In vitro and in vivo correlation of disintegration and bitter taste masking using orally disintegrating tablet containing ion exchange resin-drug complex

International Journal of Pharmaceutics

Volumn 455, Issue 1-2, 2013, Pages 31-39

  Kim, Jong Il ^a   Cho, Sang Min ^a,b   Cui, Jing Hao ^c   Cao, Qing Ri ^c   Oh, Euichaul ^d   Lee, Beom Jin ^b  

^a Global R and D Korea United Pharm Inc   (South Korea)

^b Ajou University   (South Korea)

^c SOOCHOW UNIVERSITY   (China)

^d The Catholic University of Korea   (South Korea)

Author keywords

Bitterness index; Donepezil hydrochloride; Electronic tongue; In vitro in vivo correlation; Ion exchange resin drug complex; Orally disintegrating tablet

Indexed keywords

CROSCARMELLOSE SODIUM; CROSPOVIDONE; DONEPEZIL; ION EXCHANGE RESIN; STARCH GLYCOLATE SODIUM;

ARTICLE; BITTER TASTE; DRUG RELEASE; HUMAN; IN VITRO STUDY; IN VIVO STUDY; ION EXCHANGE; MASKING; MORPHOLOGY; PALATABILITY; PATIENT COMPLIANCE; PH; PRIORITY JOURNAL; SCANNING ELECTRON MICROSCOPY; SPRAY DRYING; TABLET DISINTEGRATION; TABLET FORMULATION; X RAY POWDER DIFFRACTION;

BITTERNESS INDEX; DONEPEZIL HYDROCHLORIDE; ELECTRONIC TONGUE; IN VITRO/IN VIVO CORRELATION; ION EXCHANGE-RESIN DRUG COMPLEX; ORALLY DISINTEGRATING TABLET;

ADMINISTRATION, ORAL; ADULT; FEMALE; HUMANS; INDANS; ION EXCHANGE RESINS; MALE; PIPERIDINES; RESINS, SYNTHETIC; SOLUBILITY; TABLETS; TASTE; TONGUE; YOUNG ADULT;

EID: 84883862776     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2013.07.072     Document Type: Article

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