Cultured Human Mast Cells Are Heterogeneous for Expression of the High-Affinity IgE Receptor Fc ε RI

International Archives of Allergy and Immunology

Volumn 157, Issue 3, 2012, Pages 246-250

  Hoffmann, Hans Jürgen ^a   Frandsen, Pernille Munk ^a   Christensen, Lars Harder ^b   Schiøtz, Peter Oluf ^a   Dahl, Ronald ^a  

^a AARHUS UNIVERSITY HOSPITAL   (Denmark)

^b ALK ABELLÓ   (Denmark)

Author keywords

Anti IgE; CD203c; CD63; Cultured human mast cells; Fc RI; Histamine; IL 4; Mast cell phenotype

Indexed keywords

CD133 ANTIGEN; CD63 ANTIGEN; FC RECEPTOR; IMMUNOGLOBULIN E ANTIBODY; IMMUNOGLOBULIN E RECEPTOR;

ARTICLE; CELL CULTURE; CONTROLLED STUDY; HUMAN; HUMAN CELL; MAST CELL; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN STABILITY; RECEPTOR AFFINITY; RECEPTOR DENSITY; RECEPTOR UPREGULATION; UMBILICAL CORD BLOOD;

ANTIBODIES, ANTI-IDIOTYPIC; ANTIGENS, CD63; CELLS, CULTURED; FETAL BLOOD; HEMATOPOIETIC STEM CELLS; HUMANS; IMMUNOGLOBULIN E; INTERLEUKIN-4; MAST CELLS; PHOSPHORIC DIESTER HYDROLASES; PYROPHOSPHATASES; RECEPTORS, IGE; TRYPTASES; UP-REGULATION;

EID: 80054971708     PISSN: 10182438     EISSN: 14230097     Source Type: Journal    
DOI: 10.1159/000328756     Document Type: Article

References (26)

1. Craig SS, Schwartz LB: Tryptase and chymase, markers of distinct types of human mast cells. Immunol Res 1989; 8: 130-148. (Pubitemid 19135916)
2. Irani AM, Schwartz LB: Human mast cell heterogeneity. Allergy Proc 1994; 15: 303-308.
3. Kitamura Y: Heterogeneity of mast cells and phenotypic change between subpopulations. Annu Rev Immunol 1989; 7: 59-76. (Pubitemid 19138007)
4. Oskeritzian CA, Zhao W, Min HK, Xia HZ, Pozez A, Kiev J, et al: Surface CD88 functionally distinguishes the MCTC from the MCT type of human lung mast cell. J Allergy Clin Immunol 2005; 115: 1162-1168. (Pubitemid 40824584)
5. Godfraind C, Louahed J, Faulkner H, Vink A, Warnier G, Grencis R, et al: Intraepithelial infiltration by mast cells with both connective tissue-type and mucosal-type characteristics in gut, trachea, and kidneys of IL-9 transgenic mice. J Immunol 1998; 160: 3989-3996. (Pubitemid 28176107)
6. Andersson CK, Mori M, Bjermer L, Löfdahl CG, Erjefält JS: Novel site-specific mast cell subpopulations in the human lung. Thorax 2009; 64: 297-305.
7. Hasegawa M, Nishiyama C, Nishiyama M, Akizawa Y, Takahashi K, Ito T, et al: Regulation of the human Fc epsilon RI alpha-chain distal promoter. J Immunol 2003; 170: 3732-3738. (Pubitemid 36359243)
8. Macglashan D: IgE and Fc{epsilon}RI regulation. Ann NY Acad Sci 2005; 1050: 73-88.
9. Gomez G, Jogie-Brahim S, Shima M, Schwartz LB: Omalizumab reverses the phenotypic and functional effects of IgE-enhanced Fc epsilonRI on human skin mast cells. J Immunol 2007; 179: 1353-1361.
10. Knol EF, Mul FP, Jansen H, Calafat J, Roos D: Monitoring human basophil activation via CD63 monoclonal antibody 435. J Allergy Clin Immunol 1991; 88: 328-338.
11. Bühring HJ, Streble A, Valent P: The basophil-specific ectoenzyme E-NPP3 (CD203c) as a marker for cell activation and allergy diagnosis. Int Arch Allergy Immunol 2004; 133: 317-329. (Pubitemid 38490210)
12. Macglashan D: Expression of CD203c and CD63 in human basophils: Relationship to differential regulation of piecemeal and anaphylactic degranulation processes. Clin Exp Allergy 2010; 40: 1365-1377.
13. Mikkelsen S, Bibby BM, Dolberg MK, Dahl R, Hoffmann HJ: Basophil sensitivity through CD63 or CD203c is a functional measure for specific immunotherapy. Clin Mol Allergy 2010; 8: 2.
14. Mirkina I, Schweighoffer T, Kricek F: Inhibition of human cord blood-derived mast cell responses by anti-Fc epsilon RI mAb 15/1 versus anti-IgE Omalizumab. Immunol Lett 2007; 109: 120-128. (Pubitemid 46452748)
15. MacGlashan DW, Bochner BS, Adelman DC, Jardieu PM, Togias A, McKenzie-White J, et al: Down-regulation of Fc(epsilon)RI expression on human basophils during in vivo treatment of atopic patients with anti-IgE antibody. J Immunol 1997; 158: 1438-1445. (Pubitemid 127469971)
16. Holm M, Andersen HB, Hetland TE, Dahl C, Hoffmann HJ, Junker S, et al: Seven week culture of functional human mast cells from buffy coat preparations. J Immunol Methods 2008; 336: 213-221.
17. Andersen HB, Holm M, Hetland TE, Dahl C, Junker S, Schiøtz PO, et al: Comparison of short term in vitro cultured human mast cells from different progenitors -peripheral blood-derived progenitors generate highly mature and functional mast cells. J Immunol Methods 2008; 336: 166-174.
18. Lee JA, Spidlen J, Boyce K, Cai J, Crosbie N, Dalphin M, et al: MIFlowCyt: The minimum information about a flow cytometry experiment. Cytometry A 2008; 73: 926-930.
19. Roederer M, Hardy RR: Frequency difference gating: A multivariate method for identifying subsets that differ between samples. Cytometry 2001; 45: 56-64. (Pubitemid 32807924)
20. Johansson SG, Nopp A, Oman H, Ankerst J, Cardell LO, Grönneberg R, et al: The size of the disease relevant IgE antibody fraction in relation to 'total-IgE' predicts the efficacy of anti-IgE (Xolair) treatment. Allergy 2009; 64: 1472-1477.
21. Gould HJ, Sutton BJ: IgE in allergy and asthma today. Nat Rev Immunol 2008; 8: 205-217. (Pubitemid 351323292)
22. MacGlashan D, McKenzie-White J, Chichester K, Bochner BS, Davis FM, Schroeder JT, et al: In vitro regulation of FcepsilonRIalpha expression on human basophils by IgE antibody. Blood 1998; 91: 1633-1643. (Pubitemid 28110328)
23. MacGlashan DW: Endocytosis, recycling, and degradation of unoccupied FcepsilonRI in human basophils. J Leukoc Biol 2007; 82: 1003-1010.
24. Pols MS, Klumperman J: Trafficking and function of the tetraspanin CD63. Exp Cell Res 2009; 315: 1584-1592.
25. Hauswirth AW, Escribano L, Prados A, Nuñez R, Mirkina I, Kneidinger M, et al: CD203c is overexpressed on neoplastic mast cells in systemic mastocytosis and is upregulated upon IgE receptor cross-linking. Int J Immunopathol Pharmacol 2008; 21: 797-806.
26. Hoffmann HJ, Bøgebjerg M, Nielsen LP, Dahl R: Lysis with Saponin improves detection of the response through CD203c and CD63 in the basophil activation test after crosslinking of the high affinity IgE receptor FcepsilonRI. Clin Mol Allergy 2005; 3: 10.