The protective effect of Prunella vulgaris ethanol extract against vascular inflammation in TNF-α-stimulated human aortic smooth muscle cells

BMB Reports

Volumn 46, Issue 7, 2013, Pages 352-357

  Park, Sun Haeng ^a   Koo, Hyun Jung ^b   Sung, Yoon Young ^a   Kim, Ho Kyoung ^a  

^a Korea Institute of Oriental Medicine (KIOM)   (South Korea)

^b Gachon University College of Medicine   (South Korea)

Author keywords

Adhesion molecules; Atherosclerosis; Human aortic smooth muscle cells; Inflammation; Prunella vulgaris

Indexed keywords

ANTIINFLAMMATORY AGENT; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; NITRIC OXIDE; PLANT EXTRACT; REACTIVE OXYGEN METABOLITE; TUMOR NECROSIS FACTOR ALPHA; VASCULAR CELL ADHESION MOLECULE 1;

AORTA; ARTICLE; ATHEROSCLEROSIS; CELL LINE; CELL SURVIVAL; CHEMISTRY; CYTOLOGY; DRUG EFFECT; HUMAN; METABOLISM; MONOCYTE; PATHOLOGY; PHOSPHORYLATION; PRUNELLA; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER;

ANTI-INFLAMMATORY AGENTS; AORTA; ATHEROSCLEROSIS; CELL LINE; CELL SURVIVAL; E-SELECTIN; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HUMANS; INTERCELLULAR ADHESION MOLECULE-1; MONOCYTES; MYOCYTES, SMOOTH MUSCLE; NF-KAPPA B; NITRIC OXIDE; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PLANT EXTRACTS; PRUNELLA; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA; VASCULAR CELL ADHESION MOLECULE-1;

EID: 84883807925     PISSN: 19766696     EISSN: 1976670X     Source Type: Journal    
DOI: 10.5483/BMBRep.2013.46.7.214     Document Type: Article

References (35)

1. Kim, J. Y., Park, H. J., Um, S. H., Sohn, E. H,, Kim, B. O., Moon, E. Y., Rhee, D. K. and Pyo, S. (2012) Sulforaphane suppresses vascular adhesion molecule-1 expression in TNF-a-stimulated mouse vascular smooth muscle cells: involvement of the MAPK, NF-κB and AP-1 signaling pathways. Vascul. Pharmacol. 56, 131-141.
2. Braun, M., Pietsch, P., Schrör, K., Baumann, G. and Felix, S. B. (1999) Cellular adhesion molecules on vascular smooth muscle cells. Cardiovasc. Res. 41, 395-401.
3. Libby, P. (2002) Inflammation and Atherosclerosis. Circulation 105, 1135-1143.
4. Spagnoli, L. G., Bonanno, E., Sangiorgi, G. and Mauriello, A. (2007) Role of inflammation in atherosclerosis. J. Nucl. Med. 48, 1800-1815.
5. O'Brien, K. D., McDonald, T. O., Chait, A., Allen, M. D. and Alpers, C. E. (1996) Neovascular expression of E-selectin, intercellular adhesion molecule-1, and vascular cell adhesion molecule-1 in human atherosclerosis and their relation to intimal leukocyte content. Circulation 93, 672-682.
6. O'Brien, K. D., Allen, M. D., McDonald, T. O., Chait, A., Harlan, J. M., Fishbein, D., McCarty, J., Ferguson, M., Hudkins, K. and Benjamin, C. D. (1993) Vascular cell adhesion molecule-1 is expressed in human coronary atherosclerotic plaques. Implications for the mode of progression of advanced coronary atherosclerosis. J. Clin. Invest. 92, 945-951.
7. Chung, H. K., Lee, I. K., Kang, H., Suh, J. M., Kim, H., Park, K. C., Kim, D. W., Kim, Y. K., Ro, H. K. and Shong, M. (2002) Statin inhibits interferon-gamma-induced expression of intercellular adhesion molecule-1 (ICAM-1) in vascular endothelial and smooth muscle cells. Exp. Mol. Med. 34, 451-461.
8. Kwon, J. S., Joung, H., Kim, Y. S., Shim, Y. S., Ahn, Y., Jeong, M. H. and Kee, H. J. (2012) Sulforaphane inhibits restenosis by suppressing inflammation and the proliferation of vascular smooth muscle cells. Atherosclerosis 84, 767-801.
9. Jang, Y., Lincoff, A. M., Plow, E. F. and Topol, E. J. (1994) Cell adhesion molecules in coronary artery disease. J. Am. Coll. Cardiol. 24, 1591-1601.
10. Davies, M. J., Gordon, J. L., Gearing, A. J., Pigott, R., Woolf, N., Katz, D. and Kyriakopoulos, A. (1993) The expression of the adhesion molecules ICAM-1, VCAM-1, PECAM, and E-selectin in human atherosclerosis. J. Pathol. 171, 223-229.
11. Libby, P. and Li, H. (1993) Vascular cell adhesion molecule-1 and smooth muscle cell activation during atherogenesis. J. Clin. Invest. 92, 538-539.
12. Printseva, O., Yu., Peclo, M. M. and Gown, A. M. (1992) Various cell types in human atherosclerotic lesions express ICAM-1. Further immunocytochemical and immunochemical studies employing monoclonal antibody 10F3. Am. J. Pathol. 140, 889-896.
13. Huo, Y. and Ley, K. (2001) Adhesion molecules and atherogenesis. Acta. Physiol. Scand. 173, 35-43.
14. Park, S. H., Kim, J. H., Park, S. J., Bae, S. S., Choi, Y. W., Hong, J. W., Choi, B. T. and Shin, H. K. (2011) Protective effect of hexane extracts of Uncaria sinensis against photothrombotic ischemic injury in mice. J. Ethnopharmacol. 138, 774-779.
15. Yang, W. K., Sung, Y. Y. and Kim, H. K. (2011) Anti-thrombotic and Anti-platelet Activity of Extract from Prunelly vulgaris. J. Life. Sci. 21, 1422-1427.
16. Skottová, N., Kazdová, L., Oliyarnyk, O., Vecera, R., Sobolová, L. and Ulrichová, J. (2004) Phenolics-rich extracts from Silybum marianum and Prunella vulgaris reduce a high-sucrose diet induced oxidative stress in hereditary hypertriglyceridemic rats. Pharmacol. Res. 50, 123-130.
17. Liu, F. and Ng, T. B. (2000) Anti-oxidantive and free radical scavenging activities of selected medicinal herbal. Life. Sci. 66, 725-735.
18. Zheng, J., He, J., Ji, B., Li, Y. and Zhang, X. (2007) Antihyperglycemic activity of Prunella vulgaris L. in streptozotocin-induced diabetic mice. Asia. Pac. J. Clin. Nutr. 16, 427-431.
19. Ouchi, N., Kihara, S., Arita, Y., Maeda, K., Kuriyama, H., Okamoto, Y., Hotta, K., Nishida, M., Takahashi, M., Nakamura, T., Yamashita, S., Funahashi, T. and Matsuzawa, Y. (1999) Novel modulator for endothelial adhesion molecules: adipocyte-derived plasma protein adiponectin. Circulation 25, 2473-2476.
20. Lee, C. H., Yi, H. S., Kim, J. E., Heo, S. K. Cha, C. M., Won, C. W. and Park, S. D. (2009) Anti-oxidative and anti-inflammatory effect of fractionated extracts of smilacis glabrae rhizoma in human umbilical vein endothelial cell. Korean J. Herbology. 24, 39-50.
21. Marx, N., Neumann, F. J., Zohlnhöfer, D., Dickfeld, T., Fischer, A., Heimerl, S. and Schömig, A. (1998) Enhancement of monocyte procoagulant activity by adhesion on vascular smooth muscle cells and intercellular adhesion molecule-1-transfected Chinese hamster ovary cells. Circulation 98, 906-911.
22. Ross, R. (1993) The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature 362, 801-809.
23. Moon, M. K., Kang, D. G., Lee, Y. J., Kim, J. S. and Lee, H. S. (2009) Effect of Benincasa hispida Cogniaux on high glucose-induced vascular inflammation of human umbilical vein endothelial cells. Vascul. Pharmacol. 50, 116-122.
24. Byeon, H. E., Park, B. K., Yim, J. H., Lee, H. K., Moon, E. Y., Rhee, D. K. and Pyo, S. (2012) Stereocalpin A inhibits the expression of adhesion molecules in activated vascular smooth muscle cells. Int. Immunopharmacol. 2, 315-325.
25. Qin, P., Tang, X., Elloso, M. M. and Harnish, D. C. (2006) Bile acids induce adhesion molecule expression in endothelial cells through activation of reactive oxygen species, NF-kappaB, and p38. Am. J. Physiol. Heart Circ. Physiol. 2, H741-H747.
26. Gosset, P., Wallaert, B., Tonnel, A. B. and Fourneau, C. (1999) Thiol regulation of the production of TNF-a, IL-6 and IL-8 by human alveolar macrophages. Eur. Respir. J. 1, 98-105.
27. Gupta, A., Rosenberger, S. F. and Bowden, G. T. (1999) Increased ROS levels contribute to elevated transcription factor and MAP kinase activities in malignantly progressed mouse keratinocyte cell lines. Carcinogenesis 11, 2063-2073.
28. Park, J. G. and Oh, G. T. (2011) The role of peroxidases in the pathogenesis of atherosclerosis. BMB Rep. 8, 497-505.
29. Kim, J. S., Kang, S. S., Lee, K. S., Jang, S. Y. and Won, D. H. (2000) Quantitative Determination of ursolic acid from Prunellae Herba. Korean J. pharmacogn. 4, 426-420.
30. Pozo, M., Castilla, V., Gutierrez, C., de Nicolás, R., Egido, J. and González-Cabrero, J. (2006) Ursolic acid inhibits neointima formation in the rat carotid artery injury model. Atherosclerosis 1, 53-62.
31. Liu, J. (1995) harmacology of oleanolic acid and ursolic acid. J. Ethnopharmacol. 49, 57-68.
32. Ullevig, S. L., Zhao, Q., Zamora, D. and Asmis, R. (2011) Ursolic acid protects diabetic mice against monocyte dysfunction and accelerated atherosclerosis. Atherosclerosis 2, 109-116.
33. Wu, H., Gao, M., Ha, T., Kelley, J., Young, A. and Breuel, K. (2012) Prunella vulgaris aqueous extract attenuates IL-1ß-induced apoptosis and NF-κB activation in INS-1 cells. Exp. Ther. Med. 3, 919-924.
34. Tsuchiya, S., Yamabe, M., Yamaguchi, Y., Kobayashi, Y., Konno, T. and Tada, K. (1980) Establishment and characterization of a human acute monocytic leukemia cell line (THP-1). Int. J. Cancer 26, 171-176.
35. Chen, C., Chou, C., Sun, Y. and Huang, W. (2001) Tumor necrosis factor alpha-induced activation of downstream NF-kappaB site of the promoter mediates epithelial ICAM-1 expression and monocyte adhesion. Involvement of PKCalpha, tyrosine kinase, and IKK2, but not MAPKs. Cell Signal. 13, 543-553.