Agent-based model of epithelial host-pathogen interactions in anastomotic leak

Journal of Surgical Research

Volumn 184, Issue 2, 2013, Pages 730-738

  Stern, Jordan R ^a   Olivas, Andrea D ^a   Valuckaite, Vesta ^a   Zaborina, Olga ^a   Alverdy, John C ^a   An, Gary ^a  

^a UNIVERSITY OF CHICAGO   (United States)

Author keywords

Agent based modeling; Anastomotic leak; Bacterial virulence; Epithelial restitution; Host pathogen interaction; Preoperative radiation; Pseudomonas aeruginosa

Indexed keywords

INTEGRIN; LAMININ;

ANASTOMOSIS LEAKAGE; ANIMAL CELL; ARTICLE; BACTERIAL VIRULENCE; BINDING SITE; CELL KILLING; EPITHELIUM CELL; GENOTYPE; HOST PATHOGEN INTERACTION; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; RADIATION RESPONSE;

AGENT-BASED MODELING; ANASTOMOTIC LEAK; BACTERIAL VIRULENCE; EPITHELIAL RESTITUTION; HOST-PATHOGEN INTERACTION; PREOPERATIVE RADIATION; PSEUDOMONAS AERUGINOSA;

ANASTOMOSIS, SURGICAL; ANASTOMOTIC LEAK; ANIMALS; BACTERIAL ADHESION; BACTERIAL TRANSLOCATION; CELL MEMBRANE PERMEABILITY; CELLS, CULTURED; COMPUTER SIMULATION; DISEASE MODELS, ANIMAL; EPITHELIAL CELLS; HOST-PATHOGEN INTERACTIONS; INTESTINAL MUCOSA; MODELS, BIOLOGICAL; PHENOTYPE; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTIONS; RATS;

EID: 84883890537     PISSN: 00224804     EISSN: 10958673     Source Type: Journal    
DOI: 10.1016/j.jss.2012.12.009     Document Type: Article

References (31)

1. N. Hyman, T.L. Manchester, T. Osler, B. Burns, and P.A. Cataldo Anastomotic leaks after intestinal anastomosis: it's later than you think Ann Surg 245 2007 254
2. D. Telem, E.H. Chin, S.Q. Nguyen, and C.M. Divino Risk factors for anastomotic leak following colorectal surgery: a case-control study Arch Surg 145 2010 371
3. J. Mammen, and J.B. Matthews Mucosal repair in the gastrointestinal tract Crit Care Med 31 8 Suppl 2003 S532
4. A. Blikslager, A.J. Moeser, J.L. Gookin, S.L. Jones, and J. Odle Restoration of barrier function in injured intestinal mucosa Physiol Rev 87 2007 545
5. L. Wu, C. Holbrook, and O. Zaborina Pseudomonas aeruginosa expresses a lethal virulence determinant, the PA-I lectin/adhesin, in the intestinal tract of a stressed host: the role of epithelia cell contact and molecules of the Quorum Sensing Signaling System Ann Surg 238 2003 754
6. J. Seal, J.C. Alverdy, O. Zaborina, and G. An Agent-based dynamic knowledge representation of Pseudomonas aeruginosa virulence activation in the stressed gut: towards characterizing host-pathogen interactions in gut-derived sepsis Theor Biol Med Model 8 2011 33
7. G. An Dynamic knowledge representation using agent-based modeling: ontology instantiation and verification of conceptual models Methods Mol Biol 500 2009 445
8. G. An A model of TLR4 signaling and tolerance using a qualitative, particle-event-based method: introduction of spatially configured stochastic reaction chambers (SCSRC) Math Biosci 217 2008 43
9. G. An, Q. Mi, J. Dutta-Moscato, and Y. Vodovotz Agent-based models in translational systems biology Wiley Interdiscip Rev Syst Biol Med 1 2009 159
10. G. An Agent-based computer simulation and sirs: building a bridge between basic science and clinical trials Shock 16 2001 266
11. G. An In silico experiments of existing and hypothetical cytokine-directed clinical trials using agent-based modeling Crit Care Med 32 2004 2050
12. G. An Introduction of an agent-based multi-scale modular architecture for dynamic knowledge representation of acute inflammation Theor Biol Med Model 5 2008 11
13. D.C. Walker, G. Hill, S.M. Wood, R.H. Smallwood, and J. Southgate Agent-based computational modeling of wounded epithelial cell monolayers IEEE Trans Nanobioscience 3 2004 153
14. Q. Mi, B. Riviere, G. Clermont, D.L. Steed, and Y. Vodovotz Agent-based model of inflammation and wound healing: insights into diabetic foot ulcer pathology and the role of transforming growth factor-beta1 Wound Repair Regen 15 2007 671
15. T.S. Deisboeck, M.E. Berens, A.R. Kansal, S. Torquato, A.O. Stemmer-Rachamimov, and E.A. Chiocca Pattern of self-organization in tumour systems: complex growth dynamics in a novel brain tumour spheroid model Cell Proliferation 34 2001 115
16. Y. Mansury, M. Diggory, and T.S. Deisboeck Evolutionary game theory in an agent-based brain tumor model: exploring the 'Genotype-Phenotype' link J Theor Biol 238 2006 146
17. M. Kim, S. Christley, J.C. Alverdy, D. Liu, and G. An Immature oxidative stress management as a unifying principle in the pathogenesis of necrotizing enterocolitis: insights from an agent-based model Surg Infect 13 2012 18
18. A. Bailey, B.C. Thorne, and S.M. Peirce Multi-cell agent-based simulation of the microvasculature to study the dynamics of circulating inflammatory cell trafficking Ann Biomed Eng 35 2007 916
19. J.R. Stern, S. Christley, O. Zaborina, J.C. Alverdy, and G. An Integration of TGF-ß and EGFR based signaling pathways using an agent-based model of epithelial restitution Wound Repair Regen 20 2012 862
20. A. Olivas, B. Shogan, and V. Valuckaite Intestinal tissues induce an SNP mutation in Pseudomonas aeruginosa that enhances its virulence: possible role in anastomotic leak PLoS One 7 2012 e44326
21. F. Kheradmand, H.G. Folkesson, L. Shum, R. Derynk, R. Pytela, and M.A. Matthay Transforming growth factor-α enhances alveolar epithelial cell repair in a new in vitro model Am J Physiol 267 1994 L728 Lung Cell Mol Physiol 11
22. L. Lan, T.S. Murray, B.I. Kazmierczak, and C. He Pseudomonas aeruginosa OspR is an oxidative stress sensing regulator that affects pigment production, antibiotic resistance and dissemination during infection Mol Microbiol 75 2010 76
23. Z. Somosy, G. Bognár, G. Thuróczy, and G.J. Köteles Biological responses of tight junction to ionizing radiation and electromagnetic field expostion Cell Mol Biol (Noisy-le-grand) 48 2002 571
24. S. Moyes, E.M. Killick, J.F. Morris, M.A. Kadhim, M.A. Hill, and K.E. Carr Changes produced by external radiation in parameters influencing intestinal permeability and microparticle uptake in vitro Int J Radiat Biol 84 2008 467
25. P. Riley Free radicals in biology: oxidative stress and the effects of ionizing radiation Int J Radiat Biol 65 1994 27
26. R. Dise, M.R. Frey, R.H. Whitehead, and D.B. Polk Epidermal growth factor stimulates Rac activation through Src and phosphatidylinositol 3-kinase to promote colonic epithelial cell migration Am J Physiol Gastrointest Liver Physiol 294 2008 G276
27. D. Choma, K. Pumiglia, and C.M. DiPersio Integrin alpha3beta1 directs the stabilization of a polarized lamellipodium in epithelial cells through activation of Rac1 J Cell Sci 117 Pt 17 2004 3947
28. A. Russell, E.F. Fincher, and L. Millman Alpha 6 beta 4 integrin regulates keratinocyte chemotaxis through differential GTPase activation and antagonism of alpha 3 beta 1 integrin J Cell Sci 116 Pt 17 2003 3543
29. A. Hauser The type III secretion system of Pseudomonas aeruginosa: infection by injection Nat Rev Microbiol 7 2009 654
30. Y. Jin, H. Yang, M. Qiao, and S. Jin MexT regulates the type III secretion system through MexS and PtrC in Pseudomonas aeruginosa J Bacteriol 193 2011 399
31. G. An Closing the scientific loop: bridging correlation and causality in the petaflop age Sci Transl Med 2 2010 41ps34