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Volumn 455, Issue 1-2, 2013, Pages 213-218

Aerodynamic dose emission characteristics of dry powder inhalers using an Andersen Cascade Impactor with a mixing inlet: The influence of flow and volume

Author keywords

Different volumes; Dose emission; Dry powder inhaler; Low flows

Indexed keywords

SALBUTAMOL SULFATE; TERBUTALINE SULFATE;

EID: 84883882272     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2013.07.036     Document Type: Article
Times cited : (16)

References (36)
  • 1
    • 77951621404 scopus 로고    scopus 로고
    • Emitted dose and lung deposition of inhaled terbutaline from Turbuhaler at different conditions
    • Abdelrahim, M.E., 2010. Emitted dose and lung deposition of inhaled terbutaline from Turbuhaler at different conditions. Respir Med 104, 682-689.
    • (2010) Respir Med , vol.104 , pp. 682-689
    • Abdelrahim, M.E.1
  • 2
    • 84862644228 scopus 로고    scopus 로고
    • Clarifying the dilemmas about inhalation techniques for dry powder inhalers: Integrating science with clinical practice
    • Azouz, W., Chrystyn, H., 2012. Clarifying the dilemmas about inhalation techniques for dry powder inhalers: integrating science with clinical practice. Prim. Care Respir. J. 21, 208-213.
    • (2012) Prim. Care Respir. J. , vol.21 , pp. 208-213
    • Azouz, W.1    Chrystyn, H.2
  • 3
    • 85030415770 scopus 로고    scopus 로고
    • Inhalation characteristics of patients when they use dry powder inhalers (DPIs)
    • Abstract (P-052) presented at International Society of Medicines 2013
    • Azouz, W., Chetcuti, P., Hosker, H., Saralaya, D., Chrystyn, H., 2013. Inhalation characteristics of patients when they use dry powder inhalers (DPIs). Abstract (P-052) presented at International Society of Medicines 2013. J. Aerosol Med. Pulmonary Drug Deliv. 26, A-38.
    • (2013) J. Aerosol Med. Pulmonary Drug Deliv. , vol.26
    • Azouz, W.1    Chetcuti, P.2    Hosker, H.3    Saralaya, D.4    Chrystyn, H.5
  • 4
    • 0028354478 scopus 로고
    • Lung deposition of budesonide inhaled via Turbuhaler: A comparison with terbutaline sulphate in normal subjects
    • Borgstrom, L., Bondesson, E., Moren, E., Trofast, E., Newman, S.P., 1994. Lung deposition of budesonide inhaled via Turbuhaler. A comparison with terbutaline sulphate. Eur. Respir. J. 7, 69-73. (Pubitemid 24075127)
    • (1994) European Respiratory Journal , vol.7 , Issue.1 , pp. 69-73
    • Borgstrom, L.1    Bondesson, E.2    Moren, F.3    Trofast, E.4    Newman, S.P.5
  • 5
    • 0031841761 scopus 로고    scopus 로고
    • Fine particle mass from the Diskus inhaler and Turbuhaler inhaler in children with asthma
    • DOI 10.1183/09031936.98.11051111
    • Bisgaard, H., Klug, B., Sumby, B.S., Burnell, P.K., 1998. Fine particle mass from the Diskus inhaler and Turbuhaler inhaler in children with asthma. Eur. Respir. J. 11, 1111-1115. (Pubitemid 28281031)
    • (1998) European Respiratory Journal , vol.11 , Issue.5 , pp. 1111-1115
    • Bisgaard, H.1    Klug, B.2    Sumby, B.S.3    Burnell, P.K.P.4
  • 6
    • 0035161126 scopus 로고    scopus 로고
    • Peak inspiratory flow rate and slope of the inhalation profiles in dry powder inhalers
    • DOI 10.1183/09031936.01.00240301
    • Broeders, M., Molema, J., Vermue, N.A., Folgering, H.T.M., 2001. Peak inspiratory flow rate and slope of the inhalation profiles in dry powder inhalers. Eur. Respir. J. 18, 780-783. (Pubitemid 33076919)
    • (2001) European Respiratory Journal , vol.18 , Issue.5 , pp. 780-783
    • Broeders, M.E.A.C.1    Molema, J.2    Vermue, N.A.3    Folgering, H.Th.M.4
  • 8
    • 0034004969 scopus 로고    scopus 로고
    • The relative bioavailability of salbutamol to the lung using urinary excretion following inhalation from a novel dry powder inhaler: The effect of inhalation rate and formulation
    • DOI 10.1053/rmed.1999.0692
    • Chege, J.K., Chrystyn, H., 2000. The relative bioavailability of salbutamol to the lung using urinary excretion following inhalation from a novel dry powder inhaler: the effect of inhalation rate and formulation. Respir. Med. 94, 51-56. (Pubitemid 30113850)
    • (2000) Respiratory Medicine , vol.94 , Issue.1 , pp. 51-56
    • Chege, J.K.1    Chrystyn, H.2
  • 9
    • 78650192172 scopus 로고    scopus 로고
    • Effects of device design on patient compliance: (2009) Comparing the same drug in different devices
    • Dalby, R.N., Byron, P.R., Peart, J., Suman, J.D., Young, P.M. (Eds.), Davis Healthcare International Publishing
    • Chrystyn, H., 2009. Effects of device design on patient compliance: (2009) Comparing the same drug in different devices. In: Dalby, R.N., Byron, P.R., Peart, J., Suman, J.D., Young, P.M. (Eds.), Respiratory Drug Delivery Europe 2009. Davis Healthcare International Publishing, pp. 105-116.
    • (2009) Respiratory Drug Delivery Europe 2009 , pp. 105-116
    • Chrystyn, H.1
  • 10
    • 72149093747 scopus 로고    scopus 로고
    • Not all asthma inhalers are the same: Factors to consider when prescribing an inhaler
    • Chrystyn, H., Price, D., 2009. Not all asthma inhalers are the same: factors to consider when prescribing an inhaler. Prim. Care Respir. J. 18, 243-249.
    • (2009) Prim. Care Respir. J. , vol.18 , pp. 243-249
    • Chrystyn, H.1    Price, D.2
  • 11
    • 0030581128 scopus 로고    scopus 로고
    • Inhalation characteristics and their effects on in vitro drug delivery front dry powder inhalers Part 2: Effect of peak flow rate (PIFR) and inspiration time on the in vitro drug release from three different types of commercial dry powder inhalers
    • DOI 10.1016/0378-5173(96)04526-7
    • de Boer, A.H., Gjaltema, D., Hagedoorn, P., 1996. Inhalation characteristics and their effects on in vitro drug delivery from dry powder inhalers part 2: effect of peak flow rate (PIFR) and inspiration time on the in vitro drug release from three different types of commercial dry powder inhalers. Int. J. Pharm. 138, 45-56. (Pubitemid 26241921)
    • (1996) International Journal of Pharmaceutics , vol.138 , Issue.1 , pp. 45-56
    • De Boer, A.H.1    Gjaltema, D.2    Hagedoorn, P.3
  • 12
  • 13
    • 0026579116 scopus 로고
    • Effects, side effects and plasma concentrations of Terbutaline in adult asthmatics when inhaling from a dry powder inhaler device and different inhalation flows and volumes
    • Engel, T., Scharling, B., Skovsted, B., Heing, J., 1992. Effects, side effects and plasma concentrations of Terbutaline in adult asthmatics when inhaling from a dry powder inhaler device and different inhalation flows and volumes. Br. J. Clin. Pharmacol. 33, 439-444.
    • (1992) Br. J. Clin. Pharmacol. , vol.33 , pp. 439-444
    • Engel, T.1    Scharling, B.2    Skovsted, B.3    Heing, J.4
  • 14
    • 79251552617 scopus 로고    scopus 로고
    • Preparations for inhalation: Aerodynamic assessment of fine particles
    • European Pharmacopeia, 7.6th ed, [cited 18.01.13]
    • European Pharmacopeia, 2012. Preparations for inhalation: aerodynamic assessment of fine particles. European Pharmacopoeia, 7.6th ed, http://findpdf.net/documents/european-pharmacopoeia-7-0.html [cited 18.01.13].
    • (2012) European Pharmacopoeia
  • 15
    • 0030667831 scopus 로고    scopus 로고
    • Flow early in the inspiratory manoeuvre affects the aerosol particle size distribution from a Turbuhaler
    • DOI 10.1016/S0954-6111(97)90009-3
    • Everard, M.L., Devadason, S.G., Le Souef, P.N., 1997. Flow early in the inspiratory manoeuvre affects the aerosol particle size distribution from a Turbuhaler. Respir. Med. 91, 624-628. (Pubitemid 27453661)
    • (1997) Respiratory Medicine , vol.91 , Issue.10 , pp. 624-628
    • Everard, M.L.1    Devadason, S.G.2    Le, S.P.N.3
  • 16
    • 0034077476 scopus 로고    scopus 로고
    • Characterization of the inspiratory manoeuvre when asthmatics inhale through a Turbohaler pre- and post-counselling in a community pharmacy
    • DOI 10.1053/rmed.1999.0768
    • Hawksworth, G.M., James, L., Chrystyn, H., 2000. Characterization of the inspiratory manoeuvre when asthmatics inhale through a Turbohaler pre- and post-counselling in a community pharmacy. Respir. Med. 94, 501-504. (Pubitemid 30353009)
    • (2000) Respiratory Medicine , vol.94 , Issue.5 , pp. 501-504
    • Hawksworth, G.M.1    James, L.2    Chrystyn, H.3
  • 17
    • 0031939585 scopus 로고    scopus 로고
    • A comparison of the performance of two modern multidose dry powder asthma inhalers
    • DOI 10.1016/S0954-6111(98)90040-3
    • Hill, L.S., Slater, A.L., 1998. A comparison of the performance of two modern multidose dry powder asthma inhalers. Respir. Med. 92, 105-110. (Pubitemid 28112050)
    • (1998) Respiratory Medicine , vol.92 , Issue.1 , pp. 105-110
    • Hill, L.S.1    Slater, A.L.2
  • 18
    • 0030946946 scopus 로고    scopus 로고
    • Influence of inspiratory capacity on bronchodilatation via Turbuhaler or pressurized metered-dose inhaler in asthmatic children: A comparison
    • DOI 10.1016/S0954-6111(97)90060-3
    • Hirsch, T., Peter-Kern, M., Koch, R., Leupold, W., 1997. Influence of inspiratory capacity on bronchodilation of terbutaline via Turbuhaler or pressurised metered-dose inhaler in asthmatic children: a comparison. Respir. Med. 91, 341-346. (Pubitemid 27270348)
    • (1997) Respiratory Medicine , vol.91 , Issue.6 , pp. 341-346
    • Hirsch, T.1    Peter-Kern, M.2    Koch, R.3    Leopold, W.4
  • 22
    • 0030467360 scopus 로고    scopus 로고
    • A comparison of in-vitro drug delivery from salbutamol Diskus and terbutaline Turbohaler inhalers
    • Malton, A., Sumby, B.S., Dandiker, Y., 1996. A comparison of in-vitro drug delivery from salbutamol Diskus and terbutaline Turbuhaler inhalers. J. Pharm. Med. 6, 35-48. (Pubitemid 27013274)
    • (1996) Journal of Pharmaceutical Medicine , vol.6 , Issue.1-2 , pp. 35-48
    • Malton, A.1    Sumby, B.S.2    Dandiker, Y.3
  • 23
    • 84866125588 scopus 로고    scopus 로고
    • Effect of sampling volume on dry powder inhaler (DPI)-emitted aerosol aerodynamic particle size distributions (APSDs) measured by the Next-Generation Pharmaceutical Impactor (NGI) and the Andersen eight-stage cascade impactor (ACI)
    • Mohammed, H., Roberts, D.L., Copley, M., Hammond, M., Nichols, S.C., Mitchell, J.P., 2012. Effect of sampling volume on dry powder inhaler (DPI)-emitted aerosol aerodynamic particle size distributions (APSDs) measured by the Next-Generation Pharmaceutical Impactor (NGI) and the Andersen eight-stage cascade impactor (ACI). AAPS Pharm. SciTech. 13, 875-882.
    • (2012) AAPS Pharm. SciTech. , vol.13 , pp. 875-882
    • Mohammed, H.1    Roberts, D.L.2    Copley, M.3    Hammond, M.4    Nichols, S.C.5    Mitchell, J.P.6
  • 24
    • 77549083736 scopus 로고    scopus 로고
    • Aerodynamic characteristics of a dry powder inhaler at low inhalation flows using a mixing inlet with an Andersen Cascade Impactor
    • Nadarassan, D.K., Assi, K.H., Chrystyn, H., 2010. Aerodynamic characteristics of a dry powder inhaler at low inhalation flows using a mixing inlet with an Andersen Cascade Impactor. Eur. J. Pharm. Sci. 39, 348-354.
    • (2010) Eur. J. Pharm. Sci. , vol.39 , pp. 348-354
    • Nadarassan, D.K.1    Assi, K.H.2    Chrystyn, H.3
  • 25
    • 0032910317 scopus 로고    scopus 로고
    • Clickhaler (a novel dry powder inhaler) provides similar bronchodilation to pressurized metered-dose inhaler, even at low flow rates
    • DOI 10.1378/chest.115.4.952
    • Newhouse, M.T., Nantel, N.P., Chambers, C.B., Pratt, B., Parry-Billings, M., 1995. Clickhaler (a novel dry powder inhaler) provides similar bronchodilation to pressurized metered-dose inhaler, even at low flow rates. Chest 115, 952-956. (Pubitemid 29193660)
    • (1999) Chest , vol.115 , Issue.4 , pp. 952-956
    • Newhouse, M.T.1    Nantel, N.P.2    Chambers, C.B.3    Pratt, B.4    Parry-Billings, M.5
  • 26
    • 0025883470 scopus 로고
    • Terbutaline sulphate Turbuhaler: Effect of inhaled flow rate on deposition and efficacy
    • Newman, S., Moren, F., Trofast, E., Talaee, N., Clarke, S., 1991. Terbutaline sulphate Turbuhaler: effect of inhaled flow rate on deposition and efficacy. Int. J. Pharm. 74, 209-213.
    • (1991) Int. J. Pharm. , vol.74 , pp. 209-213
    • Newman, S.1    Moren, F.2    Trofast, E.3    Talaee, N.4    Clarke, S.5
  • 27
    • 0031596530 scopus 로고    scopus 로고
    • Clinical effects of Diskus(TM) dry-powder inhaler at low and high inspiratory flow-rates in asthmatic children
    • DOI 10.1183/09031936.98.11020350
    • Nielsen, K.G., Auk, I.L., Bojsen, K., Ifversen, M., Klug, B., Bisgaard, H., 1998. Clinical effect of Diskus dry powder inhaler at low and high inspiratory flow rates in asthmatic children. Eur. Respir. J. 11, 350-354. (Pubitemid 28108348)
    • (1998) European Respiratory Journal , vol.11 , Issue.2 , pp. 350-354
    • Nielsen, K.G.1    Auk, I.L.2    Bojsen, K.3    Ifversen, M.4    Klug, B.5    Bisgaard, H.6
  • 28
    • 84883867470 scopus 로고    scopus 로고
    • Validation of a general in vitro approach for prediction of total lung deposition in healthy adults for pharmaceutical inhalation products
    • Epub ahead of print
    • Olsson, B., Borgstrom, L., Lundback, H., Svensson, M., 2013. Validation of a general in vitro approach for prediction of total lung deposition in healthy adults for pharmaceutical inhalation products. J. Aerosol Med. Pulmonary Drug Deliv. 26 [Epub ahead of print].
    • (2013) J. Aerosol Med. Pulmonary Drug Deliv. , vol.26
    • Olsson, B.1    Borgstrom, L.2    Lundback, H.3    Svensson, M.4
  • 29
    • 0033910480 scopus 로고    scopus 로고
    • In-vitro comparison of three salbutamol-containing multidose dry powder inhalers
    • Palander, A., Mattila, T., Karhu, M., Muttonen, E., 2000. In-vitro comparison of three salbutamol-containing multidose dry powder inhalers. Clin. Drug Invest. 20, 25-33.
    • (2000) Clin. Drug Invest. , vol.20 , pp. 25-33
    • Palander, A.1    Mattila, T.2    Karhu, M.3    Muttonen, E.4
  • 30
    • 0025275637 scopus 로고
    • Influence of inspiratory flow rate upon the effect of a Turbuhaler
    • Pedersen, S., Hansen, O.R., Fuglsang, G., 1990. Influence of inspiratory flow rate upon effect of a Turbuhaler. Arch. Dis. Childhood 65, 308-310. (Pubitemid 20108901)
    • (1990) Archives of Disease in Childhood , vol.65 , Issue.3 , pp. 308-310
    • Pedersen, S.1    Hansen, O.R.2    Fuglsang, G.3
  • 31
    • 84879126899 scopus 로고    scopus 로고
    • he effect of nonideal cascade impactor stage collection ef.Cience curves on the interpretation of the size of inhaler-generated aerosols
    • Roberts, D.L., Mitchell, J.P., 2013. he effect of nonideal cascade impactor stage collection ef.cience curves on the interpretation of the size of inhaler-generated aerosols. AAPS PharmSciTech. 14, 487-509.
    • (2013) AAPS PharmSciTech. , vol.14 , pp. 487-509
    • Roberts, D.L.1    Mitchell, J.P.2
  • 33
    • 1942468906 scopus 로고    scopus 로고
    • In-Vitro Intra- and Inter-Inhaler Flow Rate-Dependent Dosage Emission from a Combination of Budesonide and Eformoterol in a Dry Powder Inhaler
    • DOI 10.1089/089426804322994433
    • Tarsin, W., Assi, K.H., Chrystyn, H., 2004. In-vitro inhalation flow rate dependent dosage emission from a combination of budesonide and eformoterol in a dry powder inhaler. J. Aerosol Med. 17, 25-32. (Pubitemid 38520670)
    • (2004) Journal of Aerosol Medicine: Deposition, Clearance, and Effects in the Lung , vol.17 , Issue.1 , pp. 25-32
    • Tarsin, W.1    Assi, K.H.2    Chrystyn, H.3
  • 34
    • 33646776034 scopus 로고    scopus 로고
    • Emitted dose estimates from Seretide Diskus and Symbicort Turbuhaler following inhalation by severe asthmatics
    • Tarsin, W.Y., Pearson, S.B., Assi, K.H., Chrystyn, H., 2006. Emitted dose estimates from Seretide Diskus and Symbicort Turbuhaler following inhalation by severe asthmatics. Int. J. Pharm. 316, 131-137.
    • (2006) Int. J. Pharm. , vol.316 , pp. 131-137
    • Tarsin, W.Y.1    Pearson, S.B.2    Assi, K.H.3    Chrystyn, H.4
  • 35
    • 84883878392 scopus 로고    scopus 로고
    • Aerosols, nasal sprays, metered dose inhalers and dry powder inhalers. The United States pharmacopeia 35 [and] the national formulary 30
    • cited 18.01.13
    • United States Pharmacopeia, 2012. Aerosols, nasal sprays, metered dose inhalers and dry powder inhalers. The United States pharmacopeia 35 [and] the national formulary 30, http://www.uspnf.com/uspnf/login [cited 18.01.13].
    • (2012) United States Pharmacopeia
  • 36
    • 0029048518 scopus 로고
    • In vitro testing of dry powder inhalers
    • Van Oort, M., 1995. In vitro testing of dry powder inhalers. Aerosol Sci. Technol. 22, 364-373.
    • (1995) Aerosol Sci. Technol. , vol.22 , pp. 364-373
    • Van Oort, M.1


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