Cultured mast cells from patients with asthma and controls respond with similar sensitivity to recombinant Der P2-Induced, IgE-mediated activation

Scandinavian Journal of Immunology

Volumn 78, Issue 4, 2013, Pages 352-356

  Krohn, I K ^a   Sverrild, A ^b   Lund, G ^c   Dahl, R ^d   Erjefalt J S ^e   Backer, V ^b   Hoffmann, H J ^a,d  

^a AARHUS UNIVERSITY HOSPITAL   (Denmark)

^b Bipsebjerg University Hospital   (Denmark)

^c ALK ABELLÓ   (Denmark)

^d AARHUS UNIVERSITY   (Denmark)

^e LUND UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ALLERGEN; DER P2; IMMUNOGLOBULIN E; INTERLEUKIN 4; UNCLASSIFIED DRUG;

ADULT; ALLERGIC REACTION; ARTICLE; ASTHMA; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IMMUNE RESPONSE; IN VITRO STUDY; INCUBATION TIME; MALE; MAST CELL; MITE; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION;

ADULT; ANTIGENS, CD63; ANTIGENS, DERMATOPHAGOIDES; ARTHROPOD PROTEINS; ASTHMA; CELLS, CULTURED; FEMALE; HUMANS; HYPERSENSITIVITY, IMMEDIATE; IMMUNOGLOBULIN E; INTERLEUKIN-4; MALE; MAST CELLS; MIDDLE AGED; RECOMBINANT PROTEINS; SKIN TESTS; YOUNG ADULT;

EID: 84883805818     PISSN: 03009475     EISSN: 13653083     Source Type: Journal    
DOI: 10.1111/sji.12085     Document Type: Article

References (21)

1. Yanagida M, Fukamachi H, Ohgami K et al. Effects of T-helper 2-type cytokines, interleukin-3 (IL-3), IL-4, IL-5, and IL-6 on the survival of cultured human mast cells. Blood 1995;86:3705-14.
2. Wiener Z, Falus A, Toth S. IL-9 increases the expression of several cytokines in activated mast cells, while the IL-9-induced IL-9 production is inhibited in mast cells of histamine-free transgenic mice. Cytokine 2004;26:122-30.
3. Toru H, Ra C, Nonoyama S, Suzuki K, Yata J, Nakahata T. Induction of the high-affinity IgE receptor (Fc epsilon RI) on human mast cells by IL-4. Int Immunol 1996;8:1367-73.
4. Mirkina I, Schweighoffer T, Kricek F. Inhibition of human cord blood-derived mast cell responses by anti-Fc epsilon RI mAb 15/1 versus anti-IgE Omalizumab. Immunol Lett 2007;109:120-8.
5. Hoffmann HJ, Frandsen PM, Christensen LH, Schiøtz PO, Dahl R. Cultured Human Mast Cells Are Heterogeneous for Expression of the High-Affinity IgE Receptor FcεRI. Int Arch Allergy Immunol 2012;157:246-50.
6. Kawakami T, Galli SJ. Regulation of mast-cell and basophil function and survival by IgE. Nat Rev Immunol 2002;2:773-86.
7. Christensen LH, Holm J, Lund G, Riise E, Lund K. Several distinct properties of the IgE repertoire determine effector cell degranulation in response to allergen challenge. J Allergy Clin Immunol 2008;122:298-304.
8. Knol EF, Mul FP, Jansen H, Calafat J, Roos D. Monitoring human basophil activation via CD63 monoclonal antibody 435. J Allergy Clin Immunol 1991;88(3 Pt 1):328-38.
9. Krohn IK, Lund G, Frandsen PM, Schiøtz PO, Dahl R, Hoffmann HJ. Mast Cell FcεRI Density and Function Dissociate from Dependence on Soluble IgE Concentration at Very Low and Very High IgE Concentrations. J Asthma 2013;50:117-21.
10. Andersen HB, Holm M, Hetland TE et al. Comparison of short term in vitro cultured human mast cells from different progenitors - Peripheral blood-derived progenitors generate highly mature and functional mast cells. J Immunol Methods 2008;336:166-74.
11. Holm M, Andersen HB, Hetland TE et al. Seven week culture of functional human mast cells from buffy coat preparations. J Immunol Methods 2008;336:213-21.
12. Bateman ED, Hurd SS, Barnes PJ et al. Global strategy for asthma management and prevention: GINA executive summary. Eur Respir J 2008;31:143-78.
13. Bousquet J, Schünemann HJ, Samolinski B et al. Allergic Rhinitis and its Impact on Asthma (ARIA): achievements in 10 years and future needs. J Allergy Clin Immunol 2012;130:1049-62.
14. Andersson CK, Mori M, Bjermer L, Löfdahl C-G, Erjefält JS. Novel site-specific mast cell subpopulations in the human lung. Thorax 2009;64:297-305.
15. Casale TB, Wood D, Richerson HB, Zehr B, Zavala D, Hunninghake GW. Direct evidence of a role for mast cells in the pathogenesis of antigen-induced bronchoconstriction. J Clin Invest 1987;80:1507-11.
16. Andersson CK, Bergqvist A, Mori M, Mauad T, Bjermer L, Erjefält JS. Mast cell-associated alveolar inflammation in patients with atopic uncontrolled asthma. J Allergy Clin Immunol 2011;127:905-12.e1-7.
17. Andersson CK, Tufvesson E, Aronsson D et al. Alveolar mast cells shift to an FcεRI-expressing phenotype in mild atopic asthma: a novel feature in allergic asthma pathology. Allergy 2011;66:1590-7.
18. Bühring HJ, Seiffert M, Bock TA et al. Expression of novel surface antigens on early hematopoietic cells. Ann N Y Acad Sci. 1999;872:25-38; discussion 38-39.
19. Sehmi R, Howie K, Sutherland DR, Schragge W, O'Byrne PM, Denburg JA. Increased levels of CD34+ hemopoietic progenitor cells in atopic subjects. Am J Respir Cell Mol Biol. 1996;15:645-55.
20. Klink M, Cline MG, Halonen M, Burrows B. Problems in defining normal limits for serum IgE. J Allergy Clin Immunol 1990;85:440-4.
21. Johansson SGO, Nopp A, Oman H et al. The size of the disease relevant IgE antibody fraction in relation to "total-IgE" predicts the efficacy of anti-IgE (Xolair) treatment. Allergy 2009;64:1472-7.