits in vitro and in vivo angiogenesis. Cancer Res 2004; 64: 644-51.
33. Gong YQ, Fan Y, Wu DZ, Yang H, Hu ZB, Wang ZT. In vivo and in vitro evaluation of erianin, a novel antiangiogenic agent. Eur J Cancer 2004; 40: 1554-65.
34. Bai X, Cerimele F, Ushio-Fukai M, et al. Honokiol, a small molecular weight natural product, inhibits angiogenesis in vitro and tumor growth in vivo. J Biol Chem 2003; 278: 35501-7.
35. Lu H, Murtagh J, Schwartz EL. The microtubule binding drug laulimalide inhibits vascular endothelial growth factor-induced human endothelial cell migration and is synergistic when combined with docetaxel (taxotere). Mol Pharmacol 2006; 69: 1207-15.
36. Eun JP, Koh GY. Suppression of angiogenesis by the plant alkaloid, sanguinarine. Biochem Biophys Res Commun 2004; 317: 618-24.
37. Kim MS, Lee YM, Moon EJ, Kim SE, Lee JJ, Kim KW. Anti-angiogenic activity of torilin, a sesquiterpene compound isolated from Torilis japonica. Int J Cancer 2000; 87: 269-75.
38. Mabjeesh NJ, Escuin D, LaVallee TM, et al. 2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF. Cancer Cell 2003; 3: 363-75.
39. Pietras RJ, Weinberg OK. Antiangiogenic steroids in human cancer therapy. Evid Based Complement Alternat Med 2005; 2: 49-57.
40. Lee YM, Ting CM, Cheng YK, et al. Mechanisms of 2-methoxyestradiol-induced apoptosis and G2/M cellcycle arrest of nasopharyngeal carcinoma cells. Cancer Lett 2008; 268: 295-307.
41. Fellner M. Recent progress in brassinosteroid research: Hormone perception and signal transduction. Amsterdam: Kluwer Academic Publishers 2003; 246p.
42. Belkhadir Y, Chory J. Brassinosteroid signaling: a paradigm for steroid hormone signaling from the cell surface. Science 2006; 314: 1410-1.
43. Losel R, Wehling M. Nongenomic actions of steroid hormones. Nat Rev Mol Cell Biol 2003; 4: 46-56.
44. Pratt WB. The role of heat shock proteins in regulating the function, folding, and trafficking of the glucocorticoid receptor. J Biol Chem 1993; 268: 21455-8.
45. Beato M, Herrlich P, Schutz G. Steroid hormone receptors: many actors in search of a plot. Cell 1995; 83: 851-7.
46. Steigerová J, Oklešťková J, Levková M, Rárová L, Kolář Z, Strnad M. Brassinosteroids cause cell cycle arrest and apoptosis of human breast cancer cells. Chem Biol Interact. 2010, 88(3): 487-96.