The type 2B p.R1306W natural mutation of von Willebrand factor dramatically enhances the multimer sensitivity to shear stress

Journal of Thrombosis and Haemostasis

Volumn 11, Issue 9, 2013, Pages 1688-1698

  Scaglione, G L ^a   Lancellotti, S ^a   Papi, M ^a   De Spirito, M ^a   Maiorana, A ^a   Baronciani, L ^b   Pagliari, M T ^b   Arcovito, A ^a   Di Stasio, E ^a   Peyvandi, F ^b   De Cristofaro, R ^a  

^a CATHOLIC UNIVERSITY   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

Author keywords

Microscopy, atomic force; Platelet adhesiveness; Surface plasmon resonance; Von Willebrand disease, Type 2; Von Willebrand diseases; Von Willebrand Factor

Indexed keywords

GLYCOPROTEIN IB ALPHA; POLYMER; UNCLASSIFIED DRUG; VON WILLEBRAND FACTOR; VON WILLEBRAND FACTOR TYPE 2B PROTEIN;

ARTICLE; ATOMIC FORCE MICROSCOPY; CONTROLLED STUDY; HUMAN; HUMAN CELL; HYDRODYNAMICS; LIGHT SCATTERING; MUTANT; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN PROTEIN INTERACTION; RECEPTOR AFFINITY; RECEPTOR BINDING; SHEAR STRESS; SPECTROSCOPY; STRETCHING; SURFACE PLASMON RESONANCE; THROMBOCYTE; THROMBOCYTE AGGREGATION; WILD TYPE;

MICROSCOPY, ATOMIC FORCE; PLATELET ADHESIVENESS; SURFACE PLASMON RESONANCE; VON WILLEBRAND DISEASE, TYPE 2; VON WILLEBRAND DISEASES; VON WILLEBRAND FACTOR;

BIOPOLYMERS; HUMANS; MICROSCOPY, ATOMIC FORCE; MUTATION; STRESS, MECHANICAL; SURFACE PLASMON RESONANCE; VON WILLEBRAND FACTOR;

EID: 84883816783     PISSN: 15387933     EISSN: 15387836     Source Type: Journal    
DOI: 10.1111/jth.12346     Document Type: Article

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