Alveolar mast cells shift to an FceRI-expressing phenotype in mild atopic asthma: A novel feature in allergic asthma pathology

Allergy: European Journal of Allergy and Clinical Immunology

Volumn 66, Issue 12, 2011, Pages 1590-1597

  Andersson, C K ^a   Tufvesson, E ^a   Aronsson, D ^a   Bergqvist, A ^a   Mori, M ^b   Bjermer, L ^a   Erjefalt J S ^a,b  

^a LUND UNIVERSITY   (Sweden)

^b LUND UNIVERSITY   (Sweden)

Author keywords

Alveolar; Asthma; FceRI; IgE; Mast cell

Indexed keywords

IMMUNOGLOBULIN E; IMMUNOGLOBULIN E RECEPTOR; METHACHOLINE; NITRIC OXIDE;

ADULT; ALLERGIC ASTHMA; ALLERGIC RHINITIS; ARTICLE; BRONCHOSCOPY; BRONCHUS HYPERREACTIVITY; CLINICAL ARTICLE; CLINICAL ASSESSMENT TOOL; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; HUMAN; HUMAN TISSUE; HYPOTHESIS; IMMUNOHISTOCHEMISTRY; LUNG ALVEOLUS; MALE; MAST CELL; METHACHOLINE INHALATION CHALLENGE TEST; OSCILLOMETRY; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; SPIROMETRY;

ADULT; ASTHMA; FEMALE; HUMANS; IMMUNOGLOBULIN E; MALE; MAST CELLS; MIDDLE AGED; PHENOTYPE; PULMONARY ALVEOLI; RECEPTORS, IGE; YOUNG ADULT;

EID: 82955219678     PISSN: 01054538     EISSN: 13989995     Source Type: Journal    
DOI: 10.1111/j.1398-9995.2011.02723.x     Document Type: Article

References (29)

1. Bradding P, Walls AF, Holgate ST. The role of the mast cell in the pathophysiology of asthma. J Allergy Clin Immunol 2006;117:1277-1284. (Pubitemid 43795741)
2. Andersson CK, Mori M, Bjermer L, Lofdahl CG, Erjefalt JS. Novel site-specific mast cell subpopulations in the human lung. Thorax 2009;64:297-305.
3. Carroll NG, Mutavdzic S, James AL. Distribution and degranulation of airway mast cells in normal and asthmatic subjects. Eur Respir J Official Journal of the European Society for Clinical Respiratory Physiology 2002;19:879-885. (Pubitemid 34567902)
4. Andersson CK, Bergqvist A, Mori M, Mauad T, Bjermer L, Erjefalt JS. Mast cell-associated alveolar inflammation in patients with atopic uncontrolled asthma. J Allergy Clin Immunol 2011;127:905.e1-7-912.e1-7.
5. Guerra S, Sherrill DL, Martinez FD, Barbee RA. Rhinitis as an independent risk factor for adult-onset asthma. J Allergy Clin Immunol 2002;109:419-425. (Pubitemid 34234190)
6. Linneberg A, Henrik Nielsen N, Frolund L, Madsen F, Dirksen A, Jorgensen T. The link between allergic rhinitis and allergic asthma: a prospective population-based study. The Copenhagen Allergy Study. Allergy 2002;57:1048-1052. (Pubitemid 35238642)
7. Settipane RJ, Hagy GW, Settipane GA. Long-term risk factors for developing asthma and allergic rhinitis: a 23-year fol-low-up study of college students. Allergy Proc 1994;15:21-25.
8. Leynaert B, Neukirch C, Kony S, Guenegou A, Bousquet J, Aubier M et al. Association between asthma and rhinitis according to atopic sensitization in a population-based study. J Allergy Clin Immunol 2004;113:86-93. (Pubitemid 38096166)
9. Alvarez MJ, Olaguibel JM, Garcia BE, Rodriquez A, Tabar AI, Urbiola E. Airway inflammation in asthma and perennial allergic rhinitis. Relationship with nonspecific bronchial responsiveness and maximal airway narrowing. Allergy 2000;55:355-362. (Pubitemid 30183054)
10. Bachert C, Vignola AM, Gevaert P, Leynaert B, Van Cauwenberge P, Bousquet J. Allergic rhinitis, rhinosinusitis, and asthma: one airway disease. Immunol Allergy Clin North Am 2004;24:19-43. (Pubitemid 38210301)
11. Tufvesson E, Aronsson D, Ankerst J, George SC, Bjermer L. Peripheral nitric oxide is increased in rhinitic patients with asthma compared to bronchial hyperrespon-siveness. Respir Med 2007;101:2321-2326. (Pubitemid 47471401)
12. Aronsson D, Tufvesson E, Ankerst J, Bjermer L. Allergic rhinitis with hyper-responsiveness differ from asthma in degree of peripheral obstruction during metacholine challenge test. Clin Physiol Funct Imaging 2008;28:81-85. (Pubitemid 351247312)
13. Bousquet J, Khaltaev N, Cruz AA, Denburg J, Fokkens WJ, Togias A et al. Allergic rhinitis and its impact on asthma (ARIA) 2008 update (in collaboration with the World Health Organization, GA(2)LEN and AllerGen). Allergy 2008;63(Suppl 86):8-160. (Pubitemid 351357811)
14. Global Initiative for Asthma. GINA report, global strategy for asthma management and prevention. Available from http://www.ginasthma.com. 2006 [cited 2010 29 April].
15. Crapo RO, Morris AH, Gardner RM. Reference spirometric values using techniques and equipment that meet ATS recommendations. Am Rev Resp Dis 1981;123:659-664. (Pubitemid 11117589)
16. Cai Y, Bjermer L, Halstensen TS. Bronchial mast cells are the dominating LTC4S-expressing cells in aspirin-tolerant asthma. Am J Respir Cell Mol Biol 2003;29:683-693. (Pubitemid 38045937)
17. Andersson CK, Mori M, Bjermer L, Lofdahl CG, Erjefalt JS. Alterations in lung mast cell populations in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2010;181:206-217.
18. Balzar S, Strand M, Rhodes D, Wenzel SE. IgE expression pattern in lung: relation to systemic IgE and asthma phenotypes. J Allergy Clin Immunol 2007;119:855-862. (Pubitemid 46546425)
19. Humbert M, Grant JA, Taborda-Barata L, Durham SR, Pfister R, Menz G et al. High-affinity IgE receptor (FcepsilonRI)-bearing cells in bronchial biopsies from atopic and nonatopic asthma. Am J Respir Crit Care Med 1996;153(6 Pt 1):1931-1937. (Pubitemid 26187923)
20. Balzar S, Chu HW, Strand M, Wenzel S. Relationship of small airway chymase-positive mast cells and lung function in severe asthma. Am J Respir Crit Care Med 2005;171:431-439. (Pubitemid 40444242)
21. Hauber HP, Gotfried M, Newman K, Danda R, Servi RJ, Christodoulopoulos P et al. Effect of HFA-flunisolide on peripheral lung inflammation in asthma. J Allergy Clin Immunol 2003;112:58-63. (Pubitemid 36819807)
22. Kraft M, Djukanovic R, Wilson S, Holgate ST, Martin RJ. Alveolar tissue inflammation in asthma. Am J Respir Crit Care Med 1996;154:1505-1510. (Pubitemid 26391205)
23. Fischer M, Harvima IT, Carvalho RF, Moller C, Naukkarinen A, Enblad G et al. Mast cell CD30 ligand is upregulated in cutaneous inflammation and mediates degranulation-independent chemokine secretion. J Clin Invest 2006;116:2748-2756. (Pubitemid 44511638)
24. Tufvesson E, Aronsson D, Bjermer L. Cysteinyl-leukotriene levels in sputum differentiate asthma from rhinitis patients with or without bronchial hyperresponsiveness. Clin Exp Allergy 2007;37:1067-1073. (Pubitemid 46955523)
25. Hamid Q, Tulic MK. New insights into the pathophysiology of the small airways in asthma. Ann Thorac Med 2007;2:28-33.
26. Martin RJ. Therapeutic significance of distal airway inflammation in asthma. J Allergy Clin Immunol 2002;2(Suppl):S447-S460. (Pubitemid 34155294)
27. Schechter NM, Irani AM, Sprows JL, Abernethy J, Wintroub B, Schwartz LB. Identification of a cathepsin G-like proteinase in the MCTC type of human mast cell. J Immunol 1990;145:2652-2661. (Pubitemid 20374592)
28. Buckley MG, McEuen AR, Walls AF. The detection of mast cell subpopulations in formalin-fixed human tissues using a new monoclonal antibody specific for chymase. J Pathol 1999;189:138-143. (Pubitemid 29406831)
29. Cooper D, Hales J, Camp R. IgE-dependent activation of T cells by allergen in atopic dermatitis: pathophysiologic relevance. J Invest Dermatol 2004;123:1086-1091. (Pubitemid 39586831)