Complexation of risperidone with a taste-masking resin: Novel application of near infra-red and chemical imaging to evaluate complexes

Pharmaceutical Development and Technology

Volumn 14, Issue 4, 2009, Pages 409-421

  Tawakkul, Mobin A ^a   Shah, Rakhi B ^a   Zidan, Ahmed ^a   Sayeed, Vilayat A ^b   Khan, Mansoor A ^a  

^a Office of Testing and Research   (United States)

^b CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

Author keywords

Amberlite; Calorimetry (DSC); Characterization; Chemical imaging; Complexation; Drug release; FTIR; Near infra red spectroscopy; Polacrilex; Raman spectroscopy; X ray diffractometry

Indexed keywords

POLACRILIN; RISPERIDONE;

ARTICLE; CALORIMETRY; CONTROLLED STUDY; DIFFERENTIAL SCANNING CALORIMETRY; DRUG RELEASE; DRUG SOLUBILITY; INFRARED SPECTROSCOPY; ION EXCHANGE; MASKING; NEAR INFRARED SPECTROSCOPY; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; RAMAN SPECTROMETRY; TASTE; THERMAL ANALYSIS; X RAY DIFFRACTION;

ANTIPSYCHOTIC AGENTS; CALORIMETRY, DIFFERENTIAL SCANNING; CHEMISTRY, PHARMACEUTICAL; RESINS, SYNTHETIC; RISPERIDONE; SOLUBILITY; SOLVENTS; SPECTRUM ANALYSIS; TASTE; X-RAY DIFFRACTION;

EID: 70350681101     PISSN: 10837450     EISSN: 10979867     Source Type: Journal    
DOI: 10.1080/10837450802712666     Document Type: Article

References (19)

1. Megens AA. Survey on the pharmacodynamics of the new antipsychotic risperidone. Psychopharmacol Berl 1994;114(1):9-23.
2. Risperdal description. Internet Drug Index for Prescription Drugs and Medications. Accessed May 2008 from the internet website: http://www rxlist com/cgi/generic/risperidhtm.
3. Sohi H, Sultana Y, Khar RK. Taste masking technologies in oral pharmaceuticals: Recent developments and approaches. Drug Dev Ind Pharm 2004;30(5):429-448.
4. Katsuragi Y, Kurihara K. Specific inhibitor for bitter taste. Nature 1993 16;365(6443):213-214.
5. Shirai Y, Sogo K, Yamamoto K, et al. A novel fine granule system for masking bitter taste. Biol Pharm Bull 1993;16(2):172-177.
6. Loftsson T, Brewster ME. Pharmaceutical applications of cyclodextrins. 1. Drug solubilization and stabilization. J Pharm Sci 1996;85(10):1017-1025.
7. Honeysett RA, Freely LC, Hoadley TH, Sims EE. Taste-masked Buflomedil preparation. Patent EP0501763. 1992; Sep 2.
8. Gao R, Shao ZJ, Fan ACL, Witchey-Lakshmanan LC, Stewart DC. Taste masking of oral Quinolone liquid preparations using ion exchance resins. US Patent 6,514,492; 2003 Feb 4.
9. Amberlite IRP, Duolite AP. 143 ion exchange resins. Accessed 10 October 2008 from the Rohm and Haas Website: http://www. rohmhaas.com/assets/ attachments/industry/pharma-medical/ adv-release-tech.pdf Amberlite IRP and Duolite AP143 Ion Exchange Resins.
10. Vitamin B12 tablets on resin 1%. Lycored 2007. Accessed May 2008 at the website: http://www.lycored.com/Retriever/web/ ui/ProductDocument.aspx?DID= 1&PID=733.
11. FDA/CDER ICH Q2A Guidance. Food and Drug Administration Website. http://www.fda.gov/cder/guidance/ichq2a.pdf. Accessed October 9, 2008.
12. Seonghoon J, Susumu, et al. Fast-melting tablets having tastemasking and sustained release properties. United States patent 20060115529. 6 A.D. Jun 1.
13. Hassan M, Sulieman M, Najib N. Improvement of the in vitro dissolution characteristics of famotidine by inclusion in d£-cyclodextrin. Int J Pharm 1990;58:19-24.
14. Nie S, Fan X, Peng Y, Yang X, Wang C, Pan W. In vitro and in vivo studies on the complexes of vinpocetine with hydroxypropylbeta- cyclodextrin. Arch Pharm Res 2007;30(8):991-1001.
15. Whiffen DH. Raman spectra. In: Whiffen DH, editor. Spectroscopy. 2nd ed. New York: John Wiley and Sons, Inc; 1968:109-114.
16. Halder A, Maiti S, Sa B. Entrapment efficiency and release characteristics of polyethyleneimine-treated or -untreated calcium alginate beads loaded with propranolol-resin complex. Int J Pharm 2005;302(1-2):84-94.
17. Shah RB, Tawakkul MA, Khan MA. Process analytical technology: chemometric analysis of Raman and near infra-red spectroscopic data for predicting physical properties of extended release matrix tablets. J Pharm Sci 2007;96(5):1356- 1365.
18. Lyon RC, Lester DS, Lewis EN. Near-infrared spectral imaging for quality assurance of pharmaceutical products: Analysis of tablets to assess powder blend homogeneity. AAPS PharmSciTech 2002 3:E17.
19. Westenberger BJ, Ellison CD, Fussner AS, et al. Quality assessment of internet pharmaceutical products using traditional and non-traditional analytical techniques. Int J Pharm 2005;306(1-2):56-70.