메뉴 건너뛰기




Volumn 167, Issue 6, 2013, Pages 2724-2733

Ghrelin induces cardiac lineage differentiation of human embryonic stem cells through ERK1/2 pathway

Author keywords

Cardiomyocytes; Differentiation; Ghrelin; Human embryonic stem cells

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; DESACYL GHRELIN; GHRELIN; GHRELIN RECEPTOR; GHRELIN RECEPTOR ANTAGONIST; HORMONE RECEPTOR BLOCKING AGENT; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MYOSIN HEAVY CHAIN ALPHA; PROTEIN KINASE B; TRANSCRIPTION FACTOR SOX9; TROPONIN I; UNCLASSIFIED DRUG; VASCULOTROPIN RECEPTOR 2; WORTMANNIN;

EID: 84883811306     PISSN: 01675273     EISSN: 18741754     Source Type: Journal    
DOI: 10.1016/j.ijcard.2012.06.106     Document Type: Article
Times cited : (23)

References (46)
  • 1
    • 37149049044 scopus 로고    scopus 로고
    • Derivation of human embryonic stem cell lines from parthenogenetic blastocysts
    • Q Mai, Y Yu, and T Li Derivation of human embryonic stem cell lines from parthenogenetic blastocysts Cell Res 17 2007 1008 1019
    • (2007) Cell Res , vol.17 , pp. 1008-1019
    • Mai, Q.1    Yu, Y.2    Li, T.3
  • 2
    • 0032491416 scopus 로고    scopus 로고
    • Embryonic stem cell lines derived from human blastocysts
    • J.A. Thomson, J. Itskovitz-Eldor, and S.S. Shapiro Embryonic stem cell lines derived from human blastocysts Science 282 1998 1145 1147
    • (1998) Science , vol.282 , pp. 1145-1147
    • Thomson, J.A.1    Itskovitz-Eldor, J.2    Shapiro, S.S.3
  • 3
    • 80054935074 scopus 로고    scopus 로고
    • Cardiomyocytes derived from human embryonic and induced pluripotent stem cells: Comparative ultrastructure
    • M. Gherghiceanu, L. Barad, and A. Novak Cardiomyocytes derived from human embryonic and induced pluripotent stem cells: comparative ultrastructure J Cell Mol Med 15 2011 2539 2551
    • (2011) J Cell Mol Med , vol.15 , pp. 2539-2551
    • Gherghiceanu, M.1    Barad, L.2    Novak, A.3
  • 4
    • 0034904645 scopus 로고    scopus 로고
    • Human embryonic stem cells can differentiate into myocytes with structural and functional properties of cardiomyocytes
    • I. Kehat, D. Kenyagin-Karsenti, and M. Snir Human embryonic stem cells can differentiate into myocytes with structural and functional properties of cardiomyocytes J Clin Invest 108 2001 407 414
    • (2001) J Clin Invest , vol.108 , pp. 407-414
    • Kehat, I.1    Kenyagin-Karsenti, D.2    Snir, M.3
  • 5
    • 0036225018 scopus 로고    scopus 로고
    • Short ghrelin peptides neither displace ghrelin binding in vitro nor stimulate GH release in vivo
    • A. Torsello, C. Ghe, and E. Bresciani Short ghrelin peptides neither displace ghrelin binding in vitro nor stimulate GH release in vivo Endocrinology 143 2002 1968 1971
    • (2002) Endocrinology , vol.143 , pp. 1968-1971
    • Torsello, A.1    Ghe, C.2    Bresciani, E.3
  • 6
    • 0033540056 scopus 로고    scopus 로고
    • Ghrelin is a growth-hormone-releasing acylated peptide from stomach
    • M. Kojima, H. Hosoda, Y. Date, M. Nakazato, H. Matsuo, and K. Kangawa Ghrelin is a growth-hormone-releasing acylated peptide from stomach Nature 402 1999 656 660
    • (1999) Nature , vol.402 , pp. 656-660
    • Kojima, M.1    Hosoda, H.2    Date, Y.3    Nakazato, M.4    Matsuo, H.5    Kangawa, K.6
  • 7
    • 2442515963 scopus 로고    scopus 로고
    • Growth hormone releasing peptide (ghrelin) is synthesized and secreted by cardiomyocytes
    • M.J. Iglesias, R. Pineiro, and M. Blanco Growth hormone releasing peptide (ghrelin) is synthesized and secreted by cardiomyocytes Cardiovasc Res 62 2004 481 488
    • (2004) Cardiovasc Res , vol.62 , pp. 481-488
    • Iglesias, M.J.1    Pineiro, R.2    Blanco, M.3
  • 8
    • 25444519434 scopus 로고    scopus 로고
    • GH-releasing peptides improve cardiac dysfunction and cachexia and suppress stress-related hormones and cardiomyocyte apoptosis in rats with heart failure
    • X.B. Xu, J.J. Pang, and J.M. Cao GH-releasing peptides improve cardiac dysfunction and cachexia and suppress stress-related hormones and cardiomyocyte apoptosis in rats with heart failure Am J Physiol Heart Circ Physiol 289 2005 H1643 H1651
    • (2005) Am J Physiol Heart Circ Physiol , vol.289
    • Xu, X.B.1    Pang, J.J.2    Cao, J.M.3
  • 9
    • 20844460120 scopus 로고    scopus 로고
    • Effects of ghrelin administration on left ventricular function, exercise capacity, and muscle wasting in patients with chronic heart failure
    • N. Nagaya, J. Moriya, and Y. Yasumura Effects of ghrelin administration on left ventricular function, exercise capacity, and muscle wasting in patients with chronic heart failure Circulation 110 2004 3674 3679
    • (2004) Circulation , vol.110 , pp. 3674-3679
    • Nagaya, N.1    Moriya, J.2    Yasumura, Y.3
  • 10
    • 80054878182 scopus 로고    scopus 로고
    • TAp63 is important for cardiac differentiation of embryonic stem cells and heart development
    • M. Rouleau, A. Medawar, and L. Hamon TAp63 is important for cardiac differentiation of embryonic stem cells and heart development Stem Cells 29 2011 1672 1683
    • (2011) Stem Cells , vol.29 , pp. 1672-1683
    • Rouleau, M.1    Medawar, A.2    Hamon, L.3
  • 11
    • 77956266191 scopus 로고    scopus 로고
    • Lessons for cardiac regeneration and repair through development
    • J.M. Alexander, and B.G. Bruneau Lessons for cardiac regeneration and repair through development Trends Mol Med 16 2010 426 434
    • (2010) Trends Mol Med , vol.16 , pp. 426-434
    • Alexander, J.M.1    Bruneau, B.G.2
  • 12
    • 34548237819 scopus 로고    scopus 로고
    • Cardiac progenitors and the embryonic cell cycle
    • S.C. Goetz, and F.L. Conlon Cardiac progenitors and the embryonic cell cycle Cell Cycle 6 2007 1974 1981
    • (2007) Cell Cycle , vol.6 , pp. 1974-1981
    • Goetz, S.C.1    Conlon, F.L.2
  • 13
    • 80053919482 scopus 로고    scopus 로고
    • Ghrelin promotes differentiation of human embryonic stem cells into cardiomyocytes
    • J. Yang, G.Q. Liu, and R. Wei Ghrelin promotes differentiation of human embryonic stem cells into cardiomyocytes Acta Pharmacol Sin 32 2011 1239 1245
    • (2011) Acta Pharmacol Sin , vol.32 , pp. 1239-1245
    • Yang, J.1    Liu, G.Q.2    Wei, R.3
  • 14
    • 29144442975 scopus 로고    scopus 로고
    • Serum-free medium cultivation to improve efficacy in establishment of human embryonic stem cell lines
    • P. Hong-mei, and C. Gui-an Serum-free medium cultivation to improve efficacy in establishment of human embryonic stem cell lines Hum Reprod 21 2006 217 222
    • (2006) Hum Reprod , vol.21 , pp. 217-222
    • Hong-Mei, P.1    Gui-An, C.2
  • 15
    • 58849146524 scopus 로고    scopus 로고
    • The reversal of hyperglycaemia in diabetic mice using PLGA scaffolds seeded with islet-like cells derived from human embryonic stem cells
    • G.H. Mao, G.A. Chen, H.Y. Bai, T.R. Song, and Y.X. Wang The reversal of hyperglycaemia in diabetic mice using PLGA scaffolds seeded with islet-like cells derived from human embryonic stem cells Biomaterials 30 2009 1706 1714
    • (2009) Biomaterials , vol.30 , pp. 1706-1714
    • Mao, G.H.1    Chen, G.A.2    Bai, H.Y.3    Song, T.R.4    Wang, Y.X.5
  • 16
    • 0037144701 scopus 로고    scopus 로고
    • Characterization and enrichment of cardiomyocytes derived from human embryonic stem cells
    • C. Xu, S. Police, N. Rao, and M.K. Carpenter Characterization and enrichment of cardiomyocytes derived from human embryonic stem cells Circ Res 91 2002 501 508
    • (2002) Circ Res , vol.91 , pp. 501-508
    • Xu, C.1    Police, S.2    Rao, N.3    Carpenter, M.K.4
  • 18
    • 53249154955 scopus 로고    scopus 로고
    • Early ghrelin treatment after myocardial infarction prevents an increase in cardiac sympathetic tone and reduces mortality
    • D.O. Schwenke, T. Tokudome, and I. Kishimoto Early ghrelin treatment after myocardial infarction prevents an increase in cardiac sympathetic tone and reduces mortality Endocrinology 149 2008 5172 5176
    • (2008) Endocrinology , vol.149 , pp. 5172-5176
    • Schwenke, D.O.1    Tokudome, T.2    Kishimoto, I.3
  • 19
    • 0035908954 scopus 로고    scopus 로고
    • Chronic administration of ghrelin improves left ventricular dysfunction and attenuates development of cardiac cachexia in rats with heart failure
    • N. Nagaya, M. Uematsu, and M. Kojima Chronic administration of ghrelin improves left ventricular dysfunction and attenuates development of cardiac cachexia in rats with heart failure Circulation 104 2001 1430 1435
    • (2001) Circulation , vol.104 , pp. 1430-1435
    • Nagaya, N.1    Uematsu, M.2    Kojima, M.3
  • 20
    • 5044221669 scopus 로고    scopus 로고
    • Electromechanical integration of cardiomyocytes derived from human embryonic stem cells
    • I. Kehat, L. Khimovich, and O. Caspi Electromechanical integration of cardiomyocytes derived from human embryonic stem cells Nat Biotechnol 22 2004 1282 1289
    • (2004) Nat Biotechnol , vol.22 , pp. 1282-1289
    • Kehat, I.1    Khimovich, L.2    Caspi, O.3
  • 21
    • 20344372655 scopus 로고    scopus 로고
    • Increased cardiomyocyte differentiation from human embryonic stem cells in serum-free cultures
    • R. Passier, D.W. Oostwaard, and J. Snapper Increased cardiomyocyte differentiation from human embryonic stem cells in serum-free cultures Stem Cells 23 2005 772 780
    • (2005) Stem Cells , vol.23 , pp. 772-780
    • Passier, R.1    Oostwaard, D.W.2    Snapper, J.3
  • 22
    • 0038210217 scopus 로고    scopus 로고
    • Differentiation of human embryonic stem cells to cardiomyocytes: Role of coculture with visceral endoderm-like cells
    • C. Mummery, D. Ward-van Oostwaard, and P. Doevendans Differentiation of human embryonic stem cells to cardiomyocytes: role of coculture with visceral endoderm-like cells Circulation 107 2003 2733 2740
    • (2003) Circulation , vol.107 , pp. 2733-2740
    • Mummery, C.1    Ward-Van Oostwaard, D.2    Doevendans, P.3
  • 23
    • 78049366735 scopus 로고    scopus 로고
    • Investigations into the metabolism of two-dimensional colony and suspended microcarrier cultures of human embryonic stem cells in serum-free media
    • X. Chen, A. Chen, T.L. Woo, A.B. Choo, S. Reuveny, and S.K. Oh Investigations into the metabolism of two-dimensional colony and suspended microcarrier cultures of human embryonic stem cells in serum-free media Stem Cells Dev 19 2010 1781 1792
    • (2010) Stem Cells Dev , vol.19 , pp. 1781-1792
    • Chen, X.1    Chen, A.2    Woo, T.L.3    Choo, A.B.4    Reuveny, S.5    Oh, S.K.6
  • 24
    • 34748896014 scopus 로고    scopus 로고
    • Differentiation in vivo of cardiac committed human embryonic stem cells in postmyocardial infarcted rats
    • A. Tomescot, J. Leschik, and V. Bellamy Differentiation in vivo of cardiac committed human embryonic stem cells in postmyocardial infarcted rats Stem Cells 25 2007 2200 2205
    • (2007) Stem Cells , vol.25 , pp. 2200-2205
    • Tomescot, A.1    Leschik, J.2    Bellamy, V.3
  • 25
    • 66949175935 scopus 로고    scopus 로고
    • Bone morphogenetic protein-4 promotes induction of cardiomyocytes from human embryonic stem cells in serum-based embryoid body development
    • S. Takei, H. Ichikawa, and K. Johkura Bone morphogenetic protein-4 promotes induction of cardiomyocytes from human embryonic stem cells in serum-based embryoid body development Am J Physiol Heart Circ Physiol 296 2009 H1793 H1803
    • (2009) Am J Physiol Heart Circ Physiol , vol.296
    • Takei, S.1    Ichikawa, H.2    Johkura, K.3
  • 26
    • 54249098708 scopus 로고    scopus 로고
    • Chemically defined medium supporting cardiomyocyte differentiation of human embryonic stem cells
    • X.Q. Xu, R. Graichen, and S.Y. Soo Chemically defined medium supporting cardiomyocyte differentiation of human embryonic stem cells Differentiation 76 2008 958 970
    • (2008) Differentiation , vol.76 , pp. 958-970
    • Xu, X.Q.1    Graichen, R.2    Soo, S.Y.3
  • 27
    • 69249121687 scopus 로고    scopus 로고
    • Wnt3a-induced mesoderm formation and cardiomyogenesis in human embryonic stem cells
    • T.H. Tran, X. Wang, and C. Browne Wnt3a-induced mesoderm formation and cardiomyogenesis in human embryonic stem cells Stem Cells 27 2009 1869 1878
    • (2009) Stem Cells , vol.27 , pp. 1869-1878
    • Tran, T.H.1    Wang, X.2    Browne, C.3
  • 28
    • 42149094990 scopus 로고    scopus 로고
    • Enhanced cardiomyogenesis of human embryonic stem cells by a small molecular inhibitor of p38 MAPK
    • R. Graichen, X. Xu, and S.R. Braam Enhanced cardiomyogenesis of human embryonic stem cells by a small molecular inhibitor of p38 MAPK Differentiation 76 2008 357 370
    • (2008) Differentiation , vol.76 , pp. 357-370
    • Graichen, R.1    Xu, X.2    Braam, S.R.3
  • 29
    • 77955843886 scopus 로고    scopus 로고
    • Inhibition of ERK1/2 prevents neural and mesendodermal differentiation and promotes human embryonic stem cell self-renewal
    • J. Na, M.K. Furue, and P.W. Andrews Inhibition of ERK1/2 prevents neural and mesendodermal differentiation and promotes human embryonic stem cell self-renewal Stem Cell Res 5 2011 157 169
    • (2011) Stem Cell Res , vol.5 , pp. 157-169
    • Na, J.1    Furue, M.K.2    Andrews, P.W.3
  • 30
    • 84862832855 scopus 로고    scopus 로고
    • Early embryonic sensitivity to cyclophosphamide in cardiac differentiation from human embryonic stem cells
    • M.X. Zhu, J.Y. Zhao, G.A. Chen, and L. Guan Early embryonic sensitivity to cyclophosphamide in cardiac differentiation from human embryonic stem cells Cell Biol Int 35 2011 927 938
    • (2011) Cell Biol Int , vol.35 , pp. 927-938
    • Zhu, M.X.1    Zhao, J.Y.2    Chen, G.A.3    Guan, L.4
  • 31
    • 77953796480 scopus 로고    scopus 로고
    • Enhancement of cardiomyocyte differentiation from human embryonic stem cells
    • Y. Wang, G. Chen, T. Song, G. Mao, and H. Bai Enhancement of cardiomyocyte differentiation from human embryonic stem cells Sci China Life Sci 53 2010 581 589
    • (2010) Sci China Life Sci , vol.53 , pp. 581-589
    • Wang, Y.1    Chen, G.2    Song, T.3    Mao, G.4    Bai, H.5
  • 32
    • 0037164747 scopus 로고    scopus 로고
    • Ghrelin and des-acyl ghrelin inhibit cell death in cardiomyocytes and endothelial cells through ERK1/2 and PI 3-kinase/AKT
    • G. Baldanzi, N. Filigheddu, and S. Cutrupi Ghrelin and des-acyl ghrelin inhibit cell death in cardiomyocytes and endothelial cells through ERK1/2 and PI 3-kinase/AKT J Cell Biol 159 2002 1029 1037
    • (2002) J Cell Biol , vol.159 , pp. 1029-1037
    • Baldanzi, G.1    Filigheddu, N.2    Cutrupi, S.3
  • 33
    • 33646527782 scopus 로고    scopus 로고
    • Early lineage segregation between epiblast and primitive endoderm in mouse blastocysts through the Grb2-MAPK pathway
    • C. Chazaud, Y. Yamanaka, T. Pawson, and J. Rossant Early lineage segregation between epiblast and primitive endoderm in mouse blastocysts through the Grb2-MAPK pathway Dev Cell 10 2006 615 624
    • (2006) Dev Cell , vol.10 , pp. 615-624
    • Chazaud, C.1    Yamanaka, Y.2    Pawson, T.3    Rossant, J.4
  • 34
    • 0242300107 scopus 로고    scopus 로고
    • Extracellular signal-regulated kinase 2 is necessary for mesoderm differentiation
    • Y. Yao, W. Li, and J. Wu Extracellular signal-regulated kinase 2 is necessary for mesoderm differentiation Proc Natl Acad Sci U S A 100 2003 12759 12764
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 12759-12764
    • Yao, Y.1    Li, W.2    Wu, J.3
  • 35
    • 34748866686 scopus 로고    scopus 로고
    • Signaling pathways in cancer and embryonic stem cells
    • O. Dreesen, and A.H. Brivanlou Signaling pathways in cancer and embryonic stem cells Stem Cell Rev 3 2007 7 17
    • (2007) Stem Cell Rev , vol.3 , pp. 7-17
    • Dreesen, O.1    Brivanlou, A.H.2
  • 36
    • 69249098573 scopus 로고    scopus 로고
    • A complex role for FGF-2 in self-renewal, survival, and adhesion of human embryonic stem cells
    • L. Eiselleova, K. Matulka, and V. Kriz A complex role for FGF-2 in self-renewal, survival, and adhesion of human embryonic stem cells Stem Cells 27 2009 1847 1857
    • (2009) Stem Cells , vol.27 , pp. 1847-1857
    • Eiselleova, L.1    Matulka, K.2    Kriz, V.3
  • 37
    • 34250206996 scopus 로고    scopus 로고
    • A ROCK inhibitor permits survival of dissociated human embryonic stem cells
    • K. Watanabe, M. Ueno, and D. Kamiya A ROCK inhibitor permits survival of dissociated human embryonic stem cells Nat Biotechnol 25 2007 681 686
    • (2007) Nat Biotechnol , vol.25 , pp. 681-686
    • Watanabe, K.1    Ueno, M.2    Kamiya, D.3
  • 38
    • 0034669139 scopus 로고    scopus 로고
    • Phylogeny of the SOX family of developmental transcription factors based on sequence and structural indicators
    • J. Bowles, G. Schepers, and P. Koopman Phylogeny of the SOX family of developmental transcription factors based on sequence and structural indicators Dev Biol 227 2000 239 255
    • (2000) Dev Biol , vol.227 , pp. 239-255
    • Bowles, J.1    Schepers, G.2    Koopman, P.3
  • 39
    • 0031796252 scopus 로고    scopus 로고
    • Direct interaction of SRY-related protein SOX9 and steroidogenic factor 1 regulates transcription of the human anti-Mullerian hormone gene
    • P. De Santa Barbara, N. Bonneaud, and B. Boizet Direct interaction of SRY-related protein SOX9 and steroidogenic factor 1 regulates transcription of the human anti-Mullerian hormone gene Mol Cell Biol 18 1998 6653 6665
    • (1998) Mol Cell Biol , vol.18 , pp. 6653-6665
    • De Santa Barbara, P.1    Bonneaud, N.2    Boizet, B.3
  • 40
    • 77949388887 scopus 로고    scopus 로고
    • Reduced sox9 function promotes heart valve calcification phenotypes in vivo
    • J.D. Peacock, A.K. Levay, D.B. Gillaspie, G. Tao, and J. Lincoln Reduced sox9 function promotes heart valve calcification phenotypes in vivo Circ Res 106 2010 712 719
    • (2010) Circ Res , vol.106 , pp. 712-719
    • Peacock, J.D.1    Levay, A.K.2    Gillaspie, D.B.3    Tao, G.4    Lincoln, J.5
  • 41
    • 79952027353 scopus 로고    scopus 로고
    • SOX9 controls epithelial branching by activating RET effector genes during kidney development
    • A. Reginensi, M. Clarkson, and Y. Neirijnck SOX9 controls epithelial branching by activating RET effector genes during kidney development Hum Mol Genet 20 2011 1143 1153
    • (2011) Hum Mol Genet , vol.20 , pp. 1143-1153
    • Reginensi, A.1    Clarkson, M.2    Neirijnck, Y.3
  • 43
    • 0031833476 scopus 로고    scopus 로고
    • Progressive lineage analysis by cell sorting and culture identifies FLK1+VE-cadherin + cells at a diverging point of endothelial and hemopoietic lineages
    • S.I. Nishikawa, S. Nishikawa, M. Hirashima, N. Matsuyoshi, and H. Kodama Progressive lineage analysis by cell sorting and culture identifies FLK1+VE-cadherin + cells at a diverging point of endothelial and hemopoietic lineages Development 125 1998 1747 1757
    • (1998) Development , vol.125 , pp. 1747-1757
    • Nishikawa, S.I.1    Nishikawa, S.2    Hirashima, M.3    Matsuyoshi, N.4    Kodama, H.5
  • 44
    • 0030734773 scopus 로고    scopus 로고
    • Expressions of PDGF receptor alpha, c-Kit and Flk1 genes clustering in mouse chromosome 5 define distinct subsets of nascent mesodermal cells
    • H. Kataoka, N. Takakura, and S. Nishikawa Expressions of PDGF receptor alpha, c-Kit and Flk1 genes clustering in mouse chromosome 5 define distinct subsets of nascent mesodermal cells Dev Growth Differ 39 1997 729 740
    • (1997) Dev Growth Differ , vol.39 , pp. 729-740
    • Kataoka, H.1    Takakura, N.2    Nishikawa, S.3
  • 45
    • 33845442108 scopus 로고    scopus 로고
    • Developmental origin of a bipotential myocardial and smooth muscle cell precursor in the mammalian heart
    • S.M. Wu, Y. Fujiwara, and S.M. Cibulsky Developmental origin of a bipotential myocardial and smooth muscle cell precursor in the mammalian heart Cell 127 2006 1137 1150
    • (2006) Cell , vol.127 , pp. 1137-1150
    • Wu, S.M.1    Fujiwara, Y.2    Cibulsky, S.M.3
  • 46
    • 44349175948 scopus 로고    scopus 로고
    • Human cardiovascular progenitor cells develop from a KDR + embryonic-stem-cell-derived population
    • L. Yang, M.H. Soonpaa, and E.D. Adler Human cardiovascular progenitor cells develop from a KDR + embryonic-stem-cell-derived population Nature 453 2008 524 528
    • (2008) Nature , vol.453 , pp. 524-528
    • Yang, L.1    Soonpaa, M.H.2    Adler, E.D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.